Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer.

abstract：:Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is typically characterized by episodic fever, myalgia, skin rash, conjunctivitis, and abdominal cramps. Recently, mutations in the TNFRSF1A gene on chromosome 12p13 encoding tumor necrosis factor receptor type 1 have been linked to this autoinflammato...

journal_title：Gastroenterology

authors： Haas SL,Lohse P,Schmitt WH,Hildenbrand R,Karaorman M,Singer MV,Böcker U

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Increased intestinal macromolecular permeability could allow absorption of substances from the bowel into the systemic circulation and contribute to multiple organ system failure. METHODS:Mild, intermediate, and severe grades of pancreatitis were induced in rats using intravenous caerulein and intraductal g...

journal_title：Gastroenterology

authors： Ryan CM,Schmidt J,Lewandrowski K,Compton CC,Rattner DW,Warshaw AL,Tompkins RG

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND & AIMS:Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Using CLE analysis of patients with irritable bowel sy...

journal_title：Gastroenterology

authors： Fritscher-Ravens A,Pflaum T,Mösinger M,Ruchay Z,Röcken C,Milla PJ,Das M,Böttner M,Wedel T,Schuppan D

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...

journal_title：Gastroenterology

authors： Sobhani I,Buyse M,Goïot H,Weber N,Laigneau JP,Henin D,Soul JC,Bado A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:The study and management of reflux esophagitis require an endoscopic classification system founded on esophageal lesions that can be reproducibly identified. The aim of this study was to investigate interobserver agreement for the identification of endoscopic lesions typical of reflux esophagitis. ME...

journal_title：Gastroenterology

authors： Armstrong D,Bennett JR,Blum AL,Dent J,De Dombal FT,Galmiche JP,Lundell L,Margulies M,Richter JE,Spechler SJ,Tytgat GN,Wallin L

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND & AIMS:Unlike adult antral cells, feline newborn antral cells are unable to contract in response to agonists in the absence of extracellular calcium or in response to exogenous inositol 1,4,5-triphosphate (IP3) after permeabilization. Changes in intracellular pathways that are associated with these differenc...

journal_title：Gastroenterology

authors： Hillemeier AC,Deutsch DE,Bitar KN

更新日期：1997-08-01 00:00:00

abstract：BACKGROUND & AIMS:Current therapy for primary sclerosing cholangitis is of limited efficacy. Multidrug resistance gene 2 knockout mice (Mdr2(-/-)) represent a well-characterized model for sclerosing cholangitis. Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(2...

journal_title：Gastroenterology

authors： Fickert P,Wagner M,Marschall HU,Fuchsbichler A,Zollner G,Tsybrovskyy O,Zatloukal K,Liu J,Waalkes MP,Cover C,Denk H,Hofmann AF,Jaeschke H,Trauner M

更新日期：2006-02-01 00:00:00

abstract：:It has recently been shown that repeated large-volume paracentesis associated with intravenous albumin infusion is a rapid, effective, and safe therapy of ascites in cirrhosis. To investigate whether intravenous albumin infusion is necessary in the treatment of cirrhotics with large-volume paracentesis, 105 patients w...

journal_title：Gastroenterology

authors： Ginès P,Titó L,Arroyo V,Planas R,Panés J,Viver J,Torres M,Humbert P,Rimola A,Llach J

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinomas appear to arise from the malignant transformation of cholangiocytes lining the biliary tract. Because the development of an in vitro model of malignant transformation can provide a powerful new tool for establishing critical events governing the molecular pathogenesis of cholangioc...

journal_title：Gastroenterology

authors： Lai GH,Zhang Z,Shen XN,Ward DJ,Dewitt JL,Holt SE,Rozich RA,Hixson DC,Sirica AE

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND/AIMS:Gastrointestinal peptides and biogenic monoamines participate in the regulation of gastrointestinal functions. The aim of this study was to examine the influence of the microflora on the distribution of endocrine cells and on the release of gastrointestinal peptides. METHODS:A quantitative morphologica...

