Abstract:
:Neuron specific enolase, the most acidic isoenzyme of the glycolytic enzyme enolase, was first believed to be present exclusively in central neurons. More recently, it has been found in peripheral autonomic nerves and in a number of endocrine cells. An immunocytochemical study was carried out concerning the distribution of neuron specific enolase in the gastrointestinal tract and pancreas of humans and rats. In addition, immunocytochemistry and histochemistry were used to obtain a characterization of the different types of cells and nerves in which neuron specific enolase can be detected. Neuron specific enolase was found in all currently identifiable endocrine cell types and nerves of the gut and pancreas. Neuron specific enolase is therefore a common marker for both endocrine cells and enteric nerves, thus providing a simple means for their simultaneous demonstration and examination of their morphologic characteristics and integration.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Bishop AE,Polak JM,Facer P,Ferri GL,Marangos PJ,Pearse AGsubject
Has Abstractpub_date
1982-10-01 00:00:00pages
902-15issue
4eissn
0016-5085issn
1528-0012pii
S001650858200211Xjournal_volume
83pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Several studies have reported that low doses of interferon can delay the development of hepatocellular carcinoma (HCC) and progression of chronic hepatitis C. We investigated the incidence of clinical events among participants of the Evaluation of PegIntron in Control of Hepatitis C Cirrhosis (EPIC)3 ...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2011.03.010
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND & AIMS:Estimates of complication rates following elective percutaneous liver biopsy vary and might not accurately reflect current practice. We studied mortality and complication rates, by indication, in patients after they underwent liver biopsies. METHODS:We performed a study using hospital episode statist...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.06.015
更新日期:2010-10-01 00:00:00
abstract::The effect of furosemide on secretin-stimulated pancreatic secretion was examined in 12 normal subjects using a perfusion method to quantitate pancreatic output. During continuous secretin infusion (0.9 U per kg per hr), secretory volume rose to a steady state level of 32.5 +/- 10.2 ml per min. When a bolus injection ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-08-01 00:00:00
abstract:BACKGROUND & AIMS:Stimulator of Fe Transport (SFT) and transferrin receptor (TfR) are proteins involved in iron transport. This study evaluated iron metabolism protein expression in duodenal biopsy specimens from controls and patients with abnormal iron metabolism. METHODS:Twelve controls, 8 patients with iron deficie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.23946
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:There is a significant interobserver and intraobserver variation in grading dysplasia in Barrett's metaplasia. New markers are needed to optimize the assessment of potential risk of cancer development in these patients. The aim of this study is to explore the use of p53 as a marker of neoplastic progression ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)91058-p
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND & AIMS:Development of pancreatic ductal adenocarcinoma (PDA) involves acinar to ductal metaplasia and genesis of tuft cells. It has been a challenge to study these rare cells because of the lack of animal models. We investigated the role of tuft cells in pancreatic tumorigenesis. METHODS:We performed studie...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2020.07.037
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND & AIMS:Agents designed to block or alter cytokinesis can kill or stop proliferation of cancer cells. We aimed to identify cytokinesis-related proteins that are overexpressed in hepatocellular carcinoma (HCC) cells and might be targeted to slow liver tumor growth. METHODS:Using the Oncomine database, we comp...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2018.07.010
更新日期:2018-10-01 00:00:00
abstract:DESCRIPTION:Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even nongastrointestinal symptoms and is increasingly implicated in lay press and media in the causation of a diverse ...
journal_title:Gastroenterology
pub_type: 实务指引
doi:10.1053/j.gastro.2020.06.090
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND/AIMS:The effectiveness of ursodeoxycholic acid in treating biliary liver diseases is limited by low bioavailability and moderate activity. A new analogue of ursodeoxycholic acid was synthesized with a fluorine atom in position 6 because this should have resulted in an analogue more hydrophilic than ursodeoxy...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90221-x
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND & AIMS:During severe pancreatitis, interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha are produced in large quantities. The aim of this study was to determine whether either one plays a more dominant role and if their detrimental effects are additive. METHODS:Necrotizing pancreatitis was induced i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v113.pm9352880
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND & AIMS:The early detection of colorectal cancer is desired because this cancer can be cured surgically if diagnosed early. The purpose of the present study was to determine the feasibility of a new methodology for isolating colonocytes from naturally evacuated feces, followed by cytology or molecular biology...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.10.007
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND & AIMS:Entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are potent antiviral agents that might have additive or synergistic antiviral activity in treatment of patients with chronic hepatitis B (CHB). We compared the efficacy and safety of ETV monotherapy with those of a combination of ETV and TDF. ME...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2012.05.037
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND & AIMS:Coffee is one of the most widely consumed beverages worldwide. Epidemiologic data indicate that coffee consumption protects against the progression of chronic liver disease and development of hepatocellular carcinoma and diabetes, but the mechanisms are not clear. UDP glucuronosyltransferases (UGT1A) ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.06.048
