Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line.

abstract：:Previous investigations demonstrated that S-adenosyl-L-methionine suppresses the cholestatic effect of ethynylestradiol and reduces the irreversible binding of the estrogen to rat liver microsomes, probably favoring ethynylestradiol transformation into its methyl-derivatives. Since it is not known whether SAMe also pr...

journal_title：Gastroenterology

authors： Stramentinoli G,Di Padova C,Gualano M,Rovagnati P,Galli-Kienle M

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic steatosis is frequent in chronic hepatitis C. Several mechanisms might be implicated, including metabolic cofactors and direct viral effects on intracellular lipid pathways. In a transgenic mouse model, hepatitis C virus (HCV) was shown to inhibit microsomal triglyceride transfer protein (MTP)...

journal_title：Gastroenterology

authors： Mirandola S,Realdon S,Iqbal J,Gerotto M,Dal Pero F,Bortoletto G,Marcolongo M,Vario A,Datz C,Hussain MM,Alberti A

更新日期：2006-05-01 00:00:00

abstract：:The range of activity and the location of lipase and pepsin were determined in the stomach and duodenum of infants, children, and adults. The range of lipase activity in biopsy specimens from the gastric body, in 29 subjects aged from 3 months to 26 years, was 1.8-5.3 U/mg protein (1 U is 1 mumol [3H]oleic acid releas...

journal_title：Gastroenterology

authors： DiPalma J,Kirk CL,Hamosh M,Colon AR,Benjamin SB,Hamosh P

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic iron toxicity may be mediated by free radical species and lipid peroxidation of biological membranes. The antioxidant property of silybin, a main constituent of natural flavonoids, was investigated in vivo during experimental iron overload. METHODS:Rats were fed a 2.5% carbonyl-iron diet and ...

journal_title：Gastroenterology

authors： Pietrangelo A,Borella F,Casalgrandi G,Montosi G,Ceccarelli D,Gallesi D,Giovannini F,Gasparetto A,Masini A

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND/AIMS:Liver fat-storing cells (FSCs) actively proliferate and secrete extracellular matrix during liver injury. Platelet-derived growth factor (PDGF) is a potent mitogen for cultured FSCs. In the present study, we investigated the regulation of PDGF gene expression and production in cultured human liver FSCs....

journal_title：Gastroenterology

authors： Marra F,Choudhury GG,Pinzani M,Abboud HE

更新日期：1994-10-01 00:00:00

abstract：:Gallbladder stasis has been implicated in gallstone formation. Gallbladder filling and emptying were quantitated by computer-assisted cholescintigraphy in 41 normal subjects versus 26 patients with gallstones. Gallbladder contraction was induced by low-dose (1.2 U/kg . h) cholecystokinin infusion. Gallstone patients e...

journal_title：Gastroenterology

authors： Pomeranz IS,Shaffer EA

更新日期：1985-03-01 00:00:00

abstract：:The cause of Ménétrier's disease is unknown, although allergic, autoimmune, and infectious, particularly viral, causes have been postulated. This case report describes a 3-year-old child with Ménétrier's disease in whom evidence of acute cytomegalovirus (CMV) infection was found. To our knowledge, this is the first ca...

journal_title：Gastroenterology

authors： Eisenstat DD,Griffiths AM,Cutz E,Petric M,Drumm B

更新日期：1995-08-01 00:00:00

abstract：:A patient is reported with eosinophilic enteritis of the jejunum with fatal evolution. Surgical resection was considered impossible and medical treatment with corticosteroids, elemental diet, parenteral nutrition, and antimicrobials to combat the intestinal bacterial overgrowth failed to control the disease. The destr...

journal_title：Gastroenterology

authors： Tytgat GN,Grijm R,Dekker W,Den Hartog NA

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND & AIMS:The liver has high regenerative potential. We attempted to establish a novel culture system for extensive expansion of fetal mouse hepatic stem/progenitor cells and to characterize cultured cells. METHODS:Hepatic spheroids collected from 6-day floating cultures were cultured on collagen-coated dishes...

journal_title：Gastroenterology

authors： Tsuchiya A,Heike T,Fujino H,Shiota M,Umeda K,Yoshimoto M,Matsuda Y,Ichida T,Aoyagi Y,Nakahata T

更新日期：2005-06-01 00:00:00

abstract：:Acute self-limited liver disease has been associated with tetracycline use. However, severe prolonged cholestatic hepatitis and bile duct paucity have not been previously attributed to tetracyclines. Hepatitis, characterized by prolonged jaundice, severe pruritus, and moderate increased transaminase values, occurred w...

