当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats.

The importance of cycling of blood alcohol levels in the pathogenesis of experimental alcoholic liver disease in rats.

Abstract：

BACKGROUND & AIMS:Rats fed ethanol at a constant rate through a permanent intragastric cannula have a regular fluctuation in blood alcohol level (BAL) and urine alcohol level (UAL). The level of ethanol peaks every 6-10 days. The question is how the liver differs at the peaks and troughs of the UAL cycle. Hypoxic injury is postulated to occur at the peaks. Therefore, liver injury may be different at the peaks and troughs. METHODS:Many parameters were measured at the peaks, troughs, and controls for comparison. RESULTS:Indicators of hypoxic injury at the peaks included ATP reduction, a shift to the reduced state in the NADH/NAD ratio, an increase in expression of vascular endothelial growth factor, an increase in the pathology score at the peaks, and an increase in adduct formation using pimonidazole. Liver nitrites, number of granulocytes, liver weight/body weight ratio, cytochrome P450 2E1 protein, and chymotrypsin-like activity changed in the same direction compared with control values. CONCLUSIONS:The results indicate that hypoxic injury occurs at the peaks. There was a marked shift in NADH/NAD redox state at the peaks caused by hypoxia. This shift could account for the reduced rate of ethanol elimination by alcohol dehydrogenase at the peaks.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Bardag-Gorce F,French BA,Li J,Riley NE,Yuan QX,Valinluck V,Fu P,Ingelman-Sundberg M,Yoon S,French SW

doi

10.1053/gast.2002.34177

keywords:

subject

Has Abstract

pub_date

2002-07-01 00:00:00

pages

325-35

issue

1

eissn

0016-5085

issn

1528-0012

pii

S0016508502000914

journal_volume

123

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.

    abstract：BACKGROUND & AIMS:The CYLD lysine 63 deubiquitinase gene (CYLD) encodes tumor suppressor protein that is mutated in familial cylindromatosus, and variants have been associated with Crohn disease (CD). Splice forms of CYLD that lack exons 7 and 8 regulate transcription factors and functions of immune cells. We examined ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.10.023

    authors： Tang Y,Reissig S,Glasmacher E,Regen T,Wanke F,Nikolaev A,Gerlach K,Popp V,Karram K,Fantini MC,Schattenberg JM,Galle PR,Neurath MF,Weigmann B,Kurschus FC,Hövelmeyer N,Waisman A

    更新日期：2019-02-01 00:00:00

  • Solute Carrier Family 39 Member 6 Gene Promotes Aggressiveness of Esophageal Carcinoma Cells by Increasing Intracellular Levels of Zinc, Activating Phosphatidylinositol 3-Kinase Signaling, and Up-regulating Genes That Regulate Metastasis.

    abstract：BACKGROUND & AIMS:A common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients with esophageal squamous cell carcinoma (ESCC). We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cel...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.02.006

    authors： Cheng X,Wei L,Huang X,Zheng J,Shao M,Feng T,Li J,Han Y,Tan W,Tan W,Lin D,Wu C

    更新日期：2017-06-01 00:00:00

  • Pancreatic secretory activity of secretin5-27 and substituted analogues.

    abstract：:The effect of secretin5-27 and four substituted analogues (9 Gln-secretin5-27, 15-Asn-secretin5-27, 9-Gln-15-Asn-secretin5-27, and 15-Lys-secretin5-27) on pancreatic secretion in the rat and guinea pig was examined. Secretin5-27 retained significant pancreatic secretory activity in both species. Its efficacy (intrinsi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Makhlouf GM,Bodanszky M,Fink ML,Schebalin M

    更新日期：1978-08-01 00:00:00

  • Stimulation of gastric inhibitory polypeptide in normal and duodenal ulcer patients.

    abstract：:To investigate the role of gastric inhibitory polypeptide (GIP), a potent inhibitor of gastric acid secretion, in the hypersecretion associated with duodenal ulcer, we compared the serum GIP concentrations in 11 healthy subjects and 16 duodenal ulcer patients after the stimulation of GIP release by a mixed meal. Fasti...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Cataland S,O'Dorisio TM,Brooks R,Mekhjian HS

    更新日期：1977-07-01 00:00:00

  • Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function.

    abstract：BACKGROUND & AIMS:Chronic hepatitis C virus infection activates an intrahepatic immune response, leading to increased expression of interferon (IFN)-stimulated genes and activation of natural killer (NK) cells-the most prevalent innate immune cell in the liver. We investigated whether the elimination of hepatitis C vir...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2015.03.004

    authors： Serti E,Chepa-Lotrea X,Kim YJ,Keane M,Fryzek N,Liang TJ,Ghany M,Rehermann B

