Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats.


BACKGROUND & AIMS:The mechanism by which gastric mucosa becomes more resistant to damage by repeated aspirin administration is not known. Transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) prevent drug-induced gastric injury. The aim of this study was to determine whether gastroduodenal tissue levels of TGF-alpha and EGF protein were altered during adaptation to aspirin-induced injury in monkeys and rats in vivo. METHODS:Animals were given aspirin daily for up to 28 days. Gross mucosal injury was assessed by computerized image analysis in rats and by endoscopy in monkeys. Mucosal concentrations of TGF-alpha and EGF were quantitated by radioimmunoassays from endoscopic biopsy samples in monkeys and from scraped mucosa in rats. RESULTS:Long-term administration of aspirin caused a significant increase in gastric and duodenal tissue levels of TGF-alpha in monkeys and rats; the increased levels of TGF-alpha significantly correlated with the decrease in aspirin-induced injury. No change in the gastroduodenal tissue levels of EGF was observed. Adaptation was not associated with any significant change in basal gastric acid secretion in monkeys and occurred despite a significant decrease in gastric mucin in rats. CONCLUSIONS:Adaptation of the gastric mucosa to the damaging effect of aspirin is associated with a significant and specific increase in TGF-alpha protein in the gastroduodenum.






Romano M,Lesch CA,Meise KS,Veljaca M,Sanchez B,Kraus ER,Boland CR,Guglietta A,Coffey RJ




Has Abstract


1996-05-01 00:00:00














  • Calretinin and calbindin-D28k immunoreactivity in the human gastrointestinal tract.

    abstract:BACKGROUND:Calretinin and calbindin-D28k are similar Ca(2+)-binding proteins previously described in specific central neurons and other cells. METHODS:The immunocytochemical distribution of these two proteins was studied in the human gastrointestinal tract. RESULTS:In gastric and small intestinal endocrine cells, cal...


    pub_type: 杂志文章


    authors: Walters JR,Bishop AE,Facer P,Lawson EM,Rogers JH,Polak JM

    更新日期:1993-05-01 00:00:00

  • Protein digestion and absorption in rats with pancreatic duct occlusion.

    abstract::The effects of pancreatic duct ligation on the digestion and absorption of a randomly 14C-labeled protein meal has been investigated in the rat. Although there was a significant reduction in luminal digestion and absorption of the protein meal in the pancreatic duct-ligated animals compared with controls, 37% of admin...


    pub_type: 杂志文章


    authors: Curtis KJ,Gaines HD,Kim YS

    更新日期:1978-06-01 00:00:00

  • Enhancement of the cyclic motor activity of the ovine small intestine by lysergic acid derivatives. Mechanism and significance.

    abstract::The effects of a variety of substances influencing the initiation of cyclic motor events at the gastroduodenal junction were studied in conscious sheep. A significant and long-lasting decrease in the frequency of cyclic events from approximately 100 min to 30-40 min was elicited by the intraduodenal bulb administratio...


    pub_type: 杂志文章


    authors: Ruckebusch Y

    更新日期:1984-11-01 00:00:00

  • Olsalazine sodium in the treatment of ulcerative colitis among patients intolerant of sulfasalazine. A prospective, randomized, placebo-controlled, double-blind, dose-ranging clinical trial.

    abstract::Sixty-six outpatients with active ulcerative colitis who were intolerant of sulfasalazine were treated in a double-blind randomized trial. They received placebo or olsalazine sodium in daily doses of 0.75, 1.5, or 3 g. Overall, 35% of patients receiving olsalazine improved clinically, compared to 16% of patients recei...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Meyers S,Sachar DB,Present DH,Janowitz HD

    更新日期:1987-12-01 00:00:00

  • Role of tumor necrosis factor alpha release and leukocyte margination in indomethacin-induced gastric injury in rats.

    abstract:BACKGROUND/AIMS:Several studies have shown that polymorphonuclear neutrophil leukocyte (PMN) margination is an early and critical event in the pathogenesis of gastric mucosal injury caused by nonsteroidal anti-inflammatory drugs. Tumor necrosis factor (TNF) alpha is a proinflammatory cytokine that causes PMN marginatio...


    pub_type: 杂志文章


    authors: Santucci L,Fiorucci S,Di Matteo FM,Morelli A

    更新日期:1995-02-01 00:00:00

  • Proton magnetic resonance spectroscopy of the brain in symptomatic and asymptomatic patients with liver cirrhosis.

    abstract:BACKGROUND & AIMS:Hepatic encephalopathy (HE) is associated with typical changes of cerebral metabolite pattern observed by proton magnetic resonance (MR) spectroscopy consisting of a depletion of myo-inositol and an increase of glutamine. The aim of this study was to determine whether abnormalities in brain metabolism...


