当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES期刊下所有文献 > Designing novel bioconjugates of hydroxyethyl cellulose and salicylates for potential pharmaceutical and pharmacological applications.

Designing novel bioconjugates of hydroxyethyl cellulose and salicylates for potential pharmaceutical and pharmacological applications.

Abstract：

:This deals with fabrication of macromolecular prodrugs (MPDs) of salicylic acid (SA) and aspirin (ASP) based on a hydrophilic cellulose ether, hydroxyethyl cellulose (HEC). Degrees of substitution (DS) of SA and ASP per HEC repeating unit (HEC-RU) were achieved ranging from 0.60 to 2.18 and 0.53 to1.50, respectively. The amphiphilic HEC-SA conjugate 2 assembled into nanowire-like structures, while HEC-ASP conjugate 6 formed nanoparticles (diameter 300-00nm) at a water/DMSO interface. After oral administration in rabbit models, conjugates 2 and 6 showed plasma half-life of 6.96 and 7.01h with maximum plasma concentration (Cmax) of 15.27 and 23.01μg L-1, respectively, and each reached peak plasma concentration (tmax) at 4.0h. Immunomodulatory assays (interleukin 6 and tumor necrosis factor-α values) revealed that anti-inflammatory properties of SA and ASP were unaltered in conjugates. Swelling inhibition of 61 and 71% was observed for conjugates 2 and 6, respectively, in a carrageenan induced paw edema test. Cytotoxic profiling (MTT assay) showed that conjugates were safe for administration in the concentration range of 2-10mM up to 24h. Thermal analyses revealed that Tdm values of SA and ASP conjugates were increased by 99 and 154̊C, respectively, indicating extraordinary thermal stability imparted to drugs after MPD formation.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Abbas K,Amin M,Hussain MA,Sher M,Bukhari SNA,Jantan I,Edgar KJ

doi

10.1016/j.ijbiomac.2017.05.061

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

441-450

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(17)30235-0

journal_volume

103

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES文献大全
  • Hydrogel synthesis based on lignin/sodium alginate and application in agriculture.

    abstract：:A new green hydrogel has been synthesized by crosslinking lignosulfonate (L), sodium alginate (SA) and konjaku flour (KJ). We have optimized the ratio of the three synthesized polymers using an orthogonal design of experiments and characterized this hydrogel using SEM, BET and FTIR spectra. We have added the hydrogel ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.12.082

    authors： Song B,Liang H,Sun R,Peng P,Jiang Y,She D

    更新日期：2020-02-01 00:00:00

  • Effect of increased PHA synthase activity on polyhydroxyalkanoates biosynthesis in Synechocystis sp. PCC6803.

    abstract：:Polyhydroxyalkanoate (PHA) synthase activity in Synechocystis sp. PCC6803 was increased two-fold by introducing the PHA biosynthetic genes of Ralstonia eutropha. The resulting recombinant Synechocystis sp. PCC6803 strain was subjected to conditions that favor PHA accumulation and the effects of various carbon sources ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/s0141-8130(02)00010-7

    authors： Sudesh K,Taguchi K,Doi Y

    更新日期：2002-04-08 00:00:00

  • Probing temperature and capsaicin-induced activation of TRPV1 channel via computationally guided point mutations in its pore and TRP domains.

    abstract：:In a recent computational study, we revealed some mechanistic aspects of TRPV1 (transient receptor potential channel 1) thermal activation and gating and proposed a set of probable functionally important residues - "hot spots" that have not been characterized experimentally yet. In this work, we analyzed TRPV1 point m...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.04.239

    authors： Lubova KI,Chugunov AO,Volynsky PE,Trofimov Y,Korolkova YV,Mosharova IV,Kozlov SA,Andreev YA,Efremov RG

    更新日期：2020-05-01 00:00:00

  • Design of a pH-sensitive magnetic composite hydrogel based on salecan graft copolymer and Fe3O4@SiO2 nanoparticles as drug carrier.