    更新日期：2015-07-01 00:00:00

  • Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats.

    abstract：BACKGROUND/AIMS:Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN marginatio...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(95)90065-9

    authors： Santucci L,Fiorucci S,Di Matteo FM,Morelli A

    更新日期：1995-02-01 00:00:00

  • Effect of nicotine on the lower esophageal sphincter. Studies on the mechanism of action.

    abstract：:Intravenous administration of nicotine sulfate caused a dose-dependent reduction in the lower exophagel sphincter pressure in anesthetized opossums. The maximal reduction in pressure of 85.0 +/- 2.6% was observed with a dose of 50 mug per kg. The effect of 50 mug per kg was not antagonized by bilateral cervical vagoto...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Rattan S,Goyal RK

    更新日期：1975-07-01 00:00:00

  • Peroxynitrite-induced apoptosis in human intestinal epithelial cells is attenuated by mesalamine.

    abstract：BACKGROUND & AIMS:Peroxynitrite (PN), a potent oxidant, has been implicated in the pathogenesis of gut inflammation and epithelial cell apoptosis. The aim of this study was to investigate mesalamine, a standard therapy for inflammatory bowel disease, to see if it attenuates PN-induced cytotoxicity in human intestinal e...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.1997.v113.pm9352850

    authors： Sandoval M,Liu X,Mannick EE,Clark DA,Miller MJ

    更新日期：1997-11-01 00:00:00

  • The effect of betazole on serum group I pepsinogen levels: studies in symptomatic patients with and without recurrent ulcer after vagotomy and gastric resection or drainage.

    abstract：:Serum group I pepsinogen (PG I) levels have been determined before and at intervals after the administration of betazole hydrochloride (Histalog) in 50 symptomatic postoperative patients, 20 with and 30 without recurrent ulcer, after either a vagotomy and gastric resection or a drainage procedure. In patients with rec...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Samloff IM,Secrist DM,Passaro E Jr

    更新日期：1976-06-01 00:00:00

  • Fluorescent PAS-reaction study of the epithelium of normal rabbit ileum and after challenge with enterotoxigenic Escherichia coli.

    abstract：:Fluorescent periodic acid-Schiff reaction (FPR) was used in the study of the normal rabbit ileal epithelium and its changes after injection of living cultures or enterotoxins of enterotoxigenic Escherichia coli. This reaction, with the use of auramine OO-SO2 complex as a Schiff-type reagent, demonstrates gut epitheliu...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Khavkin TN,Kudryavtseva MV,Dragunskaya EM,Polotsky YE,Kudryavtsev BN

    更新日期：1980-04-01 00:00:00

  • Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer.

    abstract：:Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is influenced by the local colonic environment and the patient's genetic background. Consolidating the knowledge of genetic and epigenetic events that occur with initiation, progression, and metastasis of sporadic CRC has identified so...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2015.06.047

    authors： Carethers JM,Jung BH

    更新日期：2015-10-01 00:00:00

  • Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.

    abstract：:Because the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, which has a sur...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1053/j.gastro.2017.07.041

    authors： di Pietro M,Canto MI,Fitzgerald RC

    更新日期：2018-01-01 00:00:00

  • Portal and biliary phases of enterohepatic circulation of corrinoids in humans.

    abstract：:The assimilation of labeled cobalamin and the transport of corrinoids in portal blood, peripheral venous blood, and bile were studied in eight cholecystectomized patients, after ingestion of a dose of cyano[57Co]cobalamin (0.5 microCi). The radioactivity appeared in the portal vein after a delay of 1.5-2 hours and in ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(91)90094-2

    authors： el Kholty S,Gueant JL,Bressler L,Djalali M,Boissel P,Gerard P,Nicolas JP

    更新日期：1991-11-01 00:00:00

  • An international multicenter real-life prospective study of electronic chromoendoscopy score PICaSSO in Ulcerative Colitis.

    abstract：BACKGROUND & AIMS:Endoscopic and Histologic remission are important goals in the treatment of ulcerative colitis (UC). We investigated the correlation of the recently developed Paddington International Virtual ChromoendoScopy ScOre( PICaSSO) and other established endoscopic scores against multiple histological indices ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2020.12.024

    authors： Iacucci M,Smith SC,Bazarova A,Shivaji UN,Bhandari P,Cannatelli R,Daperno M,Ferraz J,Goetz M,Gui X,Hayee B,De Hertogh G,Lazarev M,Li J,Nardone OM,Parra-Blanco A,Pastorelli L,Panaccione R,Occhipinti V,Rath T,Tontini

