Inactivation of the transcription factor Elf3 in mice results in dysmorphogenesis and altered differentiation of intestinal epithelium.

abstract：:Gastric ulcers have been thought to occur only in the pyloric gland area. However, endoscopic examinations using the Congo red test showed that 18 of the ulcers examined (7.8%) were surrounded by an acid-secreting area, and so were in the fundic gland area. Histological examination of specimens obtained by gastrectomy...

journal_title：Gastroenterology

authors： Tatsuta M,Okuda S

更新日期：1976-07-01 00:00:00

abstract：:The role of adrenal medullary discharge of catecholamines on inhibition of gastric emptying and small intestinal propulsion after laparotomy was examined in rats. The rate of movement of a 51Cr-labeled liquid test meal, which had been introduced by gastric intubation, out of the stomach and through the small intestine...

journal_title：Gastroenterology

authors： Dubois A,Henry DP,Kopin IJ

更新日期：1975-03-01 00:00:00

abstract：:The effect of methacholine, theophylline, and cyclic adenyl and guanyl nucleotides on gastric secretion from antral and proximal duodenal mucosa of the guinea pig was studied. Both 2 mM dibutyryl (db) cAMP and 5 mM theophylline produced significant increases in gastrin secretion, 4.3 +/- 0.7 (P less than 0.001) and 9....

journal_title：Gastroenterology

authors： Schebalin M,Zfass AM,Makhlouf GM

更新日期：1977-07-01 00:00:00

abstract：:The hepatic circulation is reviewed with emphasis on the role of hepatic blood vessels in hepatic and homeostatic functions. Contrasts are made with resistance, capacitance, and fluid exchange functions in other better known vascular beds. Hemodynamic changes that produce shifts in fluid exchange in other tissues are ...

journal_title：Gastroenterology

authors： Lautt WW

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND & AIMS:Early embryogenesis involves cell fate decisions that define the body axes and establish pools of progenitor cells. Development does not stop once lineages are specified; cells continue to undergo specific maturation events, and changes in gene expression patterns lead to their unique physiological fu...

journal_title：Gastroenterology

authors： Direnzo D,Hess DA,Damsz B,Hallett JE,Marshall B,Goswami C,Liu Y,Deering T,Macdonald RJ,Konieczny SF

更新日期：2012-08-01 00:00:00

abstract：:Assessment of the influence of nutritional substrates on the disposition of ingested ethanol from the blood requires, first, an understanding of the influence that these may exert upon ethanol absorption from the gastrointestinal tract. In this report, the effects of various carbohydrates on the intestinal absorption ...

journal_title：Gastroenterology

authors： Broitman SA,Gottlieb LS,Vitale JJ

更新日期：1976-06-01 00:00:00

abstract：:Intestinal handling of water and electrolytes was monitored in 5 conscious dogs with chronic 25-cm Thiry-Vella loops of proximal jejunum using a neutral isosmotic perfusate containing [14C]polyethylene glycol as a recovery marker. Under basal conditions the animals absorbed water, Na+, and Cl-, and there was minimal n...

journal_title：Gastroenterology

authors： Zinner MJ,McFadden D,Sherlock D,Jaffe BM

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...

journal_title：Gastroenterology

authors： Park SW,Davison JM,Rhee J,Hruban RH,Maitra A,Leach SD

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND & AIMS:We have shown that intestinal manipulation leads to a significant inhibition of circular muscle contraction. We hypothesized that the inflammatory mediator inducible nitric oxide (NO) plays a role in surgically induced ileus. METHODS:Rats and inducible NO synthase (iNOS) knockout and wild-type mice u...

journal_title：Gastroenterology

authors： Kalff JC,Schraut WH,Billiar TR,Simmons RL,Bauer AJ

更新日期：2000-02-01 00:00:00

abstract：:The efficacy of various adsorbents for endotoxin was tested in vitro and in vivo using a murine experimental model of gut-derived endotoxemia. A quantitative limulus amebocyte lysate microtiter test and the limulus amebocyte lysate tube test were used to determine intestinal and circulating levels of endotoxin. Kaopec...

