Altered growth and lack of responsiveness to angiotensin II in aortic vascular smooth muscle cells from cirrhotic rats.

abstract：:The mechanism of acute ulceration and the nature of mucosal protective mechanisms were investigated in rabbit antrum, which is more resistant to injury than fundus of the same species, with particular reference to the relationship between H+ back diffusion, tissue acidification, and occurrence of ulceration. Exposure ...

journal_title：Gastroenterology

authors： Kivilaakso E,Barzilai A,Schiessel R,Fromm D,Silen W

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND & AIMS:Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with nondysplastic but tumorigenic clones) might contribute to intestinal carcinogenesis. We investigated patterns of tumor development from pretumor intestinal cell clones....

journal_title：Gastroenterology

authors： Galandiuk S,Rodriguez-Justo M,Jeffery R,Nicholson AM,Cheng Y,Oukrif D,Elia G,Leedham SJ,McDonald SA,Wright NA,Graham TA

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as an im...

journal_title：Gastroenterology

authors： Nocito A,Dahm F,Jochum W,Jang JH,Georgiev P,Bader M,Renner EL,Clavien PA

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND & AIMS:Resistance of metastatic human colorectal cancer cells to drugs that block epidermal growth factor (EGF) receptor signaling could be caused by aberrant activity of other receptor tyrosine kinases, activating overlapping signaling pathways. One of these receptor tyrosine kinases could be MET, the recep...

journal_title：Gastroenterology

authors： Joosten SPJ,Zeilstra J,van Andel H,Mijnals RC,Zaunbrecher J,Duivenvoorden AAM,van de Wetering M,Clevers H,Spaargaren M,Pals ST

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...

journal_title：Gastroenterology

authors： Prat F,Malak NA,Pelletier G,Buffet C,Fritsch J,Choury AD,Altman C,Liguory C,Etienne JP

更新日期：1996-03-01 00:00:00

abstract：:Using a radioimmunoassay which detect concentrations of alpha-fetoprotein as low as 5 ng per ml, 38% of 176 patients with viral hepatitis compared with health volunteers and patients with chronic diseases not affecting the liver. When separated into two groups based on histological classification of liver biopsy speci...

journal_title：Gastroenterology

authors： Bloomer JR,Waldmann TA,McIntire R,Klatskin G

更新日期：1975-02-01 00:00:00

abstract：:Intracellular recording methods were used to study the effects of morphine on electrical behavior of myenteric neurons in cat small intestine. Two general categories of myenteric ganglion cells were found. AH/Type 2 neurons and relatively high resting membrane potentials, low input resistances, spikes only at the onse...

journal_title：Gastroenterology

authors： Wood JD

更新日期：1980-12-01 00:00:00

abstract：BACKGROUND & AIMS:Recurrence of varices and rebleeding after endoscopic therapy is very common. Data on the prediction of recurrent varices after initial obliteration by endoscopic therapy are few. The aim of this study was to correlate the presence and the size of paraesophageal varices (PEVs) in patients after endosc...

journal_title：Gastroenterology

authors： Leung VK,Sung JJ,Ahuja AT,Tumala IE,Lee YT,Lau JY,Chung SC

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND & AIMS:Ethanol causes both tolerance and sensitization of Kupffer cells. This study was designed to evaluate temporal effects of ethanol in an attempt to understand this paradox. METHODS:Rats were given ethanol (4 g/kg body wt) intragastrically, and Kupffer cells were isolated 0-48 hours later. After additi...

journal_title：Gastroenterology

authors： Enomoto N,Ikejima K,Bradford B,Rivera C,Kono H,Brenner DA,Thurman RG

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND & AIMS:Liver disease has been associated with cardiovascular disorders, but little is known about the relationship between serum levels of alanine aminotransferase (ALT) and markers of atherogenesis. We investigated the relationship between low-normal and high-normal levels of ALT and an extended panel of ca...

journal_title：Gastroenterology

authors： Siddiqui MS,Sterling RK,Luketic VA,Puri P,Stravitz RT,Bouneva I,Boyett S,Fuchs M,Sargeant C,Warnick GR,Grami S,Sanyal AJ

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND/AIMS:Butyrate and factor XIII may improve ulcerative colitis; they also affect tissue and serum transglutaminase levels. We investigated the therapeutic potential of sodium butyrate and factor XIII and the role of transglutaminase during mucosal repair in experimental colitis. METHODS:Rats with induced coli...

