Sucralfate suppresses Helicobacter pylori infection and reduces gastric acid secretion by 50% in patients with duodenal ulcer.


BACKGROUND & AIMS:The mechanism(s) by which sucralfate heals duodenal ulcers remains unclear. The aim of this study was to determine the effect of sucralfate on Helicobacter pylori infection and on the accompanying hypersecretion of gastric acid the infection induces in patients with duodenal ulcer. METHODS:Basal and gastrin-releasing peptide (GRP) stimulated gastrin release and acid secretion. H. pylori density, gastric urease activity, and severity of gastritis were studied in patients with duodenal ulcer who were positive for H. pylori before, during, and after 4 weeks' treatment with sucralfate (2 g twice daily). RESULTS:The density of H. pylori decreased by 70% during sucralfate treatment and returned to the pretreatment level after discontinuation of therapy. This suppression of H. pylori infection was accompanied by an 80% decrease in gastric urease activity. GRP-stimulated plasma gastrin concentrations, GRP-stimulated acid output, and basal acid output all decreased by approximately 50% during sucralfate therapy and returned to pretreatment levels after treatment was discontinued. CONCLUSIONS:These findings indicate that sucralfate markedly suppresses H. pylori infection and the accompanying hypersecretion of acid the infection induces in patients with duodenal ulcer. These effects are likely to be important mechanisms by which the drug promotes duodenal ulcer healing.






Banerjee S,El-Omar E,Mowat A,Ardill JE,Park RH,Watson W,Beattie AD,McColl KE




Has Abstract


1996-03-01 00:00:00














  • The effects of benzodiazepine-receptor antagonists and partial inverse agonists on acute hepatic encephalopathy in the rat.

    abstract::Two benzodiazepine-receptor partial inverse agonists (Ro 15-4513, Ro 15-3505) and one benzodiazepine-receptor antagonist (flumazenil) were administered to rats with hepatic encephalopathy due to acute liver ischemia. Significant improvement (P less than 0.002) of both the clinical grade of hepatic encephalopathy and t...


    pub_type: 杂志文章


    authors: Bosman DK,van den Buijs CA,de Haan JG,Maas MA,Chamuleau RA

    更新日期:1991-09-01 00:00:00

  • Role of calcitonin gene-related peptide and nitric oxide in the gastroprotective effect of capsaicin in the rat.

    abstract:BACKGROUND:Capsaicin-sensitive neurons contain various peptides including calcitonin gene-related peptide. This study examines (1) whether calcitonin gene-related peptide is involved in capsaicin-induced gastroprotection and (2) whether nitric oxide and prostaglandin are required for calcitonin gene-related peptide to ...


    pub_type: 杂志文章


    authors: Lambrecht N,Burchert M,Respondek M,Müller KM,Peskar BM

    更新日期:1993-05-01 00:00:00

  • Cholecystokinin cleavage to cholecystokinin-octapeptide in vivo and in vitro: accelerated cleavage in acute pancreatitis.

    abstract::We have examined the possibility that the 33- and 39-amino acid forms of cholecystokinin (CCK) are cleaved to produce CCK-octapeptide (CCK-8) during circulation in humans. When a mixture of the 33- and 39-amino acid forms of porcine CCK was infused at 0.1-2.5 pmol/kg.min into normal subjects, material indistinguishabl...


    pub_type: 杂志文章


    authors: Springer CJ,Calam J

    更新日期:1988-07-01 00:00:00

  • T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice.

    abstract:BACKGROUND & AIMS:T helper (Th) 17 cells that express the retinoid-related orphan receptor (ROR) γt contribute to the development of colitis in mice, yet are found in normal and inflamed intestine. We investigated their development and functions in intestines of mice. METHODS:We analyzed intestinal Th17 cells in healt...


    pub_type: 杂志文章


    authors: Ono Y,Kanai T,Sujino T,Nemoto Y,Kanai Y,Mikami Y,Hayashi A,Matsumoto A,Takaishi H,Ogata H,Matsuoka K,Hisamatsu T,Watanabe M,Hibi T

    更新日期:2012-11-01 00:00:00

  • Organoid Models of Human Gastrointestinal Development and Disease.

    abstract::We have greatly advanced our ability to grow a diverse range of tissue-derived and pluripotent stem cell-derived gastrointestinal (GI) tissues in vitro. These systems, broadly referred to as organoids, have allowed the field to move away from the often nonphysiological, transformed cell lines that have been used for d...


    pub_type: 杂志文章,评审


    authors: Dedhia PH,Bertaux-Skeirik N,Zavros Y,Spence JR

    更新日期:2016-05-01 00:00:00

  • Brain-gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome.