journal_title：Gastroenterology

authors： Hunt CM,Washington K

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND & AIMS:Gastroesophageal reflux disease (GERD) interferes with the quality of life and carries an increased risk for esophageal adenocarcinoma. We investigated genetic influence in the development of reflux. METHODS:We compared concordance for reflux in monozygotic (MZ) and dizygotic (DZ) twins. All twins ag...

journal_title：Gastroenterology

authors： Cameron AJ,Lagergren J,Henriksson C,Nyren O,Locke GR 3rd,Pedersen NL

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND & AIMS:Methionine adenosyltransferase (MAT) catalyzes S-adenosylmethionine biosynthesis. Two genes (MAT1A and MAT2A) encode for the catalytic subunit of MAT, while a third gene (MAT2beta) encodes for a regulatory subunit that modulates the activity of MAT2A-encoded isoenzyme. We uncovered multiple splicing v...

journal_title：Gastroenterology

authors： Yang H,Ara AI,Magilnick N,Xia M,Ramani K,Chen H,Lee TD,Mato JM,Lu SC

更新日期：2008-01-01 00:00:00

abstract：:If increased gamma-aminobutyric acid (GABA)-mediated neurotransmission contributes to the mediation of hepatic encephalopathy, it may be possible to induce ameliorations of the syndrome by pharmacologically antagonizing a component of the GABA/benzodiazepine receptor complex. To test this possibility we administered t...

journal_title：Gastroenterology

authors： Bansky G,Meier PJ,Riederer E,Walser H,Ziegler WH,Schmid M

更新日期：1989-09-01 00:00:00

abstract：:A patient with a lifelong history of asthma and hay fever was investigated because of symptoms of esophageal spasm. Esophageal biopsies revealed elongated papillae and basal zone hyperplasia of the epithelial layer with eosinophilic infiltration of the lamina propria and muscularis mucosae. There was no evidence of re...

journal_title：Gastroenterology

authors： Dobbins JW,Sheahan DG,Behar J

更新日期：1977-06-01 00:00:00

abstract：BACKGROUND:Malnutrition is common in alcoholic cirrhosis. Bedside nutritional assessment techniques may be unreliable in patients with chronic liver disease. The aim of this study was to quantify changes in body composition and compare methods for measuring body composition in alcoholic cirrhosis. METHODS:Thirty-eight...

journal_title：Gastroenterology

authors： Prijatmoko D,Strauss BJ,Lambert JR,Sievert W,Stroud DB,Wahlqvist ML,Katz B,Colman J,Jones P,Korman MG

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND & AIMS:The activation of Wnt/beta-catenin signaling causes the development of gastric and colon cancers. Sox17 represses Wnt/beta-catenin signaling and is down-regulated in colon cancer. This study was designed to elucidate the role of Sox17 during the course of gastrointestinal tumorigenesis. METHODS:Sox17...

journal_title：Gastroenterology

authors： Du YC,Oshima H,Oguma K,Kitamura T,Itadani H,Fujimura T,Piao YS,Yoshimoto T,Minamoto T,Kotani H,Taketo MM,Oshima M

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatitis C virus (HCV) infection is a leading cause of end-stage liver disease. Interferon-α (IFNα) is an important component of anti-HCV therapy; it up-regulates transcription of IFN-stimulated genes, many of which have been investigated for their antiviral effects. However, all of the genes require...

journal_title：Gastroenterology

authors： Fusco DN,Brisac C,John SP,Huang YW,Chin CR,Xie T,Zhao H,Jilg N,Zhang L,Chevaliez S,Wambua D,Lin W,Peng L,Chung RT,Brass AL

更新日期：2013-06-01 00:00:00

abstract：:Patients with chronic nausea and vomiting frequently present challenging diagnostic and therapeutic problems. In such patients, gastroparesis of unknown cause, or "idiopathic" gastroparesis, may be the only objective finding. Two middle-aged women with nausea, vomiting, and weight loss of 10 and 26 kg over 6 and 18 mo...

journal_title：Gastroenterology

authors： Liberski SM,Koch KL,Atnip RG,Stern RM

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND & AIMS:Indomethacin impairs liver microsomal monooxygenase activities mediated by cytochrome P450 (CYP). We investigated the inhibition mechanism and the isoform selectivity in vitro and in vivo. METHODS:In an in vitro study, liver microsomes from male Wistar rats were preincubated with indomethacin and a r...

journal_title：Gastroenterology

authors： Masubuchi Y,Masuda E,Horie T

更新日期：2002-03-01 00:00:00

abstract：:The asialoglycoprotein receptor is present on the plasma membrane of rat hepatocytes and mediates the endocytosis of exogenous asialoglycoproteins. The intracellular locations of the receptor are incompletely defined, and whether the receptor is present on the canalicular membrane is controversial. To investigate thes...

