Abstract:
BACKGROUND/AIMS:The diagnosis of cholangiocarcinoma in primary sclerosing cholangitis (PSC), even with the use of current imaging techniques and brush cytology, is difficult and particularly important in patients being assessed for liver transplantation. This study investigated the accuracy of serum levels of a combination of the tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in the diagnosis of cholangiocarcinoma in patients with PSC. METHODS:Seventy-four patients with PSC were studied. Fifteen patients had tumors (11 occult on imaging), 22 had severe PSC that necessitated transplantation (with explanted liver known to be free of tumor), and 37 patients had stable PSC. RESULTS:An index of the two serum tumor markers [using the formula CA19-9 + (CEA x 40)] gave an accuracy of 86% in diagnosis of cholangiocarcinoma, with 10 of the 15 cases of cholangiocarcinoma having an increased value compared with none in a group of 22 comparable cases with no tumor. In addition, 6 of the 11 patients with occult tumors had abnormal values. Ultrasonography, computerized tomographic scanning, and endoscopic retrograde cholangiopancreatography were poor predictors of the presence of tumor. CONCLUSIONS:A combination of serum tumor markers will identify most occult tumors and will improve selection of appropriate cases for orthotopic liver transplantation.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Ramage JK,Donaghy A,Farrant JM,Iorns R,Williams Rdoi
10.1016/0016-5085(95)90462-xsubject
Has Abstractpub_date
1995-03-01 00:00:00pages
865-9issue
3eissn
0016-5085issn
1528-0012pii
0016-5085(95)90462-Xjournal_volume
108pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract::A variety of noninvasive molecular approaches to colorectal cancer screening are emerging with potential to improve screening effectiveness and user-friendliness. These approaches are based on the sensitive assay of molecular markers in stool, blood, and urine samples. New methods, especially next generation stool-bas...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2010.01.055
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND & AIMS:Mechanisms responsible for crypt architectural distortion in chronic ulcerative colitis (CUC) are not well understood. Data indicate that serine/threonine protein kinase Akt (Akt) signaling cooperates with Wingless (Wnt) to activate beta-catenin in intestinal stem and progenitor cells through phosphor...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.05.037
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND & AIMS:Mutations in the APC gene result in an increased propensity to develop intestinal neoplasia; however, a complete understanding of the mechanisms resulting in tumor formation has remained elusive. Min mice possess a mutation in the APC gene and display a neoplastic phenotype similar to that observed in...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(96)70083-5
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND & AIMS:JC virus (JCV), a human polyomavirus, has been found in a limited number of normal human tissues and cancers. The oncogenic potential of this virus is mediated by a transforming protein, the T antigen (TAg). We have previously demonstrated the presence of JCV-TAg in colorectal cancers, in adjacent nor...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.19269
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND/AIMS:Staphylococcal enterotoxin B (SEB) acts as a superantigen binding to class II major histocompatibility complex proteins, and this complex stimulates T cells. The aim of this study was to investigate the pathogenic effects of SEB on hepatic injury and lethal shock in mice. METHODS:SEB was administered t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90604-1
更新日期:1994-02-01 00:00:00
abstract::Four patients who underwent transplantation for hepatitis B virus-related liver disease developed rapidly progressive liver failure attributable to recurrent hepatitis B disease typified by hyperbilirubinemia and distinctive hepatocyte ballooning and progressive fibrosis consistent with recently reported fibrosing cho...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(92)91521-5
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND & AIMS:Lamivudine inhibits hepatitis B virus replication. This study investigated 6 months of lamivudine treatment at three doses. METHODS:Fifty-one patients (43% white, 49% Asian) with chronic hepatitis B were randomly assigned to receive 25, 100, or 300 mg of lamivudine orally once daily for 24 weeks with...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.1997.v113.pm9322520
更新日期:1997-10-01 00:00:00
abstract::Endogenous pancreatic prostaglandin production in control and obstructive jaundice was investigated using isolated and perfused dog pancreas. In both groups, spontaneous production of prostaglandin E2 and prostaglandin I2 was recorded, and the levels did not change in both groups. The production of both prostaglandins...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(90)90347-4
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND & AIMS:The role of the gallbladder in gallstone pathogenesis is still unclear. We examined the effects of gallbladder mucosal lipid absorption on lipid composition and cholesterol crystallization in bile. METHODS:The in vitro-isolated, intra-arterially perfused gallbladder model was used (1) to compare the ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(00)70177-6
更新日期:2000-05-01 00:00:00
abstract::The pathogenesis of gastroesophageal reflux disease (GERD) is complex and involves changes in reflux exposure, epithelial resistance, and visceral sensitivity. The gastric refluxate is a noxious material that injures the esophagus and elicits symptoms. Esophageal exposure to gastric refluxate is the primary determinan...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2017.09.047
更新日期:2018-01-01 00:00:00
abstract::To determine the pattern of inheritance of lactase deficiency, we studied 104 American Indian and 2 white subjects in 19 families. Subjects were considered deficient in lactase if breath-hydrogen excretion exceeded 0.20 ml per min above fasting at 2 hr after a lactose load of 2 g per kg of body weight (maximum 50 g). ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND & AIMS:It is unclear whether patients with diabetes are at an increased risk of developing acute liver failure (ALF). We performed a large cohort study to examine the occurrence of ALF by using the databases of the Department of Veterans Affairs. METHODS:We identified all patients with a hospital discharge ...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2002.33650
更新日期:2002-06-01 00:00:00
abstract:BACKGROUND & AIMS:The mechanism by which antimicrobial therapy against Helicobacter pylori is enhanced by acid suppression is unknown. The aim of this study was to investigate the effect of omeprazole on gastric juice, plasma, and saliva concentrations of metronidazole, amoxicillin, and clarithromycin. METHODS:Single ...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/gast.1996.v111.pm8690200
