Effect of bethanechol or vagal nerve stimulation on ileocecal sphincter pressure in the cat.

abstract：BACKGROUND & AIMS:The peroxisome proliferator-activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has been associated with gastric and other cancers. Villin-positive epithelial cells are a small population of quiescent gastric progenitor cells. We expressed PPARD from a villi...

journal_title：Gastroenterology

authors： Zuo X,Deguchi Y,Xu W,Liu Y,Li HS,Wei D,Tian R,Chen W,Xu M,Yang Y,Gao S,Jaoude JC,Liu F,Chrieki SP,Moussalli MJ,Gagea M,Sebastian MM,Zheng X,Tan D,Broaddus R,Wang J,Ajami NJ,Swennes AG,Watowich SS,Shureiqi

更新日期：2019-07-01 00:00:00

abstract：:A case of primary liver cell carcinoma is presented in which tumor emboli to the pulmonary microvasculature resulted in pulmonary hypertension, documented by clinical, radiologic, electrocardiographic, and cardiac catheter studies. Emboli arose from tumor invading the portal vein and passed via a patent splenorenal sh...

journal_title：Gastroenterology

authors： Willett IR,Sutherland RC,O'Rourke MF,Dudley FJ

更新日期：1984-11-01 00:00:00

abstract：:Exposure of isolated gastric mucosal surface cells to NH4+ results in acidification of cells as determined by a fluorescent dye technique using acridine orange. The resulting intracellular pH gradient is maintained when cells are suspended in either buffered HCO3- -free Ringer's or choline chloride solution. Cells sus...

journal_title：Gastroenterology

authors： Olender EJ,Fromm D,Furukawa T,Kolis M

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND & AIMS:Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acq...

journal_title：Gastroenterology

authors： van der Helm J,Geskus R,Sabin C,Meyer L,Del Amo J,Chêne G,Dorrucci M,Muga R,Porter K,Prins M,CASCADE Collaboration in EuroCoord.

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:The role of cytotoxicity mediated by peripheral blood mononuclear cells for colonic epithelial cells in inflammatory bowel disease (IBD) is still controversial. To clarify it, we studied major histocompatibility antigen (MHC)-restricted T cell-mediated cytotoxicity (CTL). METHODS:Cytotoxicity was measured b...

journal_title：Gastroenterology

authors： Okazaki K,Morita M,Nishimori I,Sano S,Toyonaga M,Nakazawa Y,Yamamoto Y,Yamamoto Y

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...

journal_title：Gastroenterology

authors： Tremolaterra F,Villoria A,Azpiroz F,Serra J,Aguadé S,Malagelada JR

更新日期：2006-04-01 00:00:00

abstract：:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...

journal_title：Gastroenterology

authors： Boyd AJ,Sherman IA,Saibil FG,Mamelak M

更新日期：1990-09-01 00:00:00

abstract：:Sepsis following the placement of a transjugular intrahepatic portosystemic shunt (TIPS) has been reported in up to 10% of cases. This report describes an unusual case of polymicrobial gram-negative sepsis after placement of TIPS associated with a cholangiographically documented fistulous connection between the biliar...

journal_title：Gastroenterology

authors： Mallery S,Freeman ML,Peine CJ,Miller RP,Stanchfield WR

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIMS:Cytokines are thought to be important in mediating tissue damage in inflammatory bowel disease (IBD). Many of the in vivo activities of tumor necrosis factor alpha (TNF-alpha) match the changes found in IBD, but its importance is controversial. METHODS:A sensitive, reverse hemolytic plaque assay was us...

journal_title：Gastroenterology

authors： Breese EJ,Michie CA,Nicholls SW,Murch SH,Williams CB,Domizio P,Walker-Smith JA,MacDonald TT

更新日期：1994-06-01 00:00:00

abstract：:The assessment of disease activity in Crohn's disease involves determination of either clinical indexes (e.g., Crohn's disease activity index) or laboratory measurements (e.g., C-reactive protein and erythrocyte sedimentation rate). These have the disadvantage of being indirect and nonspecific correlates of gut inflam...

journal_title：Gastroenterology

authors： Saverymuttu SH,Peters AM,Lavender JP,Pepys MB,Hodgson HJ,Chadwick VS

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND & AIMS:Induction of colitis in mice by administration of oxazolone is mediated by T-helper (Th) 2 cells and has features of human ulcerative colitis. We investigated whether activation of interleukin (IL)-4Rα on T and B cells determines their effector functions and mediates oxazolone-induced colitis. METHOD...

