当前位置： SCI文献检索 > GASTROENTEROLOGY期刊下所有文献 > Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats.

Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats.

Abstract：

:Acute liver injury was induced experimentally in rats by a single injection of a large amount of D-galactosamine. Hepatocellular damage was apparent from decrease of total serum proteins, marked release of transaminases into the circulation, precipitous decrease of total microsomal proteins, and intracellular enzymes such as cytochrome P450 and 5'-nucleotidase. In parallel with such hepatocellular damage, serum asialoglycoproteins accumulated markedly, reaching a maximum level 4 days after the injection and then decreased to the control level. In contrast to this increase, hepatic binding protein, a receptor in the liver which specifically recognizes asialoglycoproteins, decreased very much. At the same time, survival time of [125I]asialoorosomucoid intravenously administered into rats was much prolonged in inverse proportion to the decrease of the binding protein. From these results it was concluded that the decrease of the hepatic binding protein induced by galactosamine treatment is probably responsible for the marked accumulation of serum asialoglycoproteins.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Sawamura T,Kawasato S,Shiozaki Y,Sameshima Y,Nakada H,Tashiro Y

subject

Has Abstract

pub_date

1981-09-01 00:00:00

pages

527-33

issue

3

eissn

0016-5085

issn

1528-0012

pii

S0016508581001984

journal_volume

81

pub_type

杂志文章

相关文献

GASTROENTEROLOGY文献大全
  • Ornithine decarboxylase and diamine oxidase in human colon carcinoma cell line CaCo-2 in culture.

    abstract：:The human colon carcinoma cell line CaCo-2, grown in vitro under standard culture conditions and in the absence of differentiation inducers, spontaneously exhibits structural and functional characteristics of mature small bowel enterocytes. Differentiation is complete at late confluency. High activities of ornithine d...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)91493-5

    authors： D'Agostino L,Daniele B,Pignata S,Gentile R,Tagliaferri P,Contegiacomo A,Silvestro G,Polistina C,Bianco AR,Mazzacca G

    更新日期：1989-10-01 00:00:00

  • Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites.

    abstract：BACKGROUND & AIMS:Advanced cirrhosis is associated with impaired leukocyte function, but the mechanism underlying this host defense alteration is unknown. The aim of this study was to investigate the lipoxygenase pathway of arachidonic acid metabolism and its influence in leukocyte trafficking in patients with cirrhosi...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(98)70376-2

    authors： Clària J,Titos E,Jiménez W,Ros J,Ginès P,Arroyo V,Rivera F,Rodés J

    更新日期：1998-07-01 00:00:00

  • Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.

    abstract：BACKGROUND & AIMS:Crohn's disease is a highly heterogeneous inflammatory bowel disease comprising multiple clinical phenotypes. Genome-wide association studies (GWASs) have associated a large number of loci with disease risk but have not associated any specific genetic variants with clinical phenotypes. We performed a ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2014.12.030

    authors： Alonso A,Domènech E,Julià A,Panés J,García-Sánchez V,Mateu PN,Gutiérrez A,Gomollón F,Mendoza JL,Garcia-Planella E,Barreiro-de Acosta M,Muñoz F,Vera M,Saro C,Esteve M,Andreu M,Chaparro M,Manyé J,Cabré E,López-Lasanta

    更新日期：2015-04-01 00:00:00

  • Structural analysis of a human intestinal epithelial cell line.

    abstract：:Confluent monolayers of epithelial cell lines of intestinal derivation may serve as useful models for studies of intestinal epithelial structure and function. Cells of the T84 line appear to be a useful model for studies of Cl- secretion. We now define the fine structure of this cell line, the structural events that o...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(87)91069-9

    authors： Madara JL,Stafford J,Dharmsathaphorn K,Carlson S

    更新日期：1987-05-01 00:00:00

  • Association between high-normal levels of alanine aminotransferase and risk factors for atherogenesis.

    abstract：BACKGROUND & AIMS:Liver disease has been associated with cardiovascular disorders, but little is known about the relationship between serum levels of alanine aminotransferase (ALT) and markers of atherogenesis. We investigated the relationship between low-normal and high-normal levels of ALT and an extended panel of ca...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2013.08.036

    authors： Siddiqui MS,Sterling RK,Luketic VA,Puri P,Stravitz RT,Bouneva I,Boyett S,Fuchs M,Sargeant C,Warnick GR,Grami S,Sanyal AJ

    更新日期：2013-12-01 00:00:00

  • The motor response to intestinal resection: motor activity in the canine small intestine following distal resection.

