Retinoic acid receptor gamma1 expression determines retinoid sensitivity in pancreatic carcinoma cells.

abstract：BACKGROUND/AIMS:The elevation of cytosolic free calcium concentration ([Ca2+]i) and intracellular pH mediate the growth factor-initiated proliferation of many cells, but it is not known if they trigger mitosis in resting hepatocytes. The maintenance of [Ca2+]i and intracellular pH depends partly on extracellular calciu...

journal_title：Gastroenterology

authors： Zhang BH,Farrell GC

更新日期：1995-02-01 00:00:00

abstract：:The effect of continuous intraduodenal enteral nutrition on gastric pH was compared with the effects of fasting and of parenteral and standard nutrition control regimens containing equal amounts of carbohydrate, protein, and lipid. Eleven healthy volunteers underwent four 24-hour intragastric pH-metry studies; serum g...

journal_title：Gastroenterology

authors： Armstrong D,Castiglione F,Emde C,Cilluffo T,Duroux P,Koerfer J,Temler E,Lamers CB,Jansens JB,Blum AL

更新日期：1992-05-01 00:00:00

abstract：:The hemodynamic effects of octreotide were studied in 20 patients with hepatitis B-related cirrhosis. In patients receiving a 100-micrograms bolus and a 100-micrograms/h infusion, heart rate, cardiac index, and systemic vascular resistance showed no significant changes, whereas right atrial pressure, pulmonary capilla...

journal_title：Gastroenterology

authors： Lin HC,Tsai YT,Lee FY,Lee SD,Hsia HC,Lin WJ,Lo KJ

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND & AIMS:The Raf kinase inhibitor protein (RKIP) has been identified as a suppressor of the mitogen-activated protein kinase (MAPK) pathway. Loss of RKIP function promotes tumor metastasis in prostate cancer and melanoma. The insulin-like growth factor I (IGF-I)-mediated MAPK cascade is often activated in hepa...

journal_title：Gastroenterology

authors： Lee HC,Tian B,Sedivy JM,Wands JR,Kim M

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND/AIMS:Staphylococcal enterotoxin B (SEB) acts as a superantigen binding to class II major histocompatibility complex proteins, and this complex stimulates T cells. The aim of this study was to investigate the pathogenic effects of SEB on hepatic injury and lethal shock in mice. METHODS:SEB was administered t...

journal_title：Gastroenterology

authors： Nagaki M,Muto Y,Ohnishi H,Yasuda S,Sano K,Naito T,Maeda T,Yamada T,Moriwaki H

更新日期：1994-02-01 00:00:00

abstract：:Reduction in caloric intake was associated with a greater absolute rise in the serum bilirubin concentration in patients with Gilbert's syndrome and partial hepatic bilirubin uridine diphosphate glucuronyltransferase (UDPG-T) dysfunction compared to patients with hemolytic unconjugated hyperbilirubinemia and normal su...

journal_title：Gastroenterology

authors： Felsher BF,Carpio NM

更新日期：1975-07-01 00:00:00

abstract：:To evaluate the effect of aging upon the small intestine, the distribution, content, and concentration of epithelial cell enzymes at different levels along the crypt-villus column were measured in aging and young adult, male, Fisher 344 rats. Specific activities of sucrase, maltase, lactase, and adenosine deaminase in...

journal_title：Gastroenterology

authors： Holt PR,Tierney AR,Kotler DP

更新日期：1985-11-01 00:00:00

abstract：:Much of what is currently accepted on the natural history of Helicobacter pylori-induced gastritis and its relationship with gastric adenocarcinoma rests on the assumption that atrophic gastritis can be correctly identified and reproducibly recognized. Recently, several studies have indicated that pathologists have a ...

journal_title：Gastroenterology

authors： Genta RM

更新日期：1997-12-01 00:00:00

abstract：:A 61-yr-old woman was found to have multicentric hepatocellular carcinoma associated with clinical hyperthyroidism. Marked elevations in serum thyroid-stimulating hormone, T4, T3, and free T4 were documented. These values increased with tumor progression. It is postulated that this patient's hepatoma produced a substa...

journal_title：Gastroenterology

authors： Helzberg JH,McPhee MS,Zarling EJ,Lukert BP

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...

journal_title：Gastroenterology

authors： Chen D,Zhao CM,Dockray GJ,Varro A,Van Hoek A,Sinclair NF,Wang TC,Koh TJ

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Interleukin (IL)-15 delivers signals that drive chronic inflammation in several diseases, including celiac disease. Smad3-transforming growth factor-beta (TGF-beta) signaling is instrumental to counteract proinflammatory signals and maintain immune homeostasis. Our goal has been to investigate why t...

