Abstract：
BACKGROUND:The clonality of hepatocellular carcinoma is still controversial. To evaluate the clonality of this cancer, mostly small multiple hepatocellular carcinomas of 18 patients were analyzed by DNA fingerprinting. METHODS:DNA from the liver tissues was digested with HinfI. After gel electrophoresis, in gel-hybridization with a synthetic oligonucleotide probe GTGGTGGTGGTGGTG was performed. The band patterns were compared among the tumors and the nontumor part. In patients positive for hepatitis B surface antigen (HBsAg), the integration pattern of hepatitis B viral DNA in liver tissues was also analyzed. RESULTS:Seven of the 9 HBsAg-positive patients had tumors with different clonalities by both methods. In the remaining 9 HBsAg-negative patients, 4 had different band patterns in their tumors by DNA fingerprinting. CONCLUSIONS:Multiple hepatocellular carcinomas frequently have different clonalities; this finding reiterates the importance of eliminating the underlying cause and the contributing factors of hepatocarcinogenesis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Sheu JC,Huang GT,Chou HC,Lee PH,Wang JT,Lee HS,Chen DSdoi
10.1016/0016-5085(93)90153-4subject
Has Abstractpub_date
1993-11-01 00:00:00pages
1471-6issue
5eissn
0016-5085issn
1528-0012pii
0016-5085(93)90153-4journal_volume
105pub_type
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