journal_title：Gastroenterology

authors： Mizuno M,Brown WR,Vierling JM

更新日期：1984-10-01 00:00:00

abstract：:This study examines the effects of endotoxin on intestinal water and electrolyte transport in adult male rats. Endotoxin (1.55 mg/kg, intravenously) reduced in vivo colonic saline absorption 61% in 1 hour. In vitro unidirectional and net 22Na and 36Cl fluxes showed that endotoxin significantly decreased net colonic 22...

journal_title：Gastroenterology

authors： Ciancio MJ,Vitiritti L,Dhar A,Chang EB

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of selectins in experimental colitis remains unknown. The aims of this study were to characterize the time-course expression of selectins in trinitrobenzene sulfonic acid (TNBS)-induced colitis, the functional role of selectins in colonic leukocyte-endothelial cell interactions, and the the...

journal_title：Gastroenterology

authors： Sans M,Salas A,Soriano A,Prats N,Gironella M,Pizcueta P,Elena M,Anderson DC,Piqué JM,Panés J

更新日期：2001-04-01 00:00:00

abstract：:Heterogeneity of colonic mucin glycoprotein was examined in rectal mucosal biopsy specimens from a variety of primate species (Saguinus oedipus, n = 18; Macaca mulatta, n = 2; Macaca fascicularis, n = 2; Aotus trivirgatus, n = 2; Saimiri sciureus, n = 2; and Callithrix jacchus, n = 2). After initial separation of radi...

journal_title：Gastroenterology

authors： Podolsky DK,Madara JL,King N,Sehgal P,Moore R,Winter HS

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:Infliximab is effective in closing fistulas in patients with Crohn's disease. We examined the effect of infliximab maintenance treatment on hospitalizations, surgeries, and procedures in patients with fistulizing Crohn's disease enrolled in the ACCENT II study. METHODS:After 5 mg/kg infliximab at wee...

journal_title：Gastroenterology

authors： Lichtenstein GR,Yan S,Bala M,Blank M,Sands BE

更新日期：2005-04-01 00:00:00

abstract：:The purpose of this study was to determine the utility of jejunal manometry in evaluating patients having partial small intestinal obstruction or the pseudoobstruction syndrome. We studied 10 healthy volunteers, 9 patients with documented mechanical obstruction, and 3 patients with chronic intestinal pseudoobstruction...

journal_title：Gastroenterology

authors： Summers RW,Anuras S,Green J

更新日期：1983-12-01 00:00:00

abstract：BACKGROUND & AIMS:We aimed to characterize offers of organs to candidates awaiting liver transplantation (LT). METHODS:We analyzed data from the United Network for Organ Sharing registry on all US LT candidates with nonfulminant disease who were offered livers from February 1, 2005, to January 31, 2010, and ultimately...

journal_title：Gastroenterology

authors： Lai JC,Feng S,Roberts JP

更新日期：2012-11-01 00:00:00

abstract：:Mucins synthesized in colonic cancer are known to be different from those in the normal colon; however, the biochemical differences between these mucins have not been defined. We have purified mucins from samples of nonneoplastic (normal) human colon and colon cancer and found that the carbohydrate content of the canc...

journal_title：Gastroenterology

authors： Boland CR,Deshmukh GD

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND & AIMS:Crohn's disease (CD) is an immunologically mediated inflammatory disease of the gastrointestinal tract. Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantat...

journal_title：Gastroenterology

authors： Oyama Y,Craig RM,Traynor AE,Quigley K,Statkute L,Halverson A,Brush M,Verda L,Kowalska B,Krosnjar N,Kletzel M,Whitington PF,Burt RK

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND & AIMS:Nitrate ingestion leads to high luminal concentrations of nitric oxide being generated where saliva meets gastric acid. Nitric oxide generates N-nitrosative stress on reacting with oxygen at neutral pH. We aimed to ascertain if luminal nitric oxide exerts nitrosative stress in the human upper gastroin...

journal_title：Gastroenterology

authors： Winter JW,Paterson S,Scobie G,Wirz A,Preston T,McColl KE

更新日期：2007-07-01 00:00:00

abstract：:Chronic graft-vs.-host disease occurs in 30%-50% of long-term survivors of allogeneic bone marrow grafts, and may eventuate in cirrhosis. In this study, a young woman, originally diagnosed as having acute myelogenous leukemia, underwent successful bone marrow transplantation but later developed graft-vs.-host disease-...

journal_title：Gastroenterology

authors： Rhodes DF,Lee WM,Wingard JR,Pavy MD,Santos GW,Shaw BW,Wood RP,Sorrell MF,Markin RS

更新日期：1990-08-01 00:00:00