journal_title：Gastroenterology

authors： Benahmed M,Meresse B,Arnulf B,Barbe U,Mention JJ,Verkarre V,Allez M,Cellier C,Hermine O,Cerf-Bensussan N

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND/AIMS:The diagnosis of cholangiocarcinoma in primary sclerosing cholangitis (PSC), even with the use of current imaging techniques and brush cytology, is difficult and particularly important in patients being assessed for liver transplantation. This study investigated the accuracy of serum levels of a combina...

journal_title：Gastroenterology

authors： Ramage JK,Donaghy A,Farrant JM,Iorns R,Williams R

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND & AIMS:Cholangiocarcinomas appear to arise from the malignant transformation of cholangiocytes lining the biliary tract. Because the development of an in vitro model of malignant transformation can provide a powerful new tool for establishing critical events governing the molecular pathogenesis of cholangioc...

journal_title：Gastroenterology

authors： Lai GH,Zhang Z,Shen XN,Ward DJ,Dewitt JL,Holt SE,Rozich RA,Hixson DC,Sirica AE

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND & AIMS:There is growing interest in the use of bone marrow cells to treat liver fibrosis, however, little is known about their antifibrotic efficacy or the identity of their effector cell(s). Sphingosine-1-phosphate (S1P) mediates egress of immune cells from the lymphoid organs into the lymphatic vessels; we...

journal_title：Gastroenterology

authors： King A,Houlihan DD,Kavanagh D,Haldar D,Luu N,Owen A,Suresh S,Than NN,Reynolds G,Penny J,Sumption H,Ramachandran P,Henderson NC,Kalia N,Frampton J,Adams DH,Newsome PN

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND/AIMS:Spasmolytic polypeptide (SP) is a trefoil peptide expressed in the digestive tract. This study aimed to determine the structure and distribution of SP expression in the rat gastrointestinal tract. METHODS:The structure of rat SP was determined from the sequence of complementary DNAs isolated from antra...

journal_title：Gastroenterology

authors： Jeffrey GP,Oates PS,Wang TC,Babyatsky MW,Brand SJ

更新日期：1994-02-01 00:00:00

abstract：BACKGROUND & AIMS:In one-third of hepatocellular carcinomas (HCCs), cancer cells have mutations that activate β-catenin pathway. These cells have alterations in glutamine, bile, and lipid metabolism. We investigated whether positron emission tomography (PET) imaging allows identification of altered metabolic pathways t...

journal_title：Gastroenterology

authors： Gougelet A,Sartor C,Senni N,Calderaro J,Fartoux L,Lequoy M,Wendum D,Talbot JN,Prignon A,Chalaye J,Imbeaud S,Zucman-Rossi J,Tordjmann T,Godard C,Bossard P,Rosmorduc O,Amaddeo G,Colnot S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND & AIMS:Ferroportin disease is characterized by iron overload. It has an autosomal-dominant pattern of inheritance and has been associated with mutations in the SLC40A1 gene, which encodes the cellular iron exporter ferroportin. Since the first description in 2001, about 30 mutations have been reported; the h...

journal_title：Gastroenterology

authors： Le Lan C,Mosser A,Ropert M,Detivaud L,Loustaud-Ratti V,Vital-Durand D,Roget L,Bardou-Jacquet E,Turlin B,David V,Loréal O,Deugnier Y,Brissot P,Jouanolle AM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND & AIMS:Despite intensive investigations, very little is known about the molecular identity(ies) of the intestinal folate transport system(s), especially in humans. The aim of this study was to isolate a functional human intestinal folate carrier complementary DNA (cDNA) clone and determine the distribution o...

journal_title：Gastroenterology

authors： Nguyen TT,Dyer DL,Dunning DD,Rubin SA,Grant KE,Said HM

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND & AIMS:Rotavirus infection is a leading cause of morbidity and mortality in children younger than 5 years of age. Current treatment options are limited. We assessed the efficacy of a llama-derived, heavy-chain antibody fragment called anti-rotavirus protein (ARP1), in modifying the severity and duration of d...

journal_title：Gastroenterology

authors： Sarker SA,Jäkel M,Sultana S,Alam NH,Bardhan PK,Chisti MJ,Salam MA,Theis W,Hammarström L,Frenken LG

更新日期：2013-10-01 00:00:00

abstract：:Although long-term parenteral nutrition is lifesaving in patients with intestinal failure, it is expensive and associated with serious complications such as catheter sepsis, venous occlusions, and liver failure and severely impairs the quality of life in the short bowel patients. Therefore, treatments that increase th...

