Impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity.

abstract：BACKGROUND & AIMS:Intestinal epithelial cells release antigen-presenting vesicles (exosomes) bearing major histocompatibility complex class II/peptide complexes stimulating specific immune responses in vivo. To characterize further the role of human epithelial exosomes in antigen presentation, their capacity to load an...

journal_title：Gastroenterology

authors： Mallegol J,Van Niel G,Lebreton C,Lepelletier Y,Candalh C,Dugave C,Heath JK,Raposo G,Cerf-Bensussan N,Heyman M

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of anal cancer is higher in patients with anal canal condyloma, a sexually transmitted disease, than in the general population. We determined the prevalence of anal dysplasia and cancer in patients with anal canal condyloma with respect to human immunodeficiency virus (HIV) status, immun...

journal_title：Gastroenterology

authors： Sobhani I,Vuagnat A,Walker F,Vissuzaine C,Mirin B,Hervatin F,Marmuse JP,Crémieux AC,Carbon C,Henin D,Lehy T,Mignon M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND & AIMS:It is unclear whether genomic derangement precedes the histological development of dysplasia in ulcerative colitis (UC)-related neoplastic progression. The primary aim of this study was to determine if chromosomal alterations occur early in the progression pathway of UC-related neoplasia. METHODS:Flu...

journal_title：Gastroenterology

authors： Willenbucher RF,Zelman SJ,Ferrell LD,Moore DH 2nd,Waldman FM

更新日期：1997-09-01 00:00:00

abstract：:A possible role of insulinlike growth factor I (IGF-I) and IGF-I receptors in the proliferation of human colon cancer has, to the best of the authors' knowledge, not been examined as yet. To determine a role of IGF-I in colon cancer, several human colon cancer cell lines and colon cancers were screened for specific bi...

journal_title：Gastroenterology

authors： Guo YS,Narayan S,Yallampalli C,Singh P

更新日期：1992-04-01 00:00:00

abstract：:The subcellular localization of intraduodenally administered 59Fe has been studied in control, pregnant, and nonpregnant rats absorbing iron at different rates. Binding of iron to the particulate fractions of mucosal homogenates produced by centrifugation at 500, 10,000, and 100,000 X g did not vary among groups despi...

journal_title：Gastroenterology

authors： Batey RG,Gallagher ND

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND/AIMS:The role of cholecystokinin (CCK) in the regulation of gastric acid secretion is still controversial. This study examined the effect of the CCK-A receptor antagonist loxiglumide (lox) on gastrin- or CCK-induced gastric acid secretion and meal-stimulated plasma gastrin levels in a placebo-controlled stud...

journal_title：Gastroenterology

authors： Schmidt WE,Schenk S,Nustede R,Holst JJ,Fölsch UR,Creutzfeldt W

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND/AIMS:The frequency of colorectal adenomas, the precursor lesions for most cases of colorectal carcinoma, has been generally measured as prevalence rates of adenomas at autopsy or colonoscopy. The aim of this study was to estimate the incidence rate of adenomas and compare it with the adenoma recurrence rate....

journal_title：Gastroenterology

authors： Neugut AI,Jacobson JS,Ahsan H,Santos J,Garbowski GC,Forde KA,Treat MR,Waye J

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND & AIMS:Few data are available concerning the long-term prognosis of chronic liver disease associated with hepatitis C virus infection. This study examined the morbidity and survival of patients with compensated cirrhosis type C. METHODS:A cohort of 384 European cirrhotic patients was enrolled at seven terti...

journal_title：Gastroenterology

authors： Fattovich G,Giustina G,Degos F,Tremolada F,Diodati G,Almasio P,Nevens F,Solinas A,Mura D,Brouwer JT,Thomas H,Njapoum C,Casarin C,Bonetti P,Fuschi P,Basho J,Tocco A,Bhalla A,Galassini R,Noventa F,Schalm SW,Realdi

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND & AIMS:The optimal strategy for the detection of hereditary nonpolyposis colorectal cancer (HNPCC) gene carriers remains uncertain. We evaluated whether microsatellite instability (MSI) analysis or MSH2 and MLH1 protein immunostaining of tumors will screen individuals efficiently for germline MSH2 and MLH1 t...

journal_title：Gastroenterology

authors： Terdiman JP,Gum JR Jr,Conrad PG,Miller GA,Weinberg V,Crawley SC,Levin TR,Reeves C,Schmitt A,Hepburn M,Sleisenger MH,Kim YS

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:It was recently reported that ventromedial hypothalamic (VMH) lesions produced an increase in gastrointestinal DNA content in rats. In the present study, the mechanism of this alteration was examined. METHODS:The DNA content and synthesis after VMH lesioning in rat gastrointestinal tracts were determined. ...

