Abstract：
:The prospect of a significant increase in global health-related costs associated with high cardiometabolic complications of obesity in Asians has encouraged more attention to be focused on the problem of growing obesity prevalence in these populations. Although these studies have shown that cardiometabolic complications occur more frequently and at a lower body mass index (BMI) in Asians than in European populations, the mechanisms involved have yet to be discovered. Ethnic/racial differences in body composition and fat distribution have been studied extensively. Although these studies have shown that increasing BMI is associated with larger increases in body fat content in Asians, growing evidence points to factors other than body fat content and fat distribution in determining a higher prevalence of cardiometabolic complications in these populations. Here, we provide support to our view that earlier onset of adipocyte maturation arrest/insulin resistance during weight gain could be a major factor in increasing the cardiometabolic risk of Asian populations at a lower BMI.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Abate N,Chandalia Mdoi
10.1053/j.gastro.2017.01.046subject
Has Abstractpub_date
2017-05-01 00:00:00pages
1647-1655issue
7eissn
0016-5085issn
1528-0012pii
S0016-5085(17)30140-3journal_volume
152pub_type
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