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND & AIMS:Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract. METHODS:We examined the effects of intraperitoneal (IP) administra...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.04.015
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Growth failure frequently complicates the clinical course of inflammatory bowel disease (IBD) in children. This study was designed to investigate the role of disease activity versus steroid therapy on growth faltering in this disorder. METHODS:We studied growth failure and its relationship to disease activi...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(93)90883-e
更新日期:1993-09-01 00:00:00
abstract::Much of what is currently accepted on the natural history of Helicobacter pylori-induced gastritis and its relationship with gastric adenocarcinoma rests on the assumption that atrophic gastritis can be correctly identified and reproducibly recognized. Recently, several studies have indicated that pathologists have a ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1016/s0016-5085(97)80012-1
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND & AIMS:Carcinomas of the extrahepatic bile ducts, ampulla of Vater, and duodenum are uncommon, and their epigenetic and genetic alterations are not well characterized. METHODS:We therefore compared the methylation profile and genetic alterations in 18 extrahepatic biliary, 9 ampullary, and 12 duodenal carci...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00278-6
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroesophageal reflux is common among patients with postnasal drainage. We investigated whether proton pump inhibitor therapy improved symptoms in patients with postnasal drainage without sinusitis or allergies. METHODS:In a parallel-group, double-blind, multi-specialty trial, we randomly assigned ...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2010.08.039
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND & AIMS:Differences in genetic background may play a role in the development of ulcerative colitis (UC)-related neoplasia. Loss of heterozygosity (LOH) of APC has been reported in human UC-associated neoplasia. To investigate the role of genetic differences in UC-associated neoplasia, we compared differences ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2001.29609
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND & AIMS:Glycolipid "rafts" have been shown to play a role in apical membrane trafficking in the enterocyte. The present study characterized the membrane compartments of the enterocyte involved in transepithelial transport of small intestinal immunoglobulin A (IgA). METHODS:Immunogold electron microscopy and ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(99)70183-6
更新日期:1999-03-01 00:00:00
abstract::It is possible to estimate hepatic triglyceride content by calculating the proton density fat fraction (PDFF), using proton magnetic resonance spectroscopy (1H-MRS), instead of collecting and analyzing liver biopsy specimens to detect steatosis. However, the current PDFF cut-off value (5%) used to define steatosis by ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.03.005
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND & AIMS:The vagus nerve negatively regulates macrophage cytokine production via the release of acetylcholine (ACh) and activation of nicotinic acetylcholine receptors (nAChR). In various models of intestinal inflammation, vagus nerve efferent stimulation ameliorates disease. Given the actively constrained cyt...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2009.04.057
更新日期:2009-09-01 00:00:00
abstract::The aim of the present study was to characterize rat mucosal colonic cells harvested from the crypt continuum during differentiation and dimethylhydrazine-induced neoplasia. The collection of colonocytes was performed using a modified nonenzymatic isolation procedure based on Ca2+ chelation and gentle mechanical disso...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)80013-y
更新日期:1991-03-01 00:00:00
abstract::To understand mechanisms of viral diarrhea further, we studied ileal ion transport in vitro in relation to mucosal changes and epithelial differentiation in transmissible gastroenteritis in piglets, an invasive viral enteritis thought to involve mainly proximal intestine. In infected pigs, at the height of diarrhea, s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:BACKGROUND & AIMS:Human tumors and liver cancer cell lines express the product of a fusion between the first 13 exons in the mannosidase α class 2A member 1 gene (MAN2A1) and the last 6 exons in the FER tyrosine kinase gene (FER), called MAN2A1-FER. We investigated whether MAN2A1-FER is expressed by human liver tumors ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2016.12.036
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND & AIMS:There have been conflicting results on a cell of origin in pancreatic regeneration. These discrepancies predominantly stem from lack of specific markers for the pancreatic precursors/stem cells, as well as differences in the targeted cells and severity of tissue injury in the experimental models so fa...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.07.003
更新日期:2011-10-01 00:00:00
abstract::The possible involvement of tumor necrosis factor-alpha in the pathogenesis of an experimentally induced hepatitis was investigated. Balb/c mice were primed with Propionibacterium acnes to induce the infiltration of mononuclear cells into the liver. Immunohistochemical study showed that most of the accumulated mononuc...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90965-4
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND/AIMS:Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN marginatio...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90065-9
更新日期:1995-02-01 00:00:00
abstract::We compared the inhibition of food-stimulated gastric acid secretion and changes in serum concentrations of immunoreactive gastric inhibitory polypeptide and gastrin caused by: (a) duodenal perfusion of oleic acid, and (b) intravenous infusion of pure, natural, porcine gastric inhibitory, polypeptide in dogs with gast...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract::The enterochromaffinlike cells in the rat stomach are rich in histamine and are thought to be under the influence of gastrin. The effect of sustained endogenous and exogenous hypergastrinemia on the activity and proliferation rate of the enterochromaffinlike cells was studied by determining the histidine decarboxylase...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90610-d
更新日期:1990-10-01 00:00:00