Abstract:
:We studied the influence of morphine on intestinal secretion induced by three different secretogogues in an attempt to elucidate the mechanism for its antisecretory activity. In rabbit ileal mucosa in vitro morphine (10(-4) M) did not influence the electrical response to the subsequent administration of prostaglandin E2 or of acetylcholine but did inhibit the net secretion of chloride provoked by both agents and prevented the reduction of sodium adsorption induced by the prostaglandin. Morphine reduced the peak electrical response to cholera toxin and reduced toxin-induced net chloride secretion. The modes of action of morphine appeared to be by both enhancing adsorption, as it does in control, nonsecreting mucosa, and by inhibiting secretogogue activity.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
McKay JS,Linaker BD,Higgs NB,Turnberg LAsubject
Has Abstractpub_date
1982-02-01 00:00:00pages
243-7issue
2eissn
0016-5085issn
1528-0012pii
S0016508582000213journal_volume
82pub_type
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