journal_title：Gastroenterology

authors： Hoving JC,Kirstein F,Nieuwenhuizen NE,Fick LC,Hobeika E,Reth M,Brombacher F

更新日期：2012-01-01 00:00:00

abstract：:In addition to the previously described molecular forms of gastrin, a new component has been found in high concentrations in the serum of 6 patients with Zollinger-Ellison syndrome. Serum was fractionated by gel filtration, and ion exchange chromatography, and the new component was identified in eluates by radioimmuno...

journal_title：Gastroenterology

authors： Dockray GJ,Walsh JH

更新日期：1975-02-01 00:00:00

abstract：:In this review, we speculate about future therapeutic approaches for inflammatory bowel diseases (IBDs), focusing on the need for better preclinical and clinical models and approaches beyond small molecules and systemically administered biologics. We offer ideas to change clinical trial programs and to use immunologic...

journal_title：Gastroenterology

authors： Plevy SE,Targan SR

更新日期：2011-05-01 00:00:00

abstract：:Increasing evidence has emerged that supports an important intersection between 3 fundamental cell biologic pathways in the pathogenesis of inflammatory bowel disease. These include the intersection between autophagy, as revealed by the original identification of ATG16L1 and IRGM as major genetic risk factors for Croh...

journal_title：Gastroenterology

authors： Kaser A,Blumberg RS

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND & AIMS:Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract. METHODS:We examined the effects of intraperitoneal (IP) administra...

journal_title：Gastroenterology

authors： Chen CY,Inui A,Asakawa A,Fujino K,Kato I,Chen CC,Ueno N,Fujimiya M

更新日期：2005-07-01 00:00:00

abstract：:The presence of receptors for insulinlike growth factor I and II in human colonic epithelium is demonstrated. Scatchard analysis of binding data obtained with 125I-insulinlike growth factor I showed an insulinlike growth factor I receptor with a dissociation constant of 8.6 nM and a binding capacity of 0.8 pmol/mg mem...

journal_title：Gastroenterology

authors： Rouyer-Fessard C,Gammeltoft S,Laburthe M

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND & AIMS:Math1 (Atoh1) is a basic helix-loop-helix transcription factor important for intestinal secretory cell differentiation. We hypothesized that Math1 is important in cell fate commitment, and therefore mediates proliferative homeostasis and the adaptive response following intestinal resection in the adul...

journal_title：Gastroenterology

authors： Shroyer NF,Helmrath MA,Wang VY,Antalffy B,Henning SJ,Zoghbi HY

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND & AIMS:Germline mutations in one of four mismatch repair genes have been found in the majority of families with hereditary nonpolyposis colorectal cancer (HNPCC), but only in a small part of families with atypical HNPCC. The recently cloned EXO1 gene might be involved in the pathogenesis of HNPCC because the...

journal_title：Gastroenterology

authors： Wu Y,Berends MJ,Post JG,Mensink RG,Verlind E,Van Der Sluis T,Kempinga C,Sijmons RH,van der Zee AG,Hollema H,Kleibeuker JH,Buys CH,Hofstra RM

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND & AIMS:Alcoholic patients with and without chronic liver disease have a high incidence of infection with hepatitis C virus (HCV). Long-term ethanol consumption in mice has been associated with a strikingly reduced CD8(+) cytotoxic T-lymphocyte (CTL) response to HCV nonstructural proteins following DNA-based ...

journal_title：Gastroenterology

authors： Aloman C,Gehring S,Wintermeyer P,Kuzushita N,Wands JR

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND & AIMS:Animal studies have shown that more than half of the dietary protein intake is used by the gut and that a large proportion of this utilization is devoted to (glyco-)protein synthesis. Recycling of these secretions may play a critical role in the regulation of overall dietary amino acid bioavailability...

journal_title：Gastroenterology

authors： Van Der Schoor SR,Reeds PJ,Stoll B,Henry JF,Rosenberger JR,Burrin DG,Van Goudoever JB

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND & AIMS:Advanced cirrhosis is associated with impaired leukocyte function, but the mechanism underlying this host defense alteration is unknown. The aim of this study was to investigate the lipoxygenase pathway of arachidonic acid metabolism and its influence in leukocyte trafficking in patients with cirrhosi...