journal_title：Gastroenterology

authors： Kiba T,Tanaka K,Endo O,Inoue S

更新日期：1993-02-01 00:00:00

abstract：:The clinical, endoscopic, histologic, manometric, and esophageal potential difference characteristics of 20 patients with columnar epithelia lining the lower esophagus (Barrett's esophagus) are presented. Endoscopically, two distinct types were identified: a circumferential-type and an island-type Barrett's esophagus....

journal_title：Gastroenterology

authors： Herlihy KJ,Orlando RC,Bryson JC,Bozymski EM,Carney CN,Powell DW

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND & AIMS:It is a challenge to deliver nucleic acids to gastrointestinal (GI) tissues due to their size and need for intracellular delivery. They are also extremely susceptible to degradation by nucleases, which are ubiquitous in the GI tract. We investigated whether ultrasound, which can permeabilize tissue th...

journal_title：Gastroenterology

authors： Schoellhammer CM,Lauwers GY,Goettel JA,Oberli MA,Cleveland C,Park JY,Minahan D,Chen Y,Anderson DG,Jaklenec A,Snapper SB,Langer R,Traverso G

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND & AIMS:Knowledge of temporal associations between screen-detected gallstone disease and specific cancers is limited. The objective of this study was to determine if screen-detected gallstones or cholecystectomy are associated with occurrence of gastrointestinal and nongastrointestinal cancers. METHODS:We pe...

journal_title：Gastroenterology

authors： Shabanzadeh DM,Sørensen LT,Jørgensen T

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND & AIMS:: At least half of patients with chronic hepatitis C virus (HCV) fail to respond to interferon or interferon/ribavirin therapy. Histological improvement is observed in some nonresponders. We conducted a randomized, controlled trial to determine if maintenance interferon therapy could prevent histologi...

journal_title：Gastroenterology

authors： Shiffman ML,Hofmann CM,Contos MJ,Luketic VA,Sanyal AJ,Sterling RK,Ferreira-Gonzalez A,Mills AS,Garret C

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND & AIMS:The NOD2 gene, which is strongly associated with susceptibility to Crohn's disease (CD) of the terminal ileum, interacts with bacterial lipopolysaccharide (LPS), inducing cellular activation. However, the mechanisms by which NOD2 mutations cause terminal ileitis are unknown, and NOD2 is expressed most...

journal_title：Gastroenterology

authors： Lala S,Ogura Y,Osborne C,Hor SY,Bromfield A,Davies S,Ogunbiyi O,Nuñez G,Keshav S

更新日期：2003-07-01 00:00:00

abstract：:Somatostatin receptor frequency was evaluated in 12 human exocrine pancreatic carcinomas taken after surgery. The tumors were analyzed by receptor autoradiography on tissue sections and by in vitro binding techniques on tumor homogenates. None of the tested human pancreatic carcinomas was shown to possess specific som...

journal_title：Gastroenterology

authors： Reubi JC,Horisberger U,Essed CE,Jeekel J,Klijn JG,Lamberts SW

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND & AIMS:Patients with Barrett's esophagus (BE) have a risk of esophageal adenocarcinoma of approximately 0.5% per year. Patients may have difficulty understanding this risk. This study assessed the perceived risk of cancer in patients with BE, and correlated their risk estimates with their health care use beh...

journal_title：Gastroenterology

authors： Shaheen NJ,Green B,Medapalli RK,Mitchell KL,Wei JT,Schmitz SM,West LM,Brown A,Noble M,Sultan S,Provenzale D

更新日期：2005-08-01 00:00:00

abstract：:Hepatocellular carcinoma often affects blacks at an early age. The purpose of this study was to ascertain if the association between chronic hepatitis B virus infection and hepatocellular carcinoma is the same in young and older black patients. Serum markers of hepatitis B infection were measured by radioimmunoassay i...

journal_title：Gastroenterology

authors： Kew MC,Macerollo P

更新日期：1988-02-01 00:00:00

abstract：:Secretin, substance P, and vasoactive intestinal peptide (VIP) were studied from the immunological point of view using synthetic hormones and their related peptides which were prepared by the conventional method for peptide synthesis. Immunological properties of these hormones were characterized by radioimmunoassays s...

journal_title：Gastroenterology

authors： Yanaihara N,Sakagami M,Sato H,Yammamoto K,Hashimoto T

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND & AIMS:Previous studies have indicated that serotonin-3-receptor antagonists might have a sex-specific effect in patients with irritable bowel syndrome with diarrhea (IBS-D). Alosetron has been approved for the treatment of only women, and ramosetron has been approved for the treatment for only men. We perfo...

journal_title：Gastroenterology

authors： Fukudo S,Kinoshita Y,Okumura T,Ida M,Akiho H,Nakashima Y,Nishida A,Haruma K

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIMS:Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acq...

journal_title：Gastroenterology

authors： van der Helm J,Geskus R,Sabin C,Meyer L,Del Amo J,Chêne G,Dorrucci M,Muga R,Porter K,Prins M,CASCADE Collaboration in EuroCoord.