    pub_type: 杂志文章


    authors: Laubenberger J,Häussinger D,Bayer S,Gufler H,Hennig J,Langer M

    更新日期:1997-05-01 00:00:00

  • One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome.

    abstract:BACKGROUND & AIMS:Two percent to 4% of all cases of colorectal cancer (CRC) are associated with Lynch syndrome. Dominant clustering of CRC (non-Lynch syndrome) accounts for 1%-3% of the cases. Because carcinogenesis is accelerated in Lynch syndrome, an intensive colonoscopic surveillance program has been recommended si...


    pub_type: 杂志文章


    authors: Vasen HF,Abdirahman M,Brohet R,Langers AM,Kleibeuker JH,van Kouwen M,Koornstra JJ,Boot H,Cats A,Dekker E,Sanduleanu S,Poley JW,Hardwick JC,de Vos Tot Nederveen Cappel WH,van der Meulen-de Jong AE,Tan TG,Jacobs MA,Mohame

    更新日期:2010-06-01 00:00:00

  • Monozygotic triplets with Crohn's disease of the colon.

    abstract::Female monozygotic triplets all developed Crohn's disease within a period of 11 mo. The monozygosity was demonstrated by analysis of 24 genetic markers of different chromosomal localization. Crohn's disease was diagnosed using clinical, radiologic, and endoscopic findings. Histologic evaluation of bowel tissue was con...


    pub_type: 杂志文章


    authors: Purrmann J,Bertrams J,Borchard F,Miller B,Cleveland S,Stolze T,Strohmeyer G

    更新日期:1986-12-01 00:00:00

  • Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention.

    abstract:BACKGROUND & AIMS:Quantitative neurophysiological studies have identified the presence of at least 2 spinal neuronal populations (abrupt and sustained) that are excited by the noxious visceral stimulus colorectal distention. This study examined the effects of the kappa opioid receptor agonists fedotozine and U50488H on...


    pub_type: 杂志文章


    authors: Ness TJ

    更新日期:1999-08-01 00:00:00

  • Liver adenomatosis. An entity distinct from liver adenoma?

    abstract::From 1979 to 1984, we followed the cases of 3 men (aged 13, 31, and 75 yr) and 2 women (aged 38 and 45 yr who had never used oral contraceptives) suffering from liver adenomatosis, an uncommon lesion consisting of numerous benign adenomas in an otherwise normal hepatic parenchyma. During the same period, we observed 2...


    pub_type: 杂志文章


    authors: Flejou JF,Barge J,Menu Y,Degott C,Bismuth H,Potet F,Benhamou JP

    更新日期:1985-11-01 00:00:00

  • Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudoobstruction.

    abstract::We have investigated the effect of oral cisapride (10 mg t.i.d.) in a double-blind, placebo-controlled trial in 26 patients with upper gut dysmotility: 11 with gastroparesis (8 diabetic, 3 idiopathic) and 15 with chronic idiopathic intestinal pseudoobstruction. Patients were evaluated at entry and at the end of the 6-...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Camilleri M,Malagelada JR,Abell TL,Brown ML,Hench V,Zinsmeister AR

    更新日期:1989-03-01 00:00:00

  • Relationship between patterns of bleeding and Hemoccult sensitivity in patients with colorectal cancers or adenomas.

    abstract::Although Hemoccult (Smith Kline Diagnostics, Inc., Sunnyvale, Calif.) screening for colorectal cancer is based on detection of the peroxidase activity of blood, little is known about the relationship between patterns of bleeding from cancers or adenomas and sensitivity of the test slides. 51Cr-labeled blood loss was m...


    pub_type: 杂志文章


    authors: Macrae FA,St John DJ

    更新日期:1982-05-01 00:00:00

  • Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice.

    abstract:BACKGROUND & AIMS:In the enteric nervous system, neurotransmitters initiate changes in calcium (Ca(2+) responses) in glia, but it is not clear how this process affects intestinal function. We investigated whether Ca(2+)-mediated responses in enteric glia are required to maintain gastrointestinal function. METHODS:We u...


    pub_type: 杂志文章


    authors: McClain J,Grubišić V,Fried D,Gomez-Suarez RA,Leinninger GM,Sévigny J,Parpura V,Gulbransen BD

    更新日期:2014-02-01 00:00:00

  • Primary biliary cirrhosis is associated with a genetic variant in the 3' flanking region of the CTLA4 gene.

    abstract:BACKGROUND & AIMS:Genetic variation is invoked as a strong component underlying primary biliary cirrhosis (PBC) and other autoimmune disorders. Data suggest that some of this genetic risk is shared, affecting function of the immune mechanisms controlling self-tolerance. Cytotoxic T-lymphocyte antigen 4 (CTLA4) encodes ...


