Natural history of fundic gland polyposis in patients with familial adenomatosis coli/Gardner's syndrome.

Abstract:

:In order to study the natural history of fundic gland polyposis, 23 patients with familial adenomatosis coli/Gardner's syndrome were examined over a follow-up period ranging from 17 mo to 13 yr (average 6 yr). Examinations included gastric radiography and endoscopy with biopsy. Fundic gland polyps were found in 10 individuals. The size and number of polyps varied considerably. During the follow-up period, there was an increase in number or size of polyps, or both, in 5 patients (aged 8-27 yr), a decrease or disappearance in 2 patients (aged 36 and 41 yr), an initial decrease or disappearance followed by a late-occurring increase in 2 patients (aged 28 and 35 yr), In addition, malignant or adenomatous changes of fundic gland polyps were not observed in any patient. Therefore, fundic gland polyposis in patients with familial adenomatosis coli/Gardner's syndrome may appear as early as 8 yr of age. In some patients there is a gradual increase in number and size of polyps, whereas in others, polyp proliferation ceases and polyps may even decrease in number and size. Our findings indicate that the fundic gland polyposis does not require prophylactic surgery and that careful periodic follow-up should suffice.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Iida M,Yao T,Itoh H,Watanabe H,Kohrogi N,Shigematsu A,Iwashita A,Fujishima M

doi

10.1016/0016-5085(85)90203-3

subject

Has Abstract

pub_date

1985-11-01 00:00:00

pages

1021-5

issue

5

eissn

0016-5085

issn

1528-0012

pii

0016-5085(85)90203-3

journal_volume

89

pub_type

杂志文章
  • Acknowledging joint first authors of published work: the time has come.

    abstract::We are delighted to introduce a new and simple format in the references section of the articles we publish in Gastroenterology that highlights joint first authors of citations. We believe this is an important step to acknowledging equal contribution to published work as research becomes increasingly team-oriented and ...

    journal_title:Gastroenterology

    pub_type: 社论

    doi:10.1053/j.gastro.2012.08.009

    authors: Dubnansky E,Omary MB

    更新日期:2012-10-01 00:00:00

  • Exposure Concentrations of Infants Breastfed by Women Receiving Biologic Therapies for Inflammatory Bowel Diseases and Effects of Breastfeeding on Infections and Development.

    abstract:BACKGROUND & AIMS:Exposure to biologic and immunosuppressant agents during breastfeeding is controversial, and there are limited data on safety. We investigated whether biologics are detectable in breast milk from women receiving treatment for inflammatory bowel diseases (IBDs) and whether breastfeeding while receiving...

    journal_title:Gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1053/j.gastro.2018.05.040

    authors: Matro R,Martin CF,Wolf D,Shah SA,Mahadevan U

    更新日期:2018-09-01 00:00:00

  • Macroamylase in the pleural fluid of a patient with lymphoma.

    abstract::A patient with a macroamylase in pleural fluid is described. A diagnosis of recurrent pleural effusion due to chronic relapsing pancreatitis had been made on the basis of hyperamylasemia, high pleural fluid amylase, and abdominal pain. The amylase in the pleural fluid as well as the serum was ultimately characterized ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Zimmerman HM,Bank S,Buch P,Katzka I,Lendvai S

    更新日期:1983-07-01 00:00:00

  • Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice.

    abstract:BACKGROUND & AIMS:The mechanism by which antimicrobial therapy against Helicobacter pylori is enhanced by acid suppression is unknown. The aim of this study was to investigate the effect of omeprazole on gastric juice, plasma, and saliva concentrations of metronidazole, amoxicillin, and clarithromycin. METHODS:Single ...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1053/gast.1996.v111.pm8690200

    authors: Goddard AF,Jessa MJ,Barrett DA,Shaw PN,Idström JP,Cederberg C,Spiller RC

    更新日期:1996-08-01 00:00:00

  • Effect of colchicine on guinea pig intrinsic factor-vitamin B12 receptor.

    abstract::Colchicine can induce the malabsorption of vitamin B12 and other nutrients. Previous investigations have suggested but not proved that this malabsorption was due to a lesion in the ileal mucosa. Employing the receptor assay of M. Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Stopa EG,O'Brien R,Katz M

    更新日期:1979-02-01 00:00:00

  • Impaired mixed-lymphocyte culture reactions in patients with inflammatory bowel disease.

