Increased gastroduodenal concentrations of transforming growth factor alpha in adaptation to aspirin in monkeys and rats.


BACKGROUND & AIMS:The mechanism by which gastric mucosa becomes more resistant to damage by repeated aspirin administration is not known. Transforming growth factor alpha (TGF-alpha) and epidermal growth factor (EGF) prevent drug-induced gastric injury. The aim of this study was to determine whether gastroduodenal tissue levels of TGF-alpha and EGF protein were altered during adaptation to aspirin-induced injury in monkeys and rats in vivo. METHODS:Animals were given aspirin daily for up to 28 days. Gross mucosal injury was assessed by computerized image analysis in rats and by endoscopy in monkeys. Mucosal concentrations of TGF-alpha and EGF were quantitated by radioimmunoassays from endoscopic biopsy samples in monkeys and from scraped mucosa in rats. RESULTS:Long-term administration of aspirin caused a significant increase in gastric and duodenal tissue levels of TGF-alpha in monkeys and rats; the increased levels of TGF-alpha significantly correlated with the decrease in aspirin-induced injury. No change in the gastroduodenal tissue levels of EGF was observed. Adaptation was not associated with any significant change in basal gastric acid secretion in monkeys and occurred despite a significant decrease in gastric mucin in rats. CONCLUSIONS:Adaptation of the gastric mucosa to the damaging effect of aspirin is associated with a significant and specific increase in TGF-alpha protein in the gastroduodenum.






Romano M,Lesch CA,Meise KS,Veljaca M,Sanchez B,Kraus ER,Boland CR,Guglietta A,Coffey RJ




Has Abstract


1996-05-01 00:00:00














  • Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:Prediction of relapse of inflammatory bowel disease has important implications for therapeutic strategies. We assessed whether measurement of intestinal permeability and inflammation could predict relapse of inflammatory bowel disease (IBD). METHODS:Forty-three patients with Crohn's disease (CD) and ...


    pub_type: 杂志文章


    authors: Tibble JA,Sigthorsson G,Bridger S,Fagerhol MK,Bjarnason I

    更新日期:2000-07-01 00:00:00

  • The pregnane X receptor locus is associated with susceptibility to inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:The pregnane X receptor (PXR) regulates an array of genes involved in the response to xenobiotics. Evidence from several studies suggests that xenobiotic metabolism may play a role in inflammatory bowel disease (IBD) and that low levels of PXR may be associated with disease expression. The aim of this...


    pub_type: 杂志文章


    authors: Dring MM,Goulding CA,Trimble VI,Keegan D,Ryan AW,Brophy KM,Smyth CM,Keeling PW,O'Donoghue D,O'Sullivan M,O'Morain C,Mahmud N,Wikström AC,Kelleher D,McManus R

    更新日期:2006-02-01 00:00:00

  • Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line.

    abstract::To gain further insight on the mosaic expression of specific functional intestinal markers (such as sucrase-isomaltase) in postconfluent Caco-2 cells, a human colon cancer cell line unique in its property to differentiate in vitro into a mature enterocyte-like cell type, a comparative study was undertaken to examine t...


    pub_type: 杂志文章


    authors: Vachon PH,Beaulieu JF

    更新日期:1992-08-01 00:00:00

  • The professional lives of women in gastroenterology: a Canadian comparison study with men.

    abstract::Women are underrepresented in gastroenterology. A questionnaire examined the training and career experiences of female members of the Canadian Association for Gastroenterology (CAG) and their male counterparts. A pretested questionnaire was mailed to the 50 female CAG and 100 age-matched male members. Descriptive anal...


    pub_type: 杂志文章


    authors: Heathcote J,Cauch-Dudek K,Rhyne D

    更新日期:1997-08-01 00:00:00

  • Gastroesophageal reflux disease in monozygotic and dizygotic twins.

    abstract:BACKGROUND & AIMS:Gastroesophageal reflux disease (GERD) interferes with the quality of life and carries an increased risk for esophageal adenocarcinoma. We investigated genetic influence in the development of reflux. METHODS:We compared concordance for reflux in monozygotic (MZ) and dizygotic (DZ) twins. All twins ag...


    pub_type: 杂志文章


    authors: Cameron AJ,Lagergren J,Henriksson C,Nyren O,Locke GR 3rd,Pedersen NL

    更新日期:2002-01-01 00:00:00

  • Chronic ethanol consumption impairs cellular immune responses against HCV NS5 protein due to dendritic cell dysfunction.

    abstract:BACKGROUND & AIMS:Alcoholic patients with and without chronic liver disease have a high incidence of infection with hepatitis C virus (HCV). Long-term ethanol consumption in mice has been associated with a strikingly reduced CD8(+) cytotoxic T-lymphocyte (CTL) response to HCV nonstructural proteins following DNA-based ...


