The professional lives of women in gastroenterology: a Canadian comparison study with men.

abstract：BACKGROUND & AIMS:Gastroenteropancreatic neuroendocrine cells secrete chemical messengers in a calcium-dependent fashion. So far, other second messenger systems involved in regulated secretion have gained little attention. The aim of this study was to characterize guanosine 3',5'-cyclic monophosphate (cGMP)-mediated ve...

journal_title：Gastroenterology

authors： John M,Wiedenmann B,Kruhøffer M,Adermann K,Ankorina-Stark I,Schlatter E,Ahnert-Hilger G,Forssmann WG,Kuhn M

更新日期：1998-04-01 00:00:00

abstract：:A numerically important group of patients with functional gastrointestinal disorders have chronic symptoms that can be attributed to the gastroduodenal region. Based on the consensus opinion of an international panel of clinical investigators who reviewed the available evidence, a classification of the functional gast...

journal_title：Gastroenterology

authors： Tack J,Talley NJ,Camilleri M,Holtmann G,Hu P,Malagelada JR,Stanghellini V

更新日期：2006-04-01 00:00:00

abstract：:Seven patients with persistent hyponatremia but normal or elevated serum arginine vasopressin levels and refractory ascites undergoing peritoneovenous shunting were studied in a Metabolic Unit on a 20 mEq sodium 1200 ml fluid-restricted diet to elucidate the mechanism of this response. The intravascular volume expansi...

journal_title：Gastroenterology

authors： Reznick RK,Langer B,Taylor BR,Seif S,Blendis LM

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND & AIMS:The mechanism by which antimicrobial therapy against Helicobacter pylori is enhanced by acid suppression is unknown. The aim of this study was to investigate the effect of omeprazole on gastric juice, plasma, and saliva concentrations of metronidazole, amoxicillin, and clarithromycin. METHODS:Single ...

journal_title：Gastroenterology

authors： Goddard AF,Jessa MJ,Barrett DA,Shaw PN,Idström JP,Cederberg C,Spiller RC

更新日期：1996-08-01 00:00:00

abstract：:We have conducted a double-blind controlled trial of colchicine in patients with primary biliary cirrhosis. Fifty-seven patients with biopsy-proven primary biliary cirrhosis were randomized to receive either 0.6 mg of colchicine twice daily or an identically appearing placebo. Patients underwent clinical and laborator...

journal_title：Gastroenterology

authors： Bodenheimer H Jr,Schaffner F,Pezzullo J

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND & AIMS:Celiac disease is a complex, immune-mediated disorder of the intestinal mucosa with a strong genetic component. HLA-DQ2 is the major determinant of risk, but other minor genes, still to be identified, also are involved. METHODS:We designed a strategy that combines gene expression profiling of intesti...

journal_title：Gastroenterology

authors： Castellanos-Rubio A,Martin-Pagola A,Santín I,Hualde I,Aransay AM,Castaño L,Vitoria JC,Bilbao JR

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND & AIMS:Barrier functions across epithelia and endothelia are essential for homeostatic tissue regulation. Astroglia interact with cerebral endothelia to maintain the blood-brain barrier. Whether similar interactions between astrocyte-like enteric glia and epithelia regulate intestinal barrier function is not...

journal_title：Gastroenterology

authors： Savidge TC,Newman P,Pothoulakis C,Ruhl A,Neunlist M,Bourreille A,Hurst R,Sofroniew MV

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND & AIMS:During hepatic fibrogenesis, the hepatic extracellular matrix changes to fibrillar collagens types I and III, and cirrhosis is believed to produce an irreversible scar. In this study, we investigated whether gene delivery of human matrix metalloproteinase-1, which degrades collagens types I and type I...

journal_title：Gastroenterology

authors： Iimuro Y,Nishio T,Morimoto T,Nitta T,Stefanovic B,Choi SK,Brenner DA,Yamaoka Y

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND & AIMS:Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial of patients with UC, we evaluated the safety and efficacy of SER-287, an oral formulation...

journal_title：Gastroenterology

authors： Henn MR,O'Brien EJ,Diao L,Feagan BG,Sandborn WJ,Huttenhower C,Wortman JR,McGovern BH,Wang-Weigand S,Lichter DI,Chafee M,Ford CB,Bernardo P,Zhao P,Simmons S,Tomlinson AD,Cook DN,Pomerantz RJ,Misra BK,Auninš JG,Truc

