Cholinergic effects on esophageal transit and clearance.

abstract：BACKGROUND:Calcitonin gene-related peptide (CGRP) is a 37-amino acid peptide localized to primary sensory afferent nerves in the rat stomach. The actions of CGRP in regulating antral neuroendocrine function were examined in vitro through the use of capsaicin, an agent capable of evoking neuropeptide release from periph...

journal_title：Gastroenterology

authors： Ren J,Young RL,Lassiter DC,Harty RF

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal stem and progenitor cells through phosphor...

journal_title：Gastroenterology

authors： Lee G,Goretsky T,Managlia E,Dirisina R,Singh AP,Brown JB,May R,Yang GY,Ragheb JW,Evers BM,Weber CR,Turner JR,He XC,Katzman RB,Li L,Barrett TA

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND & AIMS:Inflammation is created by the movement of leukocytes toward soluble attractants (chemokines). The aim of this study was to identify the chemokines that attract intestinal lymphocytes. METHODS:Intraepithelial and lamina propria lymphocytes were isolated from human jejunal mucosa of healthy individual...

journal_title：Gastroenterology

authors： Ebert EC

更新日期：1995-10-01 00:00:00

abstract：:Corticotropin-releasing factor (CRF) administered into the lateral cerebral ventricle significantly inhibited gastric emptying and small bowel transit, but most markedly increased large bowel transit in a dose-related fashion in freely moving rats. Inhibition of gastric emptying induced by central administration of CR...

journal_title：Gastroenterology

authors： Lenz HJ,Burlage M,Raedler A,Greten H

更新日期：1988-03-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with chronic hepatitis B virus (HBV) infection have a high risk for developing hepatocellular carcinoma (HCC). Patients with lower levels of hepatitis B surface antigen (HBsAg) have higher chances of losing HBsAg than those with high levels. However, little is known about whether higher level...

journal_title：Gastroenterology

authors： Tseng TC,Liu CJ,Yang HC,Su TH,Wang CC,Chen CL,Kuo SF,Liu CH,Chen PJ,Chen DS,Kao JH

更新日期：2012-05-01 00:00:00

abstract：:The effects of vasopressin on blood flow in the superior mesenteric artery and on mean arterial pressure and portal venous pressure were measured in 7 rhesus monkeys. Vasopressin was injected, as either a bolus, or infused both intravenously and intraarterially to assess the influence of the route of administration up...

journal_title：Gastroenterology

authors： Freedman AR,Kerr JC,Swan KG,Hobson RW

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary colorectal cancer is associated most commonly with the hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis syndromes. We investigated the prevalence of early onset colorectal cancer and the frequency of p53 germline mutations in 64 families from a Li-Fraumeni syndrom...

journal_title：Gastroenterology

authors： Wong P,Verselis SJ,Garber JE,Schneider K,DiGianni L,Stockwell DH,Li FP,Syngal S

更新日期：2006-01-01 00:00:00

abstract：:A case of a 29-year-old woman who has had two episodes both clinically and biochemically consistent with acute fatty liver of pregnancy is described. These episodes occurred in two successive pregnancies, and liver biopsy confirmed the diagnosis in the second pregnancy. Both pregnancies were managed by prompt fetal de...

journal_title：Gastroenterology

authors： Schoeman MN,Batey RG,Wilcken B

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) have a risk of esophageal adenocarcinoma of approximately 0.5% per year. Patients may have difficulty understanding this risk. This study assessed the perceived risk of cancer in patients with BE, and correlated their risk estimates with their health care use beh...

journal_title：Gastroenterology

authors： Shaheen NJ,Green B,Medapalli RK,Mitchell KL,Wei JT,Schmitz SM,West LM,Brown A,Noble M,Sultan S,Provenzale D

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND & AIMS:The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation. METHODS:Transgenic C57BL/6 mice with liver-specific expression of RNA encoding the complete viral polyprotein (FL-N transgene) or viral structu...

journal_title：Gastroenterology

authors： Lerat H,Honda M,Beard MR,Loesch K,Sun J,Yang Y,Okuda M,Gosert R,Xiao SY,Weinman SA,Lemon SM

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND & AIMS:This longitudinal study investigated the interactions and roles of hepatitis B virus (HBV) genotypes, pre-S deletions, and core promoter and precore mutations on the progression of liver disease in hepatitis B e antigen (HBeAg)-negative patients. METHODS:A total of 141 HBeAg-negative patients without...

