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Adiponectin in Chronic Kidney Disease.

Abstract：

:Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. Adiponectin is present in the kidneys, mainly in the arterial endothelium and smooth muscle cells, as well as in the capillary endothelium, and might be considered as a marker of many negative factors in chronic kidney disease. The last few years have brought a rising body of evidence that adiponectin is a multipotential protein with anti-inflammatory, metabolic, anti-atherogenic, and reactive oxygen species (ROS) protective actions. Similarly, adiponectin has shown many positive and direct actions in kidney diseases, and among many kidney cells. Data from large cross-sectional and cohort studies showed a positive correlation between serum adiponectin and mortality in chronic kidney disease. This suggests a complex interaction between local adiponectin action, comorbidities, and uremic milieu. In this review we discuss the role of adiponectin in chronic kidney disease.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Przybyciński J,Dziedziejko V,Puchałowicz K,Domański L,Pawlik A

doi

10.3390/ijms21249375

subject

Has Abstract

pub_date

2020-12-09 00:00:00

issue

24

issn

1422-0067

pii

ijms21249375

journal_volume

21

pub_type

杂志文章,评审

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