Correlations between clinical, blood leukocyte, and skin test data in the National Cooperative Crohn's Disease Study.

Abstract:

:Peripheral blood leukocyte counts, percentages of lymphocytes and granulocytes, serum albumin levels, and results of skin tests with five antigens were examined in patients randomized in the National Cooperative Crohn's Disease Study. Inspection for differences from normal and correlations with a variety of variables showed no unusual characteristics except for a high incidence of anergy (31%) at randomization, and ranging up to 47.5% after treatment.

journal_name

Gastroenterology

journal_title

Gastroenterology

authors

Beeken WL,Sessions JT Jr,Bozymski EM

subject

Has Abstract

pub_date

1979-10-01 00:00:00

pages

921-4

issue

4 Pt 2

eissn

0016-5085

issn

1528-0012

pii

S001650857900189X

journal_volume

77

pub_type

临床试验,杂志文章,随机对照试验
  • Trophic effects of pentagastrin on gastrointestinal tract in fed and fasted rats.

    abstract::In rats injected with pentagastrin (2-500 micrograms/kg subcutaneously) in saline, peak gastric acid responses occurred after 31 (30-min output) or 63 micrograms/kg (60-min output). Rats were fed or fasted for 48 h and injected every 8 h with 63, 250, or 1000 micrograms/kg pentagastrin. Fasting decreased body weight (...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(86)90446-4

    authors: Solomon TE

    更新日期:1986-07-01 00:00:00

  • Coffee consumption is associated with response to peginterferon and ribavirin therapy in patients with chronic hepatitis C.

    abstract:BACKGROUND & AIMS:High-level coffee consumption has been associated with reduced progression of pre-existing liver diseases and lower risk of hepatocellular carcinoma. However, its relationship with therapy for hepatitis C virus infection has not been evaluated. METHODS:Patients (n=885) from the lead-in phase of the H...

    journal_title:Gastroenterology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1053/j.gastro.2011.02.061

    authors: Freedman ND,Curto TM,Lindsay KL,Wright EC,Sinha R,Everhart JE,HALT-C TRIAL GROUP.

    更新日期:2011-06-01 00:00:00

  • Colobronchial fistula as a late complication of coloesophageal interposition.

    abstract::A 20-yr-old man developed recurrent respiratory symptoms and left lower lobe pneumonia 14 yr after long-segment colonic interposition for corrosive esophageal injury. A fistula, from a redundant supradiaphragmatic pouch of colon to a subsegmental bronchus of the lower lobe of the left lung, was discovered and treated ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Perlmutter DH,Tapper D,Teele RL,Winter HS

    更新日期:1984-06-01 00:00:00

  • N-nitrosamine generation from ingested nitrate via nitric oxide in subjects with and without gastroesophageal reflux.

    abstract:BACKGROUND & AIMS:Nitrate ingestion leads to high luminal concentrations of nitric oxide being generated where saliva meets gastric acid. Nitric oxide generates N-nitrosative stress on reacting with oxygen at neutral pH. We aimed to ascertain if luminal nitric oxide exerts nitrosative stress in the human upper gastroin...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1053/j.gastro.2007.04.047

    authors: Winter JW,Paterson S,Scobie G,Wirz A,Preston T,McColl KE

    更新日期:2007-07-01 00:00:00

  • The sympathetic nervous system modulates perception and reflex responses to gut distention in humans.

    abstract:BACKGROUND/AIMS:Intestinal distention induces perception and gut reflexes via sympathetic and vagal pathways, but the modulatory mechanisms of such responses remain obscure. The aim of this study was to determine the effects of sympathetic nervous activity on sympathetic and vagal reflexes as well as on intestinal and ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90439-5

    authors: Iovino P,Azpiroz F,Domingo E,Malagelada JR

    更新日期:1995-03-01 00:00:00

  • Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.

    abstract:BACKGROUND & AIMS:Modulation of the host innate immune response is an attractive means of inhibiting hepatitis C virus (HCV) replication. Having previously determined that expression of the interferon-sensitive gene (ISG)15 protease USP18 is increased in the liver biopsy specimens of patients who do not respond to inte...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2006.08.043

    authors: Randall G,Chen L,Panis M,Fischer AK,Lindenbach BD,Sun J,Heathcote J,Rice CM,Edwards AM,McGilvray ID

    更新日期:2006-11-01 00:00:00

  • Duodenal expression of a putative stimulator of Fe transport and transferrin receptor in anemia and hemochromatosis.

