Abstract:
BACKGROUND & AIMS:Fully covered self-expanding metal stents (FCSEMS) are gaining acceptance for the treatment of benign biliary strictures. We performed a large prospective multinational study to study the ability to remove these stents after extended indwell and the frequency and durability of stricture resolution. METHODS:In a nonrandomized study at 13 centers in 11 countries, 187 patients with benign biliary strictures received FCSEMS. Removal was scheduled at 10-12 months for patients with chronic pancreatitis or cholecystectomy and at 4-6 months for patients who received liver transplants. The primary outcome measure was removal success, defined as either scheduled endoscopic removal of the stent with no removal-related serious adverse events or spontaneous stent passage without the need for immediate restenting. RESULTS:Endoscopic removal of FCSEMS was not performed for 10 patients because of death (from unrelated causes), withdrawal of consent, or switch to palliative treatment. For the remaining 177 patients, removal success was accomplished in 74.6% (95% confidence interval [CI], 67.5%-80.8%). Removal success was more frequent in the chronic pancreatitis group (80.5%) than in the liver transplantation (63.4%) or cholecystectomy (61.1%) groups (P = .017). FCSEMS were removed by endoscopy from all patients in whom this procedure was attempted. Stricture resolution without restenting upon FCSEMS removal occurred in 76.3% of patients (95% CI, 69.3%-82.3%). The rate of resolution was lower in patients with FCSEMS migration (odds ratio, 0.22; 95% CI, 0.11-0.46). Over a median follow-up period of 20.3 months (interquartile range, 12.9-24.3 mo), the rate of stricture recurrence was 14.8% (95% CI, 8.2%-20.9%). Stent- or removal-related serious adverse events, most often cholangitis, occurred in 27.3% of patients. There was no stent- or removal-related mortality. CONCLUSIONS:In a large prospective multinational study, removal success of FCSEMS after extended indwell and stricture resolution were achieved for approximately 75% of patients. ClincialTrials.gov number, NCT01014390.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Devière J,Nageshwar Reddy D,Püspök A,Ponchon T,Bruno MJ,Bourke MJ,Neuhaus H,Roy A,González-Huix Lladó F,Barkun AN,Kortan PP,Navarrete C,Peetermans J,Blero D,Lakhtakia S,Dolak W,Lepilliez V,Poley JW,Tringali A,Costamdoi
10.1053/j.gastro.2014.04.043subject
Has Abstractpub_date
2014-08-01 00:00:00pages
385-95; quiz e15issue
2eissn
0016-5085issn
1528-0012pii
S0016-5085(14)00599-Xjournal_volume
147pub_type
临床试验,杂志文章,多中心研究相关文献
GASTROENTEROLOGY文献大全abstract::Phosphatase-mediated hydrolysis is the first step in the intestinal absorption of pyridoxal 5'-phosphate (PLP). Studies presented here evaluated the effects of PLP-protein binding and pH on intestinal hydrolysis in the rat. Models included in vitro PLP decay and in vivo PLP disappearance from perfused jejunal segments...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(86)90567-6
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND & AIMS:Advanced pancreatic carcinoma has a dismal prognosis despite extensive chemotherapeutic trials. The aim of this study was to evaluate the role of retinoids as an experimental therapeutic approach for pancreatic cancer. METHODS:Four ductal and one acinar pancreatic tumor cell lines were investigated. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90655-x
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND & AIMS:T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS:We analyzed intestinal Th17 cells in healt...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2012.07.108
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(95)90013-6
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND/AIMS:During liver fibrosis, there is a putative pacemaker role of fibronectin. Fibrinogen is closely linked to fibronectin during clotting processes. The aim of this study was to show fibrinogen gene expression during liver damage. METHODS:Fibrinogen/fibrin deposition in damaged livers was studied by immuno...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90211-2
更新日期:1995-04-01 00:00:00
abstract::After proximal small bowel resection, the remaining small intestine undergoes adaptive hyperplasia. The role of bile and pancreatic secretions in stimulating ileal mucosal growth after jejunectomy was studied. Male Sprague-Dawley rats were fed either standard rat chow or a liquid elemental diet, and were divided into ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND & AIMS:It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding a...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2016.09.006
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND & AIMS:Helicobacter pylori attaches to mucin oligosaccharides that are expressed on host gastric epithelium. We used the rhesus macaque model to characterize the effect of H. pylori infection on gastric mucin oligosaccharides during acute and chronic infection. METHODS:Specific pathogen (H. pylori)-free rhe...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.04.014
更新日期:2009-09-01 00:00:00
abstract::The prevalence of delta-markers among 71 patients with fulminant B viral hepatitis was found to be 33.8%. The majority of the patients with delta-markers showed serologic evidence of simultaneous acute delta-infection and B viral infection. Only 5 of the 24 patients with serologic markers of acute delta-infection in t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND & AIMS:There is growing interest in the use of bone marrow cells to treat liver fibrosis, however, little is known about their antifibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.03.022
更新日期:2017-07-01 00:00:00
abstract::Esophageal ligation in the pylorus-ligated rat significantly inhibited volume, titratable acidity, and titratable acid output and reduced the incidence of ulcers, perforations, and death of 18-hr pylorus-ligated rats. Draining the saliva outside the body of the rat by esophageal cannulation produced a significant incr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1966-06-01 00:00:00
abstract:BACKGROUND & AIMS:Regulation of blood flow and oxygen supply are important pathogenetic factors in alcoholic liver disease. Because nitric oxide may have an important role, its effects on alcoholic liver injury were investigated. METHODS:Rats were fed ethanol intragastrically with either saturated fat or corn oil. Spo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90400-x
更新日期:1995-09-01 00:00:00