    abstract:BACKGROUND & AIMS:To investigate the peripheral sensory effects of repeated stress in patients with postinfectious irritable bowel syndrome (IBS), we tested whether stress following self-limiting bacterial colitis increases colonic dorsal root ganglia (DRG) nociceptive signaling. METHODS:C57BL/6 mice were infected wit...


    pub_type: 杂志文章


    authors: Ibeakanma C,Ochoa-Cortes F,Miranda-Morales M,McDonald T,Spreadbury I,Cenac N,Cattaruzza F,Hurlbut D,Vanner S,Bunnett N,Vergnolle N,Vanner S

    更新日期:2011-12-01 00:00:00

  • Effect of iron on the guaiac reaction.

    abstract::Most studies show that oral ingestion of iron does not cause a positive stool guaiac reaction. However, all in vitro studies show that iron does cause a positive guaiac reaction and some in vivo studies have shown a positive stool guaiac reaction in response to oral iron. This study examines this unresolved question. ...


    pub_type: 杂志文章


    authors: McDonnell WM,Ryan JA,Seeger DM,Elta GH

    更新日期:1989-01-01 00:00:00

  • Dissolution of cholesterol gallstones in vitro. Gallstone matrix content and diameter, not cholesterol content, predict gallstone dissolution in monooctanoin.

    abstract::The goal of this study was to identify the structural and compositional features of human gallstones that influence in vitro gallstone dissolution in the cholesterol solvent monooctanoin. Gallstones were obtained from 86 consecutive patients who had at least three morphologically similar stones. One stone from each pa...


    pub_type: 杂志文章


    authors: Smith BF

    更新日期:1987-07-01 00:00:00

  • Platelets circulate in an activated state in inflammatory bowel disease.

    abstract:BACKGROUND/AIMS:Platelets show proinflammatory as well as prothrombotic properties. Patients with inflammatory bowel disease are at increased risk of systemic thromboembolism, and multifocal microvascular infarction has been proposed as a pathogenetic mechanism in Crohn's disease. The aim of this study was to determine...


    pub_type: 杂志文章


    authors: Collins CE,Cahill MR,Newland AC,Rampton DS

    更新日期:1994-04-01 00:00:00

  • Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency.

    abstract:BACKGROUND & AIMS:Approximately half of the families that fulfill Amsterdam criteria for Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC) do not have evidence of the germline mismatch repair gene mutations that define this syndrome and result in microsatellite instability (MSI). The carcinogenic path...


    pub_type: 杂志文章,多中心研究


    authors: Goel A,Xicola RM,Nguyen TP,Doyle BJ,Sohn VR,Bandipalliam P,Rozek LS,Reyes J,Cordero C,Balaguer F,Castells A,Jover R,Andreu M,Syngal S,Boland CR,Llor X

    更新日期:2010-05-01 00:00:00

  • Monozygotic triplets with Crohn's disease of the colon.

    abstract::Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was con...


    pub_type: 杂志文章


    authors: Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer G

    更新日期:1986-12-01 00:00:00

  • Delayed enzyme expression: a defect of aging rat gut.

    abstract::To evaluate the effect of aging upon the small intestine, the distribution, content, and concentration of epithelial cell enzymes at different levels along the crypt-villus column were measured in aging and young adult, male, Fisher 344 rats. Specific activities of sucrase, maltase, lactase, and adenosine deaminase in...


    pub_type: 杂志文章


    authors: Holt PR,Tierney AR,Kotler DP

    更新日期:1985-11-01 00:00:00

  • Survival of liver transplant recipients with hemochromatosis in the United States.

    abstract:BACKGROUND AND AIMS:Earlier studies have suggested that patients with hemochromatosis have poor post-transplantation survival. We aimed to compare patients with hemochromatosis to those with other causes of liver disease with regard to post-transplantation survival. METHODS:We compared the post-transplant survival of ...


    pub_type: 杂志文章


    authors: Yu L,Ioannou GN

    更新日期:2007-08-01 00:00:00

  • Gastric endocrine cell behavior in Zollinger-Ellison patients upon long-term potent antisecretory treatment.

    abstract::Serum gastrin and gastric endocrine cell numerical densities were examined in 22 patients with long-standing Zollinger-Ellison syndrome who were receiving either ranitidine, omeprazole, or other antisecretory drugs (SMS 201-995 or pirenzepine with or without ranitidine) for long periods of time. Fifteen patients had i...


    pub_type: 杂志文章


    authors: Lehy T,Mignon M,Cadiot G,Elouaer-Blanc L,Ruszniewski P,Lewin MJ,Bonfils S

    更新日期:1989-04-01 00:00:00

  • Inflammatory bowel disease and the risk of fracture.

