当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Multiparticulate based thermosensitive intra-pocket forming implants for better treatment of bacterial infections in periodontitis.

Multiparticulate based thermosensitive intra-pocket forming implants for better treatment of bacterial infections in periodontitis.

Abstract：

:Considering alarming projections in the prevalence of periodontitis, following study was undertaken to develop chitosan-vanillin crosslinked microspheres loaded in-situ gel (MLIG) implants containing ornidazole and doxycycline hyclate for the treatment of pocket infections. Firstly, microspheres were formulated and optimized using response surface methodology for particle size <50 μm, entrapment efficiency >80%, in-vitro drug release (T80%) >7 days and acceptable mucoadhesion. Further, MLIG were optimized for gelation temperature of 34-37 °C and viscosity <1000 cps respectively. FTIR, DSC and XRD graphs disclosed compatibility and alterations in crystallinity of drugs. In-vitro dissolution study demonstrated non-Fickian type of drug release mechanism for twelve days. Stability studies ascertained MLIG implants were sterilizable and stable for about 11.29 months on refrigeration. The formulations exhibited significant (p < 0.001) antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis, and were found biocompatible and biodegradable during preclinical studies. Ligature-induced periodontal rat model, corroborated significant growth (p < 0.05) of gingival tissue after two weeks. Clinical trials revealed, intra-pocket administration of MLIG along with SRP provided significant reduction in clinical parameters as compared to SRP alone. Conclusively, antimicrobials incorporated thermosensitive, biodegradable, mucoadhesive and syringeable MLIG implants appeared as better option for the treatment of periodontitis.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Yadav SK,Khan G,Bansal M,Thokala S,Bonde GV,Upadhyay M,Mishra B

doi

10.1016/j.ijbiomac.2018.04.179

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

394-408

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)33844-8

journal_volume

116

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Sulfated polysaccharide from the green marine algae Caulerpa racemosa reduces experimental pain in the rat temporomandibular joint.

    abstract：:Temporomandibular disorder is a clinical painful condition in the temporomandibular joint (TMJ) region. The purified sulfated polysaccharide from the green marine algae Caulerpa racemosa (Cr) has provided anti-inflammatory and antinociceptive activity. This study evaluated these effects on a TMJ hypernociception model...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.01.272

    authors： Ribeiro NA,Chaves HV,da Conceição Rivanor RL,do Val DR,de Assis EL,Silveira FD,Gomes FIF,Freitas HC,Vieira LV,da Silva Costa DV,de Castro Brito GA,Bezerra MM,Benevides NMB

    更新日期：2020-05-01 00:00:00

  • Sophora subprosrate polysaccharide inhibited cytokine/chemokine secretion via suppression of histone acetylation modification and NF-κb activation in PCV2 infected swine alveolar macrophage.

    abstract：:In the present study, effect of Sophora subprosrate polysaccharide on PCV2 infection-induced inflammation and histone acetylation modification in swine alveolar macrophage 3D4/2 cells was described for the first time. The relationship between histone acetylation modifications and inflammation response was investigated...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.06.102

    authors： Yang J,Tan HL,Gu LY,Song ML,Wu YY,Peng JB,Lan ZB,Wei YY,Hu TJ

    更新日期：2017-11-01 00:00:00

  • Chitosan-coated electrospun PLA fibers for rapid mineralization of calcium phosphate.

    abstract：:In this work, hydroxyapatite (HA) mineralized on chitosan (CS)-coated poly(lactic acid) (PLA) nanofiber mat was prepared and compared in terms of mineralization characteristics. Significant calcium phosphate crystals formed on various concentrations of CS-coated PLA fiber mat with better uniformity after 2h of incubat...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.04.039

    authors： Lin CC,Fu SJ,Lin YC,Yang IK,Gu Y

    更新日期：2014-07-01 00:00:00

  • Calcium-dependent conformational transition of calmodulin determined by Fourier transform infrared spectroscopy.