journal_title：Gastroenterology

authors： D'Argenio G,Cosenza V,Sorrentini I,De Ritis F,Gatto A,Delle Cave M,D'Armiento FP,Mazzacca G

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Bacterial proteoglycan-derived muramyl dipeptide (MDP) activates the intracellular NOD2/CARD15 gene product. How intestinal epithelial cells take up MDP is poorly understood. We hypothesized that the intestinal apical di-/tripeptide transporter, hPepT1, transports MDP, thereby activating downstream ...

journal_title：Gastroenterology

authors： Vavricka SR,Musch MW,Chang JE,Nakagawa Y,Phanvijhitsiri K,Waypa TS,Merlin D,Schneewind O,Chang EB

更新日期：2004-11-01 00:00:00

abstract：:A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. ...

journal_title：Gastroenterology

authors： Ng RC,Sigmund CJ Jr,Lagos JA,Chernin M

更新日期：1977-10-01 00:00:00

abstract：:The purpose of this study was to determine whether gamma-hydroxybutyrate provides protection against intestinal ischemia/reperfusion injury and to compare its effect with that of allopurinol and vitamin E. Thirty minutes of total regional ischemia, followed by 3 hours of reperfusion, produced intestinal damage that wa...

journal_title：Gastroenterology

authors： Boyd AJ,Sherman IA,Saibil FG,Mamelak M

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND & AIMS:Although restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) substantially reduces the risk of colorectal cancer in patients with inflammatory bowel disease (IBD), subsequent pouch neoplasia can develop. There are few data on the incidence of and risk factors for neoplasia, so there i...

journal_title：Gastroenterology

authors： Derikx LA,Kievit W,Drenth JP,de Jong DJ,Ponsioen CY,Oldenburg B,van der Meulen-de Jong AE,Dijkstra G,Grubben MJ,van Laarhoven CJ,Nagtegaal ID,Hoentjen F,Dutch Initiative on Crohn and Colitis.

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...

journal_title：Gastroenterology

authors： Kühl AA,Kakirman H,Janotta M,Dreher S,Cremer P,Pawlowski NN,Loddenkemper C,Heimesaat MM,Grollich K,Zeitz M,Farkas S,Hoffmann JC

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic bile salt secretion is an essential function of vertebrate liver. Rat and mouse bile salt export pump (Bsep) are adenosine triphosphate (ATP)-dependent bile salt transporters. Mutations in human BSEP were identified as the cause of progressive familial intrahepatic cholestasis type 2. BSEP pro...

journal_title：Gastroenterology

authors： Noé J,Stieger B,Meier PJ

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND & AIMS:The anti-cancer effects of vegetables and fruit have been investigated extensively, but the association between vegetable and fruit consumption and risk of hepatocellular carcinoma (HCC) has not been quantified. We performed a meta-analysis of observational studies to clarify the association. METHODS...

journal_title：Gastroenterology

authors： Yang Y,Zhang D,Feng N,Chen G,Liu J,Chen G,Zhu Y

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...

journal_title：Gastroenterology

authors： Micci MA,Kahrig KM,Simmons RS,Sarna SK,Espejo-Navarro MR,Pasricha PJ

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND & AIMS:The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such pro...

journal_title：Gastroenterology

authors： Gosselin RD,O'Connor RM,Tramullas M,Julio-Pieper M,Dinan TG,Cryan JF

更新日期：2010-06-01 00:00:00

abstract：:An animal model for giardiasis was developed using Giardia muris in Swiss albino mice. Intraesophageal inoculation of G. muris cysts caused a reproducible pattern of infection, with trophozoite and cyst counts reaching a maximum on days 5 to 14 after cyst inoculation and thereafter showing a progressive decline. Spont...

journal_title：Gastroenterology

authors： Roberts-Thomson IC,Stevens DP,Mahmoud AA,Warren KS

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:It is not clear whether H2-receptor antagonists (H2RAs) reduce the risk of gastrointestinal (GI) bleeding in aspirin users at high risk. We performed a double-blind randomized trial to compare the effects of a proton pump inhibitor (PPI) vs a H2RA antagonist in preventing recurrent upper GI bleeding a...

