Abstract：
:Serum amino acid levels were determined in 29 patients with severe chronic active liver disease before, during, and after administration of prednisone or placebo and in 22 healthy controls. The pretreatment molar ratio of amino acids was less in patients than in controls (p less than 0.001) and was lower in those with cirrhosis (p less than 0.02). Branched-chain amino acid levels were elevated in patients without cirrhosis (p less than 0.02) but not in those with cirrhosis; aromatic amino acid concentrations were increased in all (p less than 0.01). The ratio improved with remission and predicted behavior after discontinuation of treatment. Patients who deteriorated failed to improve the ratio and those whose ratio improved incompletely relapsed. The ratio correlated with histologic severity and serum concentrations of albumin, bilirubin, and gamma-globulin and not with clinical manifestations of encephalopathy. We conclude that amino acid abnormalities reflect liver dysfunction and that normalization of the molar ratio may have therapeutic and prognostic significance.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
McCullough AJ,Czaja AJ,Jones JD,Go VLsubject
Has Abstractpub_date
1981-10-01 00:00:00pages
645-52issue
4eissn
0016-5085issn
1528-0012pii
S0016508581002126journal_volume
81pub_type
临床试验,杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:The 70-kb pYV plasmid of Yersinia enterocolitica directs the synthesis and secretion of several virulence determinants called Yops. These proteins are produced during the invasion of the host tissues and induce a strong antibody response. The yop genes are transcribed from strong promoters activated by a common transc...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90842-m
更新日期：1992-08-01 00:00:00
abstract：:We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...
journal_title：Gastroenterology
pub_type： 社论
doi：10.1053/j.gastro.2012.08.009
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND & AIMS:Spontaneous hepatitis B surface antigen (HBsAg) seroclearance is a rare event in patients with chronic hepatitis B virus infection. The aim of this study was to clarify the controversy on long-term prognosis following spontaneous HBsAg seroclearance using a large series of patients. METHODS:A total o...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.36026
更新日期：2002-10-01 00:00:00
abstract：:Liver disease with inclusions of copper was recognized among 30 rural workers with "vineyard sprayer's lung." The pathological findings were varied: focal or diffuse swelling and proliferation of Kupffer cells; histiocytic and sarcoid-like granulomata; fibrosis of variable degree in the perisinusoidal, portal, and sub...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-02-01 00:00:00
abstract：:The hemodynamic effects of octreotide were studied in 20 patients with hepatitis B-related cirrhosis. In patients receiving a 100-micrograms bolus and a 100-micrograms/h infusion, heart rate, cardiac index, and systemic vascular resistance showed no significant changes, whereas right atrial pressure, pulmonary capilla...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91117-m
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND & AIMS:Guidelines for the management of venous thromboembolism (VTE) from the American College of Chest Physicians do not address patients with inflammatory bowel disease (IBD), a group with a high risk of both VTE and gastrointestinal bleeding. We present recommendations for the prevention and treatment of ...
journal_title：Gastroenterology
pub_type： 共识发展会议,杂志文章,评审
doi：10.1053/j.gastro.2014.01.042
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND & AIMS:Cholangiocarcinomas appear to arise from the malignant transformation of cholangiocytes lining the biliary tract. Because the development of an in vitro model of malignant transformation can provide a powerful new tool for establishing critical events governing the molecular pathogenesis of cholangioc...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.10.010
更新日期：2005-12-01 00:00:00
abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90872-3
更新日期：1986-04-01 00:00:00
abstract：:A prospective, randomized, controlled experiment using a canine model of severely bleeding gastric ulcer was performed to compare the hemostatic efficacy and tissue damage produced by one bipolar and two monopolar electrodes. Both monopolar electrodes were insulated to their tips; they differed with respect to their s...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-03-01 00:00:00
abstract：BACKGROUND & AIMS:Most previous population-based studies of mortality in inflammatory bowel disease (IBD) did not account for medication use. We evaluated mortality by IBD medication use among members of the Kaiser Permanente Northern California IBD Registry. METHODS:The retrospective, population-based cohort study in...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.09.022
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND & AIMS:The cytokine macrophage migration inhibitory factor (MIF) is expressed throughout the human gastrointestinal tract. Recently, protumorigenic activity of MIF has been described in several cancer models. Therefore, we investigated the expression and function of MIF during the early stages of intestinal ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.07.061
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND & AIMS:Immune responses to innocuous intestinal antigens appear tightly controlled by regulatory T lymphocytes. While CD4+ T lymphocytes have recently attracted the most attention, CD8+ regulatory T-cell populations are also believed to play an important role in control of mucosal immunity. However, CD8+ reg...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2006.09.008
更新日期：2006-12-01 00:00:00
