Abstract：
BACKGROUND & AIMS:We evaluated etanercept, a human soluble tumor necrosis factor receptor: Fc fusion protein, for the treatment of active Crohn's disease. METHODS:Forty-three patients with moderate to severe Crohn's disease were enrolled in an 8-week placebo-controlled trial. Patients were randomized to subcutaneous etanercept 25 mg or placebo twice weekly. The primary outcome measure was clinical response at week 4, defined as a decrease in the baseline Crohn's Disease Activity Index score > or =70 points or a Crohn's Disease Activity Index score <150 points. RESULTS:At week 4, 39% of etanercept-treated patients had clinical response as compared with 45% of placebo-treated patients (P = 0.763). The frequency of common adverse events including headache, new injection site reaction, asthenia, abdominal pain, Crohn's disease-related anemia, and skin disorders was similar in both groups. Likewise, the frequency of severe or serious adverse events was similar in both groups. CONCLUSIONS:Subcutaneous etanercept at a dose of 25 mg twice weekly is safe, but not effective, for the treatment of patients with moderate to severe Crohn's disease. The dose of etanercept administered in this study is that approved for rheumatoid arthritis. Higher doses or more frequent dosing may be required to attain a response in patients with active Crohn's disease.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Sandborn WJ,Hanauer SB,Katz S,Safdi M,Wolf DG,Baerg RD,Tremaine WJ,Johnson T,Diehl NN,Zinsmeister ARdoi
10.1053/gast.2001.28674keywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
1088-94issue
5eissn
0016-5085issn
1528-0012pii
S001650850171195Xjournal_volume
121pub_type
临床试验,杂志文章,随机对照试验相关文献
GASTROENTEROLOGY文献大全abstract：:Detailed porphyrin analysis and additional ultrastructural abnormalities of liver cells are described in a patient with features of Rotor's syndrome. Normal values of porphyrin precursors, delta-aminolevulinic acid and porphobilinogen, and porphyrins were found in plasma, urine, and erythrocytes. However, fecal porphy...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
abstract：BACKGROUND & AIMS:Liver disease has been associated with cardiovascular disorders, but little is known about the relationship between serum levels of alanine aminotransferase (ALT) and markers of atherogenesis. We investigated the relationship between low-normal and high-normal levels of ALT and an extended panel of ca...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2013.08.036
更新日期：2013-12-01 00:00:00
abstract：:The effect of deoxycholate ingestion, 750 mg per day, on bile acid kinetics, biliary bile acid composition, and biliary lipid secretion was studied in 7 healthy volunteers. Bile acid kinetics were measured by isotope dilution, and hourly outputs of bile acid, cholesterol, and phospholipid were quantitated by a duodena...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1977-01-01 00:00:00
abstract：:There are apparent similarities in the mechanisms of the intestinal phase of exocrine and pancreatic polypeptide (PP) secretion by the pancreas. To characterize this relationship, we measured incremental responses of protein, bicarbonate, and PP to graded doses of intravenous secretin, caerulein, CCK8, CCK33, bethanec...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:Phlebotomy constitutes the established treatment for HFE-related hemochromatosis. Retrospective studies have suggested proton pump inhibitors (PPIs) reduce the need for phlebotomy in this population. We conducted a randomized controlled trial to prove this. Thirty p.C282Y homozygous patients were randomly allocated to...