    pub_type: 杂志文章


    authors: Aloman C,Gehring S,Wintermeyer P,Kuzushita N,Wands JR

    更新日期:2007-02-01 00:00:00

  • Ethanol-induced damage to mucosal capillaries of rat stomach. Ultrastructural features and effects of prostaglandin F2 beta and cysteamine.

    abstract::Impairment of the mucosal microcirculation may contribute to ethanol-induced gastric mucosal damage. In this report, we describe diffuse and severe ultrastructural damage to the capillaries of the gastric glandular mucosa of the rat that occurred within 1 min after intragastric instillation of 100% ethanol. There was ...


    pub_type: 杂志文章


    authors: Trier JS,Szabo S,Allan CH

    更新日期:1987-01-01 00:00:00

  • AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review.

    abstract:DESCRIPTION:Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth (SIBO) is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even nongastrointestinal symptoms and is increasingly implicated in lay press and media in the causation of a diverse ...


    pub_type: 实务指引


    authors: Quigley EMM,Murray JA,Pimentel M

    更新日期:2020-10-01 00:00:00

  • Newly synthesized hepatocyte plasma membrane proteins are transported in transcytotic vesicles in the bile duct-ligated rat.

    abstract:BACKGROUND:Newly synthesized apical membrane proteins in hepatocytes go first to the basolateral membrane, from which they are retrieved and delivered to the apical domain. The goal of the present study was to identify the vesicular carriers of these molecules. METHODS:The common bile duct of rats was ligated for 10-7...


    pub_type: 杂志文章


    authors: Barr VA,Hubbard AL

    更新日期:1993-08-01 00:00:00

  • Chemoprevention of colorectal neoplasia: the potential for personalized medicine.

    abstract::CRC development is a multi-step process that spans 10 to 15 years, thereby providing an opportunity for early detection and even prevention. The poor survival rate of advanced CRC has prompted the emphasis on prevention of this disease. CRC screening and removal of adenomas is an effective intervention, and is the cor...


    pub_type: 杂志文章,评审


    authors: Arber N,Levin B

    更新日期:2008-04-01 00:00:00

  • Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function.

    abstract:BACKGROUND & AIMS:Chronic hepatitis C virus infection activates an intrahepatic immune response, leading to increased expression of interferon (IFN)-stimulated genes and activation of natural killer (NK) cells-the most prevalent innate immune cell in the liver. We investigated whether the elimination of hepatitis C vir...


    pub_type: 杂志文章


    authors: Serti E,Chepa-Lotrea X,Kim YJ,Keane M,Fryzek N,Liang TJ,Ghany M,Rehermann B

    更新日期:2015-07-01 00:00:00

  • Effect of short-term prednisone therapy on aminotransferase levels and hepatitis B virus markers in chronic type B hepatitis.

    abstract::We have studied the effect of short-term high-dose prednisone therapy on aminotransferase levels and hepatitis B virus markers in 6 patients with chronic type B hepatitis. All showed a decrease in amino transferase levels during treatment. This was followed by a transient increase in aminotransferase levels after pred...


    pub_type: 杂志文章


    authors: Rakela J,Redeker AG,Weliky B

    更新日期:1983-05-01 00:00:00

  • Pathogenesis of mucosal injury in the blind loop syndrome.

    abstract::Bacterial extracts were prepared from cultures originating in chronic self-filling intestinal blind loops in rats. Their ability to remove active maltase molecules from isolated brush border membranes was studied in vitro. Twelve strains in 51 tested, belonging to one of three species, Bacteroides fragilis, Clostridiu...


    pub_type: 杂志文章


    authors: Jonas A,Krishnan C,Forstner G

    更新日期:1978-11-01 00:00:00

  • Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: influence in nitric oxide biosynthesis.

    abstract:BACKGROUND & AIMS:Prostacyclin and nitric oxide have been involved in the hyperkinetic syndrome in portal hypertension. The aim of this study was to investigate the relative contribution and possible interaction between prostacyclin and NO in this circulatory abnormality. METHODS:Portal vein-ligated and sham-operated ...


    pub_type: 杂志文章


    authors: Fernández M,García-Pagán JC,Casadevall M,Mourelle MI,Piqué JM,Bosch J,Rodés J

    更新日期:1996-05-01 00:00:00

  • Effect of the acid secretory state on intramural pH of rabbit gastric mucosa.

    abstract::Intramural pH of the gastric mucosa was measured using a microelectrode technique in rabbit gastric pouches under different secretory conditions and luminal acidity. Exposure of spontaneously secreting or metiamide-treated fundic pouches to a relatively high concentration of luminal acid. HCl 120 mM, for 60 min, led ...