    更新日期：2020-12-18 00:00:00

  • Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C.

    abstract：BACKGROUND & AIMS:Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. METHODS:Phenotype and function of blood and liver NK cells were st...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.06.069

    authors： Ahlenstiel G,Edlich B,Hogdal LJ,Rotman Y,Noureddin M,Feld JJ,Holz LE,Titerence RH,Liang TJ,Rehermann B

    更新日期：2011-10-01 00:00:00

  • Dietary linoleic acid, gastric acid, and prostaglandin secretion.

    abstract：:Basal and pentagastrin-stimulated gastric acid secretion, fasting serum gastrin concentrations, and the gastric output of prostaglandin E and its major metabolite 13,14-dihydro 15-keto prostaglandin E2 were measured in 9 normal subjects before and after 14-20 days of dietary supplementation with linoleic acid. Mean ma...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(88)90553-7

    authors： Grant HW,Palmer KR,Kelly RW,Wilson NH,Misiewicz JJ

    更新日期：1988-04-01 00:00:00

  • Removal of gastrin by various organs in dogs.

    abstract：:In 6 anesthetized dogs receiving 400 pmoles kg-1 hr-1 of natural human little gastrin intravenously, blood samples for radioimmunoassay of gastrin were taken repeatedly from a carotid artery, jugular vein, femoral vein, renal vein, and mesenteric vein. The calculated removal of gastrin in a single passage through thes...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Strunz UT,Walsh JH,Grossman MI

    更新日期：1978-01-01 00:00:00

  • Successful endoscopic transection of a partially obstructing antral diaphragm.

    abstract：:A 14-yr-old girl presented with long-standing symptoms of partial gastric outlet obstruction due to an antral mucosal diaphragm that had a central aperture of 4-5 mm. The literature of this congenital malformation is reviewed with respect to diagnostic criteria and feasibility of endoscopic transection. The procedure ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90222-7

    authors： Berr F,Rienmueller R,Sauerbruch T

    更新日期：1985-11-01 00:00:00

  • Cimetidine in anastomotic ulceration after partial gastrectomy.

    abstract：:In order to assess the efficacy of cimetidine in patients with endoscopically anastomotic ulcer after partial gastrectomy, 21 such patients entered a double-blind prospective clinical trial. At endoscopy after 4 wk of treatment, 8 of 12 patients treated with 1 g of cimetidine daily compared with 1 of 9 patients who re...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Festen HP,Lamers CB,Driessen WM,Van Tongeren JH

    更新日期：1979-07-01 00:00:00

  • Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.

    abstract：BACKGROUND & AIMS:Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a domi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2004.10.005

    authors： Imamura M,Ogawa T,Sasaguri Y,Chayama K,Ueno H

    更新日期：2005-01-01 00:00:00

  • Direct-Acting Antiviral Therapy Restores Immune Tolerance to Patients With Hepatitis C Virus-Induced Cryoglobulinemia Vasculitis.

    abstract：BACKGROUND & AIMS:Interferon-free direct-acting antiviral (DAA) therapies are effective in patients with hepatitis C virus-induced cryoglobulinemia vasculitis (HCV-CV). We analyzed blood samples from patients with HCV-CV before and after DAA therapy to determine mechanisms of these drugs and their effects on cellular i...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2017.02.037

    authors： Comarmond C,Garrido M,Pol S,Desbois AC,Costopoulos M,Le Garff-Tavernier M,Si Ahmed SN,Alric L,Fontaine H,Bellier B,Maciejewski A,Rosenzwajg M,Klatzmann D,Musset L,Poynard T,Cacoub P,Saadoun D

    更新日期：2017-06-01 00:00:00

  • Role of acquired and hereditary thrombotic risk factors in colon ischemia of ambulatory patients.

    abstract：BACKGROUND & AIMS:Hypercoagulable states may play an important role in the pathogenesis of colon ischemia. Aim of this study was to assess this hypothesis investigating the role of acquired and hereditary thrombotic risk factors in patients with definite diagnosis of colon ischemia. METHODS:We compared the frequency o...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2001.27227

    authors： Koutroubakis IE,Sfiridaki A,Theodoropoulou A,Kouroumalis EA

    更新日期：2001-09-01 00:00:00

  • Phalloidin-induced cholestasis in the rat: relation to changes in microfilaments.

    abstract：:The influence of phalloidin, an agent that causes irreversible polymerisation of actin into microfilaments, on bile secretion and hepatocyte ultrastructure was examined in rats. Phalloidin was given intraperitoneally at the dose of 50 microgram per 100 g of body weight per day for 1, 3, or 7 days. The following was ob...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Dubin M,Maurice M,Feldmann G,Erlinger S