    abstract：BACKGROUND:The mucosal response to intestinal resection has been extensively studied; little is known of the motor response. Our aim was to evaluate motility in the intestinal remnant following distal resection. METHODS:Motor activity, duodenocecal transit, nutrition, and absorption were studied over a 3-month period ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(93)90897-l

    authors： Quigley EM,Thompson JS

    更新日期：1993-09-01 00:00:00

  • Thyrotropin-releasing hormone effects on guinea pig antrum.

    abstract：:Thyrotropin-releasing hormone transiently increased resting tension and spontaneous contraction amplitude more potently in longitudinal muscle than in circular muscle. The frequency of the contraction did not change. Excitation was enhanced by eserine, and blocked by atropine and tetrodotoxin; this excitation was, the...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(85)80070-6

    authors： Oouchi M,Ichikawa S

    更新日期：1985-05-01 00:00:00

  • Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload.

    abstract：BACKGROUND & AIMS:Transferrin receptor 2 (TfR2) plays a key role in the regulation of iron metabolism. Mutations of TfR2 in humans cause type 3 hereditary hemochromatosis. Although highly expressed in liver, several studies have reported TfR2 expression in other tissues. To determine the contribution of liver expressed...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.11.028

    authors： Wallace DF,Summerville L,Subramaniam VN

    更新日期：2007-01-01 00:00:00

  • Endosonography-guided fine-needle aspiration biopsy: diagnostic accuracy and complication assessment.

    abstract：BACKGROUND & AIMS:Endosonography-guided fine-needle aspiration biopsy (EUS-FNA) permits cytological confirmation of EUS findings. A multicenter prospective evaluation of EUS-FNA for primary diagnosis, staging, and/or follow-up purposes was undertaken. METHODS:EUS-FNA was performed in 457 patients with 554 lesions. Cli...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0016-5085(97)70164-1

    authors： Wiersema MJ,Vilmann P,Giovannini M,Chang KJ,Wiersema LM

    更新日期：1997-04-01 00:00:00

  • Acetazolamide inhibits basal and stimulated HCO3- secretion in the human proximal duodenum.

    abstract：BACKGROUND/AIMS:Carbonic anhydrase activity plays a role in electrolyte transport in many tissues. This study examined the effect of the carbonic anhydrase inhibitor acetazolamide on human basal and prostaglandin E2- and acid-stimulated duodenal mucosal bicarbonate secretion and transmucosal electrical potential differ...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0016-5085(95)90013-6

    authors： Knutson TW,Koss MA,Hogan DL,Isenberg JI,Knutson L

    更新日期：1995-01-01 00:00:00

  • Prospects for management of gastrointestinal injury associated with the acute radiation syndrome.

    abstract：:The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed aft...

    journal_title：Gastroenterology

    pub_type： 杂志文章,评审

    doi：10.1016/0016-5085(88)90512-4

    authors： Dubois A,Walker RI

    更新日期：1988-08-01 00:00:00

  • Murine leptin deficiency alters Kupffer cell production of cytokines that regulate the innate immune system.

    abstract：BACKGROUND & AIMS:ob/ob mice are used to study the mechanisms that regulate the progression from steatosis to nonalcoholic steatohepatitis. The livers of ob/ob mice are depleted of CD4-positive natural killer cells, components of the innate immune system that induce anti-inflammatory cytokines. Although this may explai...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2002.35997

    authors： Li Z,Lin H,Yang S,Diehl AM

    更新日期：2002-10-01 00:00:00

  • Plasma arginine vasopressin response to oral, gastric, and intravenous water load in patients with cirrhosis.

    abstract：BACKGROUND/AIMS:Hepatic osmoreceptors are sensitive to changes in portal blood osmolality and cause variations in plasma antidiuretic hormone and water diuresis, which prevent major systemic osmotic changes. Insensitivity of hepatic osmoreceptors might contribute to maintaining increased plasma levels of antidiuretic h...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(94)90702-1

    authors： Castellano G,Solis-Herruzo JA,Gonzalez A,Morillas JD,Moreno D,Muñoz T,Larrodera L

    更新日期：1994-03-01 00:00:00

  • Equivalent Accuracy of 2 Quantitative Fecal Immunochemical Tests in Detecting Advanced Neoplasia in an Organized Colorectal Cancer Screening Program.

    abstract：BACKGROUND & AIMS:Although different brands of fecal immunochemical tests (FITs) are used for colorectal cancer (CRC) screening, few studies have compared their accuracy in detecting advanced neoplasia. METHODS:We performed a large prospective cohort study within the Dutch national CRC screening program to evaluate 2 ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.07.021

    authors： Wieten E,de Klerk CM,van der Steen A,Ramakers CR,Kuipers EJ,Hansen BE,Lansdorp-Vogelaar I,Bossuyt PM,Dekker E,Spaander MCW