journal_title：Gastroenterology

authors： Chen CH,Hung CH,Lee CM,Hu TH,Wang JH,Wang JC,Lu SN,Changchien CS

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND & AIMS:Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli. We propose that fibromodulin contributes to the pathogenes...

journal_title：Gastroenterology

authors： Mormone E,Lu Y,Ge X,Fiel MI,Nieto N

更新日期：2012-03-01 00:00:00

abstract：:Caliber-persistent artery of the stomach (also known as cirsoid aneurysm, Dieulafoy's lesion, and submucosal arterial malformation) is clinically manifested as recurrent, massive, often fatal hematemesis. The lesion often is not seen endoscopically. Left gastric angiography in one patient with hematemesis showed a con...

journal_title：Gastroenterology

authors： Eidus LB,Rasuli P,Manion D,Heringer R

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The contribution of the crural diaphragm to the gastroesophageal high pressure zone (HPZ) may be important in prevention of gastroesophageal reflux. The purpose of this study was to investigate the manometric characteristics of the thoracoabdominal junction in patients after surgical removal of the lower eso...

journal_title：Gastroenterology

authors： Klein WA,Parkman HP,Dempsey DT,Fisher RS

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND & AIMS:Progressive familial intrahepatic cholestasis can be caused by mutations in ABCB4 or ATP8B1; each encodes a protein that translocates phospholipids, but in opposite directions. ABCB4 flops phosphatidylcholine from the inner to the outer leaflet, where it is extracted by bile salts. ATP8B1, in complex ...

journal_title：Gastroenterology

authors： Groen A,Romero MR,Kunne C,Hoosdally SJ,Dixon PH,Wooding C,Williamson C,Seppen J,Van den Oever K,Mok KS,Paulusma CC,Linton KJ,Oude Elferink RP

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND & AIMS:Serotonin transporter (SERT) plays a critical role in regulating serotonin (5-hydroxytryptamine [5-HT]) availability in the gut. Elevated 5-HT levels are associated with diarrheal conditions such as irritable bowel syndrome and enteric infections. Whether alteration in SERT activity contributes to the...

journal_title：Gastroenterology

authors： Esmaili A,Nazir SF,Borthakur A,Yu D,Turner JR,Saksena S,Singla A,Hecht GA,Alrefai WA,Gill RK

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND & AIMS:Narcotic bowel syndrome (NBS) is a subset of opioid bowel dysfunctions that results from prolonged treatment with narcotics and is characterized by chronic abdominal pain. NBS is under-recognized and its molecular mechanisms are unknown. We aimed to (1) develop a rat model of NBS and (2) to investigat...

journal_title：Gastroenterology

authors： Agostini S,Eutamene H,Cartier C,Broccardo M,Improta G,Houdeau E,Petrella C,Ferrier L,Theodorou V,Bueno L

更新日期：2010-08-01 00:00:00

abstract：:A randomized, double-blind comparison of lactose enemas plus placebo tablets vs. starch enemas plus neomycin tablets was performed on 18 patients with acute portal systemic encephalopathy. Ten patients received starch enemas (10%; 1000 ml t.i.d.) plus neomycin tablets and 8 patients received lactose enemas (20%; 1000 ...

journal_title：Gastroenterology

authors： Uribe M,Berthier JM,Lewis H,Mata JM,Sierra JG,García-Ramos G,Ramírez Acosta J,Dehesa M

更新日期：1981-07-01 00:00:00

abstract：BACKGROUND/AIMS:Intestinal distention induces perception and gut reflexes via sympathetic and vagal pathways, but the modulatory mechanisms of such responses remain obscure. The aim of this study was to determine the effects of sympathetic nervous activity on sympathetic and vagal reflexes as well as on intestinal and ...

journal_title：Gastroenterology

authors： Iovino P,Azpiroz F,Domingo E,Malagelada JR

更新日期：1995-03-01 00:00:00

abstract：:The histological and immunohistochemical characteristics of the liver in 44 children (28 boys, 16 girls) with extrahepatic biliary atresia at different stages of the clinical course were studied. Thirty-four wedge liver biopsy specimens taken during Kasai operations (25 specimens) and relaparotomy (9 specimens) and 20...

journal_title：Gastroenterology

authors： Nietgen GW,Vacanti JP,Perez-Atayde AR

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND & AIMS:Narrow-band imaging (NBI) allows real-time histologic classification of colorectal polyps. We investigated whether endoscopists without prior training in NBI can achieve the following thresholds recommended by the American Society for Gastrointestinal Endoscopy: for diminutive colorectal polyps charac...

