Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure.

abstract：BACKGROUND & AIMS:Peroxynitrite (PN), a potent oxidant, has been implicated in the pathogenesis of gut inflammation and epithelial cell apoptosis. The aim of this study was to investigate mesalamine, a standard therapy for inflammatory bowel disease, to see if it attenuates PN-induced cytotoxicity in human intestinal e...

journal_title：Gastroenterology

authors： Sandoval M,Liu X,Mannick EE,Clark DA,Miller MJ

更新日期：1997-11-01 00:00:00

abstract：:The results of balloon dilatation of upper digestive tract stricture in 111 patients were evaluated. Eighty-eight patients had esophageal strictures and 23 had gastric or pyloric strictures. Thirty-six patients had strictures associated with previous operations. Twenty-two percent of the patients with esophageal stric...

journal_title：Gastroenterology

authors： Lindor KD,Ott BJ,Hughes RW Jr

更新日期：1985-09-01 00:00:00

abstract：:The role of cholinergic mechanisms in the control of gallbladder emptying has not been defined. In this report a scintigraphic technique using 2,6-dimethylphenylcarbamoylmethyl iminodiacetic acid labeled with technetium 99m to visualize the gallbladder and its emptying and diethylenetriamine pentaacetic acid labeled w...

journal_title：Gastroenterology

authors： Fisher RS,Rock E,Malmud LS

更新日期：1985-10-01 00:00:00

abstract：:Cholinergic innervation in the aganglionic bowel of the piebald lethal mouse model of Hirschsprung's disease was investigated by analysis of muscarinic acetylcholine receptors before and after administration of hexamethonium. After hexamethonium administration in the normal rectum, the maximum specific binding (Bmax) ...

journal_title：Gastroenterology

authors： Ueki S,Okamoto E,Kuwata K,Toyosaka A,Nagai K

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND & AIMS:The maintenance of the intestinal mucosal barrier may be energy dependent. Tacrolimus is a potent immunosuppressive drug that decreases mitochondrial adenosine triphosphate production and increases intestinal permeability in animals. METHODS:Twelve liver graft recipients receiving tacrolimus, 9 healt...

journal_title：Gastroenterology

authors： Gabe SM,Bjarnason I,Tolou-Ghamari Z,Tredger JM,Johnson PG,Barclay GR,Williams R,Silk DB

更新日期：1998-07-01 00:00:00

abstract：:To determine the frequency and significance of alpha-fetoprotein elevation in severe hepatitis B surface antigen-negative chronic active hepatitis, 558 serum samples obtained from 83 patients were tested by an immunoenzymometric assay. All patients received corticosteroids and sampling occurred at 6-12-mo intervals du...

journal_title：Gastroenterology

authors： Czaja AJ,Beaver SJ,Wood JR,Klee GG,Go VL

更新日期：1987-10-01 00:00:00

abstract：:Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...

journal_title：Gastroenterology

authors： Koch H,Rösch W,Schaffner O,Demling L

更新日期：1977-12-01 00:00:00

abstract：BACKGROUND & AIMS:The effects of aging on pancreatic acinar cell proliferation have not been clearly defined. Phosphatidylinositol 3-kinase (PI3K)-mediated phosphorylation of Akt is a critical step for proliferation of various cell types and insulin secretion from pancreatic endocrine cells; however, its role in acinar...

journal_title：Gastroenterology

authors： Watanabe H,Saito H,Rychahou PG,Uchida T,Evers BM

更新日期：2005-05-01 00:00:00

abstract：:The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...

journal_title：Gastroenterology

authors： Eckardt VF,Grace ND,Kantrowitz PA

更新日期：1976-08-01 00:00:00

abstract：:Using in vivo and in vitro techniques, the mechanism by which intestinal mucosa obtains glutamine from luminal oligopeptides was investigated in humans. The rate of hydrolysis by mucosal brush border membrane was more than threefold greater for alanylglutamine than for glycylglutamine. Despite this difference, rates o...

journal_title：Gastroenterology

authors： Minami H,Morse EL,Adibi SA

更新日期：1992-07-01 00:00:00

abstract：:After proximal small bowel resection, the remaining small intestine undergoes adaptive hyperplasia. The role of bile and pancreatic secretions in stimulating ileal mucosal growth after jejunectomy was studied. Male Sprague-Dawley rats were fed either standard rat chow or a liquid elemental diet, and were divided into ...