    pub_type: 杂志文章


    authors: Kivilaakso E,Fromm D,Silen W

    更新日期:1978-10-01 00:00:00

  • Seasonal variation in flares of inflammatory bowel disease.

    abstract:BACKGROUND & AIMS:Previous research has yielded conflicting data as to whether the natural history of inflammatory bowel disease follows a seasonal pattern. The purpose of this study was to determine whether relapse of inflammatory bowel disease follows a seasonal pattern either across a cohort of patients or within in...


    pub_type: 杂志文章


    authors: Lewis JD,Aberra FN,Lichtenstein GR,Bilker WB,Brensinger C,Strom BL

    更新日期:2004-03-01 00:00:00

  • Leukocyte migration inhibition in response to biliary antigens in primary biliary cirrhosis, sclerosing cholangitis, and other chronic liver diseases.

    abstract::The leukocyte migration inhibition test has been used to investigate cellular immune responses to antigens in a protein fraction (BPF) of normal human gallbladder bile in patients with a variety of intra- and extrahepatic diseases. Inhibition of leukocyte migration in the presence of BPF was observed in 30 (81%) of 37...


    pub_type: 杂志文章


    authors: McFarlane IG,Wojcicka BM,Tsantoulas DC,Portmann BC,Eddleston AL,Williams R

    更新日期:1979-06-01 00:00:00

  • Helicobacter pylori Depletes Cholesterol in Gastric Glands to Prevent Interferon Gamma Signaling and Escape the Inflammatory Response.

    abstract:BACKGROUND & AIMS:Despite inducing an inflammatory response, Helicobacter pylori can persist in the gastric mucosa for decades. H pylori expression of cholesterol-α-glucosyltransferase (encoded by cgt) is required for gastric colonization and T-cell activation. We investigated how cgt affects gastric epithelial cells a...


    pub_type: 杂志文章


    authors: Morey P,Pfannkuch L,Pang E,Boccellato F,Sigal M,Imai-Matsushima A,Dyer V,Koch M,Mollenkopf HJ,Schlaermann P,Meyer TF

    更新日期:2018-04-01 00:00:00

  • APC I1307K increases risk of transition from polyp to colorectal carcinoma in Ashkenazi Jews.

    abstract:BACKGROUND & AIMS:The I1307K allele of the APC gene has been shown to confer a modestly elevated risk of colorectal cancer in the Ashkenazi Jewish population (relative risk, 1.5-1.7). However, it is unclear whether the alteration predisposes to adenomas and whether the genetic information can be used in clinical practi...


    pub_type: 杂志文章


    authors: Stern HS,Viertelhausen S,Hunter AG,O'Rourke K,Cappelli M,Perras H,Serfas K,Blumenthall A,Dewar D,Baumann E,Lagarde AE

    更新日期:2001-02-01 00:00:00

  • Efficacy of Glecaprevir and Pibrentasvir in Patients With Genotype 1 Hepatitis C Virus Infection With Treatment Failure After NS5A Inhibitor Plus Sofosbuvir Therapy.

    abstract:BACKGROUND & AIMS:Treatment options are limited for patients with hepatitis C (HCV) infection with treatment failure after sofosbuvir plus an NS5A inhibitor. There are some data for the efficacy of glecaprevir/pibrentasvir (G/P) in these patients. We performed a randomized trial of the safety and efficacy of 12 and 16 ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Lok AS,Sulkowski MS,Kort JJ,Willner I,Reddy KR,Shiffman ML,Hassan MA,Pearlman BL,Hinestrosa F,Jacobson IM,Morelli G,Peter JA,Vainorius M,Michael LC,Fried MW,Wang GP,Lu W,Larsen L,Nelson DR

    更新日期:2019-12-01 00:00:00

  • STAT3 NH2-terminal acetylation is activated by the hepatic acute-phase response and required for IL-6 induction of angiotensinogen.

    abstract:BACKGROUND & AIMS:The signal transducers and activators of transcription (STATs) are cytoplasmic transcription factors mediating acute-phase response (APR) of the human angiotensinogen (hAGT) gene in hepatocytes. The mechanisms of how STAT3 activates target genes are unknown. Here we analyzed the biochemistry of STAT3 ...


    pub_type: 杂志文章


    authors: Ray S,Boldogh I,Brasier AR

    更新日期:2005-11-01 00:00:00

  • Serine proteases excite myenteric neurons through protease-activated receptors in guinea pig small intestine.

