Gastroesophageal reflux disease in monozygotic and dizygotic twins.

abstract：:The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...

journal_title：Gastroenterology

authors： Eisenstat DD,Griffiths AM,Cutz E,Petric M,Drumm B

更新日期：1995-08-01 00:00:00

abstract：:Mucins synthesized in colonic cancer are known to be different from those in the normal colon; however, the biochemical differences between these mucins have not been defined. We have purified mucins from samples of nonneoplastic (normal) human colon and colon cancer and found that the carbohydrate content of the canc...

journal_title：Gastroenterology

authors： Boland CR,Deshmukh GD

更新日期：1990-05-01 00:00:00

abstract：:Osteopenia in the form of osteoporosis is a common clinical problem associated with chronic cholestatic liver disease, and clinical morbidity from atraumatic fractures is increasing as more patients with PBC and PSC undergo successful liver transplantation. In the absence of symptomatic fractures, the clinical diagnos...

journal_title：Gastroenterology

authors： Hay JE

更新日期：1995-01-01 00:00:00

abstract：:Spinal cord stimulation is an increasingly popular form of pain treatment. An electrode positioned on the dorsal aspect of the spinal cord at the level of the nerve roots from the painful area stimulates the spinal cord. Current from the electrode is supplied by a pulse generator in the lower anterior abdominal wall. ...

journal_title：Gastroenterology

authors： Kemler MA,Barendse GA,Van Kleef M

更新日期：1999-07-01 00:00:00

abstract：:Previous studies have suggested that Giardia infections are cleared immunologically, but have not defined the mechanism of clearance. The aim of the present work was to compare subpopulations of leukocytes harvested from the intestinal lumen of immunocompetent BALB/c mice, which clear Giardia muris infection rapidly, ...

journal_title：Gastroenterology

authors： Heyworth MF,Owen RL,Jones AL

更新日期：1985-12-01 00:00:00

abstract：:The influence of adaptive cell proliferation on colonic carcinogenesis was studied in male Fischer rats with a defunctioning transverse colostomy that was closed 4 wk later. Control observations were made in other rats after colonic transection, repeated at 4 wk, after laparotomy alone, or after permanent colostomy. T...

journal_title：Gastroenterology

authors： Terpstra OT,Dahl EP,Williamson RC,Ross JS,Malt RA

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND & AIMS:SPD476 (LIALDA in the US; MEZAVANT in the EU; otherwise known as MMX mesalamine; Shire Pharmaceuticals Inc., Wayne, PA, under license from Giuliani SpA, Milan, Italy) is a novel, once-daily, high-strength (1.2 g/tablet) formulation of mesalamine, utilizing MMX Multi Matrix System (MMX) technology desi...

journal_title：Gastroenterology

authors： Kamm MA,Sandborn WJ,Gassull M,Schreiber S,Jackowski L,Butler T,Lyne A,Stephenson D,Palmen M,Joseph RE

更新日期：2007-01-01 00:00:00

abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...

journal_title：Gastroenterology

authors： Annese V,Janssens J,Vantrappen G,Tack J,Peeters TL,Willemse P,Van Cutsem E

更新日期：1992-03-01 00:00:00

abstract：:The mechanism of acute ulceration and the nature of mucosal protective mechanisms were investigated in rabbit antrum, which is more resistant to injury than fundus of the same species, with particular reference to the relationship between H+ back diffusion, tissue acidification, and occurrence of ulceration. Exposure ...

journal_title：Gastroenterology

authors： Kivilaakso E,Barzilai A,Schiessel R,Fromm D,Silen W

更新日期：1981-01-01 00:00:00

abstract：:A case is presented of a 76-yr-old woman with primary biliary cirrhosis and adult polycystic liver disease who developed bone marrow toxicity associated with chronic low-dose colchicine therapy. Two months after starting colchicine therapy (0.6 mg b.i.d. p.o.), the patient developed hematologic toxicity as evidenced b...

journal_title：Gastroenterology

authors： Finklestein M,Goldman L,Grace ND,Foley M,Randall N

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND & AIMS:We recently showed that dietary supplementation with an analogue of 1alpha,25-dihydroxy-vitamin D3, 1alpha,25-dihydroxy-16-ene-23-yne-26,27 F6-vitamin D3 (RO24-5531), reduced the incidence of colonic tumors in rats treated with azoxymethane (AOM). The aim of this study was to determine whether alterat...