    pub_type: 杂志文章


    authors: Juran BD,Atkinson EJ,Schlicht EM,Fridley BL,Lazaridis KN

    更新日期:2008-10-01 00:00:00

  • Mapping of gluten T-cell epitopes in the bread wheat ancestors: implications for celiac disease.

    abstract:BACKGROUND AND AIMS:Celiac disease is a prevalent disorder characterized by a chronic intestinal inflammation driven by HLA-DQ2 or -DQ8-restricted T cells specific for ingested wheat gluten peptides. The dominant T-cell responses are to epitopes that cluster within a stable 33mer fragment formed by physiologic digestio...


    pub_type: 杂志文章


    authors: Molberg O,Uhlen AK,Jensen T,Flaete NS,Fleckenstein B,Arentz-Hansen H,Raki M,Lundin KE,Sollid LM

    更新日期:2005-02-01 00:00:00

  • Association between high-normal levels of alanine aminotransferase and risk factors for atherogenesis.

    abstract:BACKGROUND & AIMS:Liver disease has been associated with cardiovascular disorders, but little is known about the relationship between serum levels of alanine aminotransferase (ALT) and markers of atherogenesis. We investigated the relationship between low-normal and high-normal levels of ALT and an extended panel of ca...


    pub_type: 杂志文章


    authors: Siddiqui MS,Sterling RK,Luketic VA,Puri P,Stravitz RT,Bouneva I,Boyett S,Fuchs M,Sargeant C,Warnick GR,Grami S,Sanyal AJ

    更新日期:2013-12-01 00:00:00

  • Duct cells contribute to regeneration of endocrine and acinar cells following pancreatic damage in adult mice.

    abstract:BACKGROUND & AIMS:There have been conflicting results on a cell of origin in pancreatic regeneration. These discrepancies predominantly stem from lack of specific markers for the pancreatic precursors/stem cells, as well as differences in the targeted cells and severity of tissue injury in the experimental models so fa...


    pub_type: 杂志文章


    authors: Criscimanna A,Speicher JA,Houshmand G,Shiota C,Prasadan K,Ji B,Logsdon CD,Gittes GK,Esni F

    更新日期:2011-10-01 00:00:00

  • Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat.

    abstract:BACKGROUND & AIMS:Chronic stress is associated with visceral hyperalgesia in functional gastrointestinal disorders. We investigated whether corticosterone plays a role in chronic psychological stress-induced visceral hyperalgesia. METHODS:Male rats were subjected to 1-hour water avoidance (WA) stress or subcutaneous c...


    pub_type: 杂志文章


    authors: Hong S,Zheng G,Wu X,Snider NT,Owyang C,Wiley JW

    更新日期:2011-02-01 00:00:00

  • Silencing of USP18 potentiates the antiviral activity of interferon against hepatitis C virus infection.

    abstract:BACKGROUND & AIMS:Modulation of the host innate immune response is an attractive means of inhibiting hepatitis C virus (HCV) replication. Having previously determined that expression of the interferon-sensitive gene (ISG)15 protease USP18 is increased in the liver biopsy specimens of patients who do not respond to inte...


    pub_type: 杂志文章


    authors: Randall G,Chen L,Panis M,Fischer AK,Lindenbach BD,Sun J,Heathcote J,Rice CM,Edwards AM,McGilvray ID

    更新日期:2006-11-01 00:00:00

  • Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195.

    abstract:BACKGROUND AND AIMS:The mammalian intestinal epithelium self-renews rapidly and homeostasis is preserved via tightly controlled mechanisms. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions, but little is known about their role in maintaining the integrity of the inte...


    pub_type: 杂志文章


    authors: Xiao L,Wu J,Wang JY,Chung HK,Kalakonda S,Rao JN,Gorospe M,Wang JY

    更新日期:2018-02-01 00:00:00

  • Scanning electron microscopy of the rat liver. Studies of the effect of taurolithocholate and other models of cholestasis.

    abstract::The normal surface anatomy of rat hepatocytes, sinusoids, and bile canaliculi was examined by scanning electron microscopy following finger fracture of tissues that were perfused via the portal vein and fixed with 2.5% glutaraldehyde. These normal findings were contrasted with several models of cholestasis, including ...


    pub_type: 杂志文章


    authors: Layden TJ,Schwarz,Boyer JL

    更新日期:1975-09-01 00:00:00

  • Endoprosthesis for internal drainage of the biliary tract. Technique and results in 48 cases.

    abstract::In 48 patients with obstructive jaundice caused by unresectable lesions, a polyethylene tube was inserted into the biliary tract using a percutaneous transhepatic technique. This endoprosthesis provided permanent internal drainage without an external catheter. In 27 patients, bilirubin declined to anicteric or subicte...


