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Plasma levels of gastrin, somatostatin, and cholecystokinin immunoreactivity during pregnancy and lactation in dogs.

Abstract：

:Plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. Cholecystokinin was determined in pooled and in individual plasma samples after separation of cholecystokinin and gastrin by high-performance liquid chromatography. Gastrin and somatostatin levels were significantly increased during the 8-wk-long dog pregnancy; peak values were recorded in week 7 and week 4, respectively. The cholecystokinin level rose and peaked at week 3, and remained elevated. In response to suckling, maternal gastrin levels rose significantly when tested in week 1 and 3 of lactation. Somatostatin levels did not respond significantly to suckling, but basal levels were elevated in week 1 compared to week 3 of lactation. Cholecystokinin rose in response to suckling both in week 1 and 3 of lactation. We suggest that the increased levels of gastrointestinal hormones during pregnancy and lactation may serve to increase digestive and anabolic capacity.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Linden A,Eriksson M,Carlquist M,Uvnäs-Moberg K

doi

10.1016/0016-5085(87)90004-7

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

578-84

issue

3

eissn

0016-5085

issn

1528-0012

pii

0016-5085(87)90004-7

journal_volume

92

pub_type

杂志文章

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