Abstract：
BACKGROUND & AIMS:Rotavirus infection is a leading cause of morbidity and mortality in children younger than 5 years of age. Current treatment options are limited. We assessed the efficacy of a llama-derived, heavy-chain antibody fragment called anti-rotavirus protein (ARP1), in modifying the severity and duration of diarrhea in male infants with rotavirus infection. METHODS:We performed a double-blind, placebo-controlled trial of 176 male infants (6-24 months old) with severe rotavirus-associated diarrhea at Dhaka Hospital, Bangladesh. The infants were randomly assigned to groups given oral ARP1 (15-30 mg/kg/day, n = 88) or placebo (maltodextrin, n = 88) for a maximum of 5 days. The primary outcomes were severity (stool output) and duration of diarrhea and fecal excretion of rotavirus. Secondary outcomes were intake of oral rehydration salt solution, severity of vomiting, and serum levels of rotavirus-specific IgA. RESULTS:In infants with only rotavirus infection, total cumulative stool output was 305.47 g/kg body weight among those given placebo (n = 63) and 237.03 g/kg body weight among those given ARP1 (n = 61) (a difference of 68.44 g/kg body weight or 22.5%; 95% confidence interval: 18.27-118.59 g/kg body weight; P =.0079). There was a significant reduction in rate of stool output (g/kg/d) in the ARP1 group compared with the placebo group (61%; P = .002). ARP1 had no significant effect in infants with concomitant infections or on any other measured outcomes. No adverse events could be linked to ARP1. CONCLUSIONS:In a placebo-controlled trial, ARP1 reduced stool output in male infants with severe rotavirus-associated diarrhea. Clinicaltrials.gov number: NCT01259765.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Sarker SA,Jäkel M,Sultana S,Alam NH,Bardhan PK,Chisti MJ,Salam MA,Theis W,Hammarström L,Frenken LGdoi
10.1053/j.gastro.2013.06.053subject
Has Abstractpub_date
2013-10-01 00:00:00pages
740-748.e8issue
4eissn
0016-5085issn
1528-0012pii
S0016-5085(13)00997-9journal_volume
145pub_type
杂志文章,随机对照试验相关文献
GASTROENTEROLOGY文献大全abstract：BACKGROUND & AIMS:Although the cell of origin for pancreatic cancer remains unknown, prior studies have suggested that pancreatic neoplasia may be initiated in progenitor-like cells. To examine the effects of oncogene activation within the pancreatic progenitor pool, we devised a system for real-time visualization of b...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2008.02.084
更新日期：2008-06-01 00:00:00
abstract：:Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid particles within rat ileal absorptive cells are larger and exit at a slower rate. To evaluate the relevance of these observations to humans, we studie...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90676-2
更新日期：1988-06-01 00:00:00
abstract：:Four patients who underwent transplantation for hepatitis B virus-related liver disease developed rapidly progressive liver failure attributable to recurrent hepatitis B disease typified by hyperbilirubinemia and distinctive hepatocyte ballooning and progressive fibrosis consistent with recently reported fibrosing cho...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)91521-5
更新日期：1992-10-01 00:00:00
abstract：BACKGROUND & AIMS:Increase of T cells expressing CD4 and T-cell receptor (TCR) alpha- beta+ (beta[dim]) was observed in the mucosal and peripheral lymphoid tissues of TCR alpha-/- mice with inflammatory bowel disease (IBD). The aim of this study was to characterize the CD4+ TCR alpha-beta+ T cells. METHODS:Cytokine pr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1997.v112.pm9178680
更新日期：1997-06-01 00:00:00
abstract：:Gastrointestinal symptoms occur in a large number of patients with food allergies. Immediate hypersensitivity mechanisms may give rise to the nausea, vomiting, abdominal pain, and diarrhea experienced by these patients. However, there are limited human data about the pathophysiological basis for these symptoms. Most o...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1016/0016-5085(92)90047-3
