Abstract：
:The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with 2 days of mild restraint and was maximal (93% less damage; p less than 0.0005) when the animal was mildly restrained for 10 days. Pretreatment with indomethacin abolished the protection afforded by chronic mild restraint, suggesting a mechanism involving endogenous prostaglandin synthesis. Chronic mild restraint significantly (p less than 0.05) reduced the injury to the gastric mucosa caused by cold-restraint stress. This model of mild restraint may prove useful in future studies on the mechanism of stress-induced and other gastric mucosal lesions.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Wallace JL,Track NS,Cohen MMsubject
Has Abstractpub_date
1983-08-01 00:00:00pages
370-5issue
2eissn
0016-5085issn
1528-0012pii
S0016508583001997journal_volume
85pub_type
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