Gastrointestinal cancer studies in the human to nude mouse heterotransplant system.

abstract：BACKGROUND & AIMS:The risk for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) could have changed over time, with changes in treatment options. We studied CRC risk in a nationwide cohort of 47,374 Danish patients with IBD over a 30-year period. METHODS:We determined relative risk (RR) values ...

journal_title：Gastroenterology

authors： Jess T,Simonsen J,Jørgensen KT,Pedersen BV,Nielsen NM,Frisch M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:The prognosis of advanced cirrhosis due to chronic hepatitis B is poor, and results of therapies, including liver transplantation, have been unsatisfactory. Little is known about the effectiveness of interferon alfa in patients with cirrhosis. METHODS:Between 1984 and 1991, 18 patients with clinically-appar...

journal_title：Gastroenterology

authors： Hoofnagle JH,Di Bisceglie AM,Waggoner JG,Park Y

更新日期：1993-04-01 00:00:00

abstract：:Lymphangiectasia of the large intestine associated with protein-losing enteropathy is reported. A 33-yr-old man suffered from diarrhea, sometimes mixed with blood. Colonoscopic study revealed reddish and edematous mucosa with multiple flat elevated lesions and giant folds in the localized segment of the rectosigmoid. ...

journal_title：Gastroenterology

authors： Asakura H,Tsuchiya M,Katoh S,Kobayashi K,Yonei Y,Yoshida T,Hamada Y,Miura S,Morita A,Kuramochi S

更新日期：1986-09-01 00:00:00

abstract：:Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842...

journal_title：Gastroenterology

authors： Carvajal-Carmona LG,Zauber AG,Jones AM,Howarth K,Wang J,Cheng T,APC Trial Collaborators.,APPROVe Trial Collaborators.,CORGI Study Collaborators.,Colon Cancer Family Registry Collaborators.,CGEMS Collaborators.,Riddell R,Lanas A,

更新日期：2013-01-01 00:00:00

abstract：:Sepsis, peritonitis, and gastroenteritis developed in a 45-yr-old homosexual man 1 day after ingestion of raw oysters. The patient had chronic active hepatitis and cirrhosis with hepatitis B virus and delta-infection. He also had persistent generalized lymphadenopathy associated with HTLV-III antibody positivity. Vibr...

journal_title：Gastroenterology

authors： Chin KP,Lowe MA,Tong MJ,Koehler AL

更新日期：1987-03-01 00:00:00

abstract：DESCRIPTION:The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update is to review the available evidence and best practice advice statements regarding the use of endoscopic therapies in treating patients with non-variceal upper gastrointestinal bleeding. METHODS:This expert...

journal_title：Gastroenterology

authors： Mullady DK,Wang AY,Waschke KA

更新日期：2020-09-01 00:00:00

abstract：:First, and most importantly, the standard of care for treating adenomatous polyps is polypectomy and not therapy with NSAIDs. The initial clinical observation by Waddell and Loughry in 1983 that sulindac treatment influenced rectal polyps in patients with FAP has led to a considerable amount of research, commentary, a...

journal_title：Gastroenterology

authors： DuBois RN

更新日期：1995-04-01 00:00:00

abstract：:The effects of a variety of substances influencing the initiation of cyclic motor events at the gastroduodenal junction were studied in conscious sheep. A significant and long-lasting decrease in the frequency of cyclic events from approximately 100 min to 30-40 min was elicited by the intraduodenal bulb administratio...

journal_title：Gastroenterology

authors： Ruckebusch Y

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND & AIMS:Abdominal bloating is a frequent complaint in irritable bowel syndrome (IBS), but its underlying mechanism remains uncertain. Our aim was to determine whether the abdominal wall, specifically its adaptation to intra-abdominal volumes, plays a role. METHODS:In 12 patients complaining of abdominal bloa...

journal_title：Gastroenterology

authors： Tremolaterra F,Villoria A,Azpiroz F,Serra J,Aguadé S,Malagelada JR

更新日期：2006-04-01 00:00:00

abstract：BACKGROUND & AIMS:The ratio of liver size to body weight (hepatostat) is tightly controlled, but little is known about how the physiologic functions of the liver help determine its size. Livers of mice repopulated with human hepatocytes (humanized livers) grow to larger than normal; the human hepatocytes do not recogni...

journal_title：Gastroenterology

authors： Naugler WE,Tarlow BD,Fedorov LM,Taylor M,Pelz C,Li B,Darnell J,Grompe M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND & AIMS:Fish is a rich source of n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Although consumption of fish and n-3 PUFA has been reported to protect against the development of some types of cancer, little is known ab...

journal_title：Gastroenterology

authors： Sawada N,Inoue M,Iwasaki M,Sasazuki S,Shimazu T,Yamaji T,Takachi R,Tanaka Y,Mizokami M,Tsugane S,Japan Public Health Center-Based Prospective Study Group.