    abstract：:Salecan, a novel water-soluble extracellular β-glucan, is very suitable for the hydrogel preparation. Here, pH-sensitive magnetic composite hydrogel was fabricated by the graft copolymerization of crotonic acid (CA) and N-(hydroxymethyl) acrylamide (HMAA) onto salecan in the presence of Fe3O4@SiO2 nanoparticles for do...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2017.10.043

    authors： Hu X,Wang Y,Zhang L,Xu M,Zhang J,Dong W

    更新日期：2018-02-01 00:00:00

  • Current advancement on the isolation, characterization and application of lignin.

    abstract：:The most critical issues faced by the world nowadays is to provide the sustainability of consumption for energy and natural resources. Lignin is said to be one of the alternative new discoveries best-suited lignocellulosic biomass due to its low cost, sufficient availability and environmentally safe. The valuable prop...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.06.168

    authors： Liao JJ,Latif NHA,Trache D,Brosse N,Hussin MH

    更新日期：2020-11-01 00:00:00

  • Characterization of raw and alkali treated new natural cellulosic fibers from Tridax procumbens.

    abstract：:The aim of this study is to investigate natural cellulosic fibers extracted from Tridax procumbens plants. The obtained fibers were alkali treated for their effective usage as reinforcement in composites. The physical, chemical, crystallinity, thermal, wettability and surface characteristics were analyzed for raw, and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.12.056

    authors： Vijay R,Lenin Singaravelu D,Vinod A,Sanjay MR,Siengchin S,Jawaid M,Khan A,Parameswaranpillai J

    更新日期：2019-03-15 00:00:00

  • Unravelling property of polysaccharides from Sargassum sp. as an anti-wrinkle and skin whitening property.

    abstract：:In recent years, the natural ingredients are in high demand in formulating the cosmetic products. Seaweed polysaccharides signify the attractive natural ingredient with a wide range of functional properties that are expected for cosmeceutical formulations. The present work aimed to study the skin protection ability of...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.08.027

    authors： Jesumani V,Du H,Pei P,Zheng C,Cheong KL,Huang N

    更新日期：2019-11-01 00:00:00

  • Advances in upstream and downstream strategies of pectinase bioprocessing: A review.

    abstract：:This review aims to highlight the bioprocessing strategies behind one of the most commercially produced enzymes in the biotechnological market, pectinase. Significant steps in the upstream processing of this enzyme include its source, the selection of the substrate, the reaction conditions and the overall reactor desi...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2020.06.224

    authors： John J,Kaimal KKS,Smith ML,Rahman PKSM,Chellam PV

    更新日期：2020-11-01 00:00:00

  • Chitosan oligosaccharide-g-linalool polymer as inhibitor of hyaluronidase and collagenase activity.

    abstract：:In this study, chitosan oligosaccharide (COS) was modified by grafting Linalool (Lin) on its backbone to improve its anti-inflammatory activity. By changing the molar ratios of COS to Lin, three different degrees of substitution COS-g-Lin1-3 were prepared. The degrees of substitution of derivatives were 0.65, 0.80 and...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.036

    authors： Mao S,Liu X,Xia W

    更新日期：2021-01-01 00:00:00

  • Chemical modification of pullulan exopolysaccharide by octenyl succinic anhydride: Optimization, physicochemical, structural and functional properties.

    abstract：:Pullulan (PU) is an exo-polysaccharide used in the food and pharmaceutical industries. However, the use of PU in different industries is limited due to its highly hydrophilic nature and consequently weakness in surface properties which can be remedied by its chemical modification with octenyl succinic anhydride (OSA)....

