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Lycium barbarum polysaccharide attenuates type II collagen-induced arthritis in mice.

Abstract：

:No curative treatment is yet available for rheumatoid arthritis (RA), wherein chronic synovitis progresses to cartilage and bone destruction. Considering the recently recognized anti-inflammatory properties of Lycium barbarum polysaccharide (LBP; a derivative of the goji berry), we established the collagen type II-induced arthritis (CIA) mouse model to investigate the potential therapeutic effects and mechanisms of LBP. The CIA-induced changes and LBP-related effects were assessed by micro-computed tomography measurement of bone volume/tissue volume and by ELISA and western blotting detection of inflammatory mediators and matrix metalloproteinases (MMPs). The CIA mice showed substantial bone damage, bone loss, and increased concentrations of TNF-α, IL-6, IL-17, PGE2, MIP-1, anti-type II collagen IgG, MMP-1, and MMP-3. LBP treatments produced significant dose-dependent improvements in CIA-induced bone damage and bone loss, and significantly reduced CIA-stimulated expression of the inflammatory mediators and MMPs. Thus, LBP therapy can preserve bone integrity in CIA mice, possibly through down-regulation of inflammatory mediators.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Liu Y,Lv J,Yang B,Liu F,Tian Z,Cai Y,Yang D,Ouyang J,Sun F,Shi Y,Xia P

doi

10.1016/j.ijbiomac.2015.04.025

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

318-23

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(15)00263-9

journal_volume

78

pub_type

杂志文章

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