journal_title：Gastroenterology

authors： Clària J,Titos E,Jiménez W,Ros J,Ginès P,Arroyo V,Rivera F,Rodés J

更新日期：1998-07-01 00:00:00

abstract：:The absorption of an intact oligopeptide was investigated in rat and dog small intestine using the metabolically stable somatostatin analogue SMS 201-995. The synthetic octapeptide was coupled to 4-nitrobenzo-2-oxa-1,3-diazol to have a fluorescent label for the direct visualization. The 4-nitrobenzo-2-oxa-1,3-diazol-l...

journal_title：Gastroenterology

authors： Fricker G,Bruns C,Munzer J,Briner U,Albert R,Kissel T,Vonderscher J

更新日期：1991-06-01 00:00:00

abstract：:We studied 375 chronic hemodialysis patients for evidence of hepatitis B virus infection using first- and second-generation monoclonal radioimmunoassays. These assays employ high-affinity monoclonal antibodies produced against antigenic determinants that reside on hepatitis B surface antigen. Such assays have a lower ...

journal_title：Gastroenterology

authors： Fujita YK,Kamata K,Kameda H,Isselbacher KJ,Wands JR

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of leukotriene (LT) D(4) on intestinal epithelial cells govern events that are involved in cell survival and colon cancer, notably increased expression of cyclooxygenase (COX)-2 and enhanced production of prostaglandin E(2). We investigated possible correlations between distribution of the...

journal_title：Gastroenterology

authors： Ohd JF,Nielsen CK,Campbell J,Landberg G,Löfberg H,Sjölander A

更新日期：2003-01-01 00:00:00

abstract：:Eosinophilic esophagitis (EoE) was historically distinguished from gastroesophageal reflux disease on the basis of histology and lack of responsiveness to acid suppressive therapy, but it is now appreciated that esophageal eosinophilia can respond to proton pump inhibitors. Genetic and environmental factors contribute...

journal_title：Gastroenterology

authors： Rothenberg ME

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Leptin production has been reported in the rat and in human stomach. It initiates intestinal nutrient absorption. In this study, we analyzed the effect of vagal stimulation on leptin release in the human stomach. METHODS:We studied the secretion of gastric acid and leptin on stimulation with insulin ...

journal_title：Gastroenterology

authors： Sobhani I,Buyse M,Goïot H,Weber N,Laigneau JP,Henin D,Soul JC,Bado A

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes. Technical constraints have hampered the direct study of cccDNA maintenance and clearance mechanisms in patients. The aim of this study was ...

journal_title：Gastroenterology

authors： Werle-Lapostolle B,Bowden S,Locarnini S,Wursthorn K,Petersen J,Lau G,Trepo C,Marcellin P,Goodman Z,Delaney WE 4th,Xiong S,Brosgart CL,Chen SS,Gibbs CS,Zoulim F

更新日期：2004-06-01 00:00:00

abstract：:Strategies for management of inflammatory bowel diseases are shifting from simple control of symptoms toward full control of these diseases (clinical and endoscopic remission), with the final aim of blocking their progression and preventing bowel damage and disability. New goals have been proposed for treatment, such ...

journal_title：Gastroenterology

authors： Colombel JF,Narula N,Peyrin-Biroulet L

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux is common among patients with postnasal drainage. We investigated whether proton pump inhibitor therapy improved symptoms in patients with postnasal drainage without sinusitis or allergies. METHODS:In a parallel-group, double-blind, multi-specialty trial, we randomly assigned ...

journal_title：Gastroenterology

authors： Vaezi MF,Hagaman DD,Slaughter JC,Tanner SB,Duncavage JA,Allocco CT,Sparkman C,Clement LE,Wasden CM,Wirth D,Goutte M,McCafferty BA,Lanza DC

更新日期：2010-12-01 00:00:00

abstract：:Intestinal microbes regulate metabolic function and energy balance; an altered microbial ecology is believed to contribute to the development of several metabolic diseases. Relative species abundance and metabolic characteristics of the intestinal microbiota change substantially in those who are obese or have other me...

journal_title：Gastroenterology

authors： Nieuwdorp M,Gilijamse PW,Pai N,Kaplan LM

更新日期：2014-05-01 00:00:00