Abstract:
:The activation of murine peritoneal macrophages by Ganoderma lucidum polysaccharides liposomes (GLPL) was investigated in vitro. After treatment with GLPL, the changes of the nitric oxide (NO) secretion and iNOS (inducible nitric oxide synthase) activity were evaluated. The results showed that NO production and iNOS activity of macrophages were enhanced compared to GLP and BL group. In addition, both the phagocytic activity and levels of cytokines IL-1β, TNF-α and IFN-γ were enhanced in the peritoneal macrophages of mice by stimulation of GLPL. The expression of the major histocompatibility complex class II molecule (MHC II) on the surface of peritoneal macrophages significantly increased. These indicated that GLPL could enhance the activation of peritoneal macrophages and their potential for use as a delivery system of GLP.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Liu Z,Xing J,Huang Y,Bo R,Zheng S,Luo L,Niu Y,Zhang Y,Hu Y,Liu J,Wu Y,Wang Ddoi
10.1016/j.ijbiomac.2015.10.088subject
Has Abstractpub_date
2016-01-01 00:00:00pages
973-8eissn
0141-8130issn
1879-0003pii
S0141-8130(15)30090-8journal_volume
82pub_type
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