    abstract::We studied the response of lymphocytes from 43 patients with inflammatory bowel disease to allogeneic stimulation in one-way mixed-lymphocyte cultures. We found that 53% of patients with inflammatory bowel disease, in contrast to 4% of normal and disease controls, had significant depression of mixed-lymphocyte culture...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Fiske SC,Falchuk ZM

    更新日期:1980-10-01 00:00:00

  • Pathogenesis of mucosal injury in the blind loop syndrome.

    abstract::Bacterial extracts were prepared from cultures originating in chronic self-filling intestinal blind loops in rats. Their ability to remove active maltase molecules from isolated brush border membranes was studied in vitro. Twelve strains in 51 tested, belonging to one of three species, Bacteroides fragilis, Clostridiu...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Jonas A,Krishnan C,Forstner G

    更新日期:1978-11-01 00:00:00

  • p16(INK4a) expression begins early in human colon neoplasia and correlates inversely with markers of cell proliferation.

    abstract:BACKGROUND & AIMS:p16(INK4a) is a cell cycle inhibitor and a major tumor-suppressor protein, but the regulation of p16(INK4a) is poorly understood and the physiologic settings in which it exerts its antiproliferative effects are unknown. A role for p16(INK4a) in intestinal neoplasia is suggested by the observation that...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2000.17952

    authors: Dai CY,Furth EE,Mick R,Koh J,Takayama T,Niitsu Y,Enders GH

    更新日期:2000-10-01 00:00:00

  • Recurrent acute fatty liver of pregnancy associated with a fatty-acid oxidation defect in the offspring.

    abstract::A case of a 29-year-old woman who has had two episodes both clinically and biochemically consistent with acute fatty liver of pregnancy is described. These episodes occurred in two successive pregnancies, and liver biopsy confirmed the diagnosis in the second pregnancy. Both pregnancies were managed by prompt fetal de...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(91)90228-d

    authors: Schoeman MN,Batey RG,Wilcken B

    更新日期:1991-02-01 00:00:00

  • Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS.

    abstract:BACKGROUND & AIMS:We aimed to identify long noncoding RNAs (lncRNAs) that are up-regulated in gastric cancer tissues from patients and study their function in gastric tumor metastasis. METHODS:We collected gastric tumor and nontumor tissues from patients in China and analyzed levels of lncRNAs by microarray analysis, ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2018.10.054

    authors: Zhuo W,Liu Y,Li S,Guo D,Sun Q,Jin J,Rao X,Li M,Sun M,Jiang M,Xu Y,Teng L,Jin Y,Si J,Liu W,Kang Y,Zhou T

    更新日期:2019-02-01 00:00:00

  • Lipase and pepsin activity in the gastric mucosa of infants, children, and adults.

    abstract::The range of activity and the location of lipase and pepsin were determined in the stomach and duodenum of infants, children, and adults. The range of lipase activity in biopsy specimens from the gastric body, in 29 subjects aged from 3 months to 26 years, was 1.8-5.3 U/mg protein (1 U is 1 mumol [3H]oleic acid releas...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(91)90467-y

    authors: DiPalma J,Kirk CL,Hamosh M,Colon AR,Benjamin SB,Hamosh P

    更新日期:1991-07-01 00:00:00

  • Oncogenic KRAS induces progenitor cell expansion and malignant transformation in zebrafish exocrine pancreas.

    abstract:BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2008.02.084

    authors: Park SW,Davison JM,Rhee J,Hruban RH,Maitra A,Leach SD

    更新日期:2008-06-01 00:00:00

  • Interaction of calcium and magnesium on gastric acid secretion and serum gastrin concentration in man.

    abstract::The effect of magnesium on calcium- and pentagastrin-induced gastric acid secretion and on calcium-induced gastrin secretion were studied in healthy volunteers. Intravenous infusion of calcium gluconate increased serum gastrin concentration as well as gastric volume secretion, acidity, and acid output. Addition of mag...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Christiansen J,Rehfeld JF,Stadil F

    更新日期:1975-05-01 00:00:00

  • Guidelines for colonoscopy surveillance after polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer and the American Cancer Society.

    abstract::Adenomatous polyps are the most common neoplastic findings discovered in people who undergo colorectal screening or who have a diagnostic work-up for symptoms. It was common practice in the 1970s for these patients to have annual follow-up surveillance examinations to detect additional new adenomas and missed synchron...

