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Inhibitory effect on HT-29 colon cancer cells of a water-soluble polysaccharide obtained from highland barley.

Abstract：

:A water-soluble polysaccharide (BP-1) was obtained from highland barley (Hordeum vulgare L.) by hot water extraction and purification of sepharose column chromatography. BP-1 had an average molecular weight of about 6.7×104Da and was composed of glucose (Glc), xylose (Xyl), arabinose (Ara) and rhamnose (Rha) with a relative molar ratio of 8.82:1.92:1.50:1.00. It was found that BP-1 inhibited proliferation of human colon cancer cells (HT-29) in a time- and dose-dependent manner with half maximal inhibitory concentration at 48h of 48.18μg/mL. Western blotting results showed that BP-1 enhanced the phosphorylation of c-Jun N-terminal kinase (JNK), processes associated with the reactive oxygen species (ROS) formation and inhibited nuclear factor-κB (NF-κB) translocation from cytoplasm into nucleus. Meanwhile, the BP-1-induced apoptosis was related to the regulation of apoptosis-associated proteins, such as B-cell lymphoma-2 (Bcl-2), release of cytochrome C from mitochondria to cytoplasm and activation of caspase-8 and caspase-9. These results suggest that BP-1-induced HT-29 apoptosis through ROS-JNK and NF-κB-mediated caspase pathways.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Cheng D,Zhang X,Meng M,Han L,Li C,Hou L,Qi W,Wang C

doi

10.1016/j.ijbiomac.2016.06.099

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

88-95

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)30694-8

journal_volume

92

pub_type

杂志文章

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