更新日期：1992-09-01 00:00:00
abstract：:Sixty chronically alcoholic men who were impotent and known to have abstained from alcohol were followed prospectively to determine (a) the frequency of spontaneous recovery of normal sexual functioning, (b) indicators of spontaneous recovery, and (c) the response of those who did not achieve a spontaneous recovery to...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1983-04-01 00:00:00
abstract：:A 14-yr-old girl presented with long-standing symptoms of partial gastric outlet obstruction due to an antral mucosal diaphragm that had a central aperture of 4-5 mm. The literature of this congenital malformation is reviewed with respect to diagnostic criteria and feasibility of endoscopic transection. The procedure ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(85)90222-7
更新日期：1985-11-01 00:00:00
abstract：:Although nocturnal acid secretion has been emphasized in the pathophysiology and treatment of duodenal ulcer, its importance in gastric ulcer disease has been questioned. To explore this area, this multicenter U.S. trial compared the effect of a once-daily nighttime dose of H2-receptor antagonist with placebo on the h...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/0016-5085(89)91489-3
更新日期：1989-10-01 00:00:00
abstract：BACKGROUND & AIMS:Qualitative endoscopic ultrasound (EUS) elastography is an accurate but subjective tool for the differential diagnosis of solid pancreatic masses. Second-generation EUS elastography allows quantitative analysis of tissue stiffness. We evaluated the accuracy of quantitative, second-generation EUS elast...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.06.059
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND & AIMS:High-carbohydrate diets with a high glycemic response may exacerbate the metabolic consequences of the insulin-resistance syndrome. The effect on the incidence of gallstone disease is not clear. METHODS:We examined the associations between high-carbohydrate diets with a high glycemic response and the...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2005.05.016
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND & AIMS:Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (G-CSF) could promote hepatic regeneration. METHODS:Consecutive patients with ACLF were randomly assi...
journal_title：Gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.gastro.2011.11.027
更新日期：2012-03-01 00:00:00
abstract：:The relationship between gastric pepsin, acid secretion, and duodenal ulcer activity was studied in 33 patients with an endoscopically proven carter, in 17 patients who were studied within 3 mo of an acute crater but who no longer had a crater endoscopically, and in 10 patients who had no duodenal ulcer symptoms for l...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-07-01 00:00:00
abstract：BACKGROUND & AIMS:In intestinal inflammation the gut microbiota induces an innate immune response by activating epithelial and immune cells that initiate or maintain inflammation. We investigated whether the microbiota also can activate local microvascular cells and induce angiogenesis. METHODS:Human intestinal microv...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2012.11.005
更新日期：2013-03-01 00:00:00
abstract：BACKGROUND/AIMS:The gastric mucosa is covered by a continuous layer of bicarbonate-containing mucus gel; the question arises how acid, formed in the gastric glands, moves into the lumen. METHODS:The pH in the gastric mucus gel and gel thickness were measured in anesthetized rats with pH-sensitive microelectrodes (tip ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90075-2
更新日期：1994-07-01 00:00:00
abstract：:Interleukin 6 (IL6) is an inflammatory cytokine; signaling via its receptor (IL6R) is believed to contribute to development of inflammatory bowel diseases (IBD). The single nucleotide polymorphism rs2228145 in IL6R associates with increased levels of soluble IL6R (s-IL6R), as well as reduced IL6R signaling and risk of...
