Inflammatory bowel disease in all three members of one family.

Abstract:

:The occurrence of inflammatory bowel disease in all three members of one family is described. Studies of white blood cell chromosomes, histocompatibility antigens, and cellular and humoral immunity failed to explain this unusual phenomenon. However, the appearance of inflammatory bowel disease in an entire family reemphasizes the potential role of genetic and environmental influences in the pathogenesis of some cases of ulcerative colitis and Crohn's disease.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Rosenberg JL,Kraft SC,Kirsner JB

keywords:

subject

Has Abstract

pub_date

1976-05-01 00:00:00

pages

759-60

issue

5 PT.1

eissn

0016-5085

issn

1528-0012

pii

S0016508576001133

journal_volume

70

pub_type

杂志文章
  • Colonoscopic polypectomy in chronic colitis: conservative management after endoscopic resection of dysplastic polyps.

    abstract:BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(99)70279-9

    authors: Rubin PH,Friedman S,Harpaz N,Goldstein E,Weiser J,Schiller J,Waye JD,Present DH

    更新日期:1999-12-01 00:00:00

  • Airway responsiveness to inhaled methacholine in patients with irritable bowel syndrome.

    abstract::We examined whether patients with irritable bowel syndrome have increased airway responsiveness by measuring forced expiratory volumes in 1 second (FEV1) after inhalation of increasing concentrations of methacholine. Responses obtained in 11 IBS patients were compared with those obtained in 11 normal subjects and in 1...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(91)90584-8

    authors: White AM,Stevens WH,Upton AR,O'Byrne PM,Collins SM

    更新日期:1991-01-01 00:00:00

  • Gallbladder function in the human female: effect of the ovulatory cycle, pregnancy, and contraceptive steroids.

    abstract::We have previously shown that in pregnancy fasting gallbladder volume is increased and emptying after a small volume liquid meal is incomplete. In this study we measured gallbladder volume throughout day and night in healthy women ingesting regular meals. Pregnant women, postpartum women, contraceptive-steroid users, ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Everson GT,McKinley C,Lawson M,Johnson M,Kern F Jr

    更新日期:1982-04-01 00:00:00

  • Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line.

    abstract:BACKGROUND & AIMS:The hypothesis that progastrin-derived peptides act as autocrine growth factors for colorectal carcinomas has generated considerable interest. However, the influence of autocrine gastrins on nontumorigenic colonic cells has not been investigated. This study tested the above hypothesis in the nontumori...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1997.v113.pm9352860

    authors: Hollande F,Imdahl A,Mantamadiotis T,Ciccotosto GD,Shulkes A,Baldwin GS

    更新日期:1997-11-01 00:00:00

  • Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function.

    abstract:BACKGROUND & AIMS:Chronic hepatitis C virus infection activates an intrahepatic immune response, leading to increased expression of interferon (IFN)-stimulated genes and activation of natural killer (NK) cells-the most prevalent innate immune cell in the liver. We investigated whether the elimination of hepatitis C vir...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2015.03.004

    authors: Serti E,Chepa-Lotrea X,Kim YJ,Keane M,Fryzek N,Liang TJ,Ghany M,Rehermann B

    更新日期:2015-07-01 00:00:00

  • Effects of test meal, intragastric nutrients, and intraduodenal bile on plasma concentrations of immunoreactive somatostatin and vasoactive intestinal peptide in dogs.

    abstract::Specific radioimmunoassay were used to measure somatostatin and vasoactive peptide in portal and peripheral plasma from conscious dogs prepared with indwelling portal catheters. In six animals with intact stomachs, a test meal induced a significant rise of portal and peripheral somatostatin, while the significant resp...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Chayvialle JA,Miyata M,Rayford PL,Thompson JC

    更新日期:1980-11-01 00:00:00

  • Identification of risk loci for Crohn's disease phenotypes using a genome-wide association study.

    abstract:BACKGROUND & AIMS:Crohn's disease is a highly heterogeneous inflammatory bowel disease comprising multiple clinical phenotypes. Genome-wide association studies (GWASs) have associated a large number of loci with disease risk but have not associated any specific genetic variants with clinical phenotypes. We performed a ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2014.12.030

    authors: Alonso A,Domènech E,Julià A,Panés J,García-Sánchez V,Mateu PN,Gutiérrez A,Gomollón F,Mendoza JL,Garcia-Planella E,Barreiro-de Acosta M,Muñoz F,Vera M,Saro C,Esteve M,Andreu M,Chaparro M,Manyé J,Cabré E,López-Lasanta