journal_title：Gastroenterology

authors： Weser E,Heller R,Tawil T

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND & AIMS:The complications of diverticulosis cause considerable morbidity in the United States; health care expenditures for this disorder are estimated to be $2.5 billion per year. Many physicians and patients believe that a high-fiber diet and frequent bowel movements prevent the development of diverticulosi...

journal_title：Gastroenterology

authors： Peery AF,Barrett PR,Park D,Rogers AJ,Galanko JA,Martin CF,Sandler RS

更新日期：2012-02-01 00:00:00

abstract：:Biliary ascariasis is as frequent a cause of adult biliary disease as gallstones in Kashmir Valley, India. In the present study, we prospectively evaluated the role of sonography in the diagnosis of biliary ascariasis and its utility in monitoring the exit of worms from the bile duct. Sonography was performed on 28 pa...

journal_title：Gastroenterology

authors： Khuroo MS,Zargar SA,Mahajan R,Bhat RL,Javid G

更新日期：1987-08-01 00:00:00

abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...

journal_title：Gastroenterology

authors： Perez-Jimenez F,Bockman DE,Singh M

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND/AIMS:Approximately 50% of patients with functional dyspepsia have Helicobacter pylori infection; it remains controversial whether this infection causes chronic symptoms, but rigorously conducted therapeutic trials should establish whether H. pylori plays a role in functional dyspepsia. The aim here was to de...

journal_title：Gastroenterology

authors： Talley NJ

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND & AIMS:A Th1 clone, II-6, established from an autoimmune gastritis BALB/c mouse that underwent thymectomy 3 days after birth, recognized a 15 mer peptide constructing the alpha subunit of H+, K(+)-adenosine triphosphatase as antigen and induced gastritis in nu/nu mice by adoptive transfer. The aim of this st...

journal_title：Gastroenterology

authors： Nishio A,Katakai T,Oshima C,Kasakura S,Sakai M,Yonehara S,Suda T,Nagata S,Masuda T

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide localized to primary sensory afferent nerves in the rat stomach. The actions of CGRP in regulating antral neuroendocrine function were examined in vitro through the use of capsaicin, an agent capable of evoking neuropeptide release from periph...

journal_title：Gastroenterology

authors： Ren J,Young RL,Lassiter DC,Harty RF

更新日期：1993-02-01 00:00:00

abstract：:Circadian changes in drug absorption have been documented for several orally administered drugs in humans. To determine whether gastric emptying could account for these changes, morning (8 AM) and evening (8 PM) gastric emptying rates were measured in 16 healthy male subjects synchronized with diurnal activity and noc...

journal_title：Gastroenterology

authors： Goo RH,Moore JG,Greenberg E,Alazraki NP

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) show increased risk of developing esophageal adenocarcinoma and are routinely examined using upper endoscopy with biopsy to detect neoplastic changes. Angle-resolved low coherence interferometry (a/LCI) uses in vivo depth-resolved nuclear morphology measurements ...

journal_title：Gastroenterology

authors： Terry NG,Zhu Y,Rinehart MT,Brown WJ,Gebhart SC,Bright S,Carretta E,Ziefle CG,Panjehpour M,Galanko J,Madanick RD,Dellon ES,Trembath D,Bennett A,Goldblum JR,Overholt BF,Woosley JT,Shaheen NJ,Wax A

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND & AIMS:Among the human mucin complementary DNAs thus far identified, two (MUC5AC and MUC6) were cloned from stomach libraries. This study examines the distribution of MUC6 in normal tissues and compares it with that of MUC5AC as well as with the expression of Lewis blood group antigens. METHODS:Affinity-pur...

journal_title：Gastroenterology

authors： De Bolós C,Garrido M,Real FX

更新日期：1995-09-01 00:00:00

abstract：:Regional specific antibodies and chromatography were used to analyze the distributions and molecular forms of peptide histidine isoleucine (PHI) and vasoactive intestinal peptide (VIP) in the porcine intestine. Both peptides were present along the entire length of the intestine, the highest concentrations occurring in...

