Abstract:
:We report the synthesis of a biodegradable liposome gold nanoparticles for curcumin (Au-Lipos Cur NPs) delivery. This entrapped curcumin served as an in situ adjuvant for photothermal therapy. Curcumin was loaded in Au-Lipos NPs with an encapsulation efficiency of ∼70%. The gold coating enabled the NPs to specifically absorb NIR light (780nm) by virtue of Surface Plasmon Resonance (SPR) and this light energy was converted to heat. The generated heat destabilized the liposomal core enhancing the release of encapsulated curcumin. Photothermal transduction efficacy of Au-Lipos NPs (loaded with curcumin) showed a significant temperature rise upon laser irradiation causing irreversible cellular damage. In vitro photothermal effect and intracellular uptake was evaluated in B16 F10 (melanoma) cell line. Au-Lipos Cur NPs showed significantly enhanced uptake when compared with free curcumin. Enhancement in cancer cell cytotoxicity was observed in Au-Lipos Cur NPs treated group upon laser irradiation owing to curcumin. Our findings indicate that curcumin could serve as a potential in situ adjuvant for photothermal therapy of melanoma.
journal_name
Int J Biol Macromoljournal_title
International journal of biological macromoleculesauthors
Singh SP,Alvi SB,Pemmaraju DB,Singh AD,Manda SV,Srivastava R,Rengan AKdoi
10.1016/j.ijbiomac.2017.11.163subject
Has Abstractpub_date
2018-04-15 00:00:00pages
375-382eissn
0141-8130issn
1879-0003pii
S0141-8130(17)33281-6journal_volume
110pub_type
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