    abstract:BACKGROUND & AIMS:Stimulator of Fe Transport (SFT) and transferrin receptor (TfR) are proteins involved in iron transport. This study evaluated iron metabolism protein expression in duodenal biopsy specimens from controls and patients with abnormal iron metabolism. METHODS:Twelve controls, 8 patients with iron deficie...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.2001.23946

    authors: Barisani D,Parafioriti A,Armiraglio E,Meneveri R,Conte D

    更新日期:2001-05-01 00:00:00

  • Disordered gustatory acuity in liver disease.

    abstract::Disordered gustatory acuity was demonstrated in 22 patients with acute viral hepatitis and in 16 patients with chronic liver disease utilizing subjective responses and objective measurements of detection and recognition thresholds and scaling for NaCl, sucrose, HCl, and urea. In patients with early hepatitis and those...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Smith FR,Henkin RI,Dell RB

    更新日期:1976-04-01 00:00:00

  • Human intestinal intraepithelial lymphocytes have potent chemotactic activity.

    abstract:BACKGROUND & AIMS:Inflammation is created by the movement of leukocytes toward soluble attractants (chemokines). The aim of this study was to identify the chemokines that attract intestinal lymphocytes. METHODS:Intraepithelial and lamina propria lymphocytes were isolated from human jejunal mucosa of healthy individual...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(95)90573-1

    authors: Ebert EC

    更新日期:1995-10-01 00:00:00

  • JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

    abstract:BACKGROUND & AIMS:Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancrea...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2017.12.004

    authors: Song X,Zhu S,Xie Y,Liu J,Sun L,Zeng D,Wang P,Ma X,Kroemer G,Bartlett DL,Billiar TR,Lotze MT,Zeh HJ,Kang R,Tang D

    更新日期:2018-04-01 00:00:00

  • Hepatic subcapsular biloma. An unusual complication of endoscopic retrograde cholangiopancreatography.

    abstract::Development of an intraabdominal bile collection (biloma) usually occurs secondary to traumatic or iatrogenic injury including abdominal surgery, percutaneous catheter drainage, and transhepatic cholangiogram. We present a case of hepatic subcapsular biloma following endoscopic retrograde cholangiography and identifie...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Dupas JL,Mancheron H,Sevenet F,Delamarre J,Delcenserie R,Capron JP

    更新日期:1988-05-01 00:00:00

  • erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer.

    abstract:BACKGROUND & AIMS:Cholangiocarcinomas appear to arise from the malignant transformation of cholangiocytes lining the biliary tract. Because the development of an in vitro model of malignant transformation can provide a powerful new tool for establishing critical events governing the molecular pathogenesis of cholangioc...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2005.10.010

    authors: Lai GH,Zhang Z,Shen XN,Ward DJ,Dewitt JL,Holt SE,Rozich RA,Hixson DC,Sirica AE

    更新日期:2005-12-01 00:00:00

  • Corynebacterium parvum-elicited hepatic macrophages demonstrate enhanced respiratory burst activity compared with resident Kupffer cells in the rat.

    abstract::We have recently demonstrated that release of oxygen-derived free radicals by activated hepatic macrophages may be involved in the pathogenesis of a rat model of liver injury induced by Corynebacterium parvum and endotoxin. In the present study we have compared the respiratory burst activity of isolated normal rat Kup...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(86)90455-5

    authors: Arthur MJ,Kowalski-Saunders P,Wright R

    更新日期:1986-07-01 00:00:00

  • Pancreatic secretory activity of secretin5-27 and substituted analogues.

    abstract::The effect of secretin5-27 and four substituted analogues (9 Gln-secretin5-27, 15-Asn-secretin5-27, 9-Gln-15-Asn-secretin5-27, and 15-Lys-secretin5-27) on pancreatic secretion in the rat and guinea pig was examined. Secretin5-27 retained significant pancreatic secretory activity in both species. Its efficacy (intrinsi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Makhlouf GM,Bodanszky M,Fink ML,Schebalin M

    更新日期:1978-08-01 00:00:00

  • Effect of systemic pH on models of altered ileal transport in the rat.

    abstract::Decreases in arterial pH markedly increase sodium, chloride, and water absorption in the normal ileum and can reverse ongoing cholera toxin-induced secretion. In the current study we examined whether these effects of pH are evident in other models of ileal secretion, and in a model of increased absorption. Rats were a...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(89)91556-4

    authors: Charney AN,Ingrassia PM,Thaler SM,Keane MG

    更新日期:1989-02-01 00:00:00

  • Sites of clonidine action to inhibit gut propulsion in mice: demonstration of a central component.