journal_title：Gastroenterology

authors： Patel SG,Schoenfeld P,Kim HM,Ward EK,Bansal A,Kim Y,Hosford L,Myers A,Foster S,Craft J,Shopinski S,Wilson RH,Ahnen DJ,Rastogi A,Wani S

更新日期：2016-02-01 00:00:00

abstract：:Endogenous pancreatic prostaglandin production in control and obstructive jaundice was investigated using isolated and perfused dog pancreas. In both groups, spontaneous production of prostaglandin E2 and prostaglandin I2 was recorded, and the levels did not change in both groups. The production of both prostaglandins...

journal_title：Gastroenterology

authors： Kuroda T,Kajikawa S,Hanazaki K,Horigome N,Sodeyama H,Horiuchi A,Iwatsuki K,Chiba S,Homma T,Iida F

更新日期：1990-05-01 00:00:00

abstract：:Wilson's disease may present with severe acute hepatocellular failure. The only effective treatment for fulminant Wilson's disease is liver transplantation, which may lead to reversal of the underlying disease. Some patients with cirrhosis who are too ill to undergo orthotopic liver transplantation have been treated w...

journal_title：Gastroenterology

authors： Stampfl DA,Muñoz SJ,Moritz MJ,Rubin R,Armenti VT,Jarrell BE,Maddrey WC

更新日期：1990-12-01 00:00:00

abstract：:Sweden has one of the highest incidences of gallstone disease in the Western world. It is therefore important to characterize the mechanisms responsible for the formation of cholesterol gallstones in this population. In the present study, we have determined the kinetics of the two primary bile acids, cholic acid and c...

journal_title：Gastroenterology

authors： Nilsell K,Angelin B,Liljeqvist L,Einarsson K

更新日期：1985-08-01 00:00:00

abstract：:2-Camphanone is under clinical evaluation for alleviation of hemorrhoidal bleeding and inflammation. Reduced portal venous blood flow may distend, whereas improved portal venous blood flow may alleviate, hemorrhoidal vein distention. The effects of 2-camphanone on canine portal venous blood flow were investigated usin...

journal_title：Gastroenterology

authors： Xie JM,Greenberg SS,Longenecker G

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND & AIMS:Animal studies have shown that more than half of the dietary protein intake is used by the gut and that a large proportion of this utilization is devoted to (glyco-)protein synthesis. Recycling of these secretions may play a critical role in the regulation of overall dietary amino acid bioavailability...

journal_title：Gastroenterology

authors： Van Der Schoor SR,Reeds PJ,Stoll B,Henry JF,Rosenberger JR,Burrin DG,Van Goudoever JB

更新日期：2002-12-01 00:00:00

abstract：:Median nerve somatosensory evoked potentials were recorded from 33 patients with various degrees of hepatic failure and from 10 age-matched controls. Within 20 ms poststimulation, one negative peak (N13) could be recorded from the middle of the back of the patient's neck at the C2 vertebral level. Within 150 ms, three...

journal_title：Gastroenterology

authors： Yang SS,Chu NS,Liaw YF

更新日期：1985-09-01 00:00:00

abstract：:A multicenter study was conducted on 173 patients with active, endoscopically proven duodenal ulcers (158 men, 15 women). They were randomly assigned, in a double-blind manner, to two groups: those receiving placebo capsules (91 patients) and those receiving capsules containing 100 microgram of 15(R)-15-methyl prostag...

journal_title：Gastroenterology

authors： Vantrappen G,Janssens J,Popiela T,Kulig J,Tytgat GN,Huibregtse K,Lambert R,Pauchard JP,Robert A

更新日期：1982-08-01 00:00:00

abstract：:This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on "Use of Gastrointestinal Medications in Pregnancy." It was approved by the Clinical Practice and Economics Committee on February 22, 2006, and by the AGA Institute Governing Board on April 20, 2006. ...

journal_title：Gastroenterology

authors： Mahadevan U,Kane S

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND & AIMS:Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci ...

journal_title：Gastroenterology

authors： Dong J,Maj C,Tsavachidis S,Ostrom QT,Gharahkhani P,Anderson LA,Wu AH,Ye W,Bernstein L,Borisov O,Schröder J,Chow WH,Gammon MD,Liu G,Caldas C,Pharoah PD,Risch HA,May A,Gerges C,Anders M,Venerito M,Schmidt T,Izbi

更新日期：2020-12-01 00:00:00