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Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method.

Abstract：

:In this study, the anticancer drug letrozole (LTZ) was formulated using chitosan nanoparticles (CS-NPs) with the crosslinking agent sodium tripolyphosphate (TPP). The nano-formulation was optimized by varying the concentration of drug. The prepared particles were characterized using FTIR, TGA, XRD, SEM, TEM and DLS. From the FTIR results, the appearance of a new peak for CH, CC and CN confirms the formation of LTZ loaded chitosan nanoparticles. TEM images shows that the average particle size was in the range of 60-80nm and 20-40mm air dried and freeze dried samples respectively. Also the prepared formulation had been evaluated in vitro for determining its hemocompatability, biodegradability and serum stability. The preliminary studies supported that the chitosan nanoparticles formulation has biocompatibility and hemocompatible properties and it can act as an effective pharmaceutical excipient for letrozole.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Gomathi T,Sudha PN,Florence JAK,Venkatesan J,Anil S

doi

10.1016/j.ijbiomac.2017.01.147

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

1820-1832

issue

Pt B

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(16)32076-1

journal_volume

104

pub_type

杂志文章

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