更新日期：2013-04-01 00:00:00

abstract：:This study was undertaken because of reports of a marked increase in fecal bile acid excretion by children with cystic fibrosis. We attempted to confirm this finding by performing [1-14C]cholylglycine breath tests and by measuring fecal bile acid and fat excretion in patients with cystic fibrosis and acquired pancreat...

journal_title：Gastroenterology

authors： Roller RJ,Kern F

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND & AIMS:Studies on the early steps in the life cycle of hepatitis B virus have been hampered by the lack of readily available target cells. In this study, we mapped a defined virus attachment site to primary hepatocytes that is essential for infection. METHODS:We used purified virus particles from human carr...

journal_title：Gastroenterology

authors： Glebe D,Urban S,Knoop EV,Cag N,Krass P,Grün S,Bulavaite A,Sasnauskas K,Gerlich WH

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND & AIMS:Probiotics can reduce symptoms of irritable bowel syndrome (IBS), but little is known about their effects on psychiatric comorbidities. We performed a prospective study to evaluate the effects of Bifidobacterium longum NCC3001 (BL) on anxiety and depression in patients with IBS. METHODS:We performed ...

journal_title：Gastroenterology

authors： Pinto-Sanchez MI,Hall GB,Ghajar K,Nardelli A,Bolino C,Lau JT,Martin FP,Cominetti O,Welsh C,Rieder A,Traynor J,Gregory C,De Palma G,Pigrau M,Ford AC,Macri J,Berger B,Bergonzelli G,Surette MG,Collins SM,Moayyedi P,

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND & AIMS:The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with ...

journal_title：Gastroenterology

authors： Dill MT,Duong FH,Vogt JE,Bibert S,Bochud PY,Terracciano L,Papassotiropoulos A,Roth V,Heim MH

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND & AIMS:To investigate the efficacy and safety of certolizumab pegol (a polyethylene-glycolated Fab' fragment of anti-tumor necrosis factor, CDP870) in Crohn's disease. METHODS:In a placebo-controlled, phase II study, 292 patients with moderate to severe Crohn's disease received subcutaneous certolizumab 100...

journal_title：Gastroenterology

authors： Schreiber S,Rutgeerts P,Fedorak RN,Khaliq-Kareemi M,Kamm MA,Boivin M,Bernstein CN,Staun M,Thomsen OØ,Innes A,CDP870 Crohn's Disease Study Group.

更新日期：2005-09-01 00:00:00

abstract：:The effect of methacholine, theophylline, and cyclic adenyl and guanyl nucleotides on gastric secretion from antral and proximal duodenal mucosa of the guinea pig was studied. Both 2 mM dibutyryl (db) cAMP and 5 mM theophylline produced significant increases in gastrin secretion, 4.3 +/- 0.7 (P less than 0.001) and 9....

journal_title：Gastroenterology

authors： Schebalin M,Zfass AM,Makhlouf GM

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND & AIMS:Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to t...

journal_title：Gastroenterology

authors： Mangia A,Thompson AJ,Santoro R,Piazzolla V,Tillmann HL,Patel K,Shianna KV,Mottola L,Petruzzellis D,Bacca D,Carretta V,Minerva N,Goldstein DB,McHutchison JG

更新日期：2010-09-01 00:00:00

abstract：:We describe the clinical and laboratory features of a case of spontaneous bacterial peritonitis caused by Neisseria gonorrhoeae in a sexually active woman with Laennec's cirrhosis, ascites, and asymptomatic cervical gonorrhea. Treatment of the infection with high-dose parenteral penicillin was associated with resoluti...

journal_title：Gastroenterology

authors： Stassen WN,McCullough AJ,Hilton PK

更新日期：1985-03-01 00:00:00

abstract：:Strategies for management of inflammatory bowel diseases are shifting from simple control of symptoms toward full control of these diseases (clinical and endoscopic remission), with the final aim of blocking their progression and preventing bowel damage and disability. New goals have been proposed for treatment, such ...

journal_title：Gastroenterology

authors： Colombel JF,Narula N,Peyrin-Biroulet L

更新日期：2017-02-01 00:00:00