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Chitosan oligosaccharide-g-linalool polymer as inhibitor of hyaluronidase and collagenase activity.

Abstract：

:In this study, chitosan oligosaccharide (COS) was modified by grafting Linalool (Lin) on its backbone to improve its anti-inflammatory activity. By changing the molar ratios of COS to Lin, three different degrees of substitution COS-g-Lin1-3 were prepared. The degrees of substitution of derivatives were 0.65, 0.80 and 1.14 respectively. The structure of COS-g-Lin1-3 were characterized by UV-vis, FT-IR, 1H NMR and elemental analysis in order to show the COS-g-Lin1-3 successfully synthesized. Besides, the thermal stability, solubility, pH stability as well as crystallinity were also investigated. The results revealed that the derivatives exhibited higher thermal stability and more remarkable anti-inflammatory property against hyaluronidase and collagenase than that of COS. The good biocompatibility made this novel material a promising and effective compound for anti-inflammatory applications.

journal_name

Int J Biol Macromol

journal_title

International journal of biological macromolecules

authors

Mao S,Liu X,Xia W

doi

10.1016/j.ijbiomac.2020.11.036

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

1570-1577

eissn

0141-8130

issn

1879-0003

pii

S0141-8130(20)34961-8

journal_volume

166

pub_type

杂志文章

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