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Molecular complexes of calf thymus DNA with various bioactive compounds: Formation and characterization.

Abstract：

:The interaction between biomacromolecules and ligands has attracted great interest because of their biological properties. Calf thymus DNA (ctDNA) can interact with bioactive compounds to form complexes. Here, ctDNA-ligand complexes were studied using fluorescence, absorption, and infrared spectroscopy, circular dichroism, ABTS assay and competitive displacement. The binding constants of bioactive compounds at the intercalative site of ctDNA ranked in order kaempferol > apigenin > quercetin > curcumin > riboflavin, while the binding constants at minor groove sites ranked quercetin > kaempferol > naringenin ~ apigenin > hesperetin > curcumin ~ resveratrol ~ riboflavin > caffeic acid. CtDNA maintained stable B-form with an enhancement of base stacking and a decrease of right-handed helicity in the presence of these bioactive compounds, except for hesperetin and caffeic acid. Bioactive compounds preferentially bound to guanine bases and tended to transfer into a more hydrophobic environment upon complexation with ctDNA. The DNA complexation did not affect the ABTS·+ scavenging capacity of quercetin, kaempferol, resveratrol and apigenin but increased the ones of naringenin, caffeic acid, curcumin, hesperetin and riboflavin. The data gathered here should be useful to understand the binding modes of DNA with ligands for their potential application in pharmaceutical and food industries.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Ji C,Yin X,Duan H,Liang L

doi

10.1016/j.ijbiomac.2020.11.135

subject

Has Abstract

pub_date

2021-01-31 00:00:00

pages

775-783

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)35060-1

journal_volume

168

pub_type

杂志文章

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