    abstract::The role of central (supraspinal and spinal) and peripheral alpha-adrenoceptors in the regulation of gastrointestinal propulsion in the mouse was studied using clonidine, an alpha 2-adrenoceptor agonist. Clonidine produced a dose-dependent inhibition of propulsion when given intracerebroventricularly, intrathecally, o...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(88)90360-5

    authors: Jiang Q,Sheldon RJ,Porreca F

    更新日期:1988-11-01 00:00:00

  • Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome.

    abstract:BACKGROUND/AIMS:The pathways underlying rectal hypersensitivity to balloon distention in patients with irritable bowel syndrome (IBS) are not known. The aim of this study was to characterize the involvement of sacral and thoracolumbar afferents in the perception of rectal distention. METHODS:Rectal balloon distention ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(94)90809-5

    authors: Lembo T,Munakata J,Mertz H,Niazi N,Kodner A,Nikas V,Mayer EA

    更新日期:1994-12-01 00:00:00

  • Use of selective mesenteric vasodilator peptides in experimental nonocclusive mesenteric ischemia in the dog.

    abstract::Three structurally related peptides, ovine corticotropin-releasing factor, sauvagine, and urotensin I are selective mesenteric vasodilators in dogs. To assess the possible benefit of these peptides in nonocclusive mesenteric ischemia, they were compared with a nonselective vasodilator, sodium nitroprusside, in the ane...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(86)91122-4

    authors: MacCannell KL,Newton CA,Lederis K,Rivier J,Tiffany M

    更新日期:1986-03-01 00:00:00

  • Colony stimulating factor-1 dependence of paneth cell development in the mouse small intestine.

    abstract:BACKGROUND & AIMS:Paneth cells (PCs) secrete defensins and antimicrobial enzymes that contribute to innate immunity against pathogen infections within the mucosa of the small intestine. We examined the role of colony stimulating factor-1 (CSF-1) in PC development. METHODS:CSF-1-deficient and CSF-1 receptor (CSF-1R)-de...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2009.03.004

    authors: Huynh D,Dai XM,Nandi S,Lightowler S,Trivett M,Chan CK,Bertoncello I,Ramsay RG,Stanley ER

    更新日期:2009-07-01 00:00:00

  • p53 point mutations in dysplastic and cancerous ulcerative colitis lesions.

    abstract:BACKGROUND:The molecular basis of colorectal dysplasia and carcinoma arising in ulcerative colitis is poorly understood. Loss of heterozygosity involving the tumor suppressor gene p53 occurs frequently in neoplastic ulcerative colitis lesions. Point mutation affecting p53 is associated with loss of heterozygosity in ot...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(93)90639-t

    authors: Yin J,Harpaz N,Tong Y,Huang Y,Laurin J,Greenwald BD,Hontanosas M,Newkirk C,Meltzer SJ

    更新日期:1993-06-01 00:00:00

  • Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers.

    abstract::Of 550 patients admitted with acute upper gastrointestinal hemorrhage, 143 with peptic ulcers containing stigmata of recent hemorrhage accessible to endoscopic therapy were included in a randomized comparison of neodymium yttrium aluminum garnet laser, heater probe, and no endoscopic therapy. The rebleeding rate in la...

    journal_title:Gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0016-5085(90)90339-3

    authors: Matthewson K,Swain CP,Bland M,Kirkham JS,Bown SG,Northfield TC

    更新日期:1990-05-01 00:00:00

  • Intragastric distribution and gastric emptying assessed by three-dimensional ultrasonography.

    abstract:BACKGROUND & AIMS:Three-dimensional (3D) ultrasound imaging of the total stomach volume has not yet been achieved. The aim of this study was to investigate whether a magnetic position sensor system for acquisition of 3D ultrasonograms could be used to determine gastric emptying rates and intragastric distribution. MET...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/s0016-5085(97)70078-7

    authors: Gilja OH,Detmer PR,Jong JM,Leotta DF,Li XN,Beach KW,Martin R,Strandness DE Jr

    更新日期:1997-07-01 00:00:00

  • Computed tomographic colonography compared with colonoscopy in patients at increased risk for colorectal cancer.

    abstract:BACKGROUND & AIMS:To date, computed tomographic (CT) colonography has been compared with an imperfect test, colonoscopy, and has been mainly assessed in patients with positive screening test results or symptoms. Therefore, the available data may not apply to screening of patients with a personal or family history of co...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2004.03.055

    authors: Van Gelder RE,Nio CY,Florie J,Bartelsman JF,Snel P,De Jager SW,Van Deventer SJ,Laméris JS,Bossuyt PM,Stoker J