journal_title：Gastroenterology

authors： Uribe A,Alam M,Johansson O,Midtvedt T,Theodorsson E

更新日期：1994-11-01 00:00:00

abstract：:A 50-year-old woman with a typical history of chronic idiopathic intestinal pseudo-obstruction was admitted to hospital because of an acute episode of abdominal cramps, nausea, and vomiting. The diagnosis of chronic idiopathic intestinal pseudo-obstruction had been established in this patient who had malnutrition and ...

journal_title：Gastroenterology

authors： Allescher HD,Safrany L,Neuhaus H,Feussner H,Classen M

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND & AIMS:Dihydroxy bile acids induce a bicarbonate-rich hypercholeresis when secreted into canalicular bile in unconjugated form; the mechanism is cholehepatic shunting. The aim of this study was to identify a xenobiotic that induces hypercholeresis by a similar mechanism. METHODS:Five organic acids (sulindac...

journal_title：Gastroenterology

authors： Bolder U,Trang NV,Hagey LR,Schteingart CD,Ton-Nu HT,Cerrè C,Elferink RP,Hofmann AF

更新日期：1999-10-01 00:00:00

abstract：BACKGROUND & AIMS:Nitrate ingestion leads to high luminal concentrations of nitric oxide being generated where saliva meets gastric acid. Nitric oxide generates N-nitrosative stress on reacting with oxygen at neutral pH. We aimed to ascertain if luminal nitric oxide exerts nitrosative stress in the human upper gastroin...

journal_title：Gastroenterology

authors： Winter JW,Paterson S,Scobie G,Wirz A,Preston T,McColl KE

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND & AIMS:High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. The effect on the incidence of gallstone disease is not clear. METHODS:We examined the associations between high-carbohydrate diets with a high glycemic response and the...

journal_title：Gastroenterology

authors： Tsai CJ,Leitzmann MF,Willett WC,Giovannucci EL

更新日期：2005-07-01 00:00:00

abstract：:The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complicatio...

journal_title：Gastroenterology

authors： Abate N,Chandalia M

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Celiac disease is a prevalent disorder characterized by a chronic intestinal inflammation driven by HLA-DQ2 or -DQ8-restricted T cells specific for ingested wheat gluten peptides. The dominant T-cell responses are to epitopes that cluster within a stable 33mer fragment formed by physiologic digestio...

journal_title：Gastroenterology

authors： Molberg O,Uhlen AK,Jensen T,Flaete NS,Fleckenstein B,Arentz-Hansen H,Raki M,Lundin KE,Sollid LM

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND & AIMS:Common germline genetic variation in the 3' region of myosin IXB (MYO9B) has been associated recently with susceptibility to celiac disease, with a hypothesis that MYO9B variants might influence intestinal permeability. These findings suggested the current study investigating a possible further role f...

journal_title：Gastroenterology

authors： van Bodegraven AA,Curley CR,Hunt KA,Monsuur AJ,Linskens RK,Onnie CM,Crusius JB,Annese V,Latiano A,Silverberg MS,Bitton A,Fisher SA,Steinhart AH,Forbes A,Sanderson J,Prescott NJ,Strachan DP,Playford RJ,Mathew CG,Wijm

更新日期：2006-12-01 00:00:00

abstract：:Topical 20% benzocaine (Hurricaine, Beutlich, Inc., Niles, Ill.) spray is frequently used for oral anesthesia before upper endoscopy. Side effects attributed to this agent are exceedingly rare. The author reports one of these rare complications, drug-induced methemoglobinemia, in a patient with methemoglobin reductase...

journal_title：Gastroenterology

authors： Collins JF

更新日期：1990-01-01 00:00:00

abstract：:In vivo and in vitro ultrasonic characteristics of gallstones were compared with stone size and composition with the aim of understanding the basis for these features. In vivo and in vitro ultrasonic features of the same stone were identical. Acoustic shadowing was not due to stone type, radiodensity, or calcium conte...

journal_title：Gastroenterology

authors： Good LI,Edell SL,Soloway RD,Trotman BW,Mulhern C,Arger PA

更新日期：1979-08-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) was historically distinguished from gastroesophageal reflux disease on the basis of histology and lack of responsiveness to acid suppressive therapy, but it is now appreciated that esophageal eosinophilia can respond to proton pump inhibitors. Genetic and environmental factors contribute...