journal_title：Gastroenterology

authors： Wali RK,Bissonnette M,Khare S,Aquino B,Niedziela S,Sitrin M,Brasitus TA

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic lymphocytes are composed mainly of natural killer (NK) cells and NKT cells, which play key roles in innate immune responses against pathogens and tumors in the liver. This report analyzes the effects of activation of innate immunity by viral infection or the toll-like receptor 3 (TLR3) ligan...

journal_title：Gastroenterology

authors： Sun R,Gao B

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal stem and progenitor cells through phosphor...

journal_title：Gastroenterology

authors： Lee G,Goretsky T,Managlia E,Dirisina R,Singh AP,Brown JB,May R,Yang GY,Ragheb JW,Evers BM,Weber CR,Turner JR,He XC,Katzman RB,Li L,Barrett TA

更新日期：2010-09-01 00:00:00

abstract：:Detailed porphyrin analysis and additional ultrastructural abnormalities of liver cells are described in a patient with features of Rotor's syndrome. Normal values of porphyrin precursors, delta-aminolevulinic acid and porphobilinogen, and porphyrins were found in plasma, urine, and erythrocytes. However, fecal porphy...

journal_title：Gastroenterology

authors： Evans J,Lefkowitch J,Lim CK,Billing B

更新日期：1981-12-01 00:00:00

abstract：BACKGROUND & AIMS:De novo hepatitis B virus (HBV)-related hepatitis after chemotherapy results in high morbidity and mortality. We evaluate the clinical course of de novo HBV-related hepatitis after chemotherapy. METHODS:Two hundred forty-four consecutive hepatitis B surface antigen (HBsAg)-negative lymphoma patients ...

journal_title：Gastroenterology

authors： Hui CK,Cheung WW,Zhang HY,Au WY,Yueng YH,Leung AY,Leung N,Luk JM,Lie AK,Kwong YL,Liang R,Lau GK

更新日期：2006-07-01 00:00:00

abstract：:Receptor-dependent and -independent regulation of gastrin secretion from cultured human antral G cells was investigated. Human antral mucosal cell preparations that were enriched for G cells were obtained by sequential incubations with collagenase and ethylenediaminetetraacetic acid, centrifugal elutriation, and short...

journal_title：Gastroenterology

authors： Campos RV,Buchan AM,Meloche RM,Pederson RA,Kwok YN,Coy DH

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND & AIMS:Stimulator of Fe Transport (SFT) and transferrin receptor (TfR) are proteins involved in iron transport. This study evaluated iron metabolism protein expression in duodenal biopsy specimens from controls and patients with abnormal iron metabolism. METHODS:Twelve controls, 8 patients with iron deficie...

journal_title：Gastroenterology

authors： Barisani D,Parafioriti A,Armiraglio E,Meneveri R,Conte D

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

journal_title：Gastroenterology

authors： Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

更新日期：1996-10-01 00:00:00

abstract：:A case of acute hypervitaminosis A complicating viral hepatitis is reported. Twenty days after presenting with hepatitis B, a 42-yr-old vegetarian developed acute hypervitaminosis A in the absence of recent, massive exposure to the vitamin. Findings included headache, confusion, skin desquamation, and hypercalcemia. P...

journal_title：Gastroenterology

authors： Hatoff DE,Gertler SL,Miyai K,Parker BA,Weiss JB

更新日期：1982-01-01 00:00:00

abstract：:The growth rate of 31 asymptomatic hepatocellular carcinomas (diameter less than or equal to 5 cm) discovered in 28 patients by a prospective screening program was determined by real-time ultrasonography over 36-860 days. Except for one tumor that shrank on follow-up, the doubling time ranged from 29 to 398 days, with...

journal_title：Gastroenterology

authors： Sheu JC,Sung JL,Chen DS,Yang PM,Lai MY,Lee CS,Hsu HC,Chuang CN,Yang PC,Wang TH

更新日期：1985-08-01 00:00:00

abstract：BACKGROUND & AIMS:SMAD4 frequently is lost from colorectal cancers (CRCs), which is associated with the development of metastases and a poor prognosis. SMAD4 loss is believed to alter transforming growth factor β signaling to promote tumor progression. However, SMAD4 is also a central component of the bone morphogeneti...

journal_title：Gastroenterology

authors： Voorneveld PW,Kodach LL,Jacobs RJ,Liv N,Zonnevylle AC,Hoogenboom JP,Biemond I,Verspaget HW,Hommes DW,de Rooij K,van Noesel CJ,Morreau H,van Wezel T,Offerhaus GJ,van den Brink GR,Peppelenbosch MP,Ten Dijke P,Hardwick JC