    abstract:BACKGROUND & AIMS:Although patients with inflammatory bowel disease (IBD) have reduced bone mass, there is controversy whether there is an increased risk of fracture. This study examines the risk of fracture and its predictors in patients with IBD. METHODS:In a primary care- based nested case-control study, 231,778 fr...


    pub_type: 杂志文章


    authors: van Staa TP,Cooper C,Brusse LS,Leufkens H,Javaid MK,Arden NK

    更新日期:2003-12-01 00:00:00

  • Alcoholic foamy degeneration--a pattern of acute alcoholic injury of the liver.

    abstract::A newly recognized clinical and morphologic pattern of acute alcoholic liver disease is described. Twenty-one patients, having the hepatic morphologic features of alcoholic foamy degeneration, were retrospectively analyzed. All patients had a significant history of chronic alcoholism. Jaundice and hepatomegaly were us...


    pub_type: 杂志文章


    authors: Uchida T,Kao H,Quispe-Sjogren M,Peters RL

    更新日期:1983-04-01 00:00:00

  • Differentiation of gastric ECL cells is altered in CCK(2) receptor-deficient mice.

    abstract:BACKGROUND & AIMS:Gastrin stimulation of the type 2 cholecystokinin (CCK(2)) receptor results in ECL cell proliferation and histamine secretion. This report describes the effects of targeted disruption of the CCK(2) receptor gene on ECL cell morphology and function. METHODS:The ECL cells in the oxyntic mucosa of CCK(2...


    pub_type: 杂志文章


    authors: Chen D,Zhao CM,Al-Haider W,Håkanson R,Rehfeld JF,Kopin AS

    更新日期:2002-08-01 00:00:00

  • Spontaneous bacterial peritonitis caused by Neisseria gonorrhoeae. Evidence for a transfallopian route of infection.

    abstract::We describe the clinical and laboratory features of a case of spontaneous bacterial peritonitis caused by Neisseria gonorrhoeae in a sexually active woman with Laennec's cirrhosis, ascites, and asymptomatic cervical gonorrhea. Treatment of the infection with high-dose parenteral penicillin was associated with resoluti...


    pub_type: 杂志文章


    authors: Stassen WN,McCullough AJ,Hilton PK

    更新日期:1985-03-01 00:00:00

  • Distribution of somatostatin-14 and somatostatin-28 gastrointestinal-pancreatic cells of rats and humans.

    abstract::Somatostatin-14 and somatostatin-28 are biologically active peptides derived from the posttranslational cleavage of prosomatostatin. Because both peptides are found in variable concentrations in the gastrointestinal (GI) tract and pancreas, it has been contended that somatostatin-28 is either an intermediate in the pr...


    pub_type: 杂志文章


    authors: Francis BH,Baskin DG,Saunders DR,Ensinck JW

    更新日期:1990-11-01 00:00:00

  • Effect of cell culture on rabbit colonic smooth muscle bradykinin receptors.

    abstract::The aim of this study was to assess the effect of cell culture on the bradykinin receptor of rabbit colon myocytes. In longitudinal muscle strips prepared from distal colon, bradykinin stimulated dose-dependent contraction that was 62% of the maximal response to bethanecol. At 4 degrees C, [3H]bradykinin binding to fr...


    pub_type: 杂志文章


    authors: Hyman PE,Diego A,Ridout D,Yuan QX,Ennes H,Cominelli F,Snape WJ Jr,Tomomasa T

    更新日期:1992-05-01 00:00:00

  • Gastroesophageal reflux disease in monozygotic and dizygotic twins.

    abstract:BACKGROUND & AIMS:Gastroesophageal reflux disease (GERD) interferes with the quality of life and carries an increased risk for esophageal adenocarcinoma. We investigated genetic influence in the development of reflux. METHODS:We compared concordance for reflux in monozygotic (MZ) and dizygotic (DZ) twins. All twins ag...


    pub_type: 杂志文章


    authors: Cameron AJ,Lagergren J,Henriksson C,Nyren O,Locke GR 3rd,Pedersen NL

    更新日期:2002-01-01 00:00:00

  • Temozolomide increases the number of mismatch repair-deficient intestinal crypts and accelerates tumorigenesis in a mouse model of Lynch syndrome.

    abstract:BACKGROUND & AIMS:Lynch syndrome, a nonpolyposis form of hereditary colorectal cancer, is caused by inherited defects in DNA mismatch repair (MMR) genes. Most patients carry a germline mutation in 1 allele of the MMR genes MSH2 or MLH1. With spontaneous loss of the wild-type allele, cells with defects in MMR exist amon...


    pub_type: 杂志文章


    authors: Wojciechowicz K,Cantelli E,Van Gerwen B,Plug M,Van Der Wal A,Delzenne-Goette E,Song JY,De Vries S,Dekker M,Te Riele H