journal_title：Gastroenterology

authors： Rothenberg ME

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to identify long noncoding RNAs (lncRNAs) that are up-regulated in gastric cancer tissues from patients and study their function in gastric tumor metastasis. METHODS:We collected gastric tumor and nontumor tissues from patients in China and analyzed levels of lncRNAs by microarray analysis, ...

journal_title：Gastroenterology

authors： Zhuo W,Liu Y,Li S,Guo D,Sun Q,Jin J,Rao X,Li M,Sun M,Jiang M,Xu Y,Teng L,Jin Y,Si J,Liu W,Kang Y,Zhou T

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND & AIMS:Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples. METHODS:The expression...

journal_title：Gastroenterology

authors： Liu WH,Yeh SH,Lu CC,Yu SL,Chen HY,Lin CY,Chen DS,Chen PJ

更新日期：2009-02-01 00:00:00

abstract：:A primary malignant melanoma of the gallbladder, metastatic to the common bile duct, is reported. Both tumor sites were first visualized by abdominal sonography. The presence of the common bile duct metastasis was confirmed by endoscopic retrograde cholangiopancreatography. Histologic evidence is presented that the pr...

journal_title：Gastroenterology

authors： Verbanck JJ,Rutgeerts LJ,van Aelst FJ,Tytgat JH,Decoster JM,Noyez DN,Theunynck PJ,Geboes KJ

更新日期：1986-07-01 00:00:00

abstract：:One of the least anticipated and less heralded outcomes of mouse genetics has been to rediscover whole organism physiology. Among the many unexpected findings that it has brought to our attention has been the realization that gut-derived serotonin is a hormone-inhibiting bone formation. The importance of this discover...

journal_title：Gastroenterology

authors： Karsenty G,Gershon MD

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND & AIMS:Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological fu...

journal_title：Gastroenterology

authors： Direnzo D,Hess DA,Damsz B,Hallett JE,Marshall B,Goswami C,Liu Y,Deering T,Macdonald RJ,Konieczny SF

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND & AIMS:Interactions between genetic and environmental factors are believed to be involved in onset and initiation of inflammatory bowel disease. We analyzed the interaction between gastrointestinal mucosal microbiota and host genes in twin pairs discordant for ulcerative colitis (UC) to study the functional ...

journal_title：Gastroenterology

authors： Lepage P,Häsler R,Spehlmann ME,Rehman A,Zvirbliene A,Begun A,Ott S,Kupcinskas L,Doré J,Raedler A,Schreiber S

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...

journal_title：Gastroenterology

authors： Ohd JF,Nielsen CK,Campbell J,Landberg G,Löfberg H,Sjölander A

更新日期：2003-01-01 00:00:00

abstract：:The study of cholesterol gallstone disease would be facilitated if the nucleation time of cholesterol crystals could be measured in duodenal bile and was correlated with nucleation occurring in vivo. Therefore, our aims were to determine (a) if nucleation time could be measured in duodenal bile, (b) the effect of bact...

journal_title：Gastroenterology

authors： Marks JW,Broomfield P,Bonorris GG,Schoenfield LJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding a...

journal_title：Gastroenterology

authors： Chan FK,Kyaw M,Tanigawa T,Higuchi K,Fujimoto K,Cheong PK,Lee V,Kinoshita Y,Naito Y,Watanabe T,Ching JY,Lam K,Lo A,Chan H,Lui R,Tang RS,Sakata Y,Tse YK,Takeuchi T,Handa O,Nebiki H,Wu JC,Abe T,Mishiro T,Ng S

更新日期：2017-01-01 00:00:00

abstract：:In contrast to the "toxigenic diarrheas" caused by Vibrio cholerae and Escherichia coli, the site and mechanism of fluid loss in shigellosis are unknown. The occurrence of watery diarrhea in shigellosis suggests involvement of the small bowel. Therefore, jejunal, ileal, and colonic water and electrolyte transport was ...

journal_title：Gastroenterology

authors： Rout WR,Formal SB,Giannella RA,Dammin GJ

更新日期：1975-02-01 00:00:00