    journal_title:Gastroenterology

    pub_type: 杂志文章,实务指引,评审

    doi:10.1053/j.gastro.2006.03.012

    authors: Winawer SJ,Zauber AG,Fletcher RH,Stillman JS,O'Brien MJ,Levin B,Smith RA,Lieberman DA,Burt RW,Levin TR,Bond JH,Brooks D,Byers T,Hyman N,Kirk L,Thorson A,Simmang C,Johnson D,Rex DK,US Multi-Society Task Force on Colo

    更新日期:2006-05-01 00:00:00

  • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.

    abstract:BACKGROUND & AIMS:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes. Technical constraints have hampered the direct study of cccDNA maintenance and clearance mechanisms in patients. The aim of this study was ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2004.03.018

    authors: Werle-Lapostolle B,Bowden S,Locarnini S,Wursthorn K,Petersen J,Lau G,Trepo C,Marcellin P,Goodman Z,Delaney WE 4th,Xiong S,Brosgart CL,Chen SS,Gibbs CS,Zoulim F

    更新日期:2004-06-01 00:00:00

  • Gallbladder filling and emptying during cholesterol gallstone formation in the prairie dog. A cholescintigraphic study.

    abstract::We studied gallbladder bile flow before, during, and after cholesterol gallstone formation in the prairie dog using infusion cholescintigraphy with 99mTc-diethyl iminodiacetic acid. In 18 fasting animals partitioning of bile between gallbladder and intestine was determined every 15 min for 140 min, and gallbladder res...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(86)90086-7

    authors: Pellegrini CA,Ryan T,Broderick W,Way LW

    更新日期:1986-01-01 00:00:00

  • Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice.

    abstract:BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2000.16480

    authors: Chen D,Zhao CM,Dockray GJ,Varro A,Van Hoek A,Sinclair NF,Wang TC,Koh TJ

    更新日期:2000-09-01 00:00:00

  • Gallbladder and liver infarction occurring as a complication of acute bacterial endocarditis.

    abstract::A case of acute bacterial endocarditis is presented in which gallbladder infarction and areas of hepatic infarction were documented. Selective angiography showed findings consistent with emboli to the gallbladder and hepatic circulations. ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Henrich WL,Huehnegarth RJ,Rösch J,Melnyk CS

    更新日期:1975-06-01 00:00:00

  • Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats.

    abstract:BACKGROUND & AIMS:Monocytes/macrophages infiltrate into injured livers. We tried to clarify their roles in inflammation and subsequent fibrogenesis by inhibiting their infiltration with a mutated form (7ND; 7 amino acids at the N-terminal were deleted) of monocyte chemoattractant protein 1, which may function as a domi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2004.10.005

    authors: Imamura M,Ogawa T,Sasaguri Y,Chayama K,Ueno H

    更新日期:2005-01-01 00:00:00

  • The role of hepatitis G virus infection in patients with acute posttransfusion hepatitis in Taiwan.

    abstract:BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(97)70138-0

    authors: Hwang SJ,Lu RH,Chan CY,Wang YJ,Wu JC,Lee SD

    更新日期:1997-04-01 00:00:00

  • Comparison of methionine-enkephalin and morphine in the stimulation of gastric acid secretion in the dog.

    abstract::In dogs with Heidenhain pouches and gastric fistulas, we studied acid secretion in response to systemic or portal infusion of methionine-enkephalin (met-enkephalin), enkephalin-analog, or morphine. All these opiate compounds caused a dose-dependent increase in acid secretion under basal conditions and resulted in a si...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Konturek SJ,Tasler J,Cieszkowski M,Mikoś E,Coy DH,Schally AV

    更新日期:1980-02-01 00:00:00

  • Caloric intake and unconjugated hyperbilirubinemia.

    abstract::Reduction in caloric intake was associated with a greater absolute rise in the serum bilirubin concentration in patients with Gilbert's syndrome and partial hepatic bilirubin uridine diphosphate glucuronyltransferase (UDPG-T) dysfunction compared to patients with hemolytic unconjugated hyperbilirubinemia and normal su...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Felsher BF,Carpio NM

    更新日期:1975-07-01 00:00:00

  • Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.