    abstract：:The Ca(2+)-induced conformational changes in calmodulin (CaM) were monitored by Fourier transform infrared spectroscopy (FT-IR) at different molar ratios of Ca(2+) to CaM. The results show that these changes occur in two distinctive transitions. The first transition involves significant changes in the overall secondar...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.02.004

    authors： Yu T,Wu G,Yang H,Wang J,Yu S

    更新日期：2013-05-01 00:00:00

  • Size of the aliphatic chain of sodium houttuyfonate analogs determines their affinity for renin and angiotensin I converting enzyme.

    abstract：:Sodium houttuyfonate analogs (SHAs), CH(3)-(CH(2))(n)-CO-CH(2)-CH(OH)SO(3)Na, (n=6-14) were synthesized and their molecular interactions with renin and angiotensin I converting enzyme (ACE) studied using fluorescence quenching techniques. Unlike renin, inhibition of ACE activity was not directly proportional to the al...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.03.004

    authors： Yuan L,Wu J,Aluko RE

    更新日期：2007-08-01 00:00:00

  • Antitumor and antimetastatic activities of rhamnogalacturonan-II-type polysaccharide isolated from mature leaves of green tea via activation of macrophages and natural killer cells.

    abstract：:To investigate the antitumor and antimetastatic polysaccharide from the mature leaves of green tea, GTE-II was purified using size exclusion chromatography. GTE-II consisted of 15 different sugars including rarely observed sugars such as 2-O-methyl-fucose, 2-O-methyl-xylose, apiose, aceric acid, 3-deoxy-d-manno-2-octu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.02.043

    authors： Park HR,Hwang D,Suh HJ,Yu KW,Kim TY,Shin KS

    更新日期：2017-06-01 00:00:00

  • Conformational rearrangements of G-quadruplex topology promoted by Cu(II) 12-MCCu(II)PyrAcHA-4 metallacrown.

    abstract：:Cu(II) 12-MCCu(II)PyrAcHA-4 metallacrown was studied by several spectroscopic techniques as an interacting ligand with G-quadruplex DNA structures. Investigations were performed on oligonucleotides bearing human telomeric and protooncogenic c-myc sequences in buffered solution mimicking ionic conditions in cellular en...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.163

    authors： Rajczak E,Juskowiak B

    更新日期：2020-08-01 00:00:00

  • Structural-functional insights and studies on saccharide binding of Sophora japonica seed lectin.

    abstract：:Functional and conformational transitions of the Sophora japonica seed lectin (SJL) were studied in detail using bioinformatics and biophysical tools. Homology model of the lectin displayed all the characteristics of the legume lectin monomer and the experimental observations correlated well with the structural inform...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.05.047

    authors： Yadav P,Shahane G,Ramasamy S,Sengupta D,Gaikwad S

    更新日期：2016-10-01 00:00:00

  • Doxorubicin-loaded fucoidan capped gold nanoparticles for drug delivery and photoacoustic imaging.

    abstract：:Polymer nanoparticles are emerging as a useful tool for a wide variety of biomedical and therapeutic applications. The present study demonstrates the multifunctional doxorubicin-loaded fucoidan capped gold nanoparticles (DOX-Fu AuNPs) for drug delivery and photoacoustic imaging (PAI). Biocompatible AuNPs were synthesi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.06.007

    authors： Manivasagan P,Bharathiraja S,Bui NQ,Jang B,Oh YO,Lim IG,Oh J

    更新日期：2016-10-01 00:00:00

  • Biosynthesis of Ag nanoparticles using isolated bacteria from contaminated sites and its application as an efficient catalyst for hydrazine electrooxidation.

    abstract：:In the present study, a bacterium resistance to heavy metals was isolated from contaminated areas. An eco-friendly and simple method was found to biosynthesis of silver nanoparticles (AgNPs) by reducing of aqueous Ag+ using the heavy metals resistance MKH1 bacterium. The biosynthesized AgNPs were characterized by UV-v...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.08.179

    authors： Rostami H,Khosravi F,Mohseni M,Rostami AA

    更新日期：2018-02-01 00:00:00

  • Brönsted acidic ionic liquid based ultrasound-microwave synergistic extraction of pectin from pomelo peels.

