Abstract：
BACKGROUND & AIMS:Paneth cells (PCs) secrete defensins and antimicrobial enzymes that contribute to innate immunity against pathogen infections within the mucosa of the small intestine. We examined the role of colony stimulating factor-1 (CSF-1) in PC development. METHODS:CSF-1-deficient and CSF-1 receptor (CSF-1R)-deficient mice and administration of neutralizing anti-CSF-1R antibody were used to study the requirement of CSF-1 for the development of epithelial cells of the small intestine. CSF-1 transgenic reporter mice and mice that express only the membrane-spanning, cell-surface CSF-1 isoform were used to investigate regulation by systemic versus local CSF-1. RESULTS:Mice deficient in CSF-1 or CSF-1R had greatly reduced numbers of mature PCs. PCs express the CSF-1R, and administration of anti-CSF-1R antibody to neonatal mice significantly reduced the number of PCs. Analysis of transgenic CSF-1 reporter mice showed that CSF-1-expressing cells are in close proximity to PCs. CSF-1/CSF-1R-deficient mice also had reduced numbers of the proliferating epithelial cell progenitors and lamina propria macrophages. Expression of the membrane-spanning, cell-surface CSF-1 isoform in CSF-1-deficient mice completely rescued the deficiencies of PCs, proliferating progenitors, and lamina propria macrophages. CONCLUSIONS:These results indicate local regulation by CSF-1 of PC development, either directly, in a juxtacrine/paracrine manner, or indirectly, by lamina propria macrophages. Therefore, CSF-1R hyperstimulation could be involved in hyperproliferative disorders of the small intestine, such as Crohn's disease and ulcerative colitis.
journal_name
Gastroenterologyjournal_title
Gastroenterologyauthors
Huynh D,Dai XM,Nandi S,Lightowler S,Trivett M,Chan CK,Bertoncello I,Ramsay RG,Stanley ERdoi
10.1053/j.gastro.2009.03.004subject
Has Abstractpub_date
2009-07-01 00:00:00pages
136-44, 144.e1-3issue
1eissn
0016-5085issn
1528-0012pii
S0016-5085(09)00375-8journal_volume
137pub_type
杂志文章相关文献
GASTROENTEROLOGY文献大全abstract：:Intracerebroventricular prostaglandin E2 (PGE2) inhibits stimulated gastric acid secretion; however, the central site of action is unknown. Specific PGE2 binding sites have been localized to the ventromedial hypothalamic nucleus and central amygdala (A). The nuclear accumbens has been shown to play a role in central n...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90198-t
更新日期：1991-02-01 00:00:00
abstract：:The effects of vasopressin on blood flow in the superior mesenteric artery and on mean arterial pressure and portal venous pressure were measured in 7 rhesus monkeys. Vasopressin was injected, as either a bolus, or infused both intravenously and intraarterially to assess the influence of the route of administration up...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
abstract：BACKGROUND & AIMS:Colorectal cancer screening with diagnostic imaging can detect polyps. The management of patients whose largest polyp is less than 10 mm is uncertain. The primary aim of this study was to determine rates of advanced histology in patients undergoing colorectal cancer screening whose largest polyp is 9 ...
journal_title：Gastroenterology
pub_type： 杂志文章,多中心研究
doi：10.1053/j.gastro.2008.06.083
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND & AIMS:Dysbiosis of the intestinal microbiota has been associated with development of allergies in infants. However, it is not clear what microbes might contribute to this process. We investigated what microbe(s) might be involved in analyses of infant twins and mice. METHODS:We studied fecal specimens pros...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2017.09.006
更新日期：2018-01-01 00:00:00
abstract：:A rapid immunohistochemical method using 5'-bromo-2'-deoxyuridine (BrdU), a thymidine analog, for labeling proliferating epithelial cells was modified and tested for accuracy against standard tritiated thymidine autoradiography (3H-TdR) in rat esophagus, stomach, duodenum, and colon. Either BrdU or 3H-thymidine or bot...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(91)90610-w
更新日期：1991-01-01 00:00:00
abstract：:Excretion of hydrogen in breath commonly persists despite an overnight fast. Although elevation of hydrogen concentration above the fasting value after administration of a test sugar is evidence of malabsorption, the significance of the fasting value itself is unknown. We determined the normal limits of fasting breath...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:A 61-yr-old woman was found to have multicentric hepatocellular carcinoma associated with clinical hyperthyroidism. Marked elevations in serum thyroid-stimulating hormone, T4, T3, and free T4 were documented. These values increased with tumor progression. It is postulated that this patient's hepatoma produced a substa...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/s0016-5085(85)80152-9
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND & AIMS:Hepatic bile salt secretion is an essential function of vertebrate liver. Rat and mouse bile salt export pump (Bsep) are adenosine triphosphate (ATP)-dependent bile salt transporters. Mutations in human BSEP were identified as the cause of progressive familial intrahepatic cholestasis type 2. BSEP pro...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2002.36587
更新日期：2002-11-01 00:00:00
abstract：:A randomized, controlled trial was conducted to investigate the ability of indomethacin and chloroquine to reduce intestinal secretion in 29 adult patients with severe cholera. All patients received intravenous infusion to restore fluid balance, but no antibiotics were given. Patients treated with oral indomethacin (t...
