Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms.

abstract：BACKGROUND & AIMS:Biliary epithelial cells (BECs) are considered to be a source of regenerating hepatocytes when hepatocyte proliferation is compromised. However, there is still controversy about the extent to which BECs can contribute to the regenerating hepatocyte population, and thereby to liver recovery. To investi...

journal_title：Gastroenterology

authors： Choi TY,Ninov N,Stainier DY,Shin D

更新日期：2014-03-01 00:00:00

abstract：:Intramural pH of the gastric mucosa was measured using a microelectrode technique in rabbit gastric pouches under different secretory conditions and luminal acidity. Exposure of spontaneously secreting or metiamide-treated fundic pouches to a relatively high concentration of luminal acid. HCl 120 mM, for 60 min, led ...

journal_title：Gastroenterology

authors： Kivilaakso E,Fromm D,Silen W

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND & AIMS:There are few validated biomarkers that can be used to predict outcomes for patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have explored intratumor heterogeneity at the epigeneti...

journal_title：Gastroenterology

authors： Martínez-Cardús A,Moran S,Musulen E,Moutinho C,Manzano JL,Martinez-Balibrea E,Tierno M,Élez E,Landolfi S,Lorden P,Arribas C,Müller F,Bock C,Tabernero J,Esteller M

更新日期：2016-11-01 00:00:00

abstract：:CRC development is a multi-step process that spans 10 to 15 years, thereby providing an opportunity for early detection and even prevention. The poor survival rate of advanced CRC has prompted the emphasis on prevention of this disease. CRC screening and removal of adenomas is an effective intervention, and is the cor...

journal_title：Gastroenterology

authors： Arber N,Levin B

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND & AIMS:The hypothesis that progastrin-derived peptides act as autocrine growth factors for colorectal carcinomas has generated considerable interest. However, the influence of autocrine gastrins on nontumorigenic colonic cells has not been investigated. This study tested the above hypothesis in the nontumori...

journal_title：Gastroenterology

authors： Hollande F,Imdahl A,Mantamadiotis T,Ciccotosto GD,Shulkes A,Baldwin GS

更新日期：1997-11-01 00:00:00

abstract：:To explore the metabolic aspects of chronic liver disease, diurnal changes of arterial ketone body ratio (acetoacetate/3-hydroxybutyrate), reflecting hepatic mitochondrial redox potential, were investigated in normal subjects, patients with chronic liver disease (Child's class A or B), and patients with hepatic failur...

journal_title：Gastroenterology

authors： Iwata S,Ozawa K,Shimahara Y,Mori K,Kobayashi N,Kumada K,Yamaoka Y

更新日期：1991-05-01 00:00:00

abstract：:Because the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, which has a sur...

journal_title：Gastroenterology

authors： di Pietro M,Canto MI,Fitzgerald RC

更新日期：2018-01-01 00:00:00

abstract：:This study was undertaken because of reports of a marked increase in fecal bile acid excretion by children with cystic fibrosis. We attempted to confirm this finding by performing [1-14C]cholylglycine breath tests and by measuring fecal bile acid and fat excretion in patients with cystic fibrosis and acquired pancreat...

journal_title：Gastroenterology

authors： Roller RJ,Kern F

更新日期：1977-04-01 00:00:00

abstract：:Gastric and esophageal emptying were assessed using scintigraphic techniques in 12 patients with progressive systemic sclerosis and 22 normal volunteers. Esophageal emptying was significantly delayed in the patient group, with 7 of the 12 patients beyond the normal range. Gastric emptying was slower in patients than i...

journal_title：Gastroenterology

authors： Maddern GJ,Horowitz M,Jamieson GG,Chatterton BE,Collins PJ,Roberts-Thomson P

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Calretinin and calbindin-D28k are similar Ca(2+)-binding proteins previously described in specific central neurons and other cells. METHODS:The immunocytochemical distribution of these two proteins was studied in the human gastrointestinal tract. RESULTS:In gastric and small intestinal endocrine cells, cal...

journal_title：Gastroenterology

authors： Walters JR,Bishop AE,Facer P,Lawson EM,Rogers JH,Polak JM

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND/AIMS:Hepatic vein thrombosis is thought to be manifested by ascites, abdominal pain, and hepatomegaly, with a uniformly poor prognosis. However, new imaging techniques allow for the diagnosis of hepatic vein thrombosis in asymptomatic cases. The aim of our study was to re-evaluate symptoms and prognosis in p...