    abstract：:3-Methyl-1-(4-sulfonylbutyl) imidazolium hydrogensulfate, [HO3S(CH2)4mim]HSO4, was applied as an extractant in an ultrasound-microwave synergistic extraction approach to substitute conventional solvent for the extraction of pectin from the albedo part of pomelo peels. The analysis of variance (ANOVA) test and response...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.10.028

    authors： Liu Z,Qiao L,Yang F,Gu H,Yang L

    更新日期：2017-01-01 00:00:00

  • Characterization of the interaction between recombinant porcine aminopeptidase N and spike glycoprotein of porcine epidemic diarrhea virus.

    abstract：:Porcine epidemic diarrhea (PED) has caused huge economic losses to the global pork industry. Infection by its causative agent PED virus (PEDV), an Alpha-coronavirus, was previously proven to be mediated by its spike (S) glycoprotein and a cellular receptor porcine aminopeptidase N (pAPN). Interestingly, some recent st...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.05.167

    authors： Sun YG,Li R,Jiang L,Qiao S,Zhi Y,Chen XX,Xie S,Wu J,Li X,Deng R,Zhang G

    更新日期：2018-10-01 00:00:00

  • Production and characterization of exopolysaccharides from Chlorella zofingiensis and Chlorella vulgaris with anti-colorectal cancer activity.

    abstract：:The production, physicochemical characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from Chlorella zofingiensis, Chlorella vulgaris were investigated. The final exopolysaccharides productions were 208.4, 364.3 mg/L and the average molecular weights were 2.66×104, 1.88×104 Da, r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.05.117

    authors： Zhang J,Liu L,Chen F

    更新日期：2019-08-01 00:00:00

  • Alginate/chitosan multilayer films coated on IL-4-loaded TiO2 nanotubes for modulation of macrophage phenotype.

    abstract：:Macrophage phenotype conversion is crucial for improving post-traumatic angiogenesis and tissue repair. Biomaterials with the ability of skewing macrophage phenotype have attracted widespread attention in the field of tissue engineering. The aim of this study was to transform macrophage phenotype by a three-step proce...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.184

    authors： Yin X,Li Y,Yang C,Weng J,Wang J,Zhou J,Feng B

    更新日期：2019-07-01 00:00:00

  • Optimization to development of chitosan decorated polycaprolactone nanoparticles for improved ocular delivery of dorzolamide: In vitro, ex vivo and toxicity assessments.

    abstract：:The present research work was designed to develop dorzolamide-loaded chitosan-coated polycaprolactone nanoparticles (DRZ-CS-PCL-NPs) for improved ocular delivery. The nanoparticles were prepared by single-step emulsification technique and optimized using the three-factor three-level Box-Behnken design. The optimized D...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.185

    authors： Shahab MS,Rizwanullah M,Alshehri S,Imam SS

    更新日期：2020-11-15 00:00:00

  • Synthesis and characterization of carboxymethyl potato starch and its application in reactive dye printing.

    abstract：:Carboxymethyl potato starch (CMPS) was synthesized with a simple dry and multi-step method as a product of the reaction of native potato starch and monochloroacetic acid in the presence of sodium hydroxide. The influence of the molar ratio of sodium hydroxide to anhydroglucose unit, the volume of 95% (v/v) ethanol, th...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.07.003

    authors： Zhang B,Gong H,Lü S,Ni B,Liu M,Gao C,Huang Y,Han F

    更新日期：2012-11-01 00:00:00

  • Synthesis and characterization of a new soluble soybean polysaccharide-iron(III) complex using ion exchange column.

    abstract：:A new ion exchange column method was investigated to synthesize the soluble soybean polysaccharide-iron(III) complex (SSPS-FeIII1) using soluble soybean polysaccharides (SSPS). The feasibility of ion exchange column reaction was explored firstly. Results indicated the D730 anion macroporous adsorption resin could effe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.11.038

    authors： Gao W,Huang Y,He R,Zeng XA

    更新日期：2018-03-01 00:00:00

  • Sandwich panel biocomposite of thermoplastic corn starch and bacterial cellulose.