abstract：:Jejunal absorption of acetate, propionate, and butyrate--the three predominant short chain fatty acids (SCFA's) in small and large intestinal contents--was studied in 5 volunteer subjects. A triple-lumen perfusion technique was employed; the test solutions were isotonic and contained 0, 5, 10, 25, 40, or 50 mM of a SC...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-02-01 00:00:00
abstract：:The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90065-6
更新日期：1989-08-01 00:00:00
abstract：:This report describes a 59-year-old woman, who, after an initial reaction to hydralazine, inadvertently took the drug again. She promptly developed symptoms of acute cholangitis--fever, right upper quadrant tenderness, obtundation, and hypotension. Cholecystectomy was performed and no obstruction or infection of the b...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：BACKGROUND & AIMS:Hemosiderosis may have a detrimental effect on some chronic liver diseases. The aim of this study was to determine the prevalence and diagnostic implications of hemosiderosis in cirrhosis. METHODS:Tissue iron in 447 cirrhotic livers was studied histologically and chemically. RESULTS:Positive iron st...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1997.v112.pm9041250
更新日期：1997-03-01 00:00:00
abstract：BACKGROUND & AIMS:Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(00)70148-x
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND & AIMS:SPD476 (LIALDA in the US; MEZAVANT in the EU; otherwise known as MMX mesalamine; Shire Pharmaceuticals Inc., Wayne, PA, under license from Giuliani SpA, Milan, Italy) is a novel, once-daily, high-strength (1.2 g/tablet) formulation of mesalamine, utilizing MMX Multi Matrix System (MMX) technology desi...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1053/j.gastro.2006.10.011
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.07.046
更新日期：2011-11-01 00:00:00
abstract：:Electromyogram of the submental muscles, esophageal manometry, and pH studies were simultaneously performed in an unselected group of 12 patients with subjective and objective evidence of gastroesophageal reflux (GER) disease to determine the frequency of transient relaxation of the lower esophageal sphincter (LES) an...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(88)80003-9
更新日期：1988-09-01 00:00:00
abstract：:Fifteen (2.2%) of 693 patients with cystic fibrosis seen over an 18-year period developed clinical hepatic disease. In 13 patients all symptoms were secondary to portal hypertension. Ten had hypersplenism and 6 had variceal bleeding, including 3 who developed both conditions. All 5 patients who survived the initial ep...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：:Intestinal microbes regulate metabolic function and energy balance; an altered microbial ecology is believed to contribute to the development of several metabolic diseases. Relative species abundance and metabolic characteristics of the intestinal microbiota change substantially in those who are obese or have other me...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2014.02.008
更新日期：2014-05-01 00:00:00
abstract：:Propulsion of colonic contents after eating in the whole colon was studied in 15 volunteers by scintigraphy with injection of 111In-diethylenetriamine-pentaacetic acid and 99mTc-sulfur colloid into the colon through a nasogastric tube. The radionuclide was injected into the cecoascending colon (n = 7), the hepatic fle...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91098-o
更新日期：1992-07-01 00:00:00
abstract：:A possible role of insulinlike growth factor I (IGF-I) and IGF-I receptors in the proliferation of human colon cancer has, to the best of the authors' knowledge, not been examined as yet. To determine a role of IGF-I in colon cancer, several human colon cancer cell lines and colon cancers were screened for specific bi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND & AIMS:Therapy with interferon alfa (IFN-alpha) leads to remission of disease in one third of patients with chronic hepatitis B. The aim of this study was to better define the long-term prognosis of this outcome. METHODS:One hundred three patients with chronic hepatitis B who underwent IFN-alpha therapy in ...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/gast.1997.v113.pm9352870
更新日期：1997-11-01 00:00:00
abstract：BACKGROUND & AIMS:Based on experimental and epidemiologic studies, we investigated whether coffee and caffeine consumption reduced the risk of elevated alanine aminotransferase (ALT) activity in persons at high risk for liver injury in a national, population-based study. METHODS:Participants were 5944 adults in the Th...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2004.09.075
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND & AIMS:Intestinal microbes induce homeostatic mucosal immune responses, but can also cause inappropriate immune activation in genetically susceptible hosts. Although immune responses to bacterial products have been studied extensively, little is known about how intestinal inflammation affects functions of co...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.06.064
更新日期：2011-11-01 00:00:00
abstract：:Human intrinsic factor (IF) is found on the surface of parietal cells at the light microscopic level by immunofluorescence, but there is no direct evidence that IF is synthesized in and secreted from this cell. In order to provide this evidence, IF was localized at the ultrastructural level in human stomach, using an ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1980-09-01 00:00:00
abstract：:Superficially invasive squamous cell carcinoma of the esophagus, defined as carcinoma with invasion limited to the mucosa or submucosa regardless of the presence of lymph node metastasis, is being increasingly recognized. We found 7 cases (13%) of this entity among 54 cases of esophageal squamous cancer resected betwe...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90201-5
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2003.50011
更新日期：2003-01-01 00:00:00
