Abstract:
:Angiogenesis is one of the most important processes in repair and regeneration of many tissues and organs. Blood vessel formation also play a major role in repair of dental tissue(s) after ailments like periodontitis. Here we report the preparation of chitosan/carboxymethyl cellulose/hydroxyapatite based hydrogels, loaded with variable concentrations of thyroxin i.e., 0.1 μg/ml, 0.5 μg/ml and 1 μg/ml. Scanning electron microcopy images (SEM) showed all hydrogels were found to be porous and solution absorption study exhibited high swelling potential in aqueous media. FTIR spectra confirmed that the used materials did not change their chemical identity in synthesized hydrogels. The synthesized hydrogels demonstrated good bending, folding, rolling and stretching abilities. The hydrogels were tested in chick chorioallantoic membrane (CAM) assay to investigate their angiogenic potential. Hydrogel containing 0.1 μg/ml of thyroxine showed maximum neovascularization. For cytotoxicity analyses, preosteoblast cells (MC3T3-E1) were seeded on these hydrogels and materials were found to be non-toxic. These hydrogels with pro-angiogenic activity possess great potential to be used for periodontal regeneration.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Malik MH,Shahzadi L,Batool R,Safi SZ,Khan AS,Khan AF,Chaudhry AA,Rehman IU,Yar Mdoi
10.1016/j.ijbiomac.2019.10.043subject
Has Abstractpub_date
2020-02-15 00:00:00pages
1162-1170eissn
0141-8130issn
1879-0003pii
S0141-8130(19)34614-8journal_volume
145pub_type
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