    abstract：:Inadequate disposition and long period for degradation of Petroleum-derived polymers promote damages in the environment, which could be minimized by the use of biodegradable polymers such as starch and cellulose. Films of thermoplastic corn starch (TPS) and bacterial cellulose (BC) were used to produce sandwich panel ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.156

    authors： Santos TA,Spinacé MAS

    更新日期：2021-01-15 00:00:00

  • Fungicidal and anti-biofilm activities of trimethylchitosan-stabilized silver nanoparticles against Candida species in zebrafish embryos.

    abstract：:Herein, positively surface-charged silver nanoparticles (AgNPs) capped with trimethylchitosan nitrate (TMCN) were synthesized using an environmentally friendly method. Nano-sized TMCN-AgNPs (~80 nm) with high zeta potential (>30 mV) provide sufficient static repulsion to stabilize colloid AgNPs in aqueous solutions wi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.10.002

    authors： Wang SH,Chen CC,Lee CH,Chen XA,Chang TY,Cheng YC,Young JJ,Lu JJ

    更新日期：2020-01-15 00:00:00

  • Fabrication of biodegradable textile scaffold based on hydrophobized hyaluronic acid.

    abstract：:In this work, we report on the preparation of a novel biodegradable textile scaffold made of palmitoyl-hyaluronan (palHA). Monofilament fibres of palHA with a diameter of 120μm were prepared by wet spinning. The wet-spun fibres were subsequently processed into a warp-knitted textile. To find a compromise between swell...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.10.076

    authors： Zapotocky V,Pospisilova M,Janouchova K,Svadlak D,Batova J,Sogorkova J,Cepa M,Betak J,Stepankova V,Sulakova R,Kulhanek J,Pitucha T,Vranova J,Duffy G,Velebny V

    更新日期：2017-02-01 00:00:00

  • Synthesis of acryloylated starch-g-poly acrylates crosslinked polymer functionalized by emulsified vinyltrimethylsilane derivative as a novel EOR agent for severe polymer flooding strategy.

    abstract：:Starch is a natural polysaccharide with reasonable biodegradable properties, which grafted with vinyl monomers through different initiators to be applied in enhanced oil recovery (EOR) techniques. Several authors stated about starch modification through copolymerization and grafting of different monomers, however, the...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.056

    authors： El-Hoshoudy AN

    更新日期：2019-02-15 00:00:00

  • Lignin from oil palm empty fruit bunches: Characterization, biological activities and application in green synthesis of silver nanoparticles.

    abstract：:Lignin was extracted from oil palm empty fruit bunches under four different conditions. The lignin samples were characterized and employed in the green synthesis of silver nanoparticles. Two-dimensional HSQC NMR analysis showed that lignins extracted under more aggressive conditions (3.5% acid, 60 min) exhibited less ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.104

    authors： Zevallos Torres LA,Woiciechowski AL,Oliveira de Andrade Tanobe V,Zandoná Filho A,Alves de Freitas R,Noseda MD,Saito Szameitat E,Faulds C,Coutinho P,Bertrand E,Soccol CR

    更新日期：2021-01-15 00:00:00

  • Physicochemical functionality of 4-α-glucanotransferase-treated rice flour in food application.

    abstract：:The physicochemical properties of 4-α-glucanotransferase (4αGTase)-modified rice flours were examined by measuring the molecular weight distribution, moisture sorption isotherm, and melting enthalpy of ice crystals. The results obtained by measuring the moisture sorption isotherm and melting enthalpy of ice crystals r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.04.032

    authors： Kim YL,Mun S,Park KH,Shim JY,Kim YR

    更新日期：2013-09-01 00:00:00

  • Influences of drying methods on the structural, physicochemical and antioxidant properties of exopolysaccharide from Lactobacillus helveticus MB2-1.