journal_title：Gastroenterology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0016-5085(85)90205-7
更新日期：1985-11-01 00:00:00
abstract：BACKGROUND & AIMS:Histamine-producing enterochromaffin-like (ECL) cells play an integrative role in the regulation of acid secretion. Decreased mucosal histamine concentrations and increased levels of interleukin (IL) 1 beta, IL-6, and IL-8 have been detected in the gastric mucosa inflamed with Helicobacter pylori. The...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1997.v112.pm9024290
更新日期：1997-02-01 00:00:00
abstract：BACKGROUND & AIMS:A 3-dimensional (3D) culture system for immortalized human hepatocytes (HuS-E/2 cells) recently was shown to support the lifecycle of blood-borne hepatitis C virus (HCV). We used this system to identify proteins that are active during the HCV lifecycle under 3D culture conditions. METHODS:We compared...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2013.05.014
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND & AIMS:The anti-cancer effects of vegetables and fruit have been investigated extensively, but the association between vegetable and fruit consumption and risk of hepatocellular carcinoma (HCC) has not been quantified. We performed a meta-analysis of observational studies to clarify the association. METHODS...
journal_title：Gastroenterology
pub_type： 杂志文章,meta分析,评审
doi：10.1053/j.gastro.2014.08.005
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND & AIMS:The mechanism by which gastric mucosa becomes more resistant to damage by repeated aspirin administration is not known. Transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) prevent drug-induced gastric injury. The aim of this study was to determine whether gastroduodenal tiss...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1996.v110.pm8613050
更新日期：1996-05-01 00:00:00
abstract：:After proximal small bowel resection, the remaining small intestine undergoes adaptive hyperplasia. The role of bile and pancreatic secretions in stimulating ileal mucosal growth after jejunectomy was studied. Male Sprague-Dawley rats were fed either standard rat chow or a liquid elemental diet, and were divided into ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1977-09-01 00:00:00
abstract：:Altered gallbladder motility could predispose to, or result from, gallstone formation and could also explain the alleged relief of biliary colic seen during bile acid therapy. Therefore, in 14 controls, 25 patients with radiolucent gallstones, and 14 patients with radiopaque gallstones, we used two techniques to measu...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1984-08-01 00:00:00
abstract：BACKGROUND:Active transport of conjugated bile acids by ileal enterocytes is a key mechanism for conservation of the bile acid pool. Experiments were performed to determine whether such transport is regulated by substrate load. METHODS:Using anesthetized biliary fistula guinea pigs or rats, the ileum was perfused with...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)90833-x
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND & AIMS:Gastric histology is not well studied in patients with Crohn's disease. The aim of this study was to analyze the histological appearance of gastric mucosa in patients with Crohn's disease. METHODS:In a prospective study, biopsy specimens taken from the antrum and body of 75 patients with known Crohn'...
journal_title：Gastroenterology
pub_type： 评论,杂志文章
doi：10.1053/gast.1997.v112.pm9041230
更新日期：1997-03-01 00:00:00
abstract：:Autophagy is a lysosomal pathway that degrades and recycles intracellular organelles and proteins to maintain energy homeostasis during times of nutrient deprivation and to remove damaged cell components. Recent studies have identified new functions for autophagy under basal and stressed conditions. In the liver and p...
