Abstract：
BACKGROUND & AIMS:Cost-effectiveness of colorectal cancer screening will be maximized by selecting the widest screening intervals that effectively prevent cancer mortality. However, data on the incidence of neoplasia in persons with no abnormal findings on initial examination are limited. The aim of this study was to describe the incidence of colonic neoplasia 5 years after negative screening colonoscopy in asymptomatic average-risk persons. METHODS:We previously reported the results of screening colonoscopy in 496 asymptomatic average-risk persons, 368 of whom had no neoplasia identified. Colonoscopy to the cecum was performed in 154 of these persons at a mean of 66 months after the initial negative colonoscopy. RESULTS:Forty-one (27%) had at least one adenoma, but only 1 person had an adenoma > or = 1 cm and none had cancer, severe dysplasia, or villous or tubulovillous histology. Hyperplastic polyps at the initial examination did not predict incident adenomas. Regular nonsteroidal anti-inflammatory drug use was associated with a decreased rate of incident adenomas. CONCLUSIONS:In average-risk persons, the interval between screening examinations can be safely expanded beyond 5 years, provided the initial examination is a carefully performed complete colonoscopy that is negative for colonic adenomas or cancer.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Rex DK,Cummings OW,Helper DJ,Nowak TV,McGill JM,Chiao GZ,Kwo PY,Gottlieb KT,Ikenberry SO,Gress FG,Lehman GA,Born LJdoi
10.1053/gast.1996.v111.pm8898630subject
Has Abstractpub_date
1996-11-01 00:00:00pages
1178-81issue
5eissn
0016-5085issn
1528-0012pii
S0016508596004714journal_volume
111pub_type
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