journal_title：Gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.gastro.2017.06.006
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND & AIMS:Ischemia and reperfusion injury are common causes of oxidative tissue damage associated with many liver diseases and hepatic surgery. The Wnt-β-catenin signaling pathway is an important regulator of hepatic development, regeneration, and carcinogenesis. However, the role of Wnt signaling in the hepato...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.04.051
更新日期：2011-08-01 00:00:00
abstract：:Somatostatin-14 and somatostatin-28 are biologically active peptides derived from the posttranslational cleavage of prosomatostatin. Because both peptides are found in variable concentrations in the gastrointestinal (GI) tract and pancreas, it has been contended that somatostatin-28 is either an intermediate in the pr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)91151-u
更新日期：1990-11-01 00:00:00
abstract：:Erythromycin has been shown to act as a motilin agonist by binding to motilin receptors on gastrointestinal smooth muscle and to improve the severely impaired gastric emptying in patients with diabetic gastroparesis. To elucidate the motor pattern that accounts for this accelerated emptying, the effect of 200 mg eryth...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章
doi：10.1016/0016-5085(92)90164-t
更新日期：1992-03-01 00:00:00
abstract：:The prevalence of marginal zinc nutriture in several populations of people in this country and the lack of reports on the effect of marginal zinc nutriture in experimental animals prompted us to look at pancreatic acinar cell function and morphology in rats fed a zinc-deficient diet ad libitum: 4 and 50 ppm zinc-suppl...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(86)90872-3
更新日期：1986-04-01 00:00:00
abstract：:To evaluate the effect of aging upon the small intestine, the distribution, content, and concentration of epithelial cell enzymes at different levels along the crypt-villus column were measured in aging and young adult, male, Fisher 344 rats. Specific activities of sucrase, maltase, lactase, and adenosine deaminase in...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(85)90204-5
更新日期：1985-11-01 00:00:00
abstract：:Non-major histocompatibility complex-restricted cytotoxicity triggered by antibodies to the CD3 component of the human T-cell receptor complex is thought to be an indirect measure of in vivo primed cytotoxic T-cell activity. We have used this technique to examine the lytic activity of freshly isolated T cells from non...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90554-9
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND & AIMS:Activated pancreatic stellate cells have recently been implicated in pancreatic fibrogenesis. This study examined the role of pancreatic stellate cells in alcoholic pancreatic fibrosis by determining whether these cells are activated by ethanol itself and, if so, whether such activation is caused by t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(00)70148-x
更新日期：2000-04-01 00:00:00
abstract：:Pancreatitis is a common disorder with significant morbidity and mortality, yet little is known about its pathogenesis, and there is no specific or effective treatment. Its development involves dysregulated autophagy and unresolved inflammation, demonstrated by studies in genetic and experimental mouse models. Disease...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2017.08.071
更新日期：2017-11-01 00:00:00
abstract：:Basal and pentagastrin-stimulated gastric acid secretion, fasting serum gastrin concentrations, and the gastric output of prostaglandin E and its major metabolite 13,14-dihydro 15-keto prostaglandin E2 were measured in 9 normal subjects before and after 14-20 days of dietary supplementation with linoleic acid. Mean ma...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90553-7
更新日期：1988-04-01 00:00:00
abstract：BACKGROUND & AIMS:Patients with irritable bowel syndrome with diarrhea (IBS-D) have increased mucosal serotonin (5-hydroxytryptamine [5-HT]) availability, possibly because immune activation reduces activity of the 5-HT transporter (SERT). We investigated the relationship between mucosal and platelet SERT and immune act...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.01.052
更新日期：2011-05-01 00:00:00
abstract：:We have investigated the effect of oral cisapride (10 mg t.i.d.) in a double-blind, placebo-controlled trial in 26 patients with upper gut dysmotility: 11 with gastroparesis (8 diabetic, 3 idiopathic) and 15 with chronic idiopathic intestinal pseudoobstruction. Patients were evaluated at entry and at the end of the 6-...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1989-03-01 00:00:00
abstract：BACKGROUND/AIMS:Platelet-activating factor (PAF) is involved in the pathophysiology of motility changes induced by intestinal inflammation. The aim of this study was to evaluate a possible desensitization of PAF receptors in guinea pig intestinal smooth muscle cells after experimental inflammation induced by trinitrobe...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(95)90127-2
更新日期：1995-06-01 00:00:00
abstract：BACKGROUND & AIMS:Risk factors for cardiovascular disease, such as obesity and hypertension, have been associated with nonalcoholic fatty liver disease. Psychological distress (symptoms of anxiety and depression) is a risk factor for cardiovascular disease, so it might also be associated, directly or indirectly, with l...
