Mechanical, structural and physical aspects of chitosan-based films as antimicrobial dressings.

Abstract:

:Chitosan is a biodegradable, non-toxic, and antimicrobial polymer. Chitosan films can be used as a dressing because they promote the healing of cutaneous ulcers. In this study, the mechanical, physical, and microbiological properties films of pure chitosan and films formulated with a glycerol-honey mixture were characterized. The films were smooth, homogenous, transparent, and porous, with no fractures or cracks. Additionally, it was found that all were resistant to breaking, that the tearing force was directly related to the chitosan concentration, and that the addition of honey and glycerol improved the elongation percentage. When evaluating the antimicrobial activity of the films against Pseudomonas aeruginosa and Klebsiella pneumoniae, the films were found to have an effect only by direct contact. In the films formulated with honey, the area of contact increased to 44%. The excellent color, structural, antimicrobial, and surface morphological properties of the newly developed films make them a promising alternative for use as a dressing for the healing of skin ulcers.

journal_name

Int J Biol Macromol

authors

Escárcega-Galaz AA,Sánchez-Machado DI,López-Cervantes J,Sanches-Silva A,Madera-Santana TJ,Paseiro-Losada P

doi

10.1016/j.ijbiomac.2018.04.149

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

472-481

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(18)30537-3

journal_volume

116

pub_type

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