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.08.158

    authors： Omar-Aziz M,Yarmand MS,Khodaiyan F,Mousavi M,Gharaghani M,Kennedy JF,Hosseini SS

    更新日期：2020-12-01 00:00:00

  • Characterization of α-D-glucan produced by a probiont Enterococcus hirae KX577639 from feces of south Indian Irula tribals.

    abstract：:Exopolysaccharide (EPS) producing probiotic strain Enterococcus hirae KX577639 were isolated from the feces of South Indian Irula tribes. EPS yield was 18.57 g/L (dry weight) at 48 h in 2% sucrose supplemented MRS medium. TLC and GC-MS analysis confirmed the presence of predominant glucose monomer indicating the homop...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.07.015

    authors： Jayamanohar J,Devi PB,Kavitake D,Rajendran S,Priyadarisini VB,Shetty PH

    更新日期：2018-10-15 00:00:00

  • Basic Helix-Loop-Helix (bHLH) transcription factor family in Yellow horn (Xanthoceras sorbifolia Bunge): Genome-wide characterization, chromosome location, phylogeny, structures and expression patterns.

    abstract：:Yellow horn (Xanthoceras sorbifolia Bunge) is a oil-rich, woody deciduous shrub with exceptional economic and ecological values. Basic Helix-Loop-Helix (bHLH) transcription factor (TF) family fulfills crucial biological functions in plant. However, genome-wide survey of the bHLH genes in yellow horn has not been perfo...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.05.253

    authors： Lang Y,Liu Z

    更新日期：2020-10-01 00:00:00

  • Macromolecular agents with antimicrobial potentialities: A drive to combat antimicrobial resistance.

    abstract：:In recent years, the antimicrobial resistance (AMR) or multidrug resistance (MDR) has become a serious health concern and major challenging issue, worldwide. After decades of negligence, the AMR has now captured global attention. The increasing number of antibiotic-resistant strains has threatened the achievements of ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijbiomac.2017.05.071

    authors： Bilal M,Rasheed T,Iqbal HMN,Hu H,Wang W,Zhang X

    更新日期：2017-10-01 00:00:00

  • The benzene metabolite p-benzoquinone inhibits the catalytic activity of bovine liver catalase: A biophysical study.

    abstract：:The current communication reports the inhibitory effect of para-benzoquinone (p-BQ) on the structure and function of bovine liver catalase (BLC), a vital antioxidant enzyme. Both BLC and p-BQ were dissolved in respective buffers and the biophysical interaction was studied at physiological concentrations. For the first...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.11.044

    authors： Jena AB,Samal RR,Kumari K,Pradhan J,Chainy GBN,Subudhi U,Pal S,Dandapat J

    更新日期：2021-01-15 00:00:00

  • Electrochemical, spectroscopic, and theoretical studies on the interaction between azathioprine and DNA.

    abstract：:Possible interaction between immunosuppressive drug, azathioprine, and calf thymus DNA was explored by cyclic voltammetry, spectrophotometry, competitive spectrofluorimetry, circular dichroism spectroscopy (CD), and viscosity measurements. Cyclic voltammetry showed negative shift in the reduction peak of azathioprine ...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2015.08.025

    authors： Jalali F,Rasaee G

    更新日期：2015-11-01 00:00:00

  • Structural analysis of homologous repeated domains in alpha-actinin and spectrin.

    abstract：:The amino acid sequences of chick and slime mould alpha-actinin each contain four repeats of approximately 122 residues. These repeats are homologous to the 18-22 repeats, each of approximately 106 residues, found in the alpha and beta subunits of spectrin and fodrin, and to the multiple repeats of approximately 110 r...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(89)90047-0

    authors： Davison MD,Baron MD,Critchley DR,Wootton JC

    更新日期：1989-04-01 00:00:00

  • Size controllable one step synthesis of gold nanoparticles using carboxymethyl chitosan.

    abstract：:Gold nanoparticles (AuNPs) were synthesized by reducing chloroauric acid with nontoxic and biodegradable carboxymethyl chitosan (CMC) as dual roles of reducing agent and stabilizer. Several CMC with different molecular parameters, i.e., degree of substitution (DS), substitution position, degree of deacetylation (DD) a...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.11.006

    authors： Sun L,Pu S,Li J,Cai J,Zhou B,Ren G,Ma Q,Zhong L

    更新日期：2019-02-01 00:00:00

  • Modulating the gut microbiota and inflammation is involved in the effect of Bupleurum polysaccharides against diabetic nephropathy in mice.