更新日期：2014-07-01 00:00:00

abstract：:Gastric and esophageal emptying were assessed using scintigraphic techniques in 12 patients with progressive systemic sclerosis and 22 normal volunteers. Esophageal emptying was significantly delayed in the patient group, with 7 of the 12 patients beyond the normal range. Gastric emptying was slower in patients than i...

journal_title：Gastroenterology

authors： Maddern GJ,Horowitz M,Jamieson GG,Chatterton BE,Collins PJ,Roberts-Thomson P

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanisms by which mutations in the familial intrahepatic cholestasis-1 gene cause Byler's disease (progressive familial intrahepatic cholestasis type 1) are unknown. METHODS:Interactions among the apical sodium-dependent bile acid transporter, the farnesoid X receptor (FXR), and familial intrah...

journal_title：Gastroenterology

authors： Chen F,Ananthanarayanan M,Emre S,Neimark E,Bull LN,Knisely AS,Strautnieks SS,Thompson RJ,Magid MS,Gordon R,Balasubramanian N,Suchy FJ,Shneider BL

更新日期：2004-03-01 00:00:00

abstract：:The role of the endothelium-derived vasodilator, nitric oxide, as a mediator of the increase in gastric mucosal blood flow and as a modulator of the acid secretory response induced by pentagastrin was investigated in the anesthetised rat. Intravenous administration of the selective inhibitor of endogenous nitric oxide...

journal_title：Gastroenterology

authors： Pique JM,Esplugues JV,Whittle BJ

更新日期：1992-01-01 00:00:00

abstract：:Transient relaxation of the lower esophageal sphincter (LES) is observed fairly frequently during prolonged continuous monitoring of the LES. The aim of this study was to test whether the presence of a catheter in the pharynx through the stimulation of mechanoreceptors may induce transient LES relaxation. LES and esop...

journal_title：Gastroenterology

authors： Mittal RK,Stewart WR,Schirmer BD

更新日期：1992-10-01 00:00:00

abstract：:Severe cholestasis associated with long-term home parenteral nutrition is rare, and no treatment is known to be effective. This study shows a case of a patient who developed jaundice while receiving long-term home parenteral nutrition. Causes of jaundice, other than the patient's parenteral feedings, were excluded. Th...

journal_title：Gastroenterology

authors： Lindor KD,Burnes J

更新日期：1991-07-01 00:00:00

abstract：:Familial gastrointestinal stromal tumor (GIST) is a rare autosomal dominant genetic disorder associated with KIT germline mutations. In sporadic forms of the disease, somatic mutations target either KIT or PDGFRA genes. In a kindred in which 5 individuals had GIST, no germline mutation in KIT coding sequence has been ...

journal_title：Gastroenterology

authors： Chompret A,Kannengiesser C,Barrois M,Terrier P,Dahan P,Tursz T,Lenoir GM,Bressac-De Paillerets B

更新日期：2004-01-01 00:00:00

abstract：:Intestinal mucin and goblet cells were examined in streptozotocin-diabetic rats and age-matched controls. Mucin (tissue content and secretion) was measured using a highly specific enzyme-linked immunoassay. In contrast to the increased protein to deoxyribonucleic acid ratio, an absolute decrease was observed in the mu...

journal_title：Gastroenterology

authors： Mantle M,Thakore E,Atkins E,Mathison R,Davison JS

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND & AIMS:Confocal laser endomicroscopy (CLE) is a technique that permits real-time detection and quantification of changes in intestinal tissues and cells, including increases in intraepithelial lymphocytes and fluid extravasation through epithelial leaks. Using CLE analysis of patients with irritable bowel sy...

journal_title：Gastroenterology

authors： Fritscher-Ravens A,Pflaum T,Mösinger M,Ruchay Z,Röcken C,Milla PJ,Das M,Böttner M,Wedel T,Schuppan D

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND & AIMS:Both androgenic and estrogenic steroids have been implicated in the development and course of several liver diseases, including hepatocellular carcinoma. The aim of this study was to investigate temporal changes in hepatic estrogen and androgen receptors and hormone metabolism in a rat model of liver ...

journal_title：Gastroenterology

authors： Eagon PK,Elm MS,Epley MJ,Shinozuka H,Rao KN

更新日期：1996-04-01 00:00:00