Abstract:
:Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to PPI (pantoprazole 40 mg/day) or placebo for 12 months. Phlebotomies were performed when serum ferritin was > 100 μg/L. Phlebotomy need turned out to be significantly lower in patients taking PPI (P = .0052). PPI treatment significantly reduces the need for phlebotomies in p.C282Y homozygous patients. In view of the known long-term safety profile of PPI, they can be a valuable addition to standard therapy. Clinicaltrials.gov: NCT01524757.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Vanclooster A,van Deursen C,Jaspers R,Cassiman D,Koek Gdoi
10.1053/j.gastro.2017.06.006subject
Has Abstractpub_date
2017-09-01 00:00:00pages
678-680.e2issue
3eissn
0016-5085issn
1528-0012pii
S0016-5085(17)35740-2journal_volume
153pub_type
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