Activation effect of Ganoderma lucidum polysaccharides liposomes on murine peritoneal macrophages.

Abstract:

:The activation of murine peritoneal macrophages by Ganoderma lucidum polysaccharides liposomes (GLPL) was investigated in vitro. After treatment with GLPL, the changes of the nitric oxide (NO) secretion and iNOS (inducible nitric oxide synthase) activity were evaluated. The results showed that NO production and iNOS activity of macrophages were enhanced compared to GLP and BL group. In addition, both the phagocytic activity and levels of cytokines IL-1β, TNF-α and IFN-γ were enhanced in the peritoneal macrophages of mice by stimulation of GLPL. The expression of the major histocompatibility complex class II molecule (MHC II) on the surface of peritoneal macrophages significantly increased. These indicated that GLPL could enhance the activation of peritoneal macrophages and their potential for use as a delivery system of GLP.

journal_name

Int J Biol Macromol

authors

Liu Z,Xing J,Huang Y,Bo R,Zheng S,Luo L,Niu Y,Zhang Y,Hu Y,Liu J,Wu Y,Wang D

doi

10.1016/j.ijbiomac.2015.10.088

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

973-8

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)30090-8

journal_volume

82

pub_type

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