journal_title：Gastroenterology

authors： Ditter B,Urbaschek R,Urbaschek B

更新日期：1983-06-01 00:00:00

abstract：:In the TMC435-C101 study, 6 patients infected with hepatitis C virus genotype 1 were treated with the protease inhibitor TMC435 (200 mg once daily) as monotherapy for 5 days. Approximately 1.5 years later, 5 of these patients were re-treated with TMC435 (200 mg once daily) plus pegylated interferon alfa-2a and ribavir...

journal_title：Gastroenterology

authors： Lenz O,de Bruijne J,Vijgen L,Verbinnen T,Weegink C,Van Marck H,Vandenbroucke I,Peeters M,Simmen K,Fanning G,Verloes R,Picchio G,Reesink H

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND & AIMS:The integrin alpha(4)beta(7) mediates homing of effector/memory lymphocytes to the intestine and the mucosa-associated lymphoid tissue. This study examined the ability of alpha(4)beta(7)(hi) CD4(+) T lymphocytes to home to the stomach and their role in immunization-mediated protection against Helicoba...

journal_title：Gastroenterology

authors： Michetti M,Kelly CP,Kraehenbuhl JP,Bouzourene H,Michetti P

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND & AIMS:Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to t...

journal_title：Gastroenterology

authors： Mangia A,Thompson AJ,Santoro R,Piazzolla V,Tillmann HL,Patel K,Shianna KV,Mottola L,Petruzzellis D,Bacca D,Carretta V,Minerva N,Goldstein DB,McHutchison JG

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Although a number of epidemiologic studies have found dietary fiber and whole grains to be inversely associated with colorectal cancer incidence, studies of dietary and other risk factors for small intestinal cancer have been sparse and all of a case-control design. We conducted a prospective cohort s...

journal_title：Gastroenterology

authors： Schatzkin A,Park Y,Leitzmann MF,Hollenbeck AR,Cross AJ

更新日期：2008-10-01 00:00:00

abstract：:Biofeedback has been advocated as first-line therapy for patients whose symptoms of mild to moderate fecal incontinence have not responded to simple dietary advice or medication. Three main modalities have been described: (1) use of an intra-anal electromyographic sensor, a probe to measure intra-anal pressure, or per...

journal_title：Gastroenterology

authors： Norton C

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND & AIMS:Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions, hepatic stellate cells (HSCs) proliferate and acquire contractile properties. This study investigated the presence of receptors for ANGII and the ef...

journal_title：Gastroenterology

authors： Bataller R,Ginès P,Nicolás JM,Görbig MN,Garcia-Ramallo E,Gasull X,Bosch J,Arroyo V,Rodés J

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...

journal_title：Gastroenterology

authors： Watanabe T,Ajioka Y,Mitsuyama K,Watanabe K,Hanai H,Nakase H,Kunisaki R,Matsuda K,Iwakiri R,Hida N,Tanaka S,Takeuchi Y,Ohtsuka K,Murakami K,Kobayashi K,Iwao Y,Nagahori M,Iizuka B,Hata K,Igarashi M,Hirata I,Kudo S

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND & AIMS:Carcinogenesis in Barrett's esophagus (BE) is associated with an increased expression of cyclooxygenase (COX) 2. However, there has been no direct evidence that inhibition of COX-2 prevents cancer in BE. We studied the effect of MF-Tricyclic, a selective COX-2 inhibitor, on the development of BE and a...

journal_title：Gastroenterology

authors： Buttar NS,Wang KK,Leontovich O,Westcott JY,Pacifico RJ,Anderson MA,Krishnadath KK,Lutzke LS,Burgart LJ

更新日期：2002-04-01 00:00:00

abstract：:To determine the fate of exogenous epidermal growth factor (EGF) in regenerating liver, 125I-labeled EGF was injected into rat portal veins at various times after 70% hepatectomy. Epidermal growth factor was taken up by the liver remnant at all time points studied (0, 4, 8, 16, and 36 h), but at 8 h after hepatectomy ...

journal_title：Gastroenterology

authors： Raper SE,Burwen SJ,Barker ME,Jones AL

更新日期：1987-05-01 00:00:00

abstract：:The effects of hydroxypropylmethylcellulose on upper gastrointestinal transit, viscosity, and water flux were studied in six dogs fistulated at the proximal duodenum and/or mid-jejunum. Combinations of different grades of hydroxypropylmethylcellulose were prepared as 2% or 3.3% solutions to yield input viscosities of ...