    更新日期:2015-04-01 00:00:00

  • Functional Anorectal Disorders.

    abstract::This report defines criteria and reviews the epidemiology, pathophysiology, and management of common anorectal disorders: fecal incontinence (FI), functional anorectal pain and functional defecation disorders. FI is defined as the recurrent uncontrolled passage of fecal material for at least 3 months. The clinical fea...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2016.02.009

    authors: Rao SS,Bharucha AE,Chiarioni G,Felt-Bersma R,Knowles C,Malcolm A,Wald A

    更新日期:2016-03-25 00:00:00

  • Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium.

    abstract:BACKGROUND & AIMS:Macrophage migration inhibitory factor (MIF) inhibits macrophage migration and has pleiotropic activities on immune and inflammatory responses, cell growth, and glucose metabolism. MIF is produced by T cells, macrophages, and endothelial cells. Because intestinal epithelial cells produce mediators imp...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2002.31891

    authors: Maaser C,Eckmann L,Paesold G,Kim HS,Kagnoff MF

    更新日期:2002-03-01 00:00:00

  • Thromboxane inhibitors attenuate pathological changes in alcoholic liver disease in the rat.

    abstract:BACKGROUND & AIMS:Thromboxane levels correlate with severity of liver injury in rats given alcohol. The aim of this study was to evaluate the effect of thromboxane inhibitors on pathological changes in experimental alcoholic liver disease. METHODS:Male Wistar rats were given a liquid diet and ethanol intragastrically ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(97)70236-1

    authors: Nanji AA,Khwaja S,Rahemtulla A,Miao L,Zhao S,Tahan SR

    更新日期:1997-01-01 00:00:00

  • Growth failure in children with inflammatory bowel disease: a prospective study.

    abstract:BACKGROUND:Growth failure frequently complicates the clinical course of inflammatory bowel disease (IBD) in children. This study was designed to investigate the role of disease activity versus steroid therapy on growth faltering in this disorder. METHODS:We studied growth failure and its relationship to disease activi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(93)90883-e

    authors: Motil KJ,Grand RJ,Davis-Kraft L,Ferlic LL,Smith EO

    更新日期:1993-09-01 00:00:00

  • Influence of desalivation on acid secretory output and gastric mucosal integrity in the rat.

    abstract::Exogenous administration of substances extracted from rodent salivary glands may increase the resistance of gastric mucosal barrier to the disruptive actions of ulcerogenic agents and/or reduce acid secretory output. In the present study the influence of desalivation in the rat on acid secretory function and mucosal i...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Skinner KA,Tepperman BL

    更新日期:1981-08-01 00:00:00

  • Riluzole normalizes early-life stress-induced visceral hypersensitivity in rats: role of spinal glutamate reuptake mechanisms.

    abstract:BACKGROUND & AIMS:The molecular basis underlying visceral hypersensitivity in functional irritable bowel syndrome remains elusive, resulting in poor treatment effectiveness. Because alterations in spinal non-neuronal (astrocytic) glutamate reuptake are suspected to participate in chronic pain, we asked whether such pro...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2010.03.003

    authors: Gosselin RD,O'Connor RM,Tramullas M,Julio-Pieper M,Dinan TG,Cryan JF

    更新日期:2010-06-01 00:00:00

  • Abnormalities in the distribution of laminin and collagen type IV in Hirschsprung's disease.

    abstract::In vitro neurite outgrowth and neuronal survival are promoted by laminin, and neuronal migration is promoted by collagen type IV. This led to the hypothesis that Hirschsprung's disease (HD) could be the result of an abnormal extracellular matrix microenvironment in the affected bowel during embryogenesis. Using indire...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Parikh DH,Tam PK,Van Velzen D,Edgar D

    更新日期:1992-04-01 00:00:00

  • Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2.

    abstract:BACKGROUND & AIMS:Development of pancreatic ductal adenocarcinoma (PDA) involves acinar to ductal metaplasia and genesis of tuft cells. It has been a challenge to study these rare cells because of the lack of animal models. We investigated the role of tuft cells in pancreatic tumorigenesis. METHODS:We performed studie...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2020.07.037

    authors: DelGiorno KE,Chung CY,Vavinskaya V,Maurer HC,Novak SW,Lytle NK,Ma Z,Giraddi RR,Wang D,Fang L,Naeem RF,Andrade LR,Ali WH,Tseng H,Tsui C,Gubbala VB,Ridinger-Saison M,Ohmoto M,Erikson GA,O'Connor C,Shokhirev MN,Hah