journal_title：Gastroenterology

authors： Hadengue A,Poliquin M,Vilgrain V,Belghiti J,Degott C,Erlinger S,Benhamou JP

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with chronic hepatitis B virus (HBV) infection have a high risk for developing hepatocellular carcinoma (HCC). Patients with lower levels of hepatitis B surface antigen (HBsAg) have higher chances of losing HBsAg than those with high levels. However, little is known about whether higher level...

journal_title：Gastroenterology

authors： Tseng TC,Liu CJ,Yang HC,Su TH,Wang CC,Chen CL,Kuo SF,Liu CH,Chen PJ,Chen DS,Kao JH

更新日期：2012-05-01 00:00:00

abstract：:Although nocturnal acid secretion has been emphasized in the pathophysiology and treatment of duodenal ulcer, its importance in gastric ulcer disease has been questioned. To explore this area, this multicenter U.S. trial compared the effect of a once-daily nighttime dose of H2-receptor antagonist with placebo on the h...

journal_title：Gastroenterology

authors： McCullough AJ,Graham DY,Knuff TE,Lanza FL,Levenson HL,Lyon DT,Munsell WP,Perozza J,Roufail WM,Sinar DR

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND & AIMS:Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The Wnt-β-catenin signaling pathway is an important regulator of hepatic development, regeneration, and carcinogenesis. However, the role of Wnt signaling in the hepato...

journal_title：Gastroenterology

authors： Lehwald N,Tao GZ,Jang KY,Sorkin M,Knoefel WT,Sylvester KG

更新日期：2011-08-01 00:00:00

abstract：:To determine the frequency of a sustained remission and to assess the long-term prognosis of relapse and retreatment, 66 patients with severe hepatitis B surface antigen-negative chronic active hepatitis and prolonged follow-up after initial corticosteroid withdrawal (mean, 10 +/- 0.4 yr) were evaluated. Selection of ...

journal_title：Gastroenterology

authors： Czaja AJ,Beaver SJ,Shiels MT

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND & AIMS:The effect of endogenous hypergastrinemia on growth of human colon carcinoma is not known. Our aim was to study the growth of human colon carcinoma in an animal model with endogenous hypergastrinemia. METHODS:Human colon carcinoma was transplanted to the colon of 40 athymic rats. Of these, 25 underwe...

journal_title：Gastroenterology

authors： Chu M,Nielsen FC,Franzén L,Rehfeld JF,Holst JJ,Borch K

更新日期：1995-11-01 00:00:00

abstract：:Antibody prevalence and titer to rotavirus and Norwalk virus were studied in Crohn's disease patients and in age-, sex-, and time-matched controls. There were no significant antibody differences between the groups studied. ...

journal_title：Gastroenterology

authors： Greenberg HB,Gebhard RL,McClain CJ,Soltis RD,Kapikian AZ

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND & AIMS:Serine proteases are postulated to influence gastrointestinal function by stimulating protease-activated receptors (PARs). This study identified the effects on myenteric neurons of activating PARs and investigated underlying mechanisms of action. METHODS:Intracellular electrophysiologic methods were ...

journal_title：Gastroenterology

authors： Gao C,Liu S,Hu HZ,Gao N,Kim GY,Xia Y,Wood JD

更新日期：2002-11-01 00:00:00

abstract：:Liver disease with inclusions of copper was recognized among 30 rural workers with "vineyard sprayer's lung." The pathological findings were varied: focal or diffuse swelling and proliferation of Kupffer cells; histiocytic and sarcoid-like granulomata; fibrosis of variable degree in the perisinusoidal, portal, and sub...

journal_title：Gastroenterology

authors： Pimentel JC,Menezes AP

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) is an inflammatory bowel disease characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA is a stress-induced major histocompatibility complex-related molecule expressed on normal intestinal epithelial cells (IECs) and rec...

journal_title：Gastroenterology

authors： Allez M,Tieng V,Nakazawa A,Treton X,Pacault V,Dulphy N,Caillat-Zucman S,Paul P,Gornet JM,Douay C,Ravet S,Tamouza R,Charron D,Lémann M,Mayer L,Toubert A