更新日期：2012-06-01 00:00:00

abstract：:To understand mechanisms of viral diarrhea further, we studied ileal ion transport in vitro in relation to mucosal changes and epithelial differentiation in transmissible gastroenteritis in piglets, an invasive viral enteritis thought to involve mainly proximal intestine. In infected pigs, at the height of diarrhea, s...

journal_title：Gastroenterology

authors： Shepherd RW,Gall DG,Butler DG,Hamilton JR

更新日期：1979-01-01 00:00:00

abstract：:A patient with the acquired immunodeficiency syndrome (AIDS) with a cytomegalovirus (CMV) infection localized in the area of an ileal Kaposi sarcoma resulting in perforation is described. Because only one case of such an association of Kaposi sarcoma with CMV leading to perforation has been reported, the presence and ...

journal_title：Gastroenterology

authors： Genta RM,Bleyzer I,Cate TR,Tandon AK,Yoffe B

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND & AIMS:Colonic crypt elongation occurs during both chronic colitis and in the recovery phase of acute colitis. The impact of these alterations on epithelial cell functions is not fully defined. METHODS:DNA microarray analysis of freshly isolated colonic epithelial cells (CECs) from acute and chronic colitis...

journal_title：Gastroenterology

authors： Mizoguchi E,Xavier RJ,Reinecker HC,Uchino H,Bhan AK,Podolsky DK,Mizoguchi A

更新日期：2003-07-01 00:00:00

abstract：:The intestinal epithelium is a repetitive sheet of crypt and villus units with stem cells at the bottom of the crypts. During postnatal development, crypts multiply via fission, generating 2 daughter crypts from 1 parental crypt. In the adult intestine, crypt fission is observed at a low frequency. Using intravital mi...

journal_title：Gastroenterology

authors： Bruens L,Ellenbroek SIJ,van Rheenen J,Snippert HJ

更新日期：2017-09-01 00:00:00

abstract：:The hepatic circulation is reviewed with emphasis on the role of hepatic blood vessels in hepatic and homeostatic functions. Contrasts are made with resistance, capacitance, and fluid exchange functions in other better known vascular beds. Hemodynamic changes that produce shifts in fluid exchange in other tissues are ...

journal_title：Gastroenterology

authors： Lautt WW

更新日期：1977-11-01 00:00:00

abstract：:We have prospectively evaluated 41 patients who ingested acid for location, extent, severity, and outcome of the injury to the upper gastrointestinal tract. The injury was assessed within 36 h of acid intake by endoscopy or surgery, or at autopsy. Symptoms and signs were unreliable in predicting the extent and severit...

journal_title：Gastroenterology

authors： Zargar SA,Kochhar R,Nagi B,Mehta S,Mehta SK

更新日期：1989-09-01 00:00:00

abstract：:We have analyzed the frequency of chronicity and its distribution according to epidemiologic background following acute non-A, non-B hepatitis. Eighteen of 45 cases (40%) developed chronic liver disease. The incidence of chronicity was significantly higher following transfusion and among drug addicts (54% and 58%) tha...

journal_title：Gastroenterology

authors： Rakela J,Redeker AG

更新日期：1979-12-01 00:00:00

abstract：:To explore the metabolic aspects of chronic liver disease, diurnal changes of arterial ketone body ratio (acetoacetate/3-hydroxybutyrate), reflecting hepatic mitochondrial redox potential, were investigated in normal subjects, patients with chronic liver disease (Child's class A or B), and patients with hepatic failur...

journal_title：Gastroenterology

authors： Iwata S,Ozawa K,Shimahara Y,Mori K,Kobayashi N,Kumada K,Yamaoka Y

更新日期：1991-05-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not improved in decades. Treatments that target tumor cells have largely failed. This could be because research has focused on cancer cells and the influence of the stroma on tumor progression has been largely ignored. The focus of pa...

journal_title：Gastroenterology

authors： Apte MV,Wilson JS,Lugea A,Pandol SJ

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND & AIMS:Hepcidin is an antimicrobial peptide thought to be involved in the regulation of intestinal iron absorption. To further investigate its role in this process, we examined hepatic and duodenal gene expression in rats after the switch from a control diet to an iron-deficient diet. METHODS:Adult rats on ...