    pub_type: 杂志文章


    authors: Burcharth F,Jensen LI,Olesen K

    更新日期:1979-07-01 00:00:00

  • Gastrointestinal cancer studies in the human to nude mouse heterotransplant system.

    abstract::Human gastrointestinal cancer xenografts were established in the nude mouse. Grafts were accomplished with gastric adenocarcinomas, gastric leiomyosarcoma, histiocytic lymphoma of the stomach and gallbladder, pancreatic tumors, colonic cancers and cell lines of duodenal (HUTU-80) and pancreatic (HS-766-T) cancers, mel...


    pub_type: 杂志文章


    authors: Schmidt M,Deschner EE,Thaler HT,Clements L,Good RA

    更新日期:1977-05-01 00:00:00

  • Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa.

    abstract:BACKGROUND/AIMS:The gastric mucosa is covered by a continuous layer of bicarbonate-containing mucus gel; the question arises how acid, formed in the gastric glands, moves into the lumen. METHODS:The pH in the gastric mucus gel and gel thickness were measured in anesthetized rats with pH-sensitive microelectrodes (tip ...


    pub_type: 杂志文章


    authors: Schade C,Flemström G,Holm L

    更新日期:1994-07-01 00:00:00

  • Transforming growth factor beta type II receptor gene mutations in adenomas from hereditary nonpolyposis colorectal cancer.

    abstract:BACKGROUND & AIMS:Germline mutations of DNA mismatch repair genes are responsible for cancer susceptibility in hereditary nonpolyposis colorectal cancer (HNPCC) kindreds. Transforming growth factor beta type II receptor (TGF-beta RII) has been found to be somatically altered in HNPCC. The aim of this study was to clari...


    pub_type: 杂志文章


    authors: Akiyama Y,Iwanaga R,Saitoh K,Shiba K,Ushio K,Ikeda E,Iwama T,Nomizu T,Yuasa Y

    更新日期:1997-01-01 00:00:00

  • Liver copper levels in intrahepatic cholestasis of childhood.

    abstract::Liver copper concentration was studied in four groups of age-matched patients and in 9 patients with Wilson's disease of comparable age. Neutron activation analysis of hepatic copper concentration revealed markedly elevated hepatic copper levels, comparable with those in Wilson's disease, in 13 of 15 patients (P less ...


    pub_type: 杂志文章


    authors: Evans J,Newman S,Sherlock S

    更新日期:1978-11-01 00:00:00

  • The effect of ischemic villus cell damage on crypt cell proliferation in the small intestine: evidence for a feedback control mechanism.

    abstract::In recent years the hypothesis that the number of villus cells regulates crypt cell proliferation in the epithelium of the small intestine has been brought forward by a number of investigators. To test this hypothesis, the villus cell population was reduced by clamping the superior mesenteric artery and vein in rats f...


    pub_type: 杂志文章


    authors: Rijke RP,Hanson WR,Plaisier HM,Osborne JW

    更新日期:1976-11-01 00:00:00

  • Nonsteroidal anti-inflammatory drug use and sporadic colorectal adenomas.

    abstract::First, and most importantly, the standard of care for treating adenomatous polyps is polypectomy and not therapy with NSAIDs. The initial clinical observation by Waddell and Loughry in 1983 that sulindac treatment influenced rectal polyps in patients with FAP has led to a considerable amount of research, commentary, a...


    pub_type: 评论,社论


    authors: DuBois RN

    更新日期:1995-04-01 00:00:00

  • Superficial thrombophlebitis, dysplasia, and cholangiocarcinoma in primary sclerosing cholangitis.

    abstract::Cholangiocarcinoma occurs in approximately 10% of patients with primary sclerosing cholangitis. Usually, liver failure, rapidly progressing jaundice, and an increase in alkaline phosphatase levels are suggestive diagnostic features. We report two cases of patients with primary sclerosing cholangitis who developed chol...


    pub_type: 杂志文章


    authors: Martins EB,Fleming KA,Garrido MC,Hine KR,Chapman RW

    更新日期:1994-08-01 00:00:00

  • Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice.

    abstract:BACKGROUND & AIMS:Nitric oxide is a major inhibitory neurotransmitter in the enteric nervous system. Loss or dysfunction of nitrinergic neurons is associated with serious disruptions of motility, intractable symptoms, and long-term suffering. The aim of this study was to evaluate the effect of intrapyloric transplantat...


    pub_type: 评论,杂志文章


    authors: Micci MA,Kahrig KM,Simmons RS,Sarna SK,Espejo-Navarro MR,Pasricha PJ

    更新日期:2005-12-01 00:00:00