journal_title：Gastroenterology

authors： Reppas C,Meyer JH,Sirois PJ,Dressman JB

更新日期：1991-05-01 00:00:00

abstract：:The purpose of these experiments was to determine the contribution of gastrin to the acid secretory response to eating in healthy human subjects. To simulate the gastric and intestinal phases of eating, a meal was homogenized and then infused into the stomach through a nasogastric tube. At the same time, the cephalic ...

journal_title：Gastroenterology

authors： Blair AJ 3rd,Richardson CT,Walsh JH,Feldman M

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Although it has recently become possible to detect hepatitis C viral antigens in liver biopsy specimens, the frequency and clinical significance of this finding remains uncertain. Therefore, 49 liver biopsy specimens from 35 patients with hepatitis C were studied to make these assessments. METHODS:Hepatitis...

journal_title：Gastroenterology

authors： Di Bisceglie AM,Hoofnagle JH,Krawczynski K

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions, but little is known about their role in maintaining the integrity of the inte...

journal_title：Gastroenterology

authors： Xiao L,Wu J,Wang JY,Chung HK,Kalakonda S,Rao JN,Gorospe M,Wang JY

更新日期：2018-02-01 00:00:00

abstract：:Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6...

journal_title：Gastroenterology

authors： Costea I,Mack DR,Lemaitre RN,Israel D,Marcil V,Ahmad A,Amre DK

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND & AIMS:Regulation of blood flow and oxygen supply are important pathogenetic factors in alcoholic liver disease. Because nitric oxide may have an important role, its effects on alcoholic liver injury were investigated. METHODS:Rats were fed ethanol intragastrically with either saturated fat or corn oil. Spo...

journal_title：Gastroenterology

authors： Nanji AA,Greenberg SS,Tahan SR,Fogt F,Loscalzo J,Sadrzadeh SM,Xie J,Stamler JS

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND & AIMS:Upon liver injury in which hepatocyte proliferation is compromised, liver progenitor cells (LPCs), derived from biliary epithelial cells (BECs), differentiate into hepatocytes. Little is known about the mechanisms of LPC differentiation. We used zebrafish and mouse models of liver injury to study the ...

journal_title：Gastroenterology

authors： Ko S,Russell JO,Tian J,Gao C,Kobayashi M,Feng R,Yuan X,Shao C,Ding H,Poddar M,Singh S,Locker J,Weng HL,Monga SP,Shin D

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND & AIMS:Three-dimensional (3D) ultrasound imaging of the total stomach volume has not yet been achieved. The aim of this study was to investigate whether a magnetic position sensor system for acquisition of 3D ultrasonograms could be used to determine gastric emptying rates and intragastric distribution. MET...

journal_title：Gastroenterology

authors： Gilja OH,Detmer PR,Jong JM,Leotta DF,Li XN,Beach KW,Martin R,Strandness DE Jr

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of selectins in experimental colitis remains unknown. The aims of this study were to characterize the time-course expression of selectins in trinitrobenzene sulfonic acid (TNBS)-induced colitis, the functional role of selectins in colonic leukocyte-endothelial cell interactions, and the the...

journal_title：Gastroenterology

authors： Sans M,Salas A,Soriano A,Prats N,Gironella M,Pizcueta P,Elena M,Anderson DC,Piqué JM,Panés J

更新日期：2001-04-01 00:00:00

abstract：:A 60-year-old white male presenting with a clinical picture of obstructive jaundice was subsequently found to have erythropoietic protoporphyria. The diagnosis was suspected because of a history of life-long photosensitivity and was confirmed by finding high levels of erythrocyte protoporphyrin. Liver biopsy revealed ...

journal_title：Gastroenterology

authors： Singer JA,Plaut AG,Kaplan MM

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:The epidemiology of anorectal melanoma has not been well studied despite its potential relevance to the cutaneous melanoma epidemic, and prognostic studies have generally been based on referred cases. METHODS:Data reported to nine population-based registries in the United States during 1973 through 1987 wer...

journal_title：Gastroenterology

authors： Weinstock MA

更新日期：1993-01-01 00:00:00