更新日期:1996-08-01 00:00:00
abstract::Furosemide occasionally causes azotemia in patients with ascites, independently of induced volume depletion. To define this effect, we measured renal clearances in patients with chronic liver disease and ascites and in nonascitic controls. Furosemide (80 mg i.v.) transiently increased p-aminohippurate clearance in con...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(87)90616-0
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND & AIMS:Major histocompatibility complex (MHC) class I-restricted CD8(+) T cells are required for clearance of hepatitis C virus (HCV) infection. MHC class I expression is up-regulated by type I and II interferons (IFNs). However, little is known about the effects of HCV infection on IFN-induced expression of...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2014.01.054
更新日期:2014-05-01 00:00:00
abstract::Intestinal microbiota are involved in the pathogenesis of Crohn's disease, ulcerative colitis, and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses mediate mucosal homeostasis via their composite genes (metagenome) and metabolic products (metabolome). We explain how alterations to th...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2016.10.012
更新日期:2017-02-01 00:00:00
abstract::There is increasing evidence that ingested diet-borne components are involved in the pathogenesis of disorders such as inflammatory bowel diseases, atherosclerosis, and type 2 diabetes. Nutrients can have short- and long-term effects in shaping the composition of the microbiota. Western diets (enriched in fat, phospha...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2014.12.036
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND & AIMS:Cirrhosis and portal hypertension due to chronic common bile duct ligation reproduce the features of human hepatopulmonary syndrome, whereas portal hypertension alone due to partial portal vein ligation does not. Nitric oxide contributes to experimental hepatopulmonary syndrome, but the nitric oxide s...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/j.gastro.2003.07.005
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND/AIMS:Diarrhea is a significant problem in patients with acquired immunodeficiency syndrome (AIDS). The aim of this study was to determine octreotide effectiveness in refractory AIDS-associated diarrhea. METHODS:In a 3-week protocol, 129 patients with a stool weight of > 500 g/day despite standard antidiarrh...
journal_title:Gastroenterology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0016-5085(95)90137-x
更新日期:1995-06-01 00:00:00
abstract::A patient who developed symptomatic giardiasis after a tour of the Soviet Union is presented. The diagnosis was established by duodenal aspiration. A small intestinal biopsy revealed total villous atrophy in the absence of celiac sprue or a gastrointestinal immunodeficiency syndrome, a finding not previously described...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract::Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...
journal_title:Gastroenterology
pub_type: 杂志文章,评审
doi:10.1053/j.gastro.2011.04.038
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND & AIMS:Type 2 diabetes mellitus (DM) is associated with an increased risk of colorectal cancer (CRC); it is not clear if this association varies by sex or other factors. Insulin use might also be associated with CRC risk. We investigated associations of type 2 DM and insulin use with CRC risk. METHODS:The C...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2010.06.072
更新日期:2010-10-01 00:00:00
abstract::Cholangiocarcinoma occurs in approximately 10% of patients with primary sclerosing cholangitis. Usually, liver failure, rapidly progressing jaundice, and an increase in alkaline phosphatase levels are suggestive diagnostic features. We report two cases of patients with primary sclerosing cholangitis who developed chol...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(94)90182-1
更新日期:1994-08-01 00:00:00
abstract::Two benzodiazepine-receptor partial inverse agonists (Ro 15-4513, Ro 15-3505) and one benzodiazepine-receptor antagonist (flumazenil) were administered to rats with hepatic encephalopathy due to acute liver ischemia. Significant improvement (P less than 0.002) of both the clinical grade of hepatic encephalopathy and t...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(91)90538-v
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND & AIMS:Small epithelial wounds heal by purse-string contraction of an actomyosin ring that is regulated by myosin light chain (MLC) kinase (MLCK) and rho kinase (ROCK). These studies aimed to define the roles of these kinases in purse-string wound closure. METHODS:Oligocellular and single-cell wounds were c...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/j.gastro.2005.01.004
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND & AIMS:The morphology of acid damage to esophageal epithelium is characterized by marked cell (swelling) edema. This observation suggests that, in the process of acid damage, an increase in osmotic forces develops within the cell that accounts for the increase in cell water. The aim of this study was to docu...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(95)90328-3
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND & AIMS:This study used a low lesion prevalence population reflective of the screening setting to estimate the sensitivity and specificity of computerized tomographic (CT) colonography for detection of colorectal polyps. METHODS:This prospective, blinded study comprised 703 asymptomatic persons at higher-tha...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/s0016-5085(03)00894-1
更新日期:2003-08-01 00:00:00
abstract::In order to study the natural history of fundic gland polyposis, 23 patients with familial adenomatosis coli/Gardner's syndrome were examined over a follow-up period ranging from 17 mo to 13 yr (average 6 yr). Examinations included gastric radiography and endoscopy with biopsy. Fundic gland polyps were found in 10 ind...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90203-3
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND & AIMS:Studies in gastrin-deficient mice have demonstrated critical roles for gastrin peptides in the regulation of gastric acid secretion, but the relative contributions of amidated (G-17) and glycine-extended (G17-Gly) gastrin remain unclear. We examined the effects of these 2 forms of gastrin on acid secr...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1053/gast.2000.16480
更新日期:2000-09-01 00:00:00
abstract::Random fecal alpha 1-antitrypsin levels were determined in 34 patients, 24 with Crohn's disease, and 10 "controls" having diarrheal illnesses not associated with intestinal protein loss, in an effort to evaluate its usefulness as a measure of Crohn's disease intestinal activity. In the control group, all alpha 1-antit...
journal_title:Gastroenterology
pub_type: 杂志文章
doi:10.1016/0016-5085(85)90739-5
更新日期:1985-07-01 00:00:00