journal_title：Gastroenterology

authors： Yiangou Y,Christofides ND,Blank MA,Yanaihara N,Tatemoto K,Bishop AE,Polak JM,Bloom SR

更新日期：1985-09-01 00:00:00

abstract：:Many women report that bowel symptoms are associated with menstruation, but neither the prevalence of these complaints nor their physiological basis is known. This study aimed to estimate prevalence, to determine whether patients with irritable bowel syndrome are more likely to make such complaints, and to determine w...

journal_title：Gastroenterology

authors： Whitehead WE,Cheskin LJ,Heller BR,Robinson JC,Crowell MD,Benjamin C,Schuster MM

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND & AIMS:Most patients with esophageal adenocarcinoma (EAC) present with de novo tumors. Although this could be due to inadequate screening strategies, the precise reason for this observation is not clear. We compared survival of patients with prevalent EAC with and without synchronous Barrett esophagus (BE) w...

journal_title：Gastroenterology

authors： Sawas T,Killcoyne S,Iyer PG,Wang KK,Smyrk TC,Kisiel JB,Qin Y,Ahlquist DA,Rustgi AK,Costa RJ,Gerstung M,Fitzgerald RC,Katzka DA,OCCAMS Consortium.

更新日期：2018-12-01 00:00:00

abstract：:To explore the metabolic aspects of chronic liver disease, diurnal changes of arterial ketone body ratio (acetoacetate/3-hydroxybutyrate), reflecting hepatic mitochondrial redox potential, were investigated in normal subjects, patients with chronic liver disease (Child's class A or B), and patients with hepatic failur...

journal_title：Gastroenterology

authors： Iwata S,Ozawa K,Shimahara Y,Mori K,Kobayashi N,Kumada K,Yamaoka Y

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND & AIMS:In several rat infection experiments, we have shown that dietary calcium inhibits intestinal colonization and translocation of invasive salmonella. The aim of the present study was to find out whether calcium is also protective against enterotoxigenic Escherichia coli (ETEC) infection. This was first ...

journal_title：Gastroenterology

authors： Bovee-Oudenhoven IM,Lettink-Wissink ML,Van Doesburg W,Witteman BJ,Van Der Meer R

更新日期：2003-08-01 00:00:00

abstract：BACKGROUND & AIMS:Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (G-CSF) could promote hepatic regeneration. METHODS:Consecutive patients with ACLF were randomly assi...

journal_title：Gastroenterology

authors： Garg V,Garg H,Khan A,Trehanpati N,Kumar A,Sharma BC,Sakhuja P,Sarin SK

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:Ethanol impairs the mitochondrial transport of reduced glutathione (GSH), resulting in lower mitochondrial GSH (mGSH) levels. Our purpose was to evaluate the role of acetaldehyde on the regulation of mGSH in HepG2 cells. METHODS:mGSH levels and transport, mitochondrial membrane microviscosity, and li...

journal_title：Gastroenterology

authors： Lluis JM,Colell A,García-Ruiz C,Kaplowitz N,Fernández-Checa JC

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND & AIMS:The integrin alpha(4)beta(7) mediates homing of effector/memory lymphocytes to the intestine and the mucosa-associated lymphoid tissue. This study examined the ability of alpha(4)beta(7)(hi) CD4(+) T lymphocytes to home to the stomach and their role in immunization-mediated protection against Helicoba...

journal_title：Gastroenterology

authors： Michetti M,Kelly CP,Kraehenbuhl JP,Bouzourene H,Michetti P

更新日期：2000-07-01 00:00:00

abstract：:Crohn's disease and ulcerative colitis are heterogeneous inflammatory bowel diseases, and therapeutic requirements vary among patients. We have a limited capacity to predict disease progression for individual patients, therefore it is important that they are evaluated for the presence of active disease when symptoms a...

journal_title：Gastroenterology

authors： Panes J,Jairath V,Levesque BG

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND & AIMS:The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the l...

journal_title：Gastroenterology

authors： Kumar A,Priyamvada S,Ge Y,Jayawardena D,Singhal M,Anbazhagan AN,Chatterjee I,Dayal A,Patel M,Zadeh K,Saksena S,Alrefai WA,Gill RK,Zadeh M,Zhao N,Mohamadzadeh M,Dudeja PK

更新日期：2020-11-13 00:00:00