    更新日期：1978-09-01 00:00:00

  • Evaluation of Nd:YAG photocoagulation using a new experimental ulcer model with a single bleeding artery.

    abstract：:A new model of an acute bleeding gastric ulcer with a single bleeding artery in its base has been developed. A suction ulcer defect is created over a large, submucosal artery. Small bleeding marginal vessels are electrocoagulated with a fine-tipped bipolar forceps. The artery in the base of the ulcer is dissected free...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Dennis MB,Silverstein FE,Gilbert DA,Peoples JE

    更新日期：1981-06-01 00:00:00

  • A proinflammatory, antiapoptotic phenotype underlies the susceptibility to acute pancreatitis in cystic fibrosis transmembrane regulator (-/-) mice.

    abstract：BACKGROUND & AIMS:Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis. Chronic pancreatitis, including cystic fibrosis-related disease, may exist as a continuum between acute and chronic disease and may manifest as recurrent pain. We hypothesized t...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/j.gastro.2005.05.059

    authors： Dimagno MJ,Lee SH,Hao Y,Zhou SY,McKenna BJ,Owyang C

    更新日期：2005-08-01 00:00:00

  • Effects of Belapectin, an Inhibitor of Galectin-3, in Patients With Nonalcoholic Steatohepatitis With Cirrhosis and Portal Hypertension.

    abstract：BACKGROUND & AIMS:Increased levels of galectin 3 have been associated with nonalcoholic steatohepatitis (NASH) and contribute to toxin-induced liver fibrosis in mice. GR-MD-02 (belapectin) is an inhibitor of galectin 3 that reduces liver fibrosis and portal hypertension in rats and was safe and well tolerated in phase ...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2019.11.296

    authors： Chalasani N,Abdelmalek MF,Garcia-Tsao G,Vuppalanchi R,Alkhouri N,Rinella M,Noureddin M,Pyko M,Shiffman M,Sanyal A,Allgood A,Shlevin H,Horton R,Zomer E,Irish W,Goodman Z,Harrison SA,Traber PG,Belapectin (GR-MD-02) Stud

    更新日期：2020-04-01 00:00:00

  • Antroduodenal resistance to flow in the control of duodenogastric bile reflux during fasting.

    abstract：:Our objectives in this study were (a) to determine the role of antroduodenal resistance in the control of fasting duodenogastric bile reflux in the dog and (b) to elucidate the contribution of the pylorus both to resistance and to reflux. Thus, we measured simultaneously throughout the interdigestive motor cycle (a) a...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(87)90566-x

    authors： Mearin F,Azpiroz F,Malagelada JR,Zinsmeister AR

    更新日期：1987-11-01 00:00:00

  • Tropheryma whipplei Increases Expression of Human Leukocyte Antigen-G on Monocytes to Reduce Tumor Necrosis Factor and Promote Bacterial Replication.

    abstract：BACKGROUND & AIMS:Infection with Tropheryma whipplei has a range of effects-some patients can be chronic carriers without developing any symptoms, whereas others can develop systemic Whipple disease, characterized by a lack a protective inflammatory immune response. Alterations in HLA-G function have been associated wi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.07.034

    authors： Ben Azzouz E,Boumaza A,Mezouar S,Bardou M,Carlini F,Picard C,Raoult D,Mège JL,Desnues B

    更新日期：2018-11-01 00:00:00

  • Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa.

    abstract：BACKGROUND/AIMS:The gastric mucosa is covered by a continuous layer of bicarbonate-containing mucus gel; the question arises how acid, formed in the gastric glands, moves into the lumen. METHODS:The pH in the gastric mucus gel and gel thickness were measured in anesthetized rats with pH-sensitive microelectrodes (tip ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90075-2

    authors： Schade C,Flemström G,Holm L

    更新日期：1994-07-01 00:00:00

  • Piezoelectric lithotripsy: stone disintegration and follow-up results in patients with symptomatic gallbladder stones.

    abstract：:One hundred symptomatic patients with radiolucent gallbladder stones were treated with a new piezoelectric lithotripter and oral chemolitholytic agents. Stone disintegration was achieved in 99 of these patients (99%) with a mean (+/- SD) maximum fragment size of 5.1 +/- 4.1 mm. Significant differences were found when ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91173-4

    authors： Ell C,Kerzel W,Schneider HT,Benninger J,Wirtz P,Domschke W,Hahn EG

    更新日期：1990-11-01 00:00:00