Abstract：
BACKGROUND & AIMS:Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS:Galectin 3 expression was examined immunohistochemically in 39 samples of normal mucosae, 25 adenomas, 87 carcinomas, and 39 lymph node metastases. Galectin 1 was analyzed in 25 samples of mucosae, 15 adenomas, 25 carcinomas, and 11 metastases. Western blot analysis was also performed. RESULTS:All normal mucosae showed strong nuclear galectin 3 expression, which was down-regulated in the neoplastic progression, because only 60% of adenomas, 48% of carcinomas, and 44% of metastases were strongly positive (P < 0.0001). Cytoplasmic expression was down-regulated in adenomas (16%) but increased again in carcinomas (64%) (P < 0.0001). Galectin 1 expression was mainly detected in stromal cells and correlated with tumor progression from normal mucosae to adenomas and carcinomas (P < 0.0001). CONCLUSIONS:Galectin 3 expression is down-regulated in the initial stages of neoplastic progression, whereas a dissociated cytoplasmic expression increases in later phases of tumor progression. Galectin 1 in colorectal mucosa is predominantly a stromal product whose overexpression is associated with the neoplastic progression of colorectal cancer.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Sanjuán X,Fernández PL,Castells A,Castronovo V,van den Brule F,Liu FT,Cardesa A,Campo Edoi
10.1016/s0016-5085(97)70010-6subject
Has Abstractpub_date
1997-12-01 00:00:00pages
1906-15issue
6eissn
0016-5085issn
1528-0012pii
S0016508597005581journal_volume
113pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:Behavioral economic approaches could increase uptake for colorectal cancer screening. We performed a randomized controlled trial of 2245 employees to determine whether an email containing a phone number for scheduling (control), an email with the active choice to opt in or opt out (active choice), or the active choice...
journal_title：Gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.gastro.2017.07.015
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND & AIMS:Although bacterial bowel flora may be one of the contributing factors in the pathogenesis of chronic mucosal inflammation, antibiotic treatment has no established role in ulcerative colitis. The aim of the study was to evaluate the role of ciprofloxacin in the induction and maintenance of remission in...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0016-5085(98)70076-9
更新日期：1998-11-01 00:00:00
abstract：:The aim of this study was to correlate colonic motility with transit in 8 patients with functional diarrhea compared to 12 healthy subjects. Intraluminal pressure was measured with perfused catheter ports in the transverse colon, splenic flexure, and descending and sigmoid colons. Transit of the luminal contents was m...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90080-5
更新日期：1991-11-01 00:00:00
abstract：:Plasma levels of gastrinlike, somatostatinlike, and cholecystokininlike immunoreactivity were determined by radioimmunoassay in peripheral blood from 11 beagles during pregnancy and in response to suckling during lactation. Cholecystokinin was determined in pooled and in individual plasma samples after separation of c...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(87)90004-7
更新日期：1987-03-01 00:00:00
abstract：BACKGROUND & AIMS:The rate of 12alpha-hydroxylation of bile acid intermediates is believed to determine the ratio of cholic acid (CA) to chenodeoxycholic acid (CDCA) biosynthesis and the overall hydrophobicity of the bile acid pool. The aim of this study was to determine the effects of the level of expression of sterol...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.24833
更新日期：2001-06-01 00:00:00
abstract：:To determine the fate of exogenous epidermal growth factor (EGF) in regenerating liver, 125I-labeled EGF was injected into rat portal veins at various times after 70% hepatectomy. Epidermal growth factor was taken up by the liver remnant at all time points studied (0, 4, 8, 16, and 36 h), but at 8 h after hepatectomy ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(87)91084-5
更新日期：1987-05-01 00:00:00
abstract：:The human lower esophageal sphincter (LES) is believed to be innervated by nonadrenergic, noncholinergic inhibitory nerves, and cholinergic excitatory nerves. In idiopathic achalasia, LES relaxation is abnormal because the inhibitory nerves to the sphincter are either absent or functionally impaired. The integrity of ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90869-3
更新日期：1986-04-01 00:00:00
abstract：:Adverse effects associated with nonsteroidal antiinflammatory drug treatment are reported more commonly to regulatory authorities than the adverse effects of any other form of treatment. Epidemiologic evidence in general suggests a doubling or quadrupling of the risk of ulcer complications or death in recipients of su...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/s0016-5085(89)80060-5
更新日期：1989-02-01 00:00:00
abstract：BACKGROUND & AIMS:Small intestinal carcinomas are rare but occur with increased incidence in Crohn's disease. The aim of this study was to elucidate the genetic alterations. METHODS:Mutations and deletions involved in colorectal carcinoma were studied in sporadic and Crohn's-associated intestinal carcinomas and precur...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(97)70087-8
更新日期：1997-07-01 00:00:00
abstract：:Endosonography was performed preoperatively in 33 patients with common bile duct carcinoma and in 43 patients with carcinoma of the common hepatic duct and its bifurcation. The results were correlated with the histology of resected specimens according to the new (1987) TNM (tumor, node, metastasis) classification. End...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1991-05-01 00:00:00
abstract：BACKGROUND & AIMS:Immune-nonimmune cell interactions modulate mucosal immunity. We investigated the expression of adhesion molecules by intestinal fibroblasts, the effect of immune cell-derived factor on fibroblast binding of T cells, and the consequences of interfering with adhesion molecule expression on fibroblast-T...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(99)70447-6
更新日期：1999-09-01 00:00:00
abstract：:Characteristics of electrical activities, and the relationship between electrical and motor activities, were studied in circular and longitudinal (taenia) muscle of the human colon that was obtained from 21 individuals. Recordings were obtained with suction electrodes, the sucrose-gap method, and microelectrodes. The ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(85)90513-x
更新日期：1985-02-01 00:00:00
abstract：:The presence of autoimmune gastritis was investigated in 54 women with postpartum thyroiditis. Parietal cell antibodies (PCA) specific against H+, K(+)-adenosine triphosphatase (EC 3.6.1.36) were found in 18 women during pregnancy; in 10 of them, a 2-9-fold increase in the PCA level was observed in the postpartum peri...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90027-v