    更新日期:2020-11-01 00:00:00

  • Overexpression of glutamine synthetase in human primary liver cancer.

    abstract:BACKGROUND/AIMS:We have identified several clones specifically expressed during malignant cell proliferation by screening a complementary DNA library constructed from a human primary liver cancer with subtractive probes. One clone was identified as the glutamine synthetase (GS) transcript. Its expression is tightly reg...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(94)90024-8

    authors: Christa L,Simon MT,Flinois JP,Gebhardt R,Brechot C,Lasserre C

    更新日期:1994-05-01 00:00:00

  • Intragastric distribution and gastric emptying assessed by three-dimensional ultrasonography.

    abstract:BACKGROUND & AIMS:Three-dimensional (3D) ultrasound imaging of the total stomach volume has not yet been achieved. The aim of this study was to investigate whether a magnetic position sensor system for acquisition of 3D ultrasonograms could be used to determine gastric emptying rates and intragastric distribution. MET...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(97)70078-7

    authors: Gilja OH,Detmer PR,Jong JM,Leotta DF,Li XN,Beach KW,Martin R,Strandness DE Jr

    更新日期:1997-07-01 00:00:00

  • CD4+NKG2D+ T cells in Crohn's disease mediate inflammatory and cytotoxic responses through MICA interactions.

    abstract:BACKGROUND & AIMS:Crohn's disease (CD) is an inflammatory bowel disease characterized by uncontrolled immune responses to bacterial flora, with excessive activation of T lymphocytes. MICA is a stress-induced major histocompatibility complex-related molecule expressed on normal intestinal epithelial cells (IECs) and rec...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2007.03.025

    authors: Allez M,Tieng V,Nakazawa A,Treton X,Pacault V,Dulphy N,Caillat-Zucman S,Paul P,Gornet JM,Douay C,Ravet S,Tamouza R,Charron D,Lémann M,Mayer L,Toubert A

    更新日期:2007-06-01 00:00:00

  • Barrett's esophagus: clinical, endoscopic, histologic, manometric, and electrical potential difference characteristics.

    abstract::The clinical, endoscopic, histologic, manometric, and esophageal potential difference characteristics of 20 patients with columnar epithelia lining the lower esophagus (Barrett's esophagus) are presented. Endoscopically, two distinct types were identified: a circumferential-type and an island-type Barrett's esophagus....

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Herlihy KJ,Orlando RC,Bryson JC,Bozymski EM,Carney CN,Powell DW

    更新日期:1984-03-01 00:00:00

  • Sequential protooncogene expression during regeneration in rat stomach.

    abstract::Cellular protooncogenes such as c-myc and c-Ha-ras may play important roles in the control of regeneration of the stomach. In this study, in situ hybridization histochemistry and immunohistochemistry were used to determine how these protooncogenes and the corresponding oncoproteins are expressed at the cellular level ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(90)91085-k

    authors: Ito T,Hayashi N,Sasaki Y,Morita Y,Kawano S,Fusamoto H,Sato N,Tohyama M,Kamada T

    更新日期:1990-06-01 00:00:00

  • Endoscopic papillotomy.

    abstract::Obstruction of the common bile duct can now be relieved by endoscopic electrosurgery. This report describes our experience with 267 patients. In 192 of 222 patients with choledocholithiasis all calculi were evacuated by endoscopic papillotomy (EP). The remaining patients had EP because of papillary stenosis. Complicat...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Koch H,Rösch W,Schaffner O,Demling L

    更新日期:1977-12-01 00:00:00

  • The sympathetic nervous system modulates perception and reflex responses to gut distention in humans.

    abstract:BACKGROUND/AIMS:Intestinal distention induces perception and gut reflexes via sympathetic and vagal pathways, but the modulatory mechanisms of such responses remain obscure. The aim of this study was to determine the effects of sympathetic nervous activity on sympathetic and vagal reflexes as well as on intestinal and ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90439-5

    authors: Iovino P,Azpiroz F,Domingo E,Malagelada JR

    更新日期:1995-03-01 00:00:00

  • Altered biosynthesis of leukotrienes and lipoxins and host defense disorders in patients with cirrhosis and ascites.