    abstract:BACKGROUND & AIMS:Serine proteases are postulated to influence gastrointestinal function by stimulating protease-activated receptors (PARs). This study identified the effects on myenteric neurons of activating PARs and investigated underlying mechanisms of action. METHODS:Intracellular electrophysiologic methods were ...


    pub_type: 杂志文章


    authors: Gao C,Liu S,Hu HZ,Gao N,Kim GY,Xia Y,Wood JD

    更新日期:2002-11-01 00:00:00

  • Pathogenesis of ceftriaxone-associated biliary sludge. In vitro studies of calcium-ceftriaxone binding and solubility.

    abstract::Ceftriaxone, a semisynthetic third-generation cephalosporin, has recently been associated with biliary sludge formation. Analysis of the biliary concretions induced by this agent shows a calcium salt of ceftriaxone. The present in vitro studies were undertaken to provide insight into the pathogenesis of ceftriaxone-as...


    pub_type: 杂志文章


    authors: Shiffman ML,Keith FB,Moore EW

    更新日期:1990-12-01 00:00:00

  • Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance.

    abstract:BACKGROUND & AIMS:Significant improvements in management of hepatocellular carcinoma (HCC) have occurred in the last years, but their impact on surveillance outcome is unknown. To clarify this, we compared survival of HCC patients identified along 3 consecutive quinquennia of surveillance. METHODS:A cohort of 417 HCC-...


    pub_type: 杂志文章


    authors: Sangiovanni A,Del Ninno E,Fasani P,De Fazio C,Ronchi G,Romeo R,Morabito A,De Franchis R,Colombo M

    更新日期:2004-04-01 00:00:00

  • Rectal sparing in antibiotic-associated pseudomembranous colitis: a prospective study.

    abstract::A prospective study of 22 patients with antibiotic-associated pseudomembranous colitis demonstrated that the most distal location of the pseudomembranes was noted from 0 to 25 cm from the anus in 17 patients, from 25 to 60 cm from the anus in 3 patients, and greater than 60 cm from the anus in only 2 patients. These d...


    pub_type: 杂志文章


    authors: Tedesco FJ,Corless JK,Brownstein RE

    更新日期:1982-12-01 00:00:00

  • Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat.

    abstract::Corticotropin-releasing factor (CRF) administered into the lateral cerebral ventricle significantly inhibited gastric emptying and small bowel transit, but most markedly increased large bowel transit in a dose-related fashion in freely moving rats. Inhibition of gastric emptying induced by central administration of CR...


    pub_type: 杂志文章


    authors: Lenz HJ,Burlage M,Raedler A,Greten H

    更新日期:1988-03-01 00:00:00

  • Bile acid is a host factor that regulates the composition of the cecal microbiota in rats.

    abstract:BACKGROUND & AIMS:Alterations in the gastrointestinal microbiota have been associated with metabolic diseases. However, little is known about host factors that induce changes in gastrointestinal bacterial populations. We investigated the role of bile acids in this process because of their strong antimicrobial activitie...


    pub_type: 杂志文章


    authors: Islam KB,Fukiya S,Hagio M,Fujii N,Ishizuka S,Ooka T,Ogura Y,Hayashi T,Yokota A

    更新日期:2011-11-01 00:00:00

  • Abnormalities in the distribution of laminin and collagen type IV in Hirschsprung's disease.

    abstract::In vitro neurite outgrowth and neuronal survival are promoted by laminin, and neuronal migration is promoted by collagen type IV. This led to the hypothesis that Hirschsprung's disease (HD) could be the result of an abnormal extracellular matrix microenvironment in the affected bowel during embryogenesis. Using indire...


    pub_type: 杂志文章


    authors: Parikh DH,Tam PK,Van Velzen D,Edgar D

    更新日期:1992-04-01 00:00:00

  • Pentane clearance from inspired air by the rat: dependence on the liver.

    abstract::Pentane, a volatile hydrocarbon, is cleared from inspired air by the rat. We have studied this clearance to learn whether or not it is a function of the liver. Rats were put individually into airtight chambers which contained CO2 absorbent and were connected to an O2 reservoir. Pentane was injected into each chamber a...


    pub_type: 杂志文章


    authors: Burk RJ,Ludden TM,Lane JM

    更新日期:1983-01-01 00:00:00

  • Natural killer activity of human lymphocytes against colon cancer cells.

    abstract::A human colon cancer cell line, HCT-8, is shown to be an appropriate target cell for study of natural killer (NK) activity in man. In parallel experiments, effector cell characteristics for NK and antibody-dependent cellular cytotoxicity (ADCC) were found to be vested in a single lymphocyte subpopulation, which bore r...


    pub_type: 杂志文章


    authors: Helms RA,Bull DM

    更新日期:1980-04-01 00:00:00