journal_title：Gastroenterology
pub_type： 杂志文章,meta分析
doi：10.1053/j.gastro.2018.05.022
更新日期：2018-08-01 00:00:00
abstract：:Intestinal mucosal biopsy immunoglobulin content in a patient with eosinophilia, allergic gastroenteropathy (atopy, food sensitivities, protein-losing enteropathy, iron deficiency anemia, and growth retardation), and hyperimmunoglobulinemia E (68,000 units) was compared with that of a control group and a group with eo...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1979-09-01 00:00:00
abstract：:Flow cytometry was used to detect the presence and assess the distribution of aneuploid cell populations in eight proctocolectomy specimens from patients with ulcerative colitis. Mucosal samples were taken according to a systematic protocol for flow cytometry, the surrounding tissue was examined histologically, and th...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90068-v
更新日期：1991-11-01 00:00:00
abstract：:Fifty consecutive patients with symptomatic endoscopically proven duodenal ulcer were randomized double-blind to Mylanta II or cimetidine treatment schedules. Smoking habits were noted, but patients were not advised to alter these. Healing was determined by reendoscopy at 6 wk. Eighty percent of patients on active cim...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND & AIMS:Manganese (Mn) deposition could be responsible for the T(1)-weighted magnetic resonance signal hyperintensities observed in cirrhotic patients. These experiments were designed to assess the regional specificity of the Mn increases as well as their relationship to portal-systemic shunting or hepatobili...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(99)70457-9
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND & AIMS:There are few validated biomarkers that can be used to predict outcomes for patients with colorectal cancer. Part of the challenge is the genetic and molecular heterogeneity of colorectal tumors not only among patients, but also within tumors. We have explored intratumor heterogeneity at the epigeneti...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2016.08.001
更新日期：2016-11-01 00:00:00
abstract：:Impaired metabolism of short-chain fatty acids, as well as a modified fecal ionogram, have been reported in ulcerative colitis. Fecal water samples from 62 patients with ulcerative colitis were analyzed in the present investigation to evaluate changes in SCFAs and lactic acid in relation to activity and severity of di...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(88)80078-7
更新日期：1988-12-01 00:00:00
abstract：BACKGROUND & AIMS:Adenomatous polyps are by definition dysplastic and pathologically indistinguishable from the dysplasia-associated lesion or mass (DALM) described in 1981. Yet, adenomatous polyps in noncolitic colons are usually removed definitively endoscopically, whereas DALMs are regarded as harbingers of colon ca...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(99)70279-9
更新日期：1999-12-01 00:00:00
abstract：:Several studies suggest that bile salts are transported from the basolateral to the canalicular membrane of hepatocytes by a vesicular pathway, possibly in part via the Golgi complex. To test this hypothesis, the present study examined, in the perfused rat liver, the influence of the Na+ ionophore monensin on the bili...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90328-v
更新日期：1992-06-01 00:00:00
abstract：BACKGROUND & AIMS:We recently identified a polymorphism upstream of interleukin (IL)-28B to be associated with a 2-fold difference in sustained virologic response (SVR) rates to pegylated interferon-alfa and ribavirin therapy in a large cohort of treatment-naive, adherent patients with chronic hepatitis C virus genotyp...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.04.013
更新日期：2010-07-01 00:00:00
abstract：:Glycine protects renal tubule cells from cell death during adenosine triphosphate (ATP) depletion. Although the liver plays a key role in glycine metabolism, information is lacking regarding the effects of glycine on lethal hepatocellular injury. Thus, the aim of this study was to determine the potential cytoprotectiv...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(92)90338-y
更新日期：1992-06-01 00:00:00
abstract：:A reliable method for studying lead absorption and excretion in rats is described. Lead absorption occurs primarily in theduodenum where lead enters the epithelial mucosal cells. There is a relative mucosal block for lead with increasing intraluminal doses. Certain substances which bind lead and increase its solubilit...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-04-01 00:00:00
abstract：BACKGROUND & AIMS:Neutrophils are generally thought to play an important proinflammatory role in the pathogenesis of inflammatory bowel disease. The objective of this study was to evaluate whether blocking the invasion of neutrophils by anti-L-selectin monoclonal antibodies modulates chemically induced colitis and how ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2007.08.073
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND & AIMS:Foxl1(+) hepatic progenitor cells (HPCs) differentiate into cholangiocytes and hepatocytes after liver injury. We investigated the requirement for Foxl1(+) HPCs in recovery from liver injury in mice. METHODS:We developed mice in which we could trace and delete Foxl1-expressing HPCs and their descenda...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2014.09.039
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND/AIMS:Previous studies have shown that psychological factors play a role in symptom perception among patients with gastroesophageal reflux disease. This report describes the first controlled study showing the effects of relaxation training on symptom reports and esophageal acid exposure in patients with reflu...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0016-5085(94)90061-2
更新日期：1994-07-01 00:00:00
abstract：:These studies were designed to better understand the effects of luminal nutrition on intestinal mass and function. Parenterally nourished rats received a midjejunal infusion of either 0.9% saline, 10% glucose, 10% 3-O-methyl glucose, or 30% glucose. A fifth group underwent sham operation. After 7 days, intestinal mass...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1983-11-01 00:00:00