    abstract：:In this study, in order to evaluate influences of different drying methods on the structural characteristics, physicochemical properties and antioxidant activities of exopolysaccharides (EPS) from Lactobacillus helveticus MB2-1, three drying methods, including spray-drying (SD), freeze-drying (FD) and spray freeze-dry...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.196

    authors： Xiao L,Li Y,Tian J,Zhou J,Xu Q,Feng L,Rui X,Fan X,Zhang Q,Chen X,Dong M,Li W

    更新日期：2020-08-15 00:00:00

  • Amorphous aggregate adducts of linker histone H1 turn highly immunologic in the cancers of oesophagus, stomach, gall bladder and ovary.

    abstract：:Hyperglycaemic influence on carcinogenesis and tumour progression is emerging as a link between diabetes and cancer. This work establishes the disturbed structural integrity of nucleosomal linker histone H1 by methyglyoxal (MG) and then correlates the role of modified H1 in the auto-immunopathogenesis of multiple canc...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.12.060

    authors： Mir AR,Moinuddin,Habib S

    更新日期：2017-03-01 00:00:00

  • Antitumor and immunomodulatory activity of polysaccharides from the root of Limonium sinense Kuntze.

    abstract：:Limonium sinense (Girard) Kuntze is a traditional Chinese folk medicine used for the treatment of fever, hemorrhage, hepatitis and other disorders. The study focused on the antitumor and immunomodulatory activities of L. sinense polysaccharides (LSP) which was obtained from the root of the plant. The antitumor effects...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2012.08.037

    authors： Tang XH,Yan LF,Gao J,Yang XL,Xu YX,Ge HY,Yang HD

    更新日期：2012-12-01 00:00:00

  • Time-domain NMR relaxometry as an alternative method for analysis of chitosan-paramagnetic ion interactions in solution.

    abstract：:Chitosan (CHI)-paramagnetic ion interactions in aqueous solution as affected by pH were studied using time-domain NMR (TD-NMR) relaxometry. Longitudinal (T1) and transverse (T2) relaxation times of CHI solutions with Fe3+, Cu2+, and Mn2+ were measured using a single-shot pulse sequence named CP-CWFPx-x. The results in...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.01.083

    authors： Kock FV,Monaretto T,Colnago LA

    更新日期：2017-05-01 00:00:00

  • Preparation, characterization, and 3D printing verification of chitosan/halloysite nanotubes/tea polyphenol nanocomposite films.

    abstract：:In this study, chitosan/halloysite nanotubes/tea polyphenol (CS/HNTs/TP) nanocomposite films were prepared by the solution casting method. The scanning electron microscopy (SEM) result showed that the nanocomposite film with a CS/HNTs ratio of 6:4 and a TP content of 10% (C6H4-TP10) had a relatively smooth surface and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.09.253

    authors： Wang Y,Yi S,Lu R,Sameen DE,Ahmed S,Dai J,Qin W,Li S,Liu Y

    更新日期：2021-01-01 00:00:00

  • Characterization and origin of bacterial arginine kinases.

    abstract：:Arginine kinase (AK) plays a key role in ATP buffering systems of tissues and nerves that display high and variable rates of ATP turnover and is widely distributed in invertebrate animals. The enzyme is also found in unicellular organisms, protists and bacteria, but its occurrence is intermittent among species. The AK...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2013.02.023

    authors： Suzuki T,Soga S,Inoue M,Uda K

    更新日期：2013-06-01 00:00:00

  • Cell-specific and pH-sensitive nanostructure hydrogel based on chitosan as a photosensitizer carrier for selective photodynamic therapy.

    abstract：:The major problems of porphyrins as promising materials for photodynamic therapy (PDT) are their low solubility, subsequently aggregation in biological environments, and a lack of tumor selectivity. With this in mind, a chitosan-based hydrogel conjugated with tetrakis(4-aminophenyl)porphyrin (NH2-TPP) and 2,4,6-tris(p...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.12.169

    authors： Belali S,Karimi AR,Hadizadeh M

    更新日期：2018-04-15 00:00:00