    更新日期：2018-11-01 00:00:00

  • Antibodies against laminaribioside and chitobioside are novel serologic markers in Crohn's disease.

    abstract：BACKGROUND & AIMS:New serologic markers of inflammatory bowel disease may be useful for differentiating between Crohn's disease and ulcerative colitis and for disease stratification. We profiled sugar-binding antibodies to identify novel antiglycan antibodies that may be associated with inflammatory bowel disease. MET...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2006.04.030

    authors： Dotan I,Fishman S,Dgani Y,Schwartz M,Karban A,Lerner A,Weishauss O,Spector L,Shtevi A,Altstock RT,Dotan N,Halpern Z

    更新日期：2006-08-01 00:00:00

  • Electrophysiologic control of motility in the human colon.

    abstract：:Characteristics of electrical activities, and the relationship between electrical and motor activities, were studied in circular and longitudinal (taenia) muscle of the human colon that was obtained from 21 individuals. Recordings were obtained with suction electrodes, the sucrose-gap method, and microelectrodes. The ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(85)90513-x

    authors： Huizinga JD,Stern HS,Chow E,Diamant NE,El-Sharkawy TY

    更新日期：1985-02-01 00:00:00

  • Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C.

    abstract：BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2011.02.061

    authors： Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

    更新日期：2011-06-01 00:00:00

  • Gastrin secretion from human antral G cells in culture.

    abstract：:Receptor-dependent and -independent regulation of gastrin secretion from cultured human antral G cells was investigated. Human antral mucosal cell preparations that were enriched for G cells were obtained by sequential incubations with collagenase and ethylenediaminetetraacetic acid, centrifugal elutriation, and short...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(90)91226-v

    authors： Campos RV,Buchan AM,Meloche RM,Pederson RA,Kwok YN,Coy DH

    更新日期：1990-07-01 00:00:00

  • Apolipoprotein E polymorphism and gallstones.

    abstract：BACKGROUND & AIMS:Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/s0016-5085(96)70023-9

    authors： Bertomeu A,Ros E,Zambón D,Vela M,Pérez-Ayuso RM,Targarona E,Trías M,Sanllehy C,Casals E,Ribó JM

    更新日期：1996-12-01 00:00:00

  • Na+/H+ exchange in isolated hamster enterocytes. Its major role in intracellular pH regulation.

    abstract：:The intracellular pH (pHi) of isolated hamster intestinal cells was determined with three techniques: the null-point method with digitonin, the distribution of the weak acid 5,5-dimethyloxazolidine-2,4-dione, and the trapped fluorescent indicator 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein. In physiologic saline, ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)91492-3

    authors： Goré J,Hoinard C

    更新日期：1989-10-01 00:00:00

  • Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse.

    abstract：BACKGROUND & AIMS:Fatty acids are natural ligands of the peroxisome proliferator-activated receptor alpha (PPARalpha). Synthetic ligands of this nuclear receptor, i.e., fibrates, induce the hepatic expression of the multidrug resistance 2 gene (Mdr2), encoding the canalicular phospholipid translocator, and affect hepat...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/gast.2003.50007

    authors： Kok T,Wolters H,Bloks VW,Havinga R,Jansen PL,Staels B,Kuipers F

    更新日期：2003-01-01 00:00:00

  • Factors Associated With Shorter Colonoscopy Surveillance Intervals for Patients With Low-Risk Colorectal Adenomas and Effects on Outcome.

    abstract：BACKGROUND & AIMS:Endoscopists do not routinely follow guidelines to survey individuals with low-risk adenomas (LRAs; 1-2 small tubular adenomas, < 1 cm) every 5-10 years for colorectal cancer; many recommend shorter surveillance intervals for these individuals. We aimed to identify the reasons that endoscopists recomm...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1053/j.gastro.2017.02.010

    authors： Anderson JC,Baron JA,Ahnen DJ,Barry EL,Bostick RM,Burke CA,Bresalier RS,Church TR,Cole BF,Cruz-Correa M,Kim AS,Mott LA,Sandler RS,Robertson DJ

    更新日期：2017-06-01 00:00:00

  • Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig.

    abstract：:The distribution of sigma and phencyclindine binding sites in the gastrointestinal tract of the guinea pig was studied by autoradiography after in vitro incubation of tissue slices with (+)3H-SKF 10,047 and 3H-1-1-[(2-thienyl)cyclohexyl] piperidine to locate sigma and phencyclidine receptors, respectively. A dense dis...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1016/0016-5085(89)91418-2

    authors： Roman F,Pascaud X,Chomette G,Bueno L,Junien JL

    更新日期：1989-07-01 00:00:00

  • A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B.