    更新日期:2004-07-01 00:00:00

  • Safety and Efficacy of AJM300, an Oral Antagonist of α4 Integrin, in Induction Therapy for Patients With Active Ulcerative Colitis.

    abstract:BACKGROUND & AIMS:AJM300 is an orally active small-molecule antagonist of the α4 integrin subunit. We performed a randomized trial to investigate the efficacy and safety of AJM300 in patients with active ulcerative colitis (UC). METHODS:In a double-blind, placebo-controlled, phase 2a study, 102 patients with moderatel...

    journal_title:Gastroenterology

    pub_type: 评论,杂志文章

    doi:10.1053/j.gastro.2015.08.044

    authors: Yoshimura N,Watanabe M,Motoya S,Tominaga K,Matsuoka K,Iwakiri R,Watanabe K,Hibi T,AJM300 Study Group.

    更新日期:2015-12-01 00:00:00

  • A case of familial visceral myopathy with atrophy and fibrosis of the longitudinal muscle layer of the entire small bowel.

    abstract::The case of a 21-yr-old man, who died in cachexia after 2 yr of intermittent abdominal pain, bouts of diarrhea, and anorexia, is reported. Laboratory tests performed shortly before death disclosed signs of malabsorption. Radiologic examination of the gastrointestinal tract showed a coarse mucosal relief in the upper j...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Jacobs E,Ardichvili D,Perissino A,Gottignies P,Hanssens JF

    更新日期:1979-10-01 00:00:00

  • Ontogenesis of the intestinal transport of biotin in the rat.

    abstract::Developmental aspects of the intestinal transport of biotin were examined in suckling (16 day old) and weanling (24 day old) rats using the everted sac technique. The results were compared with those of adult rats previously reported by us using the same intestinal preparation. Transport of biotin was linear for 20 mi...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1016/0016-5085(88)90611-7

    authors: Said HM,Redah R

    更新日期:1988-01-01 00:00:00

  • Inflammasomes in intestinal inflammation and cancer.

    abstract::Inflammasomes are multi-protein complexes that mediate activation of caspase-1, which promotes secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and pyroptosis, a form of phagocyte cell death induced by bacterial pathogens. Members of the Nod-like receptor family (including Nlrp1, Nlrp3, and...

    journal_title:Gastroenterology

    pub_type: 杂志文章,评审

    doi:10.1053/j.gastro.2011.10.002

    authors: Chen GY,Núñez G

    更新日期:2011-12-01 00:00:00

  • Large paraesophageal varices on endosonography predict recurrence of esophageal varices and rebleeding.

    abstract:BACKGROUND & AIMS:Recurrence of varices and rebleeding after endoscopic therapy is very common. Data on the prediction of recurrent varices after initial obliteration by endoscopic therapy are few. The aim of this study was to correlate the presence and the size of paraesophageal varices (PEVs) in patients after endosc...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/gast.1997.v112.pm9178670

    authors: Leung VK,Sung JJ,Ahuja AT,Tumala IE,Lee YT,Lau JY,Chung SC

    更新日期:1997-06-01 00:00:00

  • Long Noncoding RNA GMAN, Up-regulated in Gastric Cancer Tissues, Is Associated With Metastasis in Patients and Promotes Translation of Ephrin A1 by Competitively Binding GMAN-AS.

    abstract:BACKGROUND & AIMS:We aimed to identify long noncoding RNAs (lncRNAs) that are up-regulated in gastric cancer tissues from patients and study their function in gastric tumor metastasis. METHODS:We collected gastric tumor and nontumor tissues from patients in China and analyzed levels of lncRNAs by microarray analysis, ...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:10.1053/j.gastro.2018.10.054

    authors: Zhuo W,Liu Y,Li S,Guo D,Sun Q,Jin J,Rao X,Li M,Sun M,Jiang M,Xu Y,Teng L,Jin Y,Si J,Liu W,Kang Y,Zhou T

    更新日期:2019-02-01 00:00:00

  • Evidence for the existence of definitive hepatic cholesterol precursor compartments for bile acids and biliary cholesterol in man.

    abstract::A bile fistula patient was administered intravenously a constant infusion of [3H]mevalonic acid for 4 hrs, and then after 2 weeks he was given a pulse of [3H]mevalonic acid. Bile and blood were collected at frequent intervals. The specific activity-time course curves did not show a precursor-product relationship betwe...

    journal_title:Gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Schwartz CC,Vlahcevic ZR,Halloran LG,Gregory DH,Meek JB,Swell L

    更新日期:1975-12-01 00:00:00