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic myelopathy is a rare complication of chronic liver disease, causing progressive spastic paraparesis. Today, no therapy of this disorder has been established. Commonly used therapeutic strategies for hepatic encephalopathy aiming at the reduction of plasma ammonia levels such as protein restric...

journal_title：Gastroenterology

authors： Weissenborn K,Tietge UJ,Bokemeyer M,Mohammadi B,Bode U,Manns MP,Caselitz M

更新日期：2003-02-01 00:00:00

abstract：:To determine if changes in intestinal motility occur during pregnancy, we studied small intestinal myoelectric activity, using monopolar electrodes, in fasted pregnant rats from day 12 to day 18 of the 22-day gestation period. We also studied fasting myoelectric activity in postpartum, nonpregnant, and castrate female...

journal_title：Gastroenterology

authors： Scott LD,Lester R,Van Thiel DH,Wald A

更新日期：1983-02-01 00:00:00

abstract：:A 36-year-old man with brittle diabetes mellitus developed hepatic infarction immediately after an episode of ketoacidosis. The infarction was documented by angiogram 99mTc sulfur colloid scan, and biopsy. Except for the association with ketoacidosis, no other possible cause of hepatic infarction was found. ...

journal_title：Gastroenterology

authors： Ng RC,Sigmund CJ Jr,Lagos JA,Chernin M

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND & AIMS:The Paris pediatric modification of the Montreal classification defines very early onset inflammatory bowel disease (VEO-IBD) as a form of IBD distinct from that of older children. We compared the incidence and outcomes of VEO-IBD with those of IBD in older children. METHODS:We performed a population...

journal_title：Gastroenterology

authors： Benchimol EI,Mack DR,Nguyen GC,Snapper SB,Li W,Mojaverian N,Quach P,Muise AM

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...

journal_title：Gastroenterology

authors： Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

更新日期：2000-07-01 00:00:00

abstract：:The effect of total-body ionizing radiation on the digestive tract is dose-dependent and time-dependent. At low doses (1.5 Gy), one observes only a short prodromal syndrome consisting of nausea, vomiting, and gastric suppression. At doses greater than 6 Gy, the prodromal syndrome is more marked, and it is followed aft...

journal_title：Gastroenterology

authors： Dubois A,Walker RI

更新日期：1988-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Factors associated with the development and malignant progression of Barrett's esophagus are poorly understood. Gastrin is a mitogen capable of inducing growth in normal and malignant gastrointestinal mucosa. It is unknown whether gastrin can influence cellular events in the esophagus in Barrett's. ...

journal_title：Gastroenterology

authors： Haigh CR,Attwood SE,Thompson DG,Jankowski JA,Kirton CM,Pritchard DM,Varro A,Dimaline R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND & AIMS:Because current therapies for chronic hepatitis C virus (HCV) infections are suboptimal and associated with severe side effects, novel treatment options are needed. A small animal model has recently been developed to study HCV infections. To examine the usefulness of this human liver-urokinase-type pl...

journal_title：Gastroenterology

authors： Vanwolleghem T,Meuleman P,Libbrecht L,Roskams T,De Vos R,Leroux-Roels G

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND & AIMS:Caspases are critical mediators of apoptosis and proliferation of peripheral blood T cells (PBT), but their role in lamina propria T cells (LPT), a cell population highly susceptible to apoptosis, has not been explored. METHODS:RA(+), RO(+) PBT, and LPT were activated with CD3, CD2, and CD28 antibodi...

journal_title：Gastroenterology

authors： Sturm A,Mohr S,Fiocchi C

更新日期：2002-05-01 00:00:00

abstract：:Gastric mucosa of the rat generates both PGE2 and PGI2 activity in significantly higher concentrations in the antrum than in the fundus. Aspirin, given intravenously or intragastrically in doses producing gastric mucosal lesions, causes a dose-dependent decrease in the generation of mucosal PGE2 and PGI2, which is fur...

journal_title：Gastroenterology

authors： Konturek SJ,Piastucki I,Brzozowski T,Radecki T,Dembińska-Kieć A,Zmuda A,Gryglewski R