abstract::Obese subjects are prone to supersaturated bile, which is maintained or increased during weight loss. In this report, two related studies were carried out on obese subjects to investigate effects of bile acid feeding on biliary lipid metabolism before and during weight reduction. In one study, chenodeoxycholic acid (...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND & AIMS:Proliferating cholangiocytes secrete and respond to neuroendocrine hormones, including secretin. We investigated whether secretin secreted by S cells and cholangiocytes stimulates biliary proliferation in mice. METHODS:Cholestasis was induced in secretin knockout (Sct(-/-)) and wild-type (control) mi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2014.02.030
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND & AIMS:In 1988, we reported the first twin study in inflammatory bowel disease. The aim of the current study was to follow up these twins regarding new cases of inflammatory bowel disease and Crohn's disease characteristics using the Vienna classification. METHODS:The official Swedish population register an...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00385-8
更新日期:2003-06-01 00:00:00
abstract:BACKGROUND & AIMS:Peroxynitrite (PN), a potent oxidant, has been implicated in the pathogenesis of gut inflammation and epithelial cell apoptosis. The aim of this study was to investigate mesalamine, a standard therapy for inflammatory bowel disease, to see if it attenuates PN-induced cytotoxicity in human intestinal e...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v113.pm9352850
更新日期:1997-11-01 00:00:00
abstract::To determine the effect of intraduodenal calcium on pancreatic, gallbladder, and gastric functions in healthy man, a validated perfusion method was employed to quantify total pancreatic, biliary, and gastric outputs during duodenal perfusion of either 6 mM, 12 mM,or 25 mM of elemental calcium (as isotonic calcium chlo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND & AIMS:Feeding intolerance because of functional gastrointestinal dysmotility and parenteral nutrition-associated cholestasis (PNAC) are common problems in preterm, very-low-birth-weight (VLBW) infants. This double-blind, randomized, placebo-controlled study aimed to assess the effectiveness of "high-dose" o...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2007.03.043
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND & AIMS:Cellular and molecular mechanisms of esophageal ulcer healing remain unexplored. We studied the sequential cellular events and the expression of keratinocyte growth factor (KGF) and its receptor (KGF-R) during the healing of experimental esophageal ulcers. METHODS:Esophageal ulcers were produced in r...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.31004
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND & AIMS:Abdominal pain is the main symptom in patients with irritable bowel syndrome (IBS). Glycerol is an irritant of colonic mucosa. The aim of this study was to evaluate the effects of an intraluminal injection of glycerol on colonic motility and tone in patients with IBS and their modulation by drugs. ME...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.1996.v110.pm8566580
更新日期:1996-02-01 00:00:00
abstract::A technique for the direct measurement of portal vein pressure in fully conscious patients is described. This uses a percutaneous transhepatic approach with a thin Chiba needle and is shown to be simple and safe. The technique has been applied to 123 patients with a variety of liver disorders and the pressure measurem...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND & AIMS:A random biopsy is recommended for surveillance of ulcerative colitis (UC)-associated colorectal cancer. However, a targeted biopsy might be more effective. We conducted a randomized controlled trial to compare rates of neoplasia detection by targeted vs random biopsies in patients with UC. METHODS:W...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2016.08.002
更新日期:2016-12-01 00:00:00
abstract::Boron may be beneficial for bone growth and maintenance, central nervous system function, and the inflammatory response, and silicon may be beneficial for bone maintenance and wound healing. Fluoride is not an essential element but amounts provided by contamination may be beneficial for bone strength. Fluoride toxicit...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2009.07.072
更新日期:2009-11-01 00:00:00
abstract::Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2011.10.002
更新日期:2011-12-01 00:00:00
abstract::Transient relaxation of the lower esophageal sphincter (LES) is observed fairly frequently during prolonged continuous monitoring of the LES. The aim of this study was to test whether the presence of a catheter in the pharynx through the stimulation of mechanoreceptors may induce transient LES relaxation. LES and esop...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91509-3
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND & AIMS:Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown. METHODS:We prospectively studied consecutive patients with bleeding gastroduodenal ulcers from January to December 2000. The incidence and etiology of ulc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.03.026
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND & AIMS:The down-regulated in adenoma (DRA) protein, encoded by SLC26A3, a key intestinal chloride anion exchanger, has recently been identified as a novel susceptibility gene for inflammatory bowel disease (IBD). However, the mechanisms underlying the increased susceptibility to inflammation induced by the l...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.11.008
更新日期:2020-11-13 00:00:00
abstract::A patient is reported with eosinophilic enteritis of the jejunum with fatal evolution. Surgical resection was considered impossible and medical treatment with corticosteroids, elemental diet, parenteral nutrition, and antimicrobials to combat the intestinal bacterial overgrowth failed to control the disease. The destr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1976-09-01 00:00:00
abstract::Two infants under 3 mo of age who presented with obstructive jaundice secondary to cholelithiasis are reported. Neither infant had any congenital anatomic abnormality of the biliary tract leading to stasis, yet both had cultures of gallbladder bile that grew abundant bacteria. In both, recovery of gallbladder bile and...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(89)91579-5
更新日期:1989-02-01 00:00:00
abstract::The leukocyte migration inhibition test has been used to investigate cellular immune responses to antigens in a protein fraction (BPF) of normal human gallbladder bile in patients with a variety of intra- and extrahepatic diseases. Inhibition of leukocyte migration in the presence of BPF was observed in 30 (81%) of 37...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00