更新日期：1992-09-01 00:00:00
abstract：:The efficacy of cimetidine (1.6 g per day) was evaluated using a double blind placebo-controlled trial in 24 patients with moderate or severe peptic reflux esophagitis. The results show that cimetidine is superior to placebo when using endoscopic and histological criteria. Improved patient symptomatology and lower ant...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1978-05-01 00:00:00
abstract：:A case of enterogenous cysts of the duodenum in a 44-yr-old man complicated by duodenal obstruction and relapsing pancreatitis is presented. The cystic duodenal lesions were visualized by endoscopic retrograde cholangiopancreatography and for the first time by computed tomography and abdominal sonography. Thus, the di...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(85)90157-x
更新日期：1985-03-01 00:00:00
abstract：BACKGROUND & AIMS:After liver injury, bone marrow-derived liver sinusoidal endothelial cell progenitor cells (BM SPCs) repopulate the sinusoid as liver sinusoidal endothelial cells (LSECs). After partial hepatectomy, BM SPCs provide hepatocyte growth factor, promote hepatocyte proliferation, and are necessary for norma...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2012.08.008
更新日期：2012-12-01 00:00:00
abstract：:The human gastrointestinal tract contains distinct microbial communities that differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host. We describe the bacterial taxa present in different locations of the GI tract, and their specific metabolic features. Th...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2014.01.052
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND & AIMS:Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. The aim of this study was to examine the influences of age at dia...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v111.pm8780560
更新日期：1996-09-01 00:00:00
abstract：:In vitro studies have shown that some bile salts inhibit the growth of intestinal bacteria. We investigated the possibility that bile salts might have a similar action in vivo in the ileum by performing serial anaerobic cultures and bile salt analyses on postprandial ileal fluid obtained anaerobically via intestinal t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:Radioactive lithocholate was administered intravenously to female rhesus monkeys with an exteriorized enterohepatic circulation, and the chemical form of biliary radioactivity was defined by thin layer chromatography. Most radioactivity was excreted in bile in the form of unsulfated conjugates (77%), indicating impair...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1976-06-01 00:00:00
abstract：BACKGROUND & AIMS:Corticotropin-releasing factor (CRF) signaling pathways play a key role in the stress response through the activation of CRF(1) and CRF(2) receptors. We investigated the CRF receptor subtypes involved in gastric postoperative ileus. METHODS:Adult male mice (C57BL/6, CRF(1)-deficient, and wild-type), ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)01069-2
更新日期：2003-09-01 00:00:00
abstract：:Endoscopic sphincterotomy has proven to be a safe alternative to surgery for selected types of biliary disease. Despite a relatively low morbidity, postprocedure complications are well described. This report presents an experience with three patients in whom acute relapsing pancreatitis developed as a possible complic...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90663-w
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND & AIMS:Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are regulated by IL1B and their effects on expression of TJ proteins ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2020.06.038
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND & AIMS:Genetic variations in proinflammatory and anti-inflammatory cytokine genes influence individual response to carcinogenic exposures. Polymorphisms in interleukin (IL)-1 beta and its endogenous receptor antagonist are associated with risk of Helicobacter pylori-related gastric cancer. The aim of this st...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(03)00157-4
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND & AIMS:Rabs are monomeric guanosine triphosphatases that regulate membrane trafficking and acid secretion in gastric parietal cells. Using a proteomics approach, we identified a new Rab, Rab27b, in tubulovesicle membranes and determined its role in parietal cell activation. METHODS:We used mass spectrometry...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.09.044
更新日期：2011-03-01 00:00:00
abstract：:Interleukin 1 (IL-1) has been shown to reduce the severity of experimental gastroduodenal ulceration, but the mechanism of action is unclear. The present study examined the possibility that the mechanism underlying the protective effects of IL-1 in experimental nonsteroidal anti-inflammatory drug (NSAID)-induced gastr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：BACKGROUND & AIMS:Activating transcription factor 4 (ATF4) regulates genes involved in the inflammatory response, amino acid metabolism, autophagy, and endoplasmic reticulum stress. We investigated whether its activity is altered in patients with inflammatory bowel diseases (IBDs) and mice with enterocolitis. METHODS:...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2018.11.033
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND & AIMS:Liver fibrosis, hepatocellular necrosis, inflammation, and proliferation of liver progenitor cells are features of chronic liver injury. Mouse models have been used to study the end-stage pathophysiology of chronic liver injury. However, little is known about differences in the mechanisms of liver inj...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2018.06.048
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Patients with celiac disease have immunoglobulin (Ig) M antibodies and IgA antigliadin antibody in gut secretions; this pattern of intestinal immunity may be a marker of latent celiac disease. Its frequency in patients referred for jejunal biopsy has been examined. METHODS:Serum IgG and IgA antigliadin anti...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90333-8
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND & AIMS:A common variant in the solute carrier family 39 member 6 gene (SLC39A6) has been associated with survival times of patients with esophageal squamous cell carcinoma (ESCC). We investigated the function of SLC39A6 and ways in which this variant affects tumor progression by studying ESCC samples and cel...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.02.006
更新日期：2017-06-01 00:00:00