    abstract：:Dysbiosis of gut microbiota and low grade inflammation has gradually become a highly potential therapeutic agent for diabetic nephropathy (DN). It has been reported that a large number of polysaccharides have positive effects on DN, including Bupleurum polysaccharides. However, the mechanism remained unclear. This stu...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.242

    authors： Feng Y,Weng H,Ling L,Zeng T,Zhang Y,Chen D,Li H

    更新日期：2019-07-01 00:00:00

  • Antinociceptive activity of a polysaccharide from the roots of Sophora flavescens.

    abstract：:A polysaccharide (SFWP), with a molecular weight of 51kDa, was successfully purified from the roots of Sophora flavescens and the antinociceptive actions of SFWP were evaluated using acetic acid induced writhing, tail flick, and formalin tests in mice. GC-MS results showed that SFWP had a backbone composed of (1→2)-li...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.08.054

    authors： Jia R,Li Q,Shen W,Zhang J,Zheng L,Wang G

    更新日期：2016-12-01 00:00:00

  • Tuning the microstructure and electrochemical behavior of lignin-based ultrafine carbon fibers via hydrogen-bonding interaction.

    abstract：:Hardwood Kraft lignin (HKL)-based ultrafine carbon fibers with different pore structures and properties were prepared by controlling the intermolecular interaction between HKL and incorporated poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG-PPG-PEG) triblock copolymer. The thermal p...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.235

    authors： Wang S,Innocent MT,Chen J,Wang Q,Ma W,Tang J

    更新日期：2020-08-15 00:00:00

  • KGM-based magnetic carbon aerogels matrix for the uptake of methylene blue and methyl orange.

    abstract：:In this study, the preparation of magnetic Fe and Mn oxides (Mag-FMBO) loaded carbon aerogels (CA) based on konjac glucomannan (KGM) and their performance for dyes adsorption were investigated. The prepared magnetic carbon aerogels (Mag-CA) materials were characterized by various methods, including BET surface area an...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2016.07.106

    authors： Ye S,Jin W,Huang Q,Hu Y,Li Y,Li B

    更新日期：2016-11-01 00:00:00

  • Effect of triglyceride on complexation between starch and fatty acid.

    abstract：:This study aimed to reveal the effect of corn oil on formation of complex between rice starch and fatty acids, including lauric acid (C12:0), myristic acid (C14:0), palmitic acid (C16:0) and stearic acid (C18:0). The RVA, XRD, DSC and CLSM analysis confirmed formation of starch-fatty acid complex but the starch-trigly...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.11.072

    authors： Li X,Luo S,Hou Y,Liu Y,Hu X,Liu C

    更新日期：2020-07-15 00:00:00

  • Rheological behavior of wheat starch and barley resistant starch (type IV) blends and their starch noodles making potential.

    abstract：:Barley starch citrate (BSC), a type IV resistant starch (RS) is associated with numerous health benefits when incorporated in bakery products. Physicochemical, pasting and rheological properties of the wheat starch (WS) and wheat starch-barley starch citrate (WS-BSC) blends and textural and sensorial attributes of whe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2019.03.009

    authors： Punia S,Siroha AK,Sandhu KS,Kaur M

    更新日期：2019-06-01 00:00:00

  • Preparation and characterization of contact active antibacterial surface based on chemically modified nanofibrillated cellulose by phenanthridinium silane salt.