    abstract：BACKGROUND & AIMS:A previous 4-week trial of telbivudine in patients with chronic hepatitis B indicated marked antiviral effects with good tolerability, leading to the present 1-year phase 2b trial. METHODS:This randomized, double-blind, multicenter trial evaluated the efficacy and safety of telbivudine 400 or 600 mg/...

    journal_title：Gastroenterology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.gastro.2005.05.053

    authors： Lai CL,Leung N,Teo EK,Tong M,Wong F,Hann HW,Han S,Poynard T,Myers M,Chao G,Lloyd D,Brown NA,Telbivudine Phase II Investigator Group.

    更新日期：2005-08-01 00:00:00

  • Genesis of Esophageal Pressurization and Bolus Flow Patterns in Patients With Achalasia Esophagus.

    abstract：BACKGROUND & AIMS:In patients with achalasia esophagus, swallows induce simultaneous pressure waves known as esophageal pressurization. We studied the mechanism of esophageal pressurization and bolus flow patterns in patients with type 2 or type 3 achalasia. METHODS:We recorded high-resolution manometry with impedance...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2018.04.033

    authors： Park S,Zifan A,Kumar D,Mittal RK

    更新日期：2018-08-01 00:00:00

  • An attempt to correlate functional and morphological data for the gastric parietal cells.

    abstract：:In fed rats, acid production was estimated to be 7 X 10(8) molecules of HCl per cell per sec or 5 X 10(5) molecules per sec per mu2 of secretory surface. In stimulated frog mucosa the corresponding values were 3 X 10(8) molecules of HCl per cell per sec 2 X 10(5) molecules per sec per mu2 or secretory surface. The gen...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：

    authors： Helander HF

    更新日期：1977-10-01 00:00:00

  • Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals.

    abstract：BACKGROUND & AIMS:Little is known about substitutions that mediate resistance of hepatitis C virus (HCV) to direct-acting antivirals (DAAs), due to the small number of patients with treatment failure in approval studies. It is important to identify resistance patterns to select effective salvage treatments. METHODS:We...

    journal_title：Gastroenterology

    pub_type： 杂志文章,多中心研究

    doi：10.1053/j.gastro.2017.11.007

    authors： Dietz J,Susser S,Vermehren J,Peiffer KH,Grammatikos G,Berger A,Ferenci P,Buti M,Müllhaupt B,Hunyady B,Hinrichsen H,Mauss S,Petersen J,Buggisch P,Felten G,Hüppe D,Knecht G,Lutz T,Schott E,Berg C,Spengler U,von Ha

    更新日期：2018-03-01 00:00:00

  • NF-kappaB activates transcription of the RNA-binding factor HuR, via PI3K-AKT signaling, to promote gastric tumorigenesis.

    abstract：BACKGROUND & AIMS:HuR is a RNA-binding factor whose expression is commonly upregulated in some human tumor types. We explored the molecular mechanism underlying HuR elevation and its role in gastric cancer tumorigenesis. METHODS:HuR expression and subcellular localization were determined by polymerase chain reaction, ...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.08.009

    authors： Kang MJ,Ryu BK,Lee MG,Han J,Lee JH,Ha TK,Byun DS,Chae KS,Lee BH,Chun HS,Lee KY,Kim HJ,Chi SG

    更新日期：2008-12-01 00:00:00

  • Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.

    abstract：BACKGROUND & AIMS:Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with nondysplastic but tumorigenic clones) might contribute to intestinal carcinogenesis. We investigated patterns of tumor development from pretumor intestinal cell clones....

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2011.12.004

    authors： Galandiuk S,Rodriguez-Justo M,Jeffery R,Nicholson AM,Cheng Y,Oukrif D,Elia G,Leedham SJ,McDonald SA,Wright NA,Graham TA

    更新日期：2012-04-01 00:00:00

  • MicroRNA-18a prevents estrogen receptor-alpha expression, promoting proliferation of hepatocellular carcinoma cells.

    abstract：BACKGROUND & AIMS:Men have a higher incidence of hepatocellular carcinoma (HCC) than women, which is believed to partly be because of protective effects of estrogen. We sought to determine whether there were differences in levels of microRNA (miRNA) molecules between male and female HCC samples. METHODS:The expression...

    journal_title：Gastroenterology

    pub_type： 杂志文章

    doi：10.1053/j.gastro.2008.10.029

    authors： Liu WH,Yeh SH,Lu CC,Yu SL,Chen HY,Lin CY,Chen DS,Chen PJ

    更新日期：2009-02-01 00:00:00