journal_title：Gastroenterology

authors： Jeppesen PB

更新日期：2006-02-01 00:00:00

abstract：:The role of the endothelium-derived vasodilator, nitric oxide, as a mediator of the increase in gastric mucosal blood flow and as a modulator of the acid secretory response induced by pentagastrin was investigated in the anesthetised rat. Intravenous administration of the selective inhibitor of endogenous nitric oxide...

journal_title：Gastroenterology

authors： Pique JM,Esplugues JV,Whittle BJ

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study is to determine whether lower esophageal sphincter (LES) incompetency is a common occurrence in patients with liver cirrhosis and contributes to the development of variceal bleeding. Resting LES pressure (17.8 +/- 1.1 mm Hg) in 35 patients with cirrhosis was similar to that of our control pop...

journal_title：Gastroenterology

authors： Eckardt VF,Grace ND,Kantrowitz PA

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND & AIMS:The lipocalin superfamily, including the mouse and human homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin, show great functional diversity including roles in olfaction, transportation, and prostaglandin synthesis in mammals. Their potential role in maintaining gastrointestinal mucos...

journal_title：Gastroenterology

authors： Playford RJ,Belo A,Poulsom R,Fitzgerald AJ,Harris K,Pawluczyk I,Ryon J,Darby T,Nilsen-Hamilton M,Ghosh S,Marchbank T

更新日期：2006-09-01 00:00:00

abstract：:We report the case of a patient in whom amitriptyline administration for 5 wk was followed by prolonged cholestasis. Jaundice and pruritus lasted 19 and 20 mo, respectively. Three liver biopsies were performed at different stages of the disease showing the course of liver lesions. Cholestasis initially located in the ...

journal_title：Gastroenterology

authors： Larrey D,Amouyal G,Pessayre D,Degott C,Danne O,Machayekhi JP,Feldmann G,Benhamou JP

更新日期：1988-01-01 00:00:00

abstract：:In order to assess the efficacy of cimetidine in patients with endoscopically anastomotic ulcer after partial gastrectomy, 21 such patients entered a double-blind prospective clinical trial. At endoscopy after 4 wk of treatment, 8 of 12 patients treated with 1 g of cimetidine daily compared with 1 of 9 patients who re...

journal_title：Gastroenterology

authors： Festen HP,Lamers CB,Driessen WM,Van Tongeren JH

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND & AIMS:Celiac disease is a complex, immune-mediated disorder of the intestinal mucosa with a strong genetic component. HLA-DQ2 is the major determinant of risk, but other minor genes, still to be identified, also are involved. METHODS:We designed a strategy that combines gene expression profiling of intesti...

journal_title：Gastroenterology

authors： Castellanos-Rubio A,Martin-Pagola A,Santín I,Hualde I,Aransay AM,Castaño L,Vitoria JC,Bilbao JR

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND & AIMS:It has been proposed that activation of the sympathetic nervous system causes a rightward shift in the renal autoregulatory curve such that renal blood flow is critically dependent on renal perfusion pressure and that this contributes to the development of the hepatorenal syndrome. The aims of the stu...

journal_title：Gastroenterology

authors： Stadlbauer V,Wright GA,Banaji M,Mukhopadhya A,Mookerjee RP,Moore K,Jalan R

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hereditary diffuse gastric cancer (HDGC) families carry CDH1 heterozygous germline mutations; their tumors acquire complete CDH1 inactivation through "2nd-hit" mechanisms. Most frequently, this occurs via promoter hypermethylation (epigenetic modification), and less frequently via CDH1 mutations and l...

journal_title：Gastroenterology

authors： Oliveira C,Sousa S,Pinheiro H,Karam R,Bordeira-Carriço R,Senz J,Kaurah P,Carvalho J,Pereira R,Gusmão L,Wen X,Cipriano MA,Yokota J,Carneiro F,Huntsman D,Seruca R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND & AIMS:Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal stem and progenitor cells through phosphor...

journal_title：Gastroenterology

authors： Lee G,Goretsky T,Managlia E,Dirisina R,Singh AP,Brown JB,May R,Yang GY,Ragheb JW,Evers BM,Weber CR,Turner JR,He XC,Katzman RB,Li L,Barrett TA

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Although it has recently become possible to detect hepatitis C viral antigens in liver biopsy specimens, the frequency and clinical significance of this finding remains uncertain. Therefore, 49 liver biopsy specimens from 35 patients with hepatitis C were studied to make these assessments. METHODS:Hepatitis...

journal_title：Gastroenterology

authors： Di Bisceglie AM,Hoofnagle JH,Krawczynski K

更新日期：1993-09-01 00:00:00