Abstract:
:Excretion of hydrogen in breath commonly persists despite an overnight fast. Although elevation of hydrogen concentration above the fasting value after administration of a test sugar is evidence of malabsorption, the significance of the fasting value itself is unknown. We determined the normal limits of fasting breath hydrogen in healthy children and adults, and in patients with chronic diarrhea or recurrent abdominal pain. Fasting breath hydrogen in 221 healthy children and 9 healthy adults averaged 7.1 +/- 5.0 parts per million (mean +/- SD), exceeding 30 parts per million in less than 1%. No value exceed 42 parts per million. In 73 patients with recurrent abdominal pain and 76 patients with chronic diarrhea, fasting breath hydrogen was less than 42 parts per million in 97% and 83%, respectively. History and laboratory data were reviewed in the 15 patients where fasting breath hydrogen exceeded 42 parts per million. Seven had documented small bowel bacterial overgrowth and an additional 3 patients had radiographic evidence of intestinal stasis. Using test dinner meals, we prospectively evaluated the effect of previously ingested foods containing complex carbohydrates on fasting breath hydrogen. Dinner meals consisting of rice, wheat, or beans influenced fasting breath hydrogen values, but did not result in elevated fasting breath hydrogen in healthy individuals. Rice bread resulted in uniformly low fasting breath hydrogen values in healthy subjects (2.0 +/- 2.5 parts per million), but fasting breath hydrogen remained elevated in patients with bacterial overgrowth. Our studies indicate that conditions for measurement of the fasting breath hydrogen value may be standardized to improve discrimination between normal and abnormal values.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Perman JA,Modler S,Barr RG,Rosenthal Psubject
Has Abstractpub_date
1984-12-01 00:00:00pages
1358-63issue
6eissn
0016-5085issn
1528-0012pii
S0016508584003140journal_volume
87pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract:BACKGROUND & AIMS:Although long-term results of endoscopic sphincterotomy (ES) have been poorly estimated, extended indications of ES have been proposed, especially in young patients. The aim of this study was to assess late biliary complications of ES. METHODS:Between 1981 and 1986, 169 patients younger than age 70 (...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v110.pm8608900
更新日期:1996-03-01 00:00:00
abstract::Propulsion of colonic contents after eating in the whole colon was studied in 15 volunteers by scintigraphy with injection of 111In-diethylenetriamine-pentaacetic acid and 99mTc-sulfur colloid into the colon through a nasogastric tube. The radionuclide was injected into the cecoascending colon (n = 7), the hepatic fle...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91098-o
更新日期:1992-07-01 00:00:00
abstract:BACKGROUND & AIMS:Previous studies indicated that the peptide neurotensin (NT) stimulates Cl(-) secretion in animal small intestinal mucosa in vitro. In this study, we investigated whether NT causes Cl(-) secretion in human colonic mucosa and examined the mechanism of this response. METHODS:Human mucosal preparations ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.9310
更新日期:2000-08-01 00:00:00
abstract:BACKGROUND & AIMS:Intrahepatic bile ducts express a range of lymphocyte adhesion molecules during episodes of inflammation. This may contribute to the susceptibility of biliary epithelium to immunologic damage during liver allograft rejection, graft-versus-host disease, and primary biliary cirrhosis. However, no previo...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v112.pm9041260
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND & AIMS:Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract. METHODS:We examined the effects of intraperitoneal (IP) administra...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.04.015
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatobiliary complications occur in inflammatory bowel disease and may be caused by the translocation of intestinal toxins from portal blood into bile through leaky hepatocyte tight junctions. The role of tight junctions in the pathogenesis of hepatobiliary complications in experimental inflammatory ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v113.pm9322530
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND & AIMS:Peroxynitrite (PN), a potent oxidant, has been implicated in the pathogenesis of gut inflammation and epithelial cell apoptosis. The aim of this study was to investigate mesalamine, a standard therapy for inflammatory bowel disease, to see if it attenuates PN-induced cytotoxicity in human intestinal e...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1997.v113.pm9352850
更新日期:1997-11-01 00:00:00
abstract::Basal and pentagastrin-stimulated gastric acid secretion, fasting serum gastrin concentrations, and the gastric output of prostaglandin E and its major metabolite 13,14-dihydro 15-keto prostaglandin E2 were measured in 9 normal subjects before and after 14-20 days of dietary supplementation with linoleic acid. Mean ma...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90553-7
更新日期:1988-04-01 00:00:00
abstract::We have examined the receptor binding of radio-iodinated murine epidermal growth factor and the effects of epidermal growth factor on both amylase release and incorporation of [3H]leucine into protein in isolated adult mouse pancreatic acini in primary culture. Binding of radioiodinated murine epidermal growth factor ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract:BACKGROUND & AIMS:It is unclear whether genomic derangement precedes the histological development of dysplasia in ulcerative colitis (UC)-related neoplastic progression. The primary aim of this study was to determine if chromosomal alterations occur early in the progression pathway of UC-related neoplasia. METHODS:Flu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70173-2
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND & AIMS:Nonalcoholic fatty liver disease (NAFLD) is associated with increased risk of hepatic, cardiovascular, and metabolic diseases. High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce liver fat, but can induce insulin resistance. We investigated the effects of d...