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND & AIMS:Biomarkers are needed to risk stratify after chemoradiotherapy for localized esophageal cancer. These could improve identification of patients at risk for cancer progression and selection of additional therapy. METHODS:We performed deep sequencing (CAncer Personalized Profiling by deep Sequencing, [C...

journal_title：Gastroenterology

authors： Azad TD,Chaudhuri AA,Fang P,Qiao Y,Esfahani MS,Chabon JJ,Hamilton EG,Yang YD,Lovejoy A,Newman AM,Kurtz DM,Jin M,Schroers-Martin J,Stehr H,Liu CL,Hui AB,Patel V,Maru D,Lin SH,Alizadeh AA,Diehn M

更新日期：2020-02-01 00:00:00

abstract：:The asialoglycoprotein receptor is present on the plasma membrane of rat hepatocytes and mediates the endocytosis of exogenous asialoglycoproteins. The intracellular locations of the receptor are incompletely defined, and whether the receptor is present on the canalicular membrane is controversial. To investigate thes...

journal_title：Gastroenterology

authors： Mizuno M,Brown WR,Vierling JM

更新日期：1984-10-01 00:00:00

abstract：:Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...

journal_title：Gastroenterology

authors： Czaja MJ

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...

journal_title：Gastroenterology

authors： de la Concha EG,Fernandez-Arquero M,Lopez-Nava G,Martin E,Allcock RJ,Conejero L,Paredes JG,Diaz-Rubio M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatobiliary secretion is generally believed to be an integral step in the pathway of cholesterol excretion from the body. Here we have investigated the validity of this paradigm in mice. METHODS:Cholesterol balance was assessed by measuring intake, excretion, and biliary output in different mouse m...

journal_title：Gastroenterology

authors： van der Velde AE,Vrins CL,van den Oever K,Kunne C,Oude Elferink RP,Kuipers F,Groen AK

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND & AIMS:A previous 4-week trial of telbivudine in patients with chronic hepatitis B indicated marked antiviral effects with good tolerability, leading to the present 1-year phase 2b trial. METHODS:This randomized, double-blind, multicenter trial evaluated the efficacy and safety of telbivudine 400 or 600 mg/...

journal_title：Gastroenterology

authors： Lai CL,Leung N,Teo EK,Tong M,Wong F,Hann HW,Han S,Poynard T,Myers M,Chao G,Lloyd D,Brown NA,Telbivudine Phase II Investigator Group.

更新日期：2005-08-01 00:00:00

abstract：BACKGROUND & AIMS:Therapy with interferon alfa (IFN-alpha) leads to remission of disease in one third of patients with chronic hepatitis B. The aim of this study was to better define the long-term prognosis of this outcome. METHODS:One hundred three patients with chronic hepatitis B who underwent IFN-alpha therapy in ...

journal_title：Gastroenterology

authors： Lau DT,Everhart J,Kleiner DE,Park Y,Vergalla J,Schmid P,Hoofnagle JH

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND & AIMS:Few data are available on the potential role of T lymphocytes in experimental acute pancreatitis. The aim of this study was to characterize their role in the inflammatory cascade of acute pancreatitis. METHODS:To type this issue, acute pancreatitis was induced by repeated injections of cerulein in nu...

journal_title：Gastroenterology

authors： Demols A,Le Moine O,Desalle F,Quertinmont E,Van Laethem JL,Devière J

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND & AIMS:Protein kinase C (PKC) has been implicated as a mediator of growth control during colorectal carcinogenesis, but the mechanisms involved are still a matter of dispute. The aim of this study was to analyze PKC patterns and tissue distribution to gain further insight in PKC function during tumor develop...

journal_title：Gastroenterology

authors： Kahl-Rainer P,Sedivy R,Marian B

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...

journal_title：Gastroenterology

authors： Kühl AA,Kakirman H,Janotta M,Dreher S,Cremer P,Pawlowski NN,Loddenkemper C,Heimesaat MM,Grollich K,Zeitz M,Farkas S,Hoffmann JC

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND & AIMS:Toll-like receptors (TLR) are innate immune receptors involved in recognition of the intestinal microflora; they are expressed by numerous cell types in the intestine, including epithelial cells, myeloid cells, and lymphocytes. Little is known about the relative contributions of TLR signaling in disti...

journal_title：Gastroenterology

authors： Asquith MJ,Boulard O,Powrie F,Maloy KJ

更新日期：2010-08-01 00:00:00