    abstract:BACKGROUND & AIMS:Advanced cirrhosis is associated with impaired leukocyte function, but the mechanism underlying this host defense alteration is unknown. The aim of this study was to investigate the lipoxygenase pathway of arachidonic acid metabolism and its influence in leukocyte trafficking in patients with cirrhosi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(98)70376-2

    authors: Clària J,Titos E,Jiménez W,Ros J,Ginès P,Arroyo V,Rivera F,Rodés J

    更新日期:1998-07-01 00:00:00

  • Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis.

    abstract:BACKGROUND & AIMS:We have shown previously that cure of Helicobacter pylori infection leads to the disappearance of acid-neutralizing substances. Also, patients with ulcer after cure may gain weight. The aim of this study was to investigate whether cure of the infection increases the risk of reflux esophagitis. METHOD...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0016-5085(97)70024-6

    authors: Labenz J,Blum AL,Bayerdörffer E,Meining A,Stolte M,Börsch G

    更新日期:1997-05-01 00:00:00

  • Control of ascites absorption in anesthetized cats: effects of intraperitoneal pressure, protein, and furosemide diuresis.

    abstract::There is considerable evidence that fluids are removed from the peritoneal cavity by drainage into lymphatics lining the surface of the diaphragm, but there is little quantitative information on the rate of reabsorption as affected by conditions which exist in cirrhotic ascites. In the present study a plethysmographic...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Zink J,Greenway CV

    更新日期:1977-11-01 00:00:00

  • No difference between high-fructose and high-glucose diets on liver triacylglycerol or biochemistry in healthy overweight men.

    abstract:BACKGROUND & AIMS:Diets high in fructose have been proposed to contribute to nonalcoholic fatty liver disease. We compared the effects of high-fructose and matched glucose intake on hepatic triacylglycerol (TAG) concentration and other liver parameters. DESIGN:In a double-blind study, we randomly assigned 32 healthy b...

    journal_title:Gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1053/j.gastro.2013.07.012

    authors: Johnston RD,Stephenson MC,Crossland H,Cordon SM,Palcidi E,Cox EF,Taylor MA,Aithal GP,Macdonald IA

    更新日期:2013-11-01 00:00:00

  • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy.

    abstract:BACKGROUND & AIMS:Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a unique episomal replicative intermediate responsible for persistent infection of hepatocytes. Technical constraints have hampered the direct study of cccDNA maintenance and clearance mechanisms in patients. The aim of this study was ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2004.03.018

    authors: Werle-Lapostolle B,Bowden S,Locarnini S,Wursthorn K,Petersen J,Lau G,Trepo C,Marcellin P,Goodman Z,Delaney WE 4th,Xiong S,Brosgart CL,Chen SS,Gibbs CS,Zoulim F

    更新日期:2004-06-01 00:00:00

  • Effect of rising intragastric pH induced by several antacids on serum gastrin concentrations in duodenal ulcer patients and in a control group.

    abstract::The interrelationship of the effects of antacids and of rising intragastric pH on serum gastrin levels was examined by comparing the effect of three antacids (Mg(OH)2Al(OH)3, and CaCO3), and their nonbuffering chloride compounds (MgCl2, AlCl3, and CaCl2), on serum gastrin and intragastric pH in duodenal ulcer patients...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Feurle GE

    更新日期:1975-01-01 00:00:00

  • Trends in Adenoma Detection Rates During the First 10 Years of the German Screening Colonoscopy Program.

    abstract:BACKGROUND & AIMS:The adenoma detection rate (ADR) is an important quality indicator of screening colonoscopy; it is inversely associated with risk of interval cancers and colorectal cancer mortality. We assessed trends in the ADR in the first 10 years of the German screening colonoscopy program. METHODS:We calculated...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2015.04.012

    authors: Brenner H,Altenhofen L,Kretschmann J,Rösch T,Pox C,Stock C,Hoffmeister M

    更新日期:2015-08-01 00:00:00

  • Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice.

    abstract:BACKGROUND & AIMS:In the enteric nervous system, neurotransmitters initiate changes in calcium (Ca(2+) responses) in glia, but it is not clear how this process affects intestinal function. We investigated whether Ca(2+)-mediated responses in enteric glia are required to maintain gastrointestinal function. METHODS:We u...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2013.10.061

    authors: McClain J,Grubišić V,Fried D,Gomez-Suarez RA,Leinninger GM,Sévigny J,Parpura V,Gulbransen BD

    更新日期:2014-02-01 00:00:00