    abstract:BACKGROUND & AIMS:The aim of this study was to evaluate the role of known colorectal adenoma and carcinoma susceptibility genes and to locate a novel susceptibility gene in an Ashkenazi family (SM1311) with dominantly inherited predisposition to colorectal adenomas and carcinomas. METHODS:Clinicopathologic and family ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(99)70061-2

    authors: Tomlinson I,Rahman N,Frayling I,Mangion J,Barfoot R,Hamoudi R,Seal S,Northover J,Thomas HJ,Neale K,Hodgson S,Talbot I,Houlston R,Stratton MR

    更新日期:1999-04-01 00:00:00

  • A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease.

    abstract:BACKGROUND & AIMS:This study was undertaken to prospectively compare the clinical outcomes of small bowel radiographs with the wireless capsule endoscopy. METHODS:Twenty-two patients were selected consecutively because of suspected small bowel disease. Two patients were excluded owing to ileal stenosis. Thus, the resu...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1053/gast.2002.35988

    authors: Costamagna G,Shah SK,Riccioni ME,Foschia F,Mutignani M,Perri V,Vecchioli A,Brizi MG,Picciocchi A,Marano P

    更新日期:2002-10-01 00:00:00

  • Increased sensitivity of propranolol clearance to reduced oxygen delivery in the isolated perfused cirrhotic rat liver.

    abstract:BACKGROUND & AIMS:Capillarization of the sinusoids in cirrhosis is proposed to reduce oxygen availability to the hepatocyte, resulting in the patterns of altered drug metabolism observed in cirrhosis. If this were true, drug metabolism in cirrhotic livers would be expected to be more sensitive to reduced oxygen deliver...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(96)70073-2

    authors: Hickey PL,McLean AJ,Angus PW,Choo EF,Morgan DJ

    更新日期:1996-10-01 00:00:00

  • Mycobacteria and inflammatory bowel disease. Results of culture.

    abstract::We have been able to isolate mycobacteria from intestinal specimens obtained by surgical resection or endoscopic biopsy from patients with Crohn's disease, ulcerative colitis, and noninflammatory bowel diseases. Nineteen slow-growing (Runyon groups I and III) and 17 rapid-growing (Runyon group IV) mycobacterial isolat...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(87)90139-9

    authors: Graham DY,Markesich DC,Yoshimura HH

    更新日期:1987-02-01 00:00:00

  • Estrogen enhances dietary cholesterol induction of saturated bile in the hamster.

    abstract::The influence of ethinyl estradiol (EE) on the effects of dietary cholesterol on the biliary saturation index and on the rate-limiting hepatic enzymes of cholesterol synthesis, hydroxymethylglutaryl-CoA-reductase, and bile acid synthesis, 7 alpha-hydroxylase, were determined. Four groups of 12 male hamsters were treat...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Coyne MJ,Bonorris GG,Chung A,Winchester R,Schoenfield LJ

    更新日期:1978-07-01 00:00:00

  • What Is Needed to Eliminate Hepatitis B Virus and Hepatitis C Virus as Global Health Threats.

    abstract::Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause 1.3 million deaths annually. To prevent more than 7 million deaths by 2030, the World Health Organization set goals to eliminate HBV and HCV, defined as a 90% reduction in new infections and a 65% reduction in deaths, and prevent more than 7 million related dea...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2018.10.048

    authors: Ward JW,Hinman AR

    更新日期:2019-01-01 00:00:00

  • MicroRNA-26a promotes cholangiocarcinoma growth by activating β-catenin.

    abstract:BACKGROUND & AIMS:MicroRNAs (miRNAs) have been implicated in the development and progression of human cancers. We investigated the roles and mechanisms of miR-26a in human cholangiocarcinoma. METHODS:We used in situ hybridization and quantitative reverse transcriptase polymerase chain reaction to measure expression of...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2012.03.045

    authors: Zhang J,Han C,Wu T

    更新日期:2012-07-01 00:00:00

  • Fecal alpha 1-antitrypsin measurement: an indicator of Crohn's disease activity.

    abstract::Random fecal alpha 1-antitrypsin levels were determined in 34 patients, 24 with Crohn's disease, and 10 "controls" having diarrheal illnesses not associated with intestinal protein loss, in an effort to evaluate its usefulness as a measure of Crohn's disease intestinal activity. In the control group, all alpha 1-antit...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(85)90739-5

    authors: Meyers S,Wolke A,Field SP,Feuer EJ,Johnson JW,Janowitz HD

    更新日期:1985-07-01 00:00:00