journal_title：Gastroenterology
pub_type： 杂志文章,meta分析
doi：10.1053/j.gastro.2015.02.004
更新日期：2015-05-01 00:00:00
abstract：:The influence of endogenous prostaglandins on secretin-mediated inhibition of gastric acid secretion was examined in 6 mongrel dogs with Thomas gastric and Herrera pancreatic cannulas. The dogs were given intravenous pentagastrin (1 microgram/kg.h) during the 180-min experiment, and graded doses of secretin (0.3-1.5 m...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(88)80007-6
更新日期：1988-09-01 00:00:00
abstract：:This study of ischemic and postischemic reperfusion intestinal injury in rats evaluates the potential therapeutic value of fructose 1-6 diphosphate on the basis of its ability to enhance anaerobic carbohydrate metabolism during ischemia and to prevent additional tissue injury after reestablishing blood flow by inhibit...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)91299-l
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND & AIMS:Krüppel-like factor 5 (KLF5) is a transcription factor that promotes proliferation, is highly expressed in dividing crypt cells of the gastrointestinal epithelium, and is induced by various stress stimuli. We sought to determine the role of KLF5 in colonic inflammation and recovery by studying mice wi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.10.061
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND & AIMS:We performed a prospective, randomized, controlled study to compare the combination of esomeprazole and clopidogrel vs clopidogrel alone in preventing recurrent peptic ulcers in patients with atherosclerosis and a history of peptic ulcers. We also investigated the effects of esomeprazole on the antipl...
journal_title：Gastroenterology
pub_type： 杂志文章,随机对照试验
doi：10.1053/j.gastro.2010.11.056
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND & AIMS:Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial of patients with UC, we evaluated the safety and efficacy of SER-287, an oral formulation...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2020.07.048
更新日期：2021-01-01 00:00:00
abstract：BACKGROUND:Recurrent hepatitis B after liver transplantation may be complicated by fibrosing cholestatic hepatitis. This syndrome is associated with rapid graft failure and is characterized by ballooning degeneration of hepatocytes and abundant viral antigen expression. METHODS:To study this disorder further, in situ ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90032-8
更新日期：1993-07-01 00:00:00
abstract：BACKGROUND & AIMS:The peroxisome proliferator-activated receptor delta (PPARD) regulates cell metabolism, proliferation, and inflammation and has been associated with gastric and other cancers. Villin-positive epithelial cells are a small population of quiescent gastric progenitor cells. We expressed PPARD from a villi...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2019.03.018
更新日期：2019-07-01 00:00:00
abstract：:We report the case of a patient in whom amitriptyline administration for 5 wk was followed by prolonged cholestasis. Jaundice and pruritus lasted 19 and 20 mo, respectively. Three liver biopsies were performed at different stages of the disease showing the course of liver lesions. Cholestasis initially located in the ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(88)90631-2
更新日期：1988-01-01 00:00:00
abstract：:A new model of an acute bleeding gastric ulcer with a single bleeding artery in its base has been developed. A suction ulcer defect is created over a large, submucosal artery. Small bleeding marginal vessels are electrocoagulated with a fine-tipped bipolar forceps. The artery in the base of the ulcer is dissected free...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND & AIMS:Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organization and is induced by fibrogenic stimuli. We propose that fibromodulin contributes to the pathogenes...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2011.11.029
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND & AIMS:Helicobacter pylori is believed to predispose to gastric cancer by inducing gastric atrophy and hypochlorhydria. First-degree relatives of patients with gastric cancer have an increased risk of developing gastric cancer. The aim of this study was to determine the prevalence of atrophy and hypochlorhyd...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(00)70410-0
更新日期：2000-01-01 00:00:00
abstract：:One hundred symptomatic patients with radiolucent gallbladder stones were treated with a new piezoelectric lithotripter and oral chemolitholytic agents. Stone disintegration was achieved in 99 of these patients (99%) with a mean (+/- SD) maximum fragment size of 5.1 +/- 4.1 mm. Significant differences were found when ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(90)91173-4
更新日期：1990-11-01 00:00:00