journal_title：Gastroenterology
pub_type： 杂志文章,评审
doi：10.1053/j.gastro.2011.04.038
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND & AIMS:Chronic pancreatitis has been suggested as a causal risk factor for pancreatic cancer in a recent study. The aim of this study was to clarify the relationship between chronic pancreatitis and pancreatic cancer. METHODS:All patients in the Swedish inpatient Register with a discharge diagnosis of pancr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.1997.v113.pm9247480
更新日期：1997-08-01 00:00:00
abstract：:Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2013.12.034
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND & AIMS:IKBL gene lies telomeric of the tumor necrosis factor cluster in the central major histocompatibility complex and carries a structural polymorphism at position +738. In the Spanish white population, we found the IKBL+738(C) allele in haplotypes carrying either HLA-DRB1(*)1501 or -DRB1(*)0103. Because ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2000.20258
更新日期：2000-12-01 00:00:00
abstract：:The effect of magnesium on calcium- and pentagastrin-induced gastric acid secretion and on calcium-induced gastrin secretion were studied in healthy volunteers. Intravenous infusion of calcium gluconate increased serum gastrin concentration as well as gastric volume secretion, acidity, and acid output. Addition of mag...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：BACKGROUND & AIMS:Adenosine mediates immune suppression and is generated by the ectonucleotidases CD39 (ENTPD1) and CD73 that are expressed on vascular endothelial cells and regulatory T cells (Tregs). Although tumor-infiltrating immune cells include Foxp3(+) Tregs, it is not clear whether local adenosine generation by...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/j.gastro.2010.05.007
更新日期：2010-09-01 00:00:00
abstract：:Most studies show that oral ingestion of iron does not cause a positive stool guaiac reaction. However, all in vitro studies show that iron does cause a positive guaiac reaction and some in vivo studies have shown a positive stool guaiac reaction in response to oral iron. This study examines this unresolved question. ...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(89)90766-x
更新日期：1989-01-01 00:00:00
abstract：:The polypeptide core of mucin glycoprotein subunits resists cleavage by proteases. To determine if the carbohydrate side chains of these subunits protect the underlying polypeptide core from proteolytic cleavage, we compared the effect of pancreatic proteases on hog gastric mucin before and after cleavage of its carbo...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：BACKGROUND AND AIMS:The role of selectins in experimental colitis remains unknown. The aims of this study were to characterize the time-course expression of selectins in trinitrobenzene sulfonic acid (TNBS)-induced colitis, the functional role of selectins in colonic leukocyte-endothelial cell interactions, and the the...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1053/gast.2001.23252
更新日期：2001-04-01 00:00:00
abstract：:Five carboxyl-terminal fragments of secretin ranging in size from 6 to 21 amino acid residues were tested for pancreatic secretory activity in the rat. None of the fragments displayed activity when given alone but each displayed significant activity when given after secretin. This apparent activity was shown to be the...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：
更新日期：1978-12-01 00:00:00
abstract：BACKGROUND:Endogenous nitric oxide has been implicated in the control of mesenteric circulation, but its role in the control of pancreatic blood flow and exocrine pancreatic secretion has not been studied. METHODS:Secretory studies were performed on conscious dogs with chronic pancreatic fistulas, and changes in pancr...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(93)91028-g
更新日期：1993-03-01 00:00:00
abstract：BACKGROUND/AIMS:The mechanisms of chemically induced injury are poorly understood. The purpose of this study was to develop a rapid method for isolation of gastric mucosal cells (GMCs) and sensitive tests for investigating cell damage and protection. METHODS:GMCs were prepared from rat glandular stomach with pronase a...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/0016-5085(94)90213-5
更新日期：1994-10-01 00:00:00
abstract：BACKGROUND & AIMS:Cystic fibrosis transmembrane regulator (CFTR) gene mutations are associated with pancreatic insufficiency and pancreatitis. Chronic pancreatitis, including cystic fibrosis-related disease, may exist as a continuum between acute and chronic disease and may manifest as recurrent pain. We hypothesized t...
journal_title：Gastroenterology
pub_type： 杂志文章
doi：10.1016/j.gastro.2005.05.059
更新日期：2005-08-01 00:00:00