    abstract：:The main object of this research is chemical modification of the nanofibrillated cellulose (NFC) surface with a phenanthridinium silane salt to develop durable non-leaching antibacterial surface. Initially, (3-trimethoxysilylpropyl) phenanthridinium iodide (TMSPhI) as an antibacterial agent was synthesized using (3-ch...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2018.03.141

    authors： Hassanpour A,Asghari S,Mansour Lakouraj M,Mohseni M

    更新日期：2018-08-01 00:00:00

  • Inhibition of ATPase activity of Escherichia coli ATP synthase by polyphenols.

    abstract：:We have studied the inhibitory effect of five polyphenols namely, resveratrol, piceatannol, quercetin, quercetrin, and quercetin-3-beta-D glucoside on Escherichia coli ATP synthase. Recently published X-ray crystal structures of bovine mitochondrial ATP synthase inhibited by resveratrol, piceatannol, and quercetin, su...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2009.04.004

    authors： Dadi PK,Ahmad M,Ahmad Z

    更新日期：2009-07-01 00:00:00

  • A peroxiredoxin of Thermus thermophilus HB27: Biochemical characterization of a new player in the antioxidant defence.

    abstract：:To fight oxidative damage due to reactive oxygen species (ROS), cells are equipped of different enzymes, among which Peroxiredoxins (Prxs) (EC 1.11.1.15) play a key role. Prxs are thiol-based enzymes containing one (1-Cys Prx) or two (2-Cys Prx) catalytic cysteine residues. In 2-Cys Prxs the cysteine residues form a d...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.03.052

    authors： Fiorentino G,Contursi P,Gallo G,Bartolucci S,Limauro D

    更新日期：2020-06-15 00:00:00

  • Two-step purification procedure for recombinant human asialoerythropoietin expressed in transgenic plants.

    abstract：:Asialoerythropoietin (asialo-EPO) is a desialylated form of human glycoprotein hormone erythropoietin (EPO), which has been reported to be neuro-, cardio-, and renoprotective in animal models of organ injuries. Since the current method of production of asialo-EPO from mammalian cell-made recombinant human EPO (rhuEPO(...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2014.10.033

    authors： Kittur FS,Arthur E,Nguyen M,Hung CY,Sane DC,Xie J

    更新日期：2015-01-01 00:00:00

  • Laccase immobilization on the tailored cellulose-based Granocel carriers.

    abstract：:Extracellular laccase produced by Cerrena unicolor was immobilized by adsorption or covalent bonds formation on the cellulose-based carrier Granocel. Immobilization was optimized by changing the anchor groups and the methods of activation/immobilization. On the base of measured activity and stability of immobilized pr...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2007.09.014

    authors： Rekuć A,Kruczkiewicz P,Jastrzembska B,Liesiene J,Peczyńska-Czoch W,Bryjak J

    更新日期：2008-03-01 00:00:00

  • Applications of gellan natural polymer microspheres in recombinant catechol-O-methyltransferase direct capture from a Komagataella pastoris lysate.

    abstract：:The present work shows the application of nickel- and magnesium-crosslinked gellan microspheres in ionic and affinity capture strategies to directly extract hSCOMT from the complex Komagataella pastoris lysate through a simple batch method. Both formulations present similar morphology, but nickel-crosslinked microsphe...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/j.ijbiomac.2020.12.225

    authors： Gomes D,Gonçalves C,Gonçalves AM,Queiroz JA,Sousa A,Passarinha LA

    更新日期：2021-01-07 00:00:00

  • Enzymatic degradation of poly(hydroxyalkanoates) by Pseudomonas pickettii.

    abstract：:A bacterium capable of degrading poly(3-hydroxybutyrate) [P(3HB)] was isolated from laboratory media and identified as Pseudomonas pickettii. The strain P. pickettii excreted an extracellular poly(hydroxyalkanoate) (PHA) depolymerase and grew on P(3HB) as the sole carbon source. P. pickettii also grew on 3-hydroxybuty...

    journal_title：International journal of biological macromolecules

    pub_type： 杂志文章

    doi：10.1016/0141-8130(93)90040-s

    authors： Yamada K,Mukai K,Doi Y

    更新日期：1993-08-01 00:00:00