Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals.

Abstract:

:Death associated protein kinase (DAPK) is a calcium/calmodulin-regulated serine/threonine kinase; its main function is to regulate cell death. DAPK family proteins consist of DAPK1, DAPK2, DAPK3, DAPK-related apoptosis-inducing protein kinases (DRAK)-1 and DRAK-2. In this review, we discuss the roles and regulatory mechanisms of DAPK family members and their relevance to diseases. Furthermore, a special focus is given to several reports describing cross-talks between DAPKs and mitogen-activated protein kinases (MAPK) family members in various pathologies. We also discuss small molecule inhibitors of DAPKs and their potential as therapeutic targets against human diseases.

journal_name

Int J Mol Sci

authors

Elbadawy M,Usui T,Yamawaki H,Sasaki K

doi

10.3390/ijms19103031

subject

Has Abstract

pub_date

2018-10-04 00:00:00

issue

10

issn

1422-0067

pii

ijms19103031

journal_volume

19

pub_type

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