journal_title:Gastroenterology
pub_type: 杂志文章,随机对照试验
doi:10.1053/j.gastro.2016.10.007
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND & AIMS:Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in diverse metabolic pathways that involve hepatic accumulation of triglycerides. Features of these aberrations might determine whether NAFLD progresses to nonalcoholic steatohepatitis (NASH). We investigated whether the diverse defe...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2017.01.015
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND & AIMS:Gastroenteropancreatic neuroendocrine cells secrete chemical messengers in a calcium-dependent fashion. So far, other second messenger systems involved in regulated secretion have gained little attention. The aim of this study was to characterize guanosine 3',5'-cyclic monophosphate (cGMP)-mediated ve...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(98)70593-1
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND & AIMS:Aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) lower the risk of colorectal cancer (CRC). We investigated whether plasma inflammatory markers were associated with risk of CRC and if use of anti-inflammatory drugs was differentially associated with risk of CRC according to levels of inflamma...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.11.041
更新日期:2011-03-01 00:00:00
abstract::Hepatocellular carcinoma often affects blacks at an early age. The purpose of this study was to ascertain if the association between chronic hepatitis B virus infection and hepatocellular carcinoma is the same in young and older black patients. Serum markers of hepatitis B infection were measured by radioimmunoassay i...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90434-9
更新日期:1988-02-01 00:00:00
abstract::Rising trends in the incidence and mortality of early-onset CRC in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and ...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2020.12.068
更新日期:2021-01-05 00:00:00
abstract:BACKGROUND/AIMS:After massive small bowel resection, malabsorbed carbohydrates reach the colon and undergo fermentation. This study investigates the role of colonic fermentation in rats with 80% small bowel resection on weight gain, nitrogen balance, body composition, and intestinal adaptation. METHODS:Resected or tra...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90109-0
更新日期:1994-09-01 00:00:00
abstract::In vitro studies have shown that some bile salts inhibit the growth of intestinal bacteria. We investigated the possibility that bile salts might have a similar action in vivo in the ileum by performing serial anaerobic cultures and bile salt analyses on postprandial ileal fluid obtained anaerobically via intestinal t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-08-01 00:00:00
abstract:BACKGROUND & AIMS:Corticosteroids have been shown to significantly decrease short-term mortality in patients with severe alcoholic hepatitis. However, independent factors associated with a favorable outcome and long-term survival are unknown. The aim of this study was to examine prognostic factors and long-term surviva...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.1996.v110.pm8964410
更新日期:1996-06-01 00:00:00
abstract::A reliable method for studying lead absorption and excretion in rats is described. Lead absorption occurs primarily in theduodenum where lead enters the epithelial mucosal cells. There is a relative mucosal block for lead with increasing intraluminal doses. Certain substances which bind lead and increase its solubilit...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract::A patient with ulcerative ileojejunitis was studied by determination of HL-A phenotype, by measurement of jejunal IgA synthesis using a labeled amino acid incorporation technique, and by in vitro organ culture. The patient carried the HL-A8 phenotype in common with 87.5% of patients with gluten-sensitive enteropathy. ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract::Primary sclerosing cholangitis is a chronic cholestatic liver disease that is commonly associated with chronic ulcerative colitis. We observed the development of varices in the abdominal wall surrounding the ileostomy stoma of patients with primary sclerosing cholangitis who underwent proctocolectomy and ileostomy for...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章
doi:10.1016/0016-5085(86)90926-1
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND & AIMS:The study and management of reflux esophagitis require an endoscopic classification system founded on esophageal lesions that can be reproducibly identified. The aim of this study was to investigate interobserver agreement for the identification of endoscopic lesions typical of reflux esophagitis. ME...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.1996.v111.pm8698230
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND & AIMS:The long-term outcomes of patients treated for autoimmune hepatitis (AIH) are considered to be good. However, follow-up data beyond 10 years are limited and confined to tertiary referral centers. We assessed long-term outcomes and determinants of outcome in patients with AIH from a nontransplant cente...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2011.02.065
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND & AIMS:Osteoporosis is common in patients with Crohn's disease, but less is known about their risk of actual fractures. METHODS:The medical records of all 238 Olmsted County, Minnesota, residents diagnosed with Crohn's disease between 1940 and 1993 were reviewed for evidence of subsequent fractures compared...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.34779
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND & AIMS:Hepatitis G virus (HGV) has been recently identified as a new transfusion-transmissible agent. This study was performed to evaluate the role of HGV infection in patients with acute posttransfusion hepatitis in Taiwan. METHODS:Sera from 63 patients with acute posttransfusion hepatitis and 61 patients ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(97)70138-0
更新日期:1997-04-01 00:00:00
abstract::This study was performed to ascertain whether testosterone metabolism is altered in male rats with portal bypass, and whether such changes could contribute to the reduction in serum testosterone concentration and raised serum estrogen levels that are observed in this situation. The metabolic clearance rate of testoste...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(88)90500-8
更新日期:1988-08-01 00:00:00
abstract::Congenital esophageal stenosis (CES) is a rare disorder with narrowed esophageal lumen that presents as dysphagia from childhood and that is often associated with tracheobronchial remnants or webs. The pathogenesis of CES is unknown. The aim of this study was to examine the histological and immunohistochemical feature...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90294-5
更新日期:1995-07-01 00:00:00
abstract::An in vitro fecal incubation system was used to demonstrate how lactulose influences ammonia metabolism in the colon. Lactulose and other fermentable substrates (glucose, mannitol, and sorbitol), pH and organic acid were varied independently so that their different effects could be determined. Fermentable substrate ca...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-03-01 00:00:00
abstract:BACKGROUND & AIMS:Polymorphisms in the region of the interleukin (IL)-28B gene on chromosome 19 have been associated with peginterferon-alfa-induced clearance of genotype 1 hepatitis C virus (HCV); there are no data for patients with genotype 2 or 3 HCV. We evaluated the effects of IL-28B polymorphisms on response to t...
journal_title:Gastroenterology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1053/j.gastro.2010.05.079
更新日期:2010-09-01 00:00:00