Abstract：
:This study examines restitution of the gastric surface epithelium at luminal pH 1 after damage to the gastric mucosa by instillation of 2 M NaCl for 10 min. After mucosal damage, potential difference decreased to zero and H+ back-diffusion increased. Gastric blood flow increased after exposure to 2 M NaCl, irrespective of the secretory state of mucosa. Neither pentagastrin nor cimetidine showed any protective effect against mucosal damage produced by 2 M NaCl. Ninety minutes after mucosal exposure to 2 M NaCl there was an almost complete restitution of the gastric surface epithelium in pentagastrin-stimulated and cimetidine-treated animals, whereas about 15% of the gastric surface still showed damage in animals in which acid secretion was not interfered with. These findings show that restitution of the surface epithelium, in vivo, is a rapid and resistant process even at a very low luminal pH. The secretory state of mucosa may have some influence on this process.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Grönbech JE,Grong K,Varhaug JE,Lekven J,Svanes Kdoi
10.1016/0016-5085(87)90437-9subject
Has Abstractpub_date
1987-10-01 00:00:00pages
753-64issue
4eissn
0016-5085issn
1528-0012pii
0016-5085(87)90437-9journal_volume
93pub_type
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