journal_title：Gastroenterology

authors： Chan FK,Kyaw M,Tanigawa T,Higuchi K,Fujimoto K,Cheong PK,Lee V,Kinoshita Y,Naito Y,Watanabe T,Ching JY,Lam K,Lo A,Chan H,Lui R,Tang RS,Sakata Y,Tse YK,Takeuchi T,Handa O,Nebiki H,Wu JC,Abe T,Mishiro T,Ng S

更新日期：2017-01-01 00:00:00

abstract：:Gastric ulcers have been thought to occur only in the pyloric gland area. However, endoscopic examinations using the Congo red test showed that 18 of the ulcers examined (7.8%) were surrounded by an acid-secreting area, and so were in the fundic gland area. Histological examination of specimens obtained by gastrectomy...

journal_title：Gastroenterology

authors： Tatsuta M,Okuda S

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND & AIMS:Galectins are beta-galactoside-binding proteins possibly involved in tumor progression. The aim of this study was to determine the pattern of galectin 3 and galectin 1 expression and involvement in colorectal cancer progression. METHODS:Galectin 3 expression was examined immunohistochemically in 39 s...

journal_title：Gastroenterology

authors： Sanjuán X,Fernández PL,Castells A,Castronovo V,van den Brule F,Liu FT,Cardesa A,Campo E

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND & AIMS:Conventional transarterial chemoembolization (cTACE) is used to treat patients with hepatocellular carcinoma (HCC). Radioembolization is a minimally invasive procedure that involves implantation of radioactive micron-sized particles loaded with yttrium-90 (Y90) inside the blood vessels that supply a t...

journal_title：Gastroenterology

authors： Salem R,Gordon AC,Mouli S,Hickey R,Kallini J,Gabr A,Mulcahy MF,Baker T,Abecassis M,Miller FH,Yaghmai V,Sato K,Desai K,Thornburg B,Benson AB,Rademaker A,Ganger D,Kulik L,Lewandowski RJ

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Diffuse-type gastric cancer (GC) is currently subdivided into signet-ring cell carcinoma (SRCC) and non-SRCC, referred to as poorly cohesive carcinoma not otherwise specified (PCC-NOS). Although these subtypes are considered to be independent, they often coexist in the same tumors, raising a questio...

journal_title：Gastroenterology

authors： Togasaki K,Sugimoto S,Ohta Y,Nanki K,Matano M,Takahashi S,Fujii M,Kanai T,Sato T

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND & AIMS:Calcitonin gene-related peptide (CGRP) protects the gastric mucosa against injurious stimuli in various experimental models. The underlying mechanism could be the increase in gastric mucosal blood flow (GMBF). A number of endogenous vasodilators exert their effects through the activation of adenosine ...

journal_title：Gastroenterology

authors： Doi K,Nagao T,Kawakubo K,Ibayashi S,Aoyagi K,Yano Y,Yamamoto C,Kanamoto K,Iida M,Sadoshima S,Fujishima M

更新日期：1998-01-01 00:00:00

abstract：:The amount of bile acid excreted via an ileostomy at the end of the ileum should give an estimate of the amount of bile acid transported to the colon. In the present study, 8 patients with ileostomies at the end of the ileum but without disease or resection of the small intestine excreted 1690 +/- 205 mumol/day (mean ...

journal_title：Gastroenterology

authors： Stiehl A,Raedsch R,Rudolph G

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND & AIMS:Oral linaclotide, a novel agonist of guanylate cylase-C, stimulates intestinal fluid secretion and transit, and decreases visceral hypersensitivity in animal studies. In healthy volunteers, linaclotide was safe, well tolerated, increased stool frequency, and decreased stool consistency and time to fir...

journal_title：Gastroenterology

authors： Andresen V,Camilleri M,Busciglio IA,Grudell A,Burton D,McKinzie S,Foxx-Orenstein A,Kurtz CB,Sharma V,Johnston JM,Currie MG,Zinsmeister AR

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND & AIMS:Clearance of hepatitis C virus (HCV) via antiviral treatment changes the course of liver disease. We evaluated the benefit of sustained virologic response (SVR) in patients with HCV and cirrhosis without (stage 1) and with (stage 2) esophageal varices (EV). METHODS:We performed a prospective cohort s...

journal_title：Gastroenterology

authors： Di Marco V,Calvaruso V,Ferraro D,Bavetta MG,Cabibbo G,Conte E,Cammà C,Grimaudo S,Pipitone RM,Simone F,Peralta S,Arini A,Craxì A

更新日期：2016-07-01 00:00:00