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND/AIMS:Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN marginatio...

journal_title：Gastroenterology

authors： Santucci L,Fiorucci S,Di Matteo FM,Morelli A

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND & AIMS:Gain-of-function mutations in the KIT receptor tyrosine kinase gene and rare mutations in the platelet-derived growth factor receptor alpha (PDGFRA) gene are important events in gastrointestinal stromal tumor (GIST) development. Different mutations are reportedly associated with distinctive phenotypes...

journal_title：Gastroenterology

authors： Andersson J,Bümming P,Meis-Kindblom JM,Sihto H,Nupponen N,Joensuu H,Odén A,Gustavsson B,Kindblom LG,Nilsson B

更新日期：2006-05-01 00:00:00

abstract：:Six patients (4 women, 2 men) with malignant gastrinoma developed multiple bone metastases; osteolytic as well as osteoblastic lesions occurred. All lesions involved the central skeleton, most caused symptoms, and, in 2 cases, there was associated hypercalcemia with normal serum parathormone levels. Poor responses wer...

journal_title：Gastroenterology

authors： Barton JC,Hirschowitz BI,Maton PN,Jensen RT

更新日期：1986-11-01 00:00:00

abstract：:We describe a novel "silvering" method to determine the surface area of nonspherical objects and have applied this method to human cholesterol gallstones. A standard curve is first constructed, using data obtained from the dissolution rates of silver-coated plastic spheres of known dimensions in unstirred thiosulfate-...

journal_title：Gastroenterology

authors： Park YH,Igimi H,Carey MC

更新日期：1982-11-01 00:00:00

abstract：:Fetal bile salt metabolism was assessed by the intravenous infusion of e114C]cholate into 6 monkey fetuses. The placental transfer, fetal plasma clearance, and fetal hepatic excretion of the administered radiolabeled bile salt were measured. Placental transfer averaged 30% of the injected dose, while biliary excretion...

journal_title：Gastroenterology

authors： Little JM,Smallwood RA,Lester R,Piasecki GJ,Jackson BT

更新日期：1975-12-01 00:00:00

abstract：:The role of lipoxygenase metabolites in ethanol-induced gastric mucosal injury and submucosal microvascular change in the rat was studied by in vivo microscopy. Intragastric ethanol-instillation caused marked submucosal venular constriction, dilatation of small arterioles, and corpus mucosal gross lesion formation. Th...

journal_title：Gastroenterology

authors： Yonei Y,Guth PH

更新日期：1989-08-01 00:00:00

abstract：:Water and electrolyte transport were determined in rat ileum and colon using the single-pass perfusion technique. Intraperitoneal dopamine caused prompt stimulation of both ileal and colonic water absorption. The dopamine effect was mediated by both specific dopamine and alpha 2-adrenergic receptors. Haloperidol, a sp...

journal_title：Gastroenterology

authors： Donowitz M,Elta G,Battisti L,Fogel R,Label-Schwartz E

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND & AIMS:Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli. We propose that fibromodulin contributes to the pathogenes...

journal_title：Gastroenterology

authors： Mormone E,Lu Y,Ge X,Fiel MI,Nieto N

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND & AIMS:Dilutional hyponatremia is a frequent complication of cirrhosis partly because of nonosmotic vasopressin release. No effective therapy exists for this complication. Therefore, we investigated the effects of VPA-985, an orally active vasopressin V2 receptor antagonist, in patients with cirrhosis and di...

journal_title：Gastroenterology

authors： Gerbes AL,Gülberg V,Ginès P,Decaux G,Gross P,Gandjini H,Djian J,VPA Study Group.

更新日期：2003-04-01 00:00:00

abstract：:The effects of hydroxypropylmethylcellulose on upper gastrointestinal transit, viscosity, and water flux were studied in six dogs fistulated at the proximal duodenum and/or mid-jejunum. Combinations of different grades of hydroxypropylmethylcellulose were prepared as 2% or 3.3% solutions to yield input viscosities of ...

journal_title：Gastroenterology

authors： Reppas C,Meyer JH,Sirois PJ,Dressman JB

更新日期：1991-05-01 00:00:00