    更新日期:2014-11-01 00:00:00

  • Polycystic liver diseases: congenital disorders of cholangiocyte signaling.

    abstract::Polycystic liver diseases (PLD) are inherited disorders of the biliary epithelium, caused by genetic defects in proteins associated with intracellular organelles, mainly the endoplasmic reticulum and the cilium. PLD are characterized by the formation and progressive enlargement of multiple cysts scattered throughout t...


    pub_type: 杂志文章,评审


    authors: Strazzabosco M,Somlo S

    更新日期:2011-06-01 00:00:00

  • p53 protein accumulation in Barrett's metaplasia, dysplasia, and carcinoma: a follow-up study.

    abstract:BACKGROUND:There is a significant interobserver and intraobserver variation in grading dysplasia in Barrett's metaplasia. New markers are needed to optimize the assessment of potential risk of cancer development in these patients. The aim of this study is to explore the use of p53 as a marker of neoplastic progression ...


    pub_type: 杂志文章


    authors: Younes M,Lebovitz RM,Lechago LV,Lechago J

    更新日期:1993-12-01 00:00:00

  • Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.

    abstract:BACKGROUND & AIMS:Trinitrobenzene sulfonic acid (TNBS)-induced colitis is a T-helper 1 (Th1) T cell-mediated inflammation that is rapidly reversed by administration of anti-interleukin (IL) 12. This study sought to define the mechanism of this curative effect. METHODS:Cells and tissue from mice with TNBS colitis recei...


    pub_type: 杂志文章


    authors: Fuss IJ,Marth T,Neurath MF,Pearlstein GR,Jain A,Strober W

    更新日期:1999-11-01 00:00:00

  • Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin.

    abstract:BACKGROUND & AIMS:Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies. We aimed to confirm these findings in an adequately powered randomized trial. METHODS:...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Moayyedi P,Eikelboom JW,Bosch J,Connolly SJ,Dyal L,Shestakovska O,Leong D,Anand SS,Störk S,Branch KRH,Bhatt DL,Verhamme PB,O'Donnell M,Maggioni AP,Lonn EM,Piegas LS,Ertl G,Keltai M,Bruns NC,Muehlhofer E,Dagenais G

    更新日期:2019-09-01 00:00:00

  • Targeted metabolomics identifies glucuronides of dietary phytoestrogens as a major class of MRP3 substrates in vivo.

    abstract:BACKGROUND & AIMS:The physiologic function of the efflux transporter Multidrug Resistance Protein 3 (MRP3) remains poorly defined. In vitro, MRP3 transports several glucuronidated compounds, but the compounds transported under physiologic conditions are unknown. Knowledge of the compounds transported by MRP3 in vivo wo...


    pub_type: 杂志文章


    authors: van de Wetering K,Feddema W,Helms JB,Brouwers JF,Borst P

    更新日期:2009-11-01 00:00:00

  • Comparison of clearance and metabolism of infused cholecystokinins 8 and 58 in dogs.

    abstract:BACKGROUND:Cholecystokinin (CCK) 58 is the predominant molecular form of CCK in canine and human intestine and circulating blood. There is no report on the metabolism and clearance rate of CCK-58. The aim of this study was to compare the in vivo half-life and metabolism of CCK-58 with that of synthetic CCK-8. METHODS:...


    pub_type: 杂志文章


    authors: Hoffmann P,Eberlein GA,Reeve JR Jr,Bünte RH,Grandt D,Goebell H,Eysselein VE

    更新日期:1993-12-01 00:00:00

  • Abnormal resting brain activity in patients with functional dyspepsia is related to symptom severity.

    abstract:BACKGROUND & AIMS:Abnormal processing of visceral sensation at the level of the central nervous system is believed to be involved in functional dyspepsia. However, compared with studies of stimulation-related changes in brain activity, few studies have focused on resting brain activity, which also is important in patho...


    pub_type: 杂志文章


    authors: Zeng F,Qin W,Liang F,Liu J,Tang Y,Liu X,Yuan K,Yu S,Song W,Liu M,Lan L,Gao X,Liu Y,Tian J

    更新日期:2011-08-01 00:00:00

  • Reduced migration of fibroblasts in inflammatory bowel disease: role of inflammatory mediators and focal adhesion kinase.

    abstract:BACKGROUND & AIMS:Crohn's disease (CD) and ulcerative colitis (UC) are associated with chronic tissue damage and continuous tissue repair. A central, but not well-characterized, event during this process is the migration of activated fibroblasts to the wound. METHODS:Human colonic lamina propria fibroblasts (CLPF) wer...


    pub_type: 杂志文章


    authors: Leeb SN,Vogl D,Gunckel M,Kiessling S,Falk W,Göke M,Schölmerich J,Gelbmann CM,Rogler G

    更新日期:2003-11-01 00:00:00