journal_title：Gastroenterology

authors： Frazer DM,Wilkins SJ,Becker EM,Vulpe CD,McKie AT,Trinder D,Anderson GJ

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND & AIMS:Microsatellite instability is a property of most tumors occurring in the context of hereditary nonpolyposis colon cancer. Instability also occurs in 10%-15% of apparently sporadic colorectal cancers, and it has been hypothesized that this instability may indicate a genetic predisposition to colonic ca...

journal_title：Gastroenterology

authors： Samowitz WS,Slattery ML,Kerber RA

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Malnutrition is common in alcoholic cirrhosis. Bedside nutritional assessment techniques may be unreliable in patients with chronic liver disease. The aim of this study was to quantify changes in body composition and compare methods for measuring body composition in alcoholic cirrhosis. METHODS:Thirty-eight...

journal_title：Gastroenterology

authors： Prijatmoko D,Strauss BJ,Lambert JR,Sievert W,Stroud DB,Wahlqvist ML,Katz B,Colman J,Jones P,Korman MG

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND & AIMS:Spontaneous hepatitis B surface antigen (HBsAg) seroclearance is a rare event in patients with chronic hepatitis B virus infection. The aim of this study was to clarify the controversy on long-term prognosis following spontaneous HBsAg seroclearance using a large series of patients. METHODS:A total o...

journal_title：Gastroenterology

authors： Chen YC,Sheen IS,Chu CM,Liaw YF

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND & AIMS:We previously isolated a monoclonal antibody against a Necturus gallbladder epitope that blocks native adenosine 3',5'-cyclic monophosphate (cAMP)-dependent chloride channels in intestine, gallbladder, urinary bladder, and airway epithelia in various animals. METHODS:Using this antibody, we purified ...

journal_title：Gastroenterology

authors： Finn AL,Kuzhikandathil EV,Oxford GS,Itoh-Lindstrom Y

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND & AIMS:To investigate the efficacy and safety of certolizumab pegol (a polyethylene-glycolated Fab' fragment of anti-tumor necrosis factor, CDP870) in Crohn's disease. METHODS:In a placebo-controlled, phase II study, 292 patients with moderate to severe Crohn's disease received subcutaneous certolizumab 100...

journal_title：Gastroenterology

authors： Schreiber S,Rutgeerts P,Fedorak RN,Khaliq-Kareemi M,Kamm MA,Boivin M,Bernstein CN,Staun M,Thomsen OØ,Innes A,CDP870 Crohn's Disease Study Group.

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Bacterial proteoglycan-derived muramyl dipeptide (MDP) activates the intracellular NOD2/CARD15 gene product. How intestinal epithelial cells take up MDP is poorly understood. We hypothesized that the intestinal apical di-/tripeptide transporter, hPepT1, transports MDP, thereby activating downstream ...

journal_title：Gastroenterology

authors： Vavricka SR,Musch MW,Chang JE,Nakagawa Y,Phanvijhitsiri K,Waypa TS,Merlin D,Schneewind O,Chang EB

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND & AIMS:Tumors that develop in patients with Crohn's disease tend be multifocal, so field cancerization (the replacement of normal cells with nondysplastic but tumorigenic clones) might contribute to intestinal carcinogenesis. We investigated patterns of tumor development from pretumor intestinal cell clones....

journal_title：Gastroenterology

authors： Galandiuk S,Rodriguez-Justo M,Jeffery R,Nicholson AM,Cheng Y,Oukrif D,Elia G,Leedham SJ,McDonald SA,Wright NA,Graham TA

更新日期：2012-04-01 00:00:00

abstract：:S-Adenosylmethionine (800 mg i.v. per day) was used to treat two brothers and a brother and sister from each of two kindreds with benign recurrent intrahepatic cholestasis. Symptoms, routine tests of liver function, concentrations of total bile acids, and the oral clearances of [11,12-2H]chenodeoxycholic acid and [24-...

journal_title：Gastroenterology

authors： Everson GT,Ahnen D,Harper PC,Krawitt EL

更新日期：1989-05-01 00:00:00

abstract：:Altered gallbladder motility could predispose to, or result from, gallstone formation and could also explain the alleged relief of biliary colic seen during bile acid therapy. Therefore, in 14 controls, 25 patients with radiolucent gallstones, and 14 patients with radiopaque gallstones, we used two techniques to measu...

journal_title：Gastroenterology

authors： Forgacs IC,Maisey MN